navitoclax and its Impurities

Navitoclax is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins. It has been used in trials studying the treatment and basic science of Solid Tumors, Non-Hodgkin's Lymphoma, EGFR Activating Mutation, Chronic Lymphoid Leukemia, and Hematological Malignancies, among others. Reference standards of Navitoclax API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.