Osimertinib-impurities | Pharmaffiliates

osimertinib and its Impurities

Osimertinib is used to treat locally advanced or metastatic non-small-cell lung cancer. It is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor.Reference standards of Osimertinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 47 results for osimertinib Impurities
PA 15 51000

Osimertinib - API Standards

Osimertinib

  • Catalogue No.:PA 15 51000

  • CAS :

    1421373-65-0

  • Molecular Formula : C28H33N7O2

  • Molecular Weight : 499.61

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PA 15 51510

3,3'-(Pyrimidine-2,4-diyl)bis(1-methyl-1H-indole)

3,3'-(Pyrimidine-2,4-diyl)bis(1-methyl-1H-indole)

  • Catalogue No.:PA 15 51510

  • CAS :

    2364486-24-6

  • Molecular Formula : C22H18N4

  • Molecular Weight : 338.41

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PA 15 51520

3-(4-Chloropyrimidin-2-yl)-1-methyl-1H-indole

3-(4-Chloropyrimidin-2-yl)-1-methyl-1H-indole

  • Catalogue No.:PA 15 51520

  • CAS :

    2364486-23-5

  • Molecular Formula : C13H10ClN3

  • Molecular Weight : 243.69

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PA 15 51530

4-Fluoro-2-methoxy-3-nitroaniline

4-Fluoro-2-methoxy-3-nitroaniline

  • Catalogue No.:PA 15 51530

  • CAS :

    2090542-75-7

  • Molecular Formula : C7H7FN2O3

  • Molecular Weight : 186.14

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PA 15 51540

2,4-Difluoronitrobenzene

2,4-Difluoronitrobenzene

  • Catalogue No.:PA 15 51540

  • CAS :

    446-35-5

  • Molecular Formula : C6H3F2NO2

  • Molecular Weight : 159.09

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PA 15 51550

2-Dimethylaminoethanol

2-Dimethylaminoethanol

  • Catalogue No.:PA 15 51550

  • CAS :

    108-01-0

  • Molecular Formula : C4H11NO

  • Molecular Weight : 89.14

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PA 15 51560

2-(tert-Butoxy)-4-fluoro-5-nitroaniline

2-(tert-Butoxy)-4-fluoro-5-nitroaniline

  • Catalogue No.:PA 15 51560

  • CAS :

    NA

  • Molecular Formula : C10H13FN2O3

  • Molecular Weight : 228.22

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PA 15 51570

4-Fluoro-6-methoxy-2,3-dinitroaniline

4-Fluoro-6-methoxy-2,3-dinitroaniline

  • Catalogue No.:PA 15 51570

  • CAS :

    NA

  • Molecular Formula : C7H6FN3O5

  • Molecular Weight : 231.14

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PA STI 070432

Osimertinib-d6

Osimertinib-d6

  • Catalogue No.:PA STI 070432

  • CAS :

    1638281-44-3

  • Molecular Formula : C28H27D6N7O2

  • Molecular Weight : 505.66

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PA STI 070433

Osimertinib-13CD3

Osimertinib-13CD3

  • Catalogue No.:PA STI 070433

  • CAS :

    NA

  • Molecular Formula : C2713CH30D3N7O2

  • Molecular Weight : 503.63

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PA 15 51580

Osimertinib N,N'-Dioxide

Osimertinib N,N'-Dioxide

  • Catalogue No.:PA 15 51580

  • CAS :

    2411395-23-6

  • Molecular Formula : C28H33N7O4

  • Molecular Weight : 531.62

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PA 15 51590

N-Acryloyl Osimertinib

N-Acryloyl Osimertinib

  • Catalogue No.:PA 15 51590

  • CAS :

    1932710-29-6

  • Molecular Formula : C31H35N7O3

  • Molecular Weight : 553.65

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PA 15 0511000

Osimertinib N-Oxide

Osimertinib N-Oxide

  • Catalogue No.:PA 15 0511000

  • CAS :

    2411395-22-5

  • Molecular Formula : C28H33N7O3

  • Molecular Weight : 515.62

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PA 15 0511001

N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanamide

N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanamide

  • Catalogue No.:PA 15 0511001

  • CAS :

    2919324-15-3

  • Molecular Formula : C53H64N14O3

  • Molecular Weight : 945.19

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PA 15 0511002

N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-N-(3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-3-oxopropyl)acrylamide

N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-N-(3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-3-oxopropyl)acrylamide

  • Catalogue No.:PA 15 0511002

  • CAS :

    NA

  • Molecular Formula : C56H66N14O4

  • Molecular Weight : 999.24

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PA 15 0511003

N-(2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)ethyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium Chloride

