Displaying 26 results for nintedanib

Nintedanib - API

Nintedanib


  • Catalogue No.:PA 14 54000

  • CAS : 656247-17-5

  • Molecular Formula : C31H33N5O4

  • Molecular Weight : 539.62

Nintedanib - In house impurity

Intedanib E-isomer


  • Catalogue No.:PA 14 54510

  • CAS : NA

  • Molecular Formula : C31H33N5O4

  • Molecular Weight : 539.62

Nintedanib - In house impurity

(Z)-3-(((4-(N-Methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic Acid


  • Catalogue No.:PA 14 54520

  • CAS : 894783-71-2

  • Molecular Formula : C30H31N5O4

  • Molecular Weight : 525.60

Nintedanib - In house impurity

(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide


  • Catalogue No.:PA 14 54530

  • CAS : NA

  • Molecular Formula : C31H33N5O6

  • Molecular Weight : 571.62

Nintedanib - In house impurity

(Z)-Methyl 3-((methyl(4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate


  • Catalogue No.:PA 14 54540

  • CAS : NA

  • Molecular Formula : C32H35N5O4

  • Molecular Weight : 553.65

Nintedanib - In house impurity

(Z)-Methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate


  • Catalogue No.:PA 14 54550

  • CAS : NA

  • Molecular Formula : C24H21N3O3

  • Molecular Weight : 399.44

Nintedanib - In house impurity

(Z)-Methyl 1-acetyl-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate


  • Catalogue No.:PA 14 54560

  • CAS : NA

  • Molecular Formula : C33H35N5O5

  • Molecular Weight : 581.66

Nintedanib - In house impurity

(Z)-Methyl 3-(((4-(N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate


  • Catalogue No.:PA 14 54570

  • CAS : NA

  • Molecular Formula : C26H23N3O4

  • Molecular Weight : 441.48

Nintedanib - In house impurity

(3Z,3'Z)-Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(2-oxoindoline-6-carboxylate)


  • Catalogue No.:PA 14 54580

  • CAS : NA

  • Molecular Formula : C56H52N8O8

  • Molecular Weight : 965.06

Nintedanib - In house impurity

Methyl (3Z)-3-[({4-[2-(4-ethylpiperazin-1-yl)-N-methylacetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate


  • Catalogue No.:PA 14 54590

  • CAS : NA

  • Molecular Formula : C32H35N5O4

  • Molecular Weight : 553.65

Nintedanib - In house impurity

(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1-oxide


  • Catalogue No.:PA 14 54600

  • CAS : NA

  • Molecular Formula : C31H33N5O5

  • Molecular Weight : 555.62

Nintedanib - In house impurity

Ethyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate


  • Catalogue No.:PA 14 54610

  • CAS : NA

  • Molecular Formula : C32H35N5O4

  • Molecular Weight : 553.65

Nintedanib - In house impurity

Nintedanib Esylate


  • Catalogue No.:PA 14 54620

  • CAS : 656247-18-6

  • Molecular Formula : C33H39N5O7S

  • Molecular Weight : 649.76

Nintedanib - In house impurity

Methyl Ethanesulfonate


  • Catalogue No.:PA 14 54630

  • CAS : 1912-28-3

  • Molecular Formula : C3H8O3S

  • Molecular Weight : 124.16

Nintedanib - In house impurity

Ethyl Ethanesulfonate


  • Catalogue No.:PA 14 54640

  • CAS : 1912-30-7

  • Molecular Formula : C4H10O3S

  • Molecular Weight : 138.19

Intedanib-d3


  • Catalogue No.:PA STI 053200

  • CAS : 1624587-84-3

  • Molecular Formula : C31H30D3N5O4

  • Molecular Weight : 542.64

Nintedanib - In house impurity

Methyl (Z)-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate


  • Catalogue No.:PA 14 54650

  • CAS : 2093243-16-2

  • Molecular Formula : C17H13NO4

  • Molecular Weight : 295.29

Nintedanib - In house impurity

(3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester


  • Catalogue No.:PA 14 54660

  • CAS : 1168152-06-4

  • Molecular Formula : C21H19NO5

  • Molecular Weight : 365.38

Nintedanib - In house impurity

Methyl (Z)-3-(((4-hydroxyphenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate


