everolimus and its Impurities
Everolimus is currently used as an immunosuppressant to prevent rejection of organ transplants. It is a derivative of Rapamycin, and works similarly to Rapamycin as an mTOR inhibitor. Reference standards of Everolimus API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
(2S)-1-[[(2R,3R,6S)-6-[(2S,3E,5E,7E,9S,11R)-2,13-Dimethoxy-3,9,11-trimethyl-12-oxo-3,5,7-tridecatrienyl]tetrahydro-2-hydroxy-3-methyl-2H-pyran-2-yl]oxoacetyl]-2-piperidinecarboxylic Acid
(2S)-1-[[(2R,3R,6S)-6-[(2S,3E,5E,7E,9S,11R)-2,13-Dimethoxy-3,9,11-trimethyl-12-oxo-3,5,7-tridecatrienyl]tetrahydro-2-hydroxy-3-methyl-2H-pyran-2-yl]oxoacetyl]-2-piperidinecarboxylic Acid
Catalogue No.:PA 05 73550
CAS :
147438-30-0
Molecular Formula : C32H49NO9
Molecular Weight : 591.73
1-(2-((2R,3R,6S)-2-Hydroxy-6-((2S,3E,5E,7E,9S,11R,14R,15E,17R,19E,21R)-14-hydroxy-22-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl)-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic Acid
1-(2-((2R,3R,6S)-2-Hydroxy-6-((2S,3E,5E,7E,9S,11R,14R,15E,17R,19E,21R)-14-hydroxy-22-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl)-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 05 73570
CAS :
NA
Molecular Formula : C53H83NO14
Molecular Weight : 958.22
(S)-(2R,3S,6R,E)-1-((1S,3R,4R)-4-(2-Hydroxyethoxy)-3-methoxycyclohexyl)-2,6,8-trimethyl-5,9-dioxonon-7-en-3-yl 1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylate
(S)-(2R,3S,6R,E)-1-((1S,3R,4R)-4-(2-Hydroxyethoxy)-3-methoxycyclohexyl)-2,6,8-trimethyl-5,9-dioxonon-7-en-3-yl 1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylate
Catalogue No.:PA 05 73580
CAS :
1708118-13-1
Molecular Formula : C53H83NO14
Molecular Weight : 958.22
1-(2-((2R,6S)-2-Hydroxy-6-((2R,3E,5E,7E,9R,11S,14R,15E,17S,19E,22R)-14-hydroxy-22-((1S,3R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxotricosa-3,5,7,15,19-pentaen-1-yl)tetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic Acid
1-(2-((2R,6S)-2-Hydroxy-6-((2R,3E,5E,7E,9R,11S,14R,15E,17S,19E,22R)-14-hydroxy-22-((1S,3R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxotricosa-3,5,7,15,19-pentaen-1-yl)tetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 05 73590
CAS :
NA
Molecular Formula : C53H83NO14
Molecular Weight : 958.22
(1R,9S,12S,15S,16E,18R,19R,21R,23S,24Z,26E,28E,30S,35R)-1-18-Dihydroxy-12{(1R)-2-[1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04.9]-hexatriaconta-16,24,26,28,-tetraene-2,3,10,14,20-pentanone
(1R,9S,12S,15S,16E,18R,19R,21R,23S,24Z,26E,28E,30S,35R)-1-18-Dihydroxy-12{(1R)-2-[1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04.9]-hexatriaconta-16,24,26,28,-tetraene-2,3,10,14,20-pentanone
Catalogue No.:PA 05 73630
CAS :
NA
Molecular Formula : C53H83NO14
Molecular Weight : 958.22
(1R,9S,12S,15S,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-1-Hydroxy-12{(1R)-2-[1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04.9]-hexatriaconta-16,24,26,28,-tetraene-2,3,10,14,18,20-Hexanone
(1R,9S,12S,15S,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-1-Hydroxy-12{(1R)-2-[1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04.9]-hexatriaconta-16,24,26,28,-tetraene-2,3,10,14,18,20-Hexanone
Catalogue No.:PA 05 73640
CAS :
NA
Molecular Formula : C53H81NO14
Molecular Weight : 956.21
Everolimus - Impurity B
(2S)-1-[[(2R,3R,6S)-2-Hydroxy-6-[(2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19E,21R)-14- hydroxy-22-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2,13-dimethoxy-3,9, 11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl]-3-methyloxan-2- yl](oxo)acetyl]piperidine-2-carboxylic Acid
Catalogue No.:PA 05 73660
CAS :
1062122-63-7
Molecular Formula : C53H83NO14
Molecular Weight : 958.22
(S)-1-(2-((2R,3R,6S)-2-Hydroxy-6-((2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19Z,21R)-14-hydroxy-22-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl)-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic Acid
(2S)-1-[[(2R,3R,6S)-2-Hydroxy-6-[(2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19Z,21R)-14-hydroxy-22-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl]-3-methyltetrahydro-2H-pyran-2-yl](oxo)acetyl]piperidine-2-carboxylic Acid
Catalogue No.:PA 05 73020
CAS :
763911-41-7
Molecular Formula : C53H83NO14
Molecular Weight : 958.24
1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-Dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic acid;
1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-Dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic acid;
Catalogue No.:PA 05 0731002
CAS :
NA
Molecular Formula : C32H49NO9
Molecular Weight : 591.74