Displaying 31 results for esomeprazole

Esomeprazole - API

Esomeprazole


  • Catalogue No.:PA 05 17000

  • CAS : 119141-88-7

  • Molecular Formula : C17H19N3O3S

  • Molecular Weight : 345.42

Esomeprazole - Impurity A

5-Methoxy-2-mercaptobenzimidazole


  • Catalogue No.:PA 05 18010

  • CAS : 37052-78-1

  • Molecular Formula : C8H8N2OS

  • Molecular Weight : 180.23

Esomeprazole - Impurity B

4-Desmethoxy Omeprazole


  • Catalogue No.:PA 05 18020

  • CAS : 110374-16-8

  • Molecular Formula : C16H17N3O2S

  • Molecular Weight : 315.39

Esomeprazole - Impurity C

Omeprazole Sulfide


  • Catalogue No.:PA 05 18030

  • CAS : 73590-85-9

  • Molecular Formula : C17H19N3O2S

  • Molecular Weight : 329.42

Esomeprazole - Impurity D

Omeprazole Sulphone


  • Catalogue No.:PA 05 18040

  • CAS : 88546-55-8

  • Molecular Formula : C17H19N3O4S

  • Molecular Weight : 361.42

Esomeprazole - Impurity E

Omeprazole N-Oxide


  • Catalogue No.:PA 05 18050

  • CAS : 176219-04-8

  • Molecular Formula : C17H19N3O4S

  • Molecular Weight : 361.42

Esomeprazole - Impurity F

Esomeprazole R-Isomer Sodium Salt


  • Catalogue No.:PA 05 18060

  • CAS : 161796-77-6

  • Molecular Formula : C17H18N3NaO3S

  • Molecular Weight : 367.40

Esomeprazole - Impurity H

4-Desmethoxy-4-chloro Omeprazole


  • Catalogue No.:PA 05 18080

  • CAS : 863029-89-4

  • Molecular Formula : C16H16ClN3O2S

  • Molecular Weight : 349.84

Esomeprazole - Impurity I

Omeprazole Sulfone N-Oxide


  • Catalogue No.:PA 05 18090

  • CAS : 158812-85-2

  • Molecular Formula : C17H19N3O5S

  • Molecular Weight : 377.41

Esomeprazole - In house impurity

Esomeprazole Potassium


  • Catalogue No.:PA 05 18510

  • CAS : 161796-84-5

  • Molecular Formula : C17H19KN3O3S

  • Molecular Weight : 384.51

Esomeprazole - In house impurity

Esomeprazole Sodium


  • Catalogue No.:PA 05 18520

  • CAS : 161796-78-7

  • Molecular Formula : C17H18N3NaO3S

  • Molecular Weight : 367.40

Esomeprazole - In house impurity

2-(5-Methoxy-1H-benzoimidazole-2-ylmethyl)-3,5-dimethyl-1H-pyridin-4-one


  • Catalogue No.:PA 05 18530

  • CAS : NA

  • Molecular Formula : C16H17N3O2

  • Molecular Weight : 283.33

Esomeprazole - In house impurity

2-((5-Methoxy-1H-benzo[d]imidazole-2-ylthio)methyl)-3,5-dimethylpyridin-4-ol


  • Catalogue No.:PA 05 18540

  • CAS : 103876-98-8

  • Molecular Formula : C16H17N3O2S

  • Molecular Weight : 315.39

Esomeprazole - In house impurity

1-(6-Methoxy-1H-benzo[d]imidazol-2-yl)-3,5-dimethyl-4-oxo-1,4-dihydropyridine-2-carboxylic Acid


