Ivacaftor is used for the treatment of cystic fibrosis in people having one of several specific mutations in the cystic fibrosis transmembrane conductance regulator protein. It is one of the most expensive drugs. Reference standards of Ivacaftor API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Ivacaftor
Catalogue No.:PA 09 40000
CAS :
Molecular Formula : C24H28N2O3
Molecular Weight : 392.49
4-Oxo-1,4-dihydroquinoline-3-carboxylic Acid
Catalogue No.:PA 09 40510
Molecular Formula : C10H7NO3
Molecular Weight : 189.17
1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester
Catalogue No.:PA 09 40520
Molecular Formula : C12H11NO3
Molecular Weight : 217.22
5-Amino-2,4-di-tert-butylphenol
Catalogue No.:PA 09 40530
Molecular Formula : C14H23NO
Molecular Weight : 221.34
N-(3,5-Di-tert-butyl-2-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
Catalogue No.:PA 09 40540
Ivacaftor N-glucuronide
Catalogue No.:PA 09 40550
Molecular Formula : C30H36N2O9
Molecular Weight : 568.61
Ivacaftor Carboxylic Acid
Catalogue No.:PA 09 40560
Molecular Formula : C24H26N2O5
Molecular Weight : 422.47
Hydroxymethyl Ivacaftor
Catalogue No.:PA 09 40570
Molecular Formula : C24H28N2O4
Molecular Weight : 408.49
diethyl 2-((phenylamino)methylene)malonate
Catalogue No.:PA 09 0401000
Molecular Formula : C14H17NO4
Molecular Weight : 263.29
De-Alkylated Ivacaftor
Catalogue No.:PA 09 0401001
Molecular Formula : C20H20N2O3
Molecular Weight : 336.39
Ivacaftor D4
Catalogue No.:PA STI 089107
Molecular Formula : C24H24D4N2O3
Molecular Weight : 396.52
4-Hydroxyquinoline-3-carboxylic Acid
Catalogue No.:PA 09 0401002
Ivacaftor D18
Catalogue No.:PA STI 089190
Molecular Formula : C24H10D18N2O3
Molecular Weight : 410.61
2,4-Di-tert-butyl-6-nitrophenol
Catalogue No.:PA 09 0401003
Molecular Formula : C14H21NO3
Molecular Weight : 251.33
4-(3-((2,4-Di-tert-butyl-5-hydroxyphenyl)carbamoyl)-4-oxoquinolin-1(4H)-yl)-4-oxobutanoic Acid
Catalogue No.:PA 09 0401004
Molecular Formula : C28H32N2O6
Molecular Weight : 492.57
1-Nitroso-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid
Catalogue No.:PA 09 0401005
Molecular Formula : C10H6N2O4
Molecular Weight : 218.17
2,4-Di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl 4-oxo-1,4-dihydroquinoline-3-carboxylate
Catalogue No.:PA 09 0401006
Molecular Formula : C34H33N3O5
Molecular Weight : 563.65
N-(4-(Tert-butyl)-3-hydroxyphenyl)-1-nitroso-4-oxo-1,4-dihydroquinoline-3-carboxamide
Catalogue No.:PA 09 0401007
Molecular Formula : C20H19N3O4
Molecular Weight : 365.39
Ivacaftor Nitroso Impurity
Catalogue No.:PA 09 0401008
Molecular Formula : C24H27N3O4
Molecular Weight : 421.5
5-Amino-2,4-di-tert-butylphenyl methyl carbonate
Catalogue No.:PA 09 0401009
Molecular Formula : C16H25NO3
Molecular Weight : 279.38
N-Nitroso Ivacaftor Ortho Isomer
Catalogue No.:PA 09 0401010
Ethyl 1-nitroso-4-oxo-1,4-dihydroquinoline-3-carboxylate
Catalogue No.:PA 09 0401011
Molecular Formula : C12H10N2O4
Molecular Weight : 246.22
2,4-Di-tert-butyl-6-nitrophenyl methyl carbonate
Catalogue No.:PA 09 0401012
Molecular Formula : C16H23NO5
Molecular Weight : 309.36
Ivacaftor-d19
Catalogue No.:PA STI 089610
Molecular Formula : C24H9D19N2O3
Molecular Weight : 411.61
Diethyl 2-((nitroso(phenyl)amino)methylene)malonate
Catalogue No.:PA 09 0401013
Molecular Formula : C14H16N2O5
Molecular Weight : 292.29
N-(4,6-Di-tert-butyl-3-hydroxy-2-nitrosophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
Catalogue No.:PA 09 0401014
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