Ibrutinib is used to treat chronic lymphocytic leukemia Waldenström's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease. It is a small molecule drug. Reference standards of Ibrutinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Ibrutinib
Catalogue No.:PA 09 27000
CAS :
Molecular Formula : C25H24N6O2
Molecular Weight : 440.50
1,3-bis((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
Catalogue No.:PA 09 27510
Molecular Formula : C47H46N12O3
Molecular Weight : 826.95
(R)-3-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl Acrylate
Catalogue No.:PA 09 27520
Molecular Formula : C28H28N6O4
Molecular Weight : 512.56
1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidyl]-3-[[(1R)-3-(4-phenoxyphenyl)-1-(1-prop-2-enoyl-3-piperidyl)pyrazolo[3,4-d]pyrimidin-4-yl]amino]propan-1-one
Catalogue No.:PA 09 27530
Molecular Formula : C50H48N12O4
Molecular Weight : 880.99
(S)-Ibrutinib
Catalogue No.:PA 09 27540
Molecular Weight : 440.5
Dihydrodiol Ibrutinib
Catalogue No.:PA 09 27550
Molecular Formula : C25H26N6O4
Molecular Weight : 474.52
(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Catalogue No.:PA 09 27560
Molecular Formula : C22H22N6O
Molecular Weight : 386.45
(E)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-hydroxyprop-2-en-1-one
Catalogue No.:PA 09 27570
Molecular Formula : C25H24N6O3
Molecular Weight : 456.5
N-(1-((S)-1-Acryloylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-((S)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propanamide
Catalogue No.:PA 09 27580
Molecular Weight : 881.01
Ibrutinib-d5
Catalogue No.:PA STI 052370
Molecular Formula : C25H19D5N6O2
Molecular Weight : 445.53
(S)-Ibrutinib-d5
Catalogue No.:PA STI 052380
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Catalogue No.:PAI 09 007010
Molecular Formula : C5H4IN5
Molecular Weight : 261.03
3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Catalogue No.:PAI 09 007020
Molecular Formula : C17H13N5O
Molecular Weight : 303.33
(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Catalogue No.:PAI 09 007030
Molecular Formula : C27H30N6O3
Molecular Weight : 486.58
Ethyl (R)-3-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propanoate
Catalogue No.:PAI 09 007040
(R)-3-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propanoic Acid
Catalogue No.:PAI 09 007050
Molecular Formula : C25H26N6O3
Molecular Weight : 458.52
Methyl (R)-3-((1-(1-acryloylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)propanoate
Catalogue No.:PAI 09 007060
Molecular Formula : C29H30N6O4
Molecular Weight : 526.60
N6-(2-Carboxyethyl) Ibrutinib
Catalogue No.:PAI 09 007070
Molecular Weight : 512.57
4-Aminopyrazolo[3,4-d]pyrimidine
Catalogue No.:PAI 09 007080
Molecular Formula : C5H5N5
Molecular Weight : 135.13
Ibrutinib Methoxy Impurity
Catalogue No.:PA 09 27590
Molecular Formula : C26H28N6O3
Molecular Weight : 472.55
1-((R)-3-(4-((3-((S)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)amino)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 09 27600
(R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
Catalogue No.:PA 09 27610
Molecular Formula : C42H37N11O3
Molecular Weight : 743.83
N6-Acryloyl Ibrutinib
Catalogue No.:PA 09 27620
Molecular Formula : C28H26N6O3
Molecular Weight : 494.56
(R)-1-(3-(4-Hydroxy-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 09 27630
Molecular Formula : C25H23N5O3
Molecular Weight : 441.49
(R)-1-(1-Acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine 2-oxide
Catalogue No.:PA 09 27640
Molecular Weight : 456.51
1-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-((S)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
Catalogue No.:PA 09 27650
Molecular Weight : 826.97
Ibrutinib Hydroxy
Catalogue No.:PA 09 27660
N-(1-(1-Acryloylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propanamide
Catalogue No.:PA 09 27670
(R)-4-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)pent-4-enoic Acid
Catalogue No.:PA 09 27680
1-((R)-3-(5-(3-((S)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)-4-imino-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 09 27690
(R)-1-Boc-3-Hydroxypiperidine
Catalogue No.:PA 09 0271000
Molecular Formula : C10H19NO3
Molecular Weight : 201.27
Ibrutinib-biotin
Catalogue No.:PA 09 0271001
Molecular Formula : C56H80N12O9S
Molecular Weight : 1097.39
(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethan-1-one
Catalogue No.:PA 09 0271002
Molecular Formula : C24H24N6O2
Molecular Weight : 428.5
(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-chloropropan-1-one
Catalogue No.:PA 09 0271003
Molecular Formula : C25H25ClN6O2
Molecular Weight : 476.97
(R)-N-(3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-1,1,1-triphenyl-l5-phosphanimine
Catalogue No.:PA 09 0271004
Molecular Formula : C40H35N6OP
Molecular Weight : 646.73
(R)-1-(3-(3-(4-Phenoxyphenyl)-4-((triphenyl-l5-phosphanylidene)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 09 0271005