  • Catalogue No.:PA 05 18550

  • CAS : NA

  • Molecular Formula : C16H15N3O4

  • Molecular Weight : 313.31

Esomeprazole - In house impurity

3,5-Dimethyl-4-nitropyridine 1-Oxide


  • Catalogue No.:PA 05 18560

  • CAS : 14248-66-9

  • Molecular Formula : C7H8N2O3

  • Molecular Weight : 168.15

Esomeprazole - In house impurity

2-(Chloromethyl)-3,5-dimethylpyridine Hydrochloride


  • Catalogue No.:PA 05 18570

  • CAS : 73590-93-9

  • Molecular Formula : C8H11Cl2N

  • Molecular Weight : 192.09

Esomeprazole - In house impurity

2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine Hydrochloride


  • Catalogue No.:PA 05 18580

  • CAS : NA

  • Molecular Formula : C8H10Cl2N2O2

  • Molecular Weight : 237.08

Esomeprazole - In house impurity

1-(5-Methoxy-1H-benzimidazol-2-yl)-3,5-dimethyl-4-oxo-1,4-dihydro-2-pyridinecarboxylic Acid


  • Catalogue No.:PA 05 18590

  • CAS : 1227380-90-6

  • Molecular Formula : C16H15N3O4

  • Molecular Weight : 313.31

Esomeprazole - In house impurity

2-(Mercaptomethyl)-4-methoxy-1-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3,5-dimethylpyridin-1-ium Chloride


  • Catalogue No.:PA 05 18600

  • CAS : NA

  • Molecular Formula : C17H20ClN3O2S

  • Molecular Weight : 365.88

Esomeprazole-d3 Sodium Salt


  • Catalogue No.:PA STI 037810

  • CAS : NA

  • Molecular Formula : C17H15D3N3NaO3S

  • Molecular Weight : 370.42

Esomeprazole-D6


  • Catalogue No.:PA STI 037811

  • CAS : 922800-06-4

  • Molecular Formula : C17H13D6N3O3S

  • Molecular Weight : 351.45

Esomeprazole-d3 Potassium Salt


  • Catalogue No.:PA STI 037812

  • CAS : NA

  • Molecular Formula : C17H15D3KN3O3S

  • Molecular Weight : 386.52

Esomeprazole - In house impurity

12-Mercapto-8-methoxy-1,3-dimethylbenzo[4',5']imidazo[2',1':2,3]imidazo[1,5-a]pyridin-2-ol


  • Catalogue No.:PA 05 18610

  • CAS : NA

  • Molecular Formula : C16H15N3O2S

  • Molecular Weight : 313.38

Esomeprazole - In house impurity

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine 1-Oxide


  • Catalogue No.:PA 05 18620

  • CAS : 848694-10-0

  • Molecular Formula : C9H12ClNO2

  • Molecular Weight : 201.65

Esomeprazole - In house impurity

Lithium 1-(6-methoxy-1H-benzo[d]imidazol-2-yl)-3,5-dimethyl-4-oxo-1,4-dihydropyridine-2-carboxylate


  • Catalogue No.:PA 05 18630

  • CAS : NA

  • Molecular Formula : C16H14LiN3O4

  • Molecular Weight : 319.25

Esomeprazole Magnesium Trihydrate (IPRS/52/11)


  • Catalogue No.:PA IP-IPRS 52 11

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Esomeprazole magnesium trihydrate (Y0001028)


  • Catalogue No.:PA EP-Y0001028

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Esomeprazole magnesium dihydrate (Y0001660)


  • Catalogue No.:PA EP-Y0001660

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Esomeprazole Magnesium (1249789)


  • Catalogue No.:PA USP-1249789

  • CAS : 217087-09-7

  • Molecular Formula :

  • Molecular Weight : 0.00

Esomeprazole Strontium (1249803)


  • Catalogue No.:PA USP-1249803

  • CAS : 934714-36-0

  • Molecular Formula :

  • Molecular Weight : 0.00

Esomeprazole - Impurity F (Potassium Salt)