  • Catalogue No.:PA 14 54670

  • CAS : NA

  • Molecular Formula : C23H18N2O4

  • Molecular Weight : 386.41

Nintedanib - In house impurity

N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide


  • Catalogue No.:PA 14 54680

  • CAS : 262368-30-9

  • Molecular Formula : C14H22N4O

  • Molecular Weight : 262.36

Nintedanib - In house impurity

Desmethyl Nintedanib Carboxylic Acid


  • Catalogue No.:PA 14 54690

  • CAS : NA

  • Molecular Formula : C29H29N5O5

  • Molecular Weight : 527.58

Nintedanib - In house impurity

Desmethyl 5-Methoxycarbonyl Nintedanib


  • Catalogue No.:PA 14 54700

  • CAS : NA

  • Molecular Formula : C30H31N5O4

  • Molecular Weight : 525.61

Nintedanib - In house impurity

Desmethyl 7-Methoxycarbonyl Nintedanib


  • Catalogue No.:PA 14 54710

  • CAS : NA

  • Molecular Formula : C30H31N5O4

  • Molecular Weight : 525.61

Nintedanib - In house impurity

Methyl (E)-3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate


  • Catalogue No.:PA 14 54720

  • CAS : NA

  • Molecular Formula : C24H21N3O3

  • Molecular Weight : 399.45

Nintedanib - In house impurity

Desmethoxycarbonyl Nintedanib


  • Catalogue No.:PA 14 54730

  • CAS : 262366-32-5

  • Molecular Formula : C29H31N5O2

  • Molecular Weight : 481.60

Nintedanib - In house impurity

4-Methyl-1-piperazinyl-acetyl Nintedanib Amide


  • Catalogue No.:PA 14 54740

  • CAS : NA

  • Molecular Formula : C44H51N9O4

  • Molecular Weight : 769.95

Whoops! There was an error.
UnexpectedValueException
The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied UnexpectedValueException thrown with message "The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied" Stacktrace: #10 UnexpectedValueException in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php:107 #9 Monolog\Handler\StreamHandler:write in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Handler/AbstractProcessingHandler.php:37 #8 Monolog\Handler\AbstractProcessingHandler:handle in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Logger.php:337 #7 Monolog\Logger:addRecord in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Logger.php:616 #6 Monolog\Logger:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php:179 #5 Illuminate\Log\Logger:writeLog in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php:90 #4 Illuminate\Log\Logger:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/LogManager.php:524 #3 Illuminate\Log\LogManager:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Exceptions/Handler.php:113 #2 Illuminate\Foundation\Exceptions\Handler:report in /home/pharmaaffiliates/public_html/app/Exceptions/Handler.php:43 #1 App\Exceptions\Handler:report in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Bootstrap/HandleExceptions.php:81 #0 Illuminate\Foundation\Bootstrap\HandleExceptions:handleException in [internal]:0
10
UnexpectedValueException
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Logger.php
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Logger.php
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LogManager.php
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Handler.php
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Handler.php
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HandleExceptions.php
81
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Foundation
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Bootstrap
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HandleExceptions
handleException
[internal]
0
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StreamHandler.php
    /**
     * {@inheritdoc}
     */
    protected function write(array $record)
    {
        if (!is_resource($this->stream)) {
            if (null === $this->url || '' === $this->url) {
                throw new \LogicException('Missing stream url, the stream can not be opened. This may be caused by a premature call to close().');
            }
            $this->createDir();
            $this->errorMessage = null;
            set_error_handler(array($this, 'customErrorHandler'));
            $this->stream = fopen($this->url, 'a');
            if ($this->filePermission !== null) {
                @chmod($this->url, $this->filePermission);
            }
            restore_error_handler();
            if (!is_resource($this->stream)) {
                $this->stream = null;
                throw new \UnexpectedValueException(sprintf('The stream or file "%s" could not be opened: '.$this->errorMessage, $this->url));
            }
        }
 
        if ($this->useLocking) {
            // ignoring errors here, there's not much we can do about them
            flock($this->stream, LOCK_EX);
        }
 
        $this->streamWrite($this->stream, $record);
 
        if ($this->useLocking) {
            flock($this->stream, LOCK_UN);
        }
    }
 
    /**
     * Write to stream
     * @param resource $stream
     * @param array $record
     */
Arguments
  1. "The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied"
    
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AbstractProcessingHandler.php
 *
 * @author Jordi Boggiano <j.boggiano@seld.be>
 * @author Christophe Coevoet <stof@notk.org>
 */
abstract class AbstractProcessingHandler extends AbstractHandler
{
    /**
     * {@inheritdoc}
     */
    public function handle(array $record)
    {
        if (!$this->isHandling($record)) {
            return false;
        }
 
        $record = $this->processRecord($record);
 