Molecular Formula : C43H37N6O2P
Molecular Weight : 700.78
1-((S)-3-(2-(3-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)-4-imino-3-(4-phenoxyphenyl)-2,4-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 09 0271006
(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Dihydrochloride
Catalogue No.:PA 09 0271007
Molecular Formula : C22H24Cl2N6O
Molecular Weight : 459.38
Ibrutinib N-Oxide impurity
Catalogue No.:PA 09 0271008
(R)-N-Desacryloyl N-Propionyl Ibrutinib
Catalogue No.:PA 09 0271009
Molecular Formula : C25H26N6O2
Molecular Weight : 442.52
1-((R)-3-(5-(3-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)-4-imino-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 09 0271012
1-((R)-3-(4-Amino-3-(4-(phenoxy-d5)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2,3-dihydroxypropan-1-one
Catalogue No.:PA STI 088988
Molecular Formula : C25H21D5N6O4
Molecular Weight : 479.55
1-Methyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Catalogue No.:PA 09 0271010
Molecular Formula : C18H15N5O
Molecular Weight : 317.35
1,1'-(((Oxybis(4,1-phenylene))bis(4-amino-1H-pyrazolo[3,4-d]pyrimidine-3,1-diyl))bis(piperidine-3,1-diyl))bis(prop-2-en-1-one)
Catalogue No.:PA 09 0271011
Molecular Formula : C38H38N12O3
Molecular Weight : 710.8
(S)-1-Boc-3-Hydroxypiperidine
Catalogue No.:PA 09 0271013
(R)-8-(1-Acryloylpiperidin-3-yl)-10-(4-phenoxyphenyl)-3,4-dihydropyrazolo[4,3-e]pyrimido[1,2-c]pyrimidin-2(8H)-one
Catalogue No.:PA 09 0271014
(S)-8-(1-Acryloylpiperidin-3-yl)-10-(4-phenoxyphenyl)-3,4-dihydropyrazolo[4,3-e]pyrimido[1,2-c]pyrimidin-2(8H)-one
Catalogue No.:PA 09 0271015
Ibrutinib N1-Oxide
Catalogue No.:PA 09 0271016
(R)-1-(1-Acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine 7-oxide
Catalogue No.:PA 09 0271017
N-(1-((R)-1-Acryloylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propanamide
Catalogue No.:PA 09 0271018
N1-(2-Carboxyethyl) Ibrutinib
Catalogue No.:PA 09 0271019
1-((S)-3-(5-(3-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)-4-imino-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 09 0271020
1-(1-Nitrosopiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Catalogue No.:PA 09 0271021
Molecular Formula : C22H21N7O2
Molecular Weight : 415.46
(R,Z)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-hydroxyprop-2-en-1-one
Catalogue No.:PA 09 0271022
Ibrutinib Racemate
Catalogue No.:PA 09 0271023
Molecular Weight : 440.51
Ibrutinib Diacrylate Analog Impurity
Catalogue No.:PA 09 0271024
1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea
Catalogue No.:PA 09 0271025
Molecular Formula : C31H35N9O4
Molecular Weight : 597.68
tert-Butyl (S)-3-((methylsulfonyl)oxy)piperidine-1-carboxylate
Catalogue No.:PAI 09 007081
Molecular Formula : C11H21NO5S
Molecular Weight : 279.35
3-Methoxypropanoyl Chloride
Catalogue No.:PAI 09 007082
Molecular Formula : C4H7ClO2
Molecular Weight : 122.55
3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-ol
Catalogue No.:PAI 09 007083
Molecular Formula : C5H3BrN4O
Molecular Weight : 215.01
3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol
Catalogue No.:PAI 09 007084
Molecular Formula : C17H12N4O2
Molecular Weight : 304.31
tert-Butyl (R)-3-(4-hydroxy-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Catalogue No.:PAI 09 007085
Molecular Formula : C27H29N5O4
Molecular Weight : 487.56
(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol
Catalogue No.:PAI 09 007086
Molecular Formula : C22H21N5O2
Molecular Weight : 387.44
tert-Butyl (R)-3-(3-bromo-4-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Catalogue No.:PAI 09 007087
Molecular Formula : C15H20BrN5O3
Molecular Weight : 398.26
tert-Butyl (R)-3-(4-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Catalogue No.:PAI 09 007088
Molecular Formula : C15H21BrN6O2
Molecular Weight : 397.28
(R)-1-(3-(4-Chloro-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Catalogue No.:PAI 09 007089
Molecular Formula : C25H22ClN5O2
Molecular Weight : 459.93
3-Bromo-4-((tert-butyldimethylsilyl)oxy)-1H-pyrazolo[3,4-d]pyrimidine
Catalogue No.:PAI 09 007090
Molecular Formula : C11H17BrN4OSi
Molecular Weight : 329.27
tert-Butyl 3-bromo-4-hydroxy-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate
Catalogue No.:PAI 09 007091
Molecular Formula : C10H11BrN4O3
Molecular Weight : 315.13
Ethyl (R)-3-(1-(1-acryloylpiperidin-3-yl)-4-imino-3-(4-phenoxyphenyl)-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)propanoate
Catalogue No.:PAI 09 007092
Molecular Formula : C30H32N6O4
Molecular Weight : 540.62
(R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-imino-3-(4-phenoxyphenyl)-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)propanoyl Chloride
Catalogue No.:PAI 09 007093
Molecular Formula : C28H27ClN6O3
Molecular Weight : 531.01
(R)-3-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propanoyl Chloride
Catalogue No.:PAI 09 007094
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