Esomeprazole R-Isomer Potassium Salt


  • Catalogue No.:PA 05 18061

  • CAS : NA

  • Molecular Formula : C17H18KN3O3S

  • Molecular Weight : 383.51

Whoops! There was an error.
UnexpectedValueException
The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied UnexpectedValueException thrown with message "The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied" Stacktrace: #10 UnexpectedValueException in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php:107 #9 Monolog\Handler\StreamHandler:write in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Handler/AbstractProcessingHandler.php:37 #8 Monolog\Handler\AbstractProcessingHandler:handle in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Logger.php:337 #7 Monolog\Logger:addRecord in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Logger.php:616 #6 Monolog\Logger:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php:179 #5 Illuminate\Log\Logger:writeLog in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php:90 #4 Illuminate\Log\Logger:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/LogManager.php:524 #3 Illuminate\Log\LogManager:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Exceptions/Handler.php:113 #2 Illuminate\Foundation\Exceptions\Handler:report in /home/pharmaaffiliates/public_html/app/Exceptions/Handler.php:43 #1 App\Exceptions\Handler:report in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Bootstrap/HandleExceptions.php:81 #0 Illuminate\Foundation\Bootstrap\HandleExceptions:handleException in [internal]:0
10
UnexpectedValueException
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Handler.php
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Handler.php
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HandleExceptions.php
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HandleExceptions
handleException
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StreamHandler.php
    /**
     * {@inheritdoc}
     */
    protected function write(array $record)
    {
        if (!is_resource($this->stream)) {
            if (null === $this->url || '' === $this->url) {
                throw new \LogicException('Missing stream url, the stream can not be opened. This may be caused by a premature call to close().');
            }
            $this->createDir();
            $this->errorMessage = null;
            set_error_handler(array($this, 'customErrorHandler'));
            $this->stream = fopen($this->url, 'a');
            if ($this->filePermission !== null) {
                @chmod($this->url, $this->filePermission);
            }
            restore_error_handler();
            if (!is_resource($this->stream)) {
                $this->stream = null;
                throw new \UnexpectedValueException(sprintf('The stream or file "%s" could not be opened: '.$this->errorMessage, $this->url));
            }
        }
 
        if ($this->useLocking) {
            // ignoring errors here, there's not much we can do about them
            flock($this->stream, LOCK_EX);
        }
 
        $this->streamWrite($this->stream, $record);
 
        if ($this->useLocking) {
            flock($this->stream, LOCK_UN);
        }
    }
 
    /**
     * Write to stream
     * @param resource $stream
     * @param array $record
     */
Arguments
  1. "The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied"
    
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AbstractProcessingHandler.php
 *
 * @author Jordi Boggiano <j.boggiano@seld.be>
 * @author Christophe Coevoet <stof@notk.org>
 */
abstract class AbstractProcessingHandler extends AbstractHandler
{
    /**
     * {@inheritdoc}
     */
    public function handle(array $record)
    {
        if (!$this->isHandling($record)) {
            return false;
        }
 
        $record = $this->processRecord($record);
 
        $record['formatted'] = $this->getFormatter()->format($record);
 
        $this->write($record);
 
        return false === $this->bubble;
    }
 
    /**
     * Writes the record down to the log of the implementing handler
     *
     * @param  array $record
     * @return void
     */
    abstract protected function write(array $record);
 
    /**
     * Processes a record.
     *
     * @param  array $record
     * @return array
     */
    protected function processRecord(array $record)
    {
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571597990 {#33
        date: 2019-10-20 18:59:50.121104 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 18:59:50] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6InVBVWx...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6InVBVWx...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('wDRunsEnapCt99F...', 'eyJpdiI6InVBVWx...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
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Logger.php
            $ts = new \DateTime(null, static::$timezone);
        }
        $ts->setTimezone(static::$timezone);
 