        $record['formatted'] = $this->getFormatter()->format($record);
 
        $this->write($record);
 
        return false === $this->bubble;
    }
 
    /**
     * Writes the record down to the log of the implementing handler
     *
     * @param  array $record
     * @return void
     */
    abstract protected function write(array $record);
 
    /**
     * Processes a record.
     *
     * @param  array $record
     * @return array
     */
    protected function processRecord(array $record)
    {
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571597473 {#33
        date: 2019-10-20 18:51:13.069647 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 18:51:13] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6IkMrN0p...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6IkMrN0p...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('0GgG2OKGrl2mkhk...', 'eyJpdiI6IkMrN0p...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
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Logger.php
            $ts = new \DateTime(null, static::$timezone);
        }
        $ts->setTimezone(static::$timezone);
 
        $record = array(
            'message' => (string) $message,
            'context' => $context,
            'level' => $level,
            'level_name' => $levelName,
            'channel' => $this->name,
            'datetime' => $ts,
            'extra' => array(),
        );
 
        foreach ($this->processors as $processor) {
            $record = call_user_func($processor, $record);
        }
 
        while ($handler = current($this->handlers)) {
            if (true === $handler->handle($record)) {
                break;
            }
 
            next($this->handlers);
        }
 
        return true;
    }
 
    /**
     * Adds a log record at the DEBUG level.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function addDebug($message, array $context = array())
    {
        return $this->addRecord(static::DEBUG, $message, $context);
    }
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571597473 {#33
        date: 2019-10-20 18:51:13.069647 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 18:51:13] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6IkMrN0p...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6IkMrN0p...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('0GgG2OKGrl2mkhk...', 'eyJpdiI6IkMrN0p...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
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Logger.php
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function err($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the ERROR level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function error($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function crit($message, array $context = array())
    {
        return $this->addRecord(static::CRITICAL, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
Arguments
  1. 400
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
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Logger.php
     * @return void
     */
    public function write($level, $message, array $context = [])
    {
        $this->writeLog($level, $message, $context);
    }
 
    /**
     * Write a message to the log.
     *
     * @param  string  $level
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    protected function writeLog($level, $message, $context)
    {
        $this->fireLogEvent($level, $message = $this->formatMessage($message), $context);
 
        $this->logger->{$level}($message, $context);
    }
 
    /**
     * Register a new callback handler for when a log event is triggered.
     *
     * @param  \Closure  $callback
     * @return void
     *
     * @throws \RuntimeException
     */
    public function listen(Closure $callback)
    {
        if (! isset($this->dispatcher)) {
            throw new RuntimeException('Events dispatcher has not been set.');
        }
 
        $this->dispatcher->listen(MessageLogged::class, $callback);
    }
 
    /**
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
Logger.php
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function critical($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log an error message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function error($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a warning message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function warning($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a notice to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
Arguments
  1. "error"
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
LogManager.php
     *
     * @return void
     */
    public function critical($message, array $context = [])
    {
        return $this->driver()->critical($message, $context);
    }
 
    /**
     * Runtime errors that do not require immediate action but should typically
     * be logged and monitored.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function error($message, array $context = [])
    {
        return $this->driver()->error($message, $context);
    }
 
    /**
     * Exceptional occurrences that are not errors.
     *
     * Example: Use of deprecated APIs, poor use of an API, undesirable things
     * that are not necessarily wrong.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function warning($message, array $context = [])
    {
        return $this->driver()->warning($message, $context);
    }
 
    /**
     * Normal but significant events.
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Exceptions
/
Handler.php
     */
    public function report(Exception $e)
    {
        if ($this->shouldntReport($e)) {
            return;
        }
 
        if (method_exists($e, 'report')) {
            return $e->report();
        }
 
        try {
            $logger = $this->container->make(LoggerInterface::class);
        } catch (Exception $ex) {
            throw $e;
        }
 
        $logger->error(
            $e->getMessage(),
            array_merge($this->context(), ['exception' => $e]
        ));
    }
 
    /**
     * Determine if the exception should be reported.
     *
     * @param  \Exception  $e
     * @return bool
     */
    public function shouldReport(Exception $e)
    {
        return ! $this->shouldntReport($e);
    }
 
    /**
     * Determine if the exception is in the "do not report" list.
     *
     * @param  \Exception  $e
     * @return bool
     */
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
app
/
Exceptions
/
Handler.php
        \Illuminate\Auth\AuthenticationException::class,
        \Illuminate\Auth\Access\AuthorizationException::class,
        \Symfony\Component\HttpKernel\Exception\HttpException::class,
        \Illuminate\Database\Eloquent\ModelNotFoundException::class,
        \Illuminate\Session\TokenMismatchException::class,
        \Illuminate\Validation\ValidationException::class,
    ];
 