N-(2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)ethyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium Chloride

  • Catalogue No.:PA 15 0511003

  • CAS :

    NA

  • Molecular Formula : C56H67ClN14O4

  • Molecular Weight : 1035.7

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PA 15 0511004

N-(5-((4-(1H-Indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

N-(5-((4-(1H-Indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

  • Catalogue No.:PA 15 0511004

  • CAS :

    1421373-98-9

  • Molecular Formula : C27H31N7O2

  • Molecular Weight : 485.59

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PA 15 0511005

5-Methoxy-N1,N1-dimethyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine hydrochloride

5-Methoxy-N1,N1-dimethyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine hydrochloride

  • Catalogue No.:PA 15 0511005

  • CAS :

    2044702-55-6

  • Molecular Formula : C22H25ClN6O

  • Molecular Weight : 424.93

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PA 15 0511006

2-Methoxy-N4,N4-dimethyl-N1-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-5-nitrobenzene-1,4-diamine

2-Methoxy-N4,N4-dimethyl-N1-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-5-nitrobenzene-1,4-diamine

  • Catalogue No.:PA 15 0511006

  • CAS :

    1820891-36-8

  • Molecular Formula : C22H22N6O3

  • Molecular Weight : 418.46

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PA 15 0511007

 N-(4-Methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

N-(4-Methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

  • Catalogue No.:PA 15 0511007

  • CAS :

    1421373-99-0

  • Molecular Formula : C27H31N7O2

  • Molecular Weight : 485.59

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PA STI 088985

N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)-5-methoxy-N1-methyl-N1-(2-(methyl(methyl-d3)amino)ethyl)benzene-1,2,4-triamine

N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)-5-methoxy-N1-methyl-N1-(2-(methyl(methyl-d3)amino)ethyl)benzene-1,2,4-triamine

  • Catalogue No.:PA STI 088985

  • CAS :

    2211116-74-2

  • Molecular Formula : C27H30D3N7O

  • Molecular Weight : 474.63

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PA STI 088986

N-(5-((4-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(2-(methyl(methyl-d3)amino)ethyl)amino)phenyl)acrylamide

N-(5-((4-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(2-(methyl(methyl-d3)amino)ethyl)amino)phenyl)acrylamide

  • Catalogue No.:PA STI 088986

  • CAS :

    2211116-92-4

  • Molecular Formula : C30H32D3N7O2

  • Molecular Weight : 528.68

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PA 15 0511008

N-(2-(Dimethylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

N-(2-(Dimethylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

  • Catalogue No.:PA 15 0511008

  • CAS :

    2044702-39-6

  • Molecular Formula : C25H26N6O2

  • Molecular Weight : 442.52

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PA 15 0511009

2-Amino-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenol

2-Amino-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenol

  • Catalogue No.:PA 15 0511009

  • CAS :

    NA

  • Molecular Formula : C20H19N5O2

  • Molecular Weight : 361.41

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PA 15 0511010

N-(2-((2-acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)ethyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium

N-(2-((2-acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)ethyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium

  • Catalogue No.:PA 15 0511010

  • CAS :

    2564638-97-5

  • Molecular Formula : C56H67N14O4

  • Molecular Weight : 1000.25

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PA 15 0511011

N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide hydrochloride

N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide hydrochloride

  • Catalogue No.:PA 15 0511011

  • CAS :

    2469006-57-1

  • Molecular Formula : C27H32ClN7O2

  • Molecular Weight : 522.05

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PA 15 0511012

2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)-N,N-dimethyl-N-((2-oxopyrrolidin-1-yl)methyl)ethan-1-aminium chloride

2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)-N,N-dimethyl-N-((2-oxopyrrolidin-1-yl)methyl)ethan-1-aminium chloride

  • Catalogue No.:PA 15 0511012

  • CAS :

    2411395-25-8

  • Molecular Formula : C33H41ClN8O3

  • Molecular Weight : 633.19

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PA 15 0511013

N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)-N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methylbenzene-1,2,4-triamine

N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)-N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methylbenzene-1,2,4-triamine

  • Catalogue No.:PA 15 0511013

  • CAS :

    1825290-88-7

  • Molecular Formula : C27H33N7O

  • Molecular Weight : 471.61

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PA 15 0511015

N-(5-((4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

N-(5-((4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

  • Catalogue No.:PA 15 0511015

  • CAS :

    1825287-91-9

  • Molecular Formula : C30H35N7O2

  • Molecular Weight : 525.66

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PA 15 0511016

2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)-N,N-dimethylethan-1-amine oxide

2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)-N,N-dimethylethan-1-amine oxide