        $record = array(
            'message' => (string) $message,
            'context' => $context,
            'level' => $level,
            'level_name' => $levelName,
            'channel' => $this->name,
            'datetime' => $ts,
            'extra' => array(),
        );
 
        foreach ($this->processors as $processor) {
            $record = call_user_func($processor, $record);
        }
 
        while ($handler = current($this->handlers)) {
            if (true === $handler->handle($record)) {
                break;
            }
 
            next($this->handlers);
        }
 
        return true;
    }
 
    /**
     * Adds a log record at the DEBUG level.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function addDebug($message, array $context = array())
    {
        return $this->addRecord(static::DEBUG, $message, $context);
    }
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571597990 {#33
        date: 2019-10-20 18:59:50.121104 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 18:59:50] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6InVBVWx...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6InVBVWx...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('wDRunsEnapCt99F...', 'eyJpdiI6InVBVWx...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
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Logger.php
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function err($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the ERROR level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function error($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function crit($message, array $context = array())
    {
        return $this->addRecord(static::CRITICAL, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
Arguments
  1. 400
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
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Logger.php
     * @return void
     */
    public function write($level, $message, array $context = [])
    {
        $this->writeLog($level, $message, $context);
    }
 
    /**
     * Write a message to the log.
     *
     * @param  string  $level
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    protected function writeLog($level, $message, $context)
    {
        $this->fireLogEvent($level, $message = $this->formatMessage($message), $context);
 
        $this->logger->{$level}($message, $context);
    }
 
    /**
     * Register a new callback handler for when a log event is triggered.
     *
     * @param  \Closure  $callback
     * @return void
     *
     * @throws \RuntimeException
     */
    public function listen(Closure $callback)
    {
        if (! isset($this->dispatcher)) {
            throw new RuntimeException('Events dispatcher has not been set.');
        }
 
        $this->dispatcher->listen(MessageLogged::class, $callback);
    }
 
    /**
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
Logger.php
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function critical($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log an error message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function error($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a warning message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function warning($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a notice to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
Arguments
  1. "error"
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
LogManager.php
     *
     * @return void
     */
    public function critical($message, array $context = [])
    {
        return $this->driver()->critical($message, $context);
    }
 
    /**
     * Runtime errors that do not require immediate action but should typically
     * be logged and monitored.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function error($message, array $context = [])
    {
        return $this->driver()->error($message, $context);
    }
 
    /**
     * Exceptional occurrences that are not errors.
     *
     * Example: Use of deprecated APIs, poor use of an API, undesirable things
     * that are not necessarily wrong.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function warning($message, array $context = [])
    {
        return $this->driver()->warning($message, $context);
    }
 
    /**
     * Normal but significant events.
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Exceptions
/
Handler.php
     */
    public function report(Exception $e)
    {
        if ($this->shouldntReport($e)) {
            return;
        }
 
        if (method_exists($e, 'report')) {
            return $e->report();
        }
 
        try {
            $logger = $this->container->make(LoggerInterface::class);
        } catch (Exception $ex) {
            throw $e;
        }
 
        $logger->error(
            $e->getMessage(),
            array_merge($this->context(), ['exception' => $e]
        ));
    }
 
    /**
     * Determine if the exception should be reported.
     *
     * @param  \Exception  $e
     * @return bool
     */
    public function shouldReport(Exception $e)
    {
        return ! $this->shouldntReport($e);
    }
 
    /**
     * Determine if the exception is in the "do not report" list.
     *
     * @param  \Exception  $e
     * @return bool
     */
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
app
/
Exceptions
/
Handler.php
        \Illuminate\Auth\AuthenticationException::class,
        \Illuminate\Auth\Access\AuthorizationException::class,
        \Symfony\Component\HttpKernel\Exception\HttpException::class,
        \Illuminate\Database\Eloquent\ModelNotFoundException::class,
        \Illuminate\Session\TokenMismatchException::class,
        \Illuminate\Validation\ValidationException::class,
    ];
 
    /**
     * Report or log an exception.
     *
     * This is a great spot to send exceptions to Sentry, Bugsnag, etc.
     *
     * @param \Exception $exception
     *
     * @return void
     */
    public function report(Exception $exception)
    {
        parent::report($exception);
    }
 