    /**
     * Report or log an exception.
     *
     * This is a great spot to send exceptions to Sentry, Bugsnag, etc.
     *
     * @param \Exception $exception
     *
     * @return void
     */
    public function report(Exception $exception)
    {
        parent::report($exception);
    }
 
    /**
     * Render an exception into an HTTP response.
     *
     * @param \Illuminate\Http\Request $request
     * @param \Exception               $exception
     *
     * @return \Illuminate\Http\Response
     */
    public function render($request, Exception $exception)
    {
        //dd($exception);
        if (strpos($request->url(), '/api/') !== false) {
            \Log::debug('API Request Exception - '.$request->url().' - '.$exception->getMessage().(!empty($request->all()) ? ' - '.json_encode($request->except(['password'])) : ''));
 
            if ($exception instanceof AuthorizationException) {
                return $this->setStatusCode(403)->respondWithError($exception->getMessage());
            }
 
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Bootstrap
/
HandleExceptions.php
    }
 
    /**
     * Handle an uncaught exception from the application.
     *
     * Note: Most exceptions can be handled via the try / catch block in
     * the HTTP and Console kernels. But, fatal error exceptions must
     * be handled differently since they are not normal exceptions.
     *
     * @param  \Throwable  $e
     * @return void
     */
    public function handleException($e)
    {
        if (! $e instanceof Exception) {
            $e = new FatalThrowableError($e);
        }
 
        try {
            $this->getExceptionHandler()->report($e);
        } catch (Exception $e) {
            //
        }
 
        if ($this->app->runningInConsole()) {
            $this->renderForConsole($e);
        } else {
            $this->renderHttpResponse($e);
        }
    }
 
    /**
     * Render an exception to the console.
     *
     * @param  \Exception  $e
     * @return void
     */
    protected function renderForConsole(Exception $e)
    {
        $this->getExceptionHandler()->renderForConsole(new ConsoleOutput, $e);
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
[internal]
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/0GgG2OKGrl2mkhkuX07kAiGuboEE0Uljm28r1tp1): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    

Environment & details:

empty
empty
empty
empty
empty
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
HTTP_ACCEPT
"text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8"
HTTP_ACCEPT_ENCODING
"gzip"
HTTP_ACCEPT_LANGUAGE
"en-US,en;q=0.5"
HTTP_CONNECTION
"Keep-Alive"
HTTP_HOST
"www.pharmaffiliates.com"
HTTP_USER_AGENT
"CCBot/2.0 (https://commoncrawl.org/faq/)"
HTTP_IF_MODIFIED_SINCE
"Wed, 17 Jul 2019 01:23:25 PDT"
DOCUMENT_ROOT
"/home/pharmaaffiliates/public_html"
REMOTE_ADDR
"3.228.24.192"
REMOTE_PORT
"46558"
SERVER_ADDR
"172.105.43.57"
SERVER_NAME
"www.pharmaffiliates.com"
SERVER_ADMIN
"webmaster@pharmaffiliates.com"
SERVER_PORT
"443"
REQUEST_URI
"/en/parentapi/nintedanib"
REDIRECT_URL
"/en/parentapi/nintedanib"
HTTPS
"on"
REDIRECT_STATUS
"200"
SSL_PROTOCOL
"TLSv1.2"
SSL_SESSION_ID
"a5c8822606718116a0081671b5b40e37d3e6cb43d07dbb02efcde8d240dc8e8d"
SSL_CIPHER
"ECDHE-RSA-AES256-GCM-SHA384"
SSL_CIPHER_USEKEYSIZE
"256"
SSL_CIPHER_ALGKEYSIZE
"256"
SCRIPT_FILENAME
"/home/pharmaaffiliates/public_html/index.php"
QUERY_STRING
""
SCRIPT_URI
"https://www.pharmaffiliates.com/en/parentapi/nintedanib"
SCRIPT_URL
"/en/parentapi/nintedanib"
SCRIPT_NAME
"/index.php"
SERVER_PROTOCOL
"HTTP/1.1"
SERVER_SOFTWARE
"LiteSpeed"
REQUEST_METHOD
"GET"
X-LSCACHE
"on"
PHP_SELF
"/index.php"
REQUEST_TIME_FLOAT
1571597472.828
REQUEST_TIME
1571597472
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
0. Whoops\Handler\PrettyPageHandler