Aprobarbital and its Impurities

Aprobarbital (or aprobarbitone), sold as Oramon, Somnifaine, and Allonal, is a barbiturate derivative. It has sedative, hypnotic and anticonvulsant properties, and was used primarily for the treatment of insomnia. Reference standards of Aprobarbital API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.