    /**
     * Render an exception into an HTTP response.
     *
     * @param \Illuminate\Http\Request $request
     * @param \Exception               $exception
     *
     * @return \Illuminate\Http\Response
     */
    public function render($request, Exception $exception)
    {
        //dd($exception);
        if (strpos($request->url(), '/api/') !== false) {
            \Log::debug('API Request Exception - '.$request->url().' - '.$exception->getMessage().(!empty($request->all()) ? ' - '.json_encode($request->except(['password'])) : ''));
 
            if ($exception instanceof AuthorizationException) {
                return $this->setStatusCode(403)->respondWithError($exception->getMessage());
            }
 
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Bootstrap
/
HandleExceptions.php
    }
 
    /**
     * Handle an uncaught exception from the application.
     *
     * Note: Most exceptions can be handled via the try / catch block in
     * the HTTP and Console kernels. But, fatal error exceptions must
     * be handled differently since they are not normal exceptions.
     *
     * @param  \Throwable  $e
     * @return void
     */
    public function handleException($e)
    {
        if (! $e instanceof Exception) {
            $e = new FatalThrowableError($e);
        }
 
        try {
            $this->getExceptionHandler()->report($e);
        } catch (Exception $e) {
            //
        }
 
        if ($this->app->runningInConsole()) {
            $this->renderForConsole($e);
        } else {
            $this->renderHttpResponse($e);
        }
    }
 
    /**
     * Render an exception to the console.
     *
     * @param  \Exception  $e
     * @return void
     */
    protected function renderForConsole(Exception $e)
    {
        $this->getExceptionHandler()->renderForConsole(new ConsoleOutput, $e);
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
[internal]
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/wDRunsEnapCt99FwYAjFwMIOSVpay4tq7WYn4uVm): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    

Environment & details:

empty
empty
empty
empty
empty
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
HTTP_ACCEPT
"text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8"
HTTP_ACCEPT_ENCODING
"gzip"
HTTP_ACCEPT_LANGUAGE
"en-US,en;q=0.5"
HTTP_CONNECTION
"Keep-Alive"
HTTP_HOST
"www.pharmaffiliates.com"
HTTP_USER_AGENT
"CCBot/2.0 (https://commoncrawl.org/faq/)"
HTTP_IF_MODIFIED_SINCE
"Tue, 16 Jul 2019 13:28:15 PDT"
DOCUMENT_ROOT
"/home/pharmaaffiliates/public_html"
REMOTE_ADDR
"3.228.24.192"
REMOTE_PORT
"35324"
SERVER_ADDR
"172.105.43.57"
SERVER_NAME
"www.pharmaffiliates.com"
SERVER_ADMIN
"webmaster@pharmaffiliates.com"
SERVER_PORT
"443"
REQUEST_URI
"/en/parentapi/esomeprazole"
REDIRECT_URL
"/en/parentapi/esomeprazole"
HTTPS
"on"
REDIRECT_STATUS
"200"
SSL_PROTOCOL
"TLSv1.2"
SSL_SESSION_ID
"d6e40b116f582aac04c1036ddbd60890eb93824f20a9614010edb98c3a347688"
SSL_CIPHER
"ECDHE-RSA-AES256-GCM-SHA384"
SSL_CIPHER_USEKEYSIZE
"256"
SSL_CIPHER_ALGKEYSIZE
"256"
SCRIPT_FILENAME
"/home/pharmaaffiliates/public_html/index.php"
QUERY_STRING
""
SCRIPT_URI
"https://www.pharmaffiliates.com/en/parentapi/esomeprazole"
SCRIPT_URL
"/en/parentapi/esomeprazole"
SCRIPT_NAME
"/index.php"
SERVER_PROTOCOL
"HTTP/1.1"
SERVER_SOFTWARE
"LiteSpeed"
REQUEST_METHOD
"GET"
X-LSCACHE
"on"
PHP_SELF
"/index.php"
REQUEST_TIME_FLOAT
1571597989.8438
REQUEST_TIME
1571597989
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
0. Whoops\Handler\PrettyPageHandler