  • Catalogue No.:PA 15 0511016

  • CAS :

    1975982-94-5

  • Molecular Formula : C28H33N7O3

  • Molecular Weight : 515.62

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PA 15 0511017

Osimertinib Acetyl Impurity

Osimertinib Acetyl Impurity

  • Catalogue No.:PA 15 0511017

  • CAS :

    2227103-37-7

  • Molecular Formula : C27H33N7O2

  • Molecular Weight : 487.61

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PA 15 0511018

Osimertinib 2-Amide Impurity

Osimertinib 2-Amide Impurity

  • Catalogue No.:PA 15 0511018

  • CAS :

    2213409-62-0

  • Molecular Formula : C23H20FN5O2

  • Molecular Weight : 417.44

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PA 15 0511020

3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole

3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole

  • Catalogue No.:PA 15 0511020

  • CAS :

    1032452-86-0

  • Molecular Formula : C13H10ClN3

  • Molecular Weight : 243.69

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PA 15 0511019

4-Fluoro-2-methoxy-5-nitroaniline

4-Fluoro-2-methoxy-5-nitroaniline

  • Catalogue No.:PA 15 0511019

  • CAS :

    1075705-01-9

  • Molecular Formula : C7H7FN2O3

  • Molecular Weight : 186.14

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PA 15 0511021

3-Chloro-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)propanamide

3-Chloro-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)propanamide

  • Catalogue No.:PA 15 0511021

  • CAS :

    1421373-36-5

  • Molecular Formula : C28H34ClN7O2

  • Molecular Weight : 536.08

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PA 15 0511022

N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine

N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine

  • Catalogue No.:PA 15 0511022

  • CAS :

    1421372-66-8

  • Molecular Formula : C25H31N7O

  • Molecular Weight : 445.57

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PA 15 0511023

N1,N5-Bis(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-2-methylenepentanediamide

N1,N5-Bis(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-2-methylenepentanediamide

  • Catalogue No.:PA 15 0511023

  • CAS :

    NA

  • Molecular Formula : C56H66N14O4

  • Molecular Weight : 999.24

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PA 15 0511024

Osimertinib Methoxy Impurity

Osimertinib Methoxy Impurity

  • Catalogue No.:PA 15 0511024

  • CAS :

    NA

  • Molecular Formula : C29H37N7O3

  • Molecular Weight : 531.66

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PA 15 0511025

N-(2-Hydroxy-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

N-(2-Hydroxy-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

  • Catalogue No.:PA 15 0511025

  • CAS :

    NA

  • Molecular Formula : C23H21N5O3

  • Molecular Weight : 415.45

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PA 15 0511026

Osimertinib Dimer 2

Osimertinib Dimer 2

  • Catalogue No.:PA 15 0511026

  • CAS :

    NA

  • Molecular Formula : C57H68N14O4

  • Molecular Weight : 1013.27

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PA 15 0511027

Osimertinib N-Methylacrylamide Impurity

Osimertinib N-Methylacrylamide Impurity

  • Catalogue No.:PA 15 0511027

  • CAS :

    2850389-35-2

  • Molecular Formula : C30H33N7O3

  • Molecular Weight : 539.64

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PA 15 0511028

1-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)azetidin-2-one

1-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)azetidin-2-one

  • Catalogue No.:PA 15 0511028

  • CAS :

    NA

  • Molecular Formula : C28H33N7O2

  • Molecular Weight : 499.62

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PAI 15 051001

N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

  • Catalogue No.:PAI 15 051001

  • CAS :

    NA

  • Molecular Formula : C28H33N7O2

  • Molecular Weight : 499.62

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PAI 15 051002

3-((2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanoic acid

3-((2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanoic acid

  • Catalogue No.:PAI 15 051002

  • CAS :

    NA

  • Molecular Formula : C28H35N7O3

  • Molecular Weight : 517.63

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PA 15 0511029

N-(4-Fluoro-2-methoxyphenyl)acetamide

N-(4-Fluoro-2-methoxyphenyl)acetamide

  • Catalogue No.:PA 15 0511029

  • CAS :

    582-11-6

  • Molecular Formula : C9H10FNO2

  • Molecular Weight : 183.18

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PA 15 0511030

1-Fluoro-5-methoxy-2,4-dinitrobenzene

1-Fluoro-5-methoxy-2,4-dinitrobenzene

  • Catalogue No.:PA 15 0511030

  • CAS :

    394-18-3

  • Molecular Formula : C7H5FN2O5

  • Molecular Weight : 216.12

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PA 15 0511031

N-(4-Fluoro-2-methoxy-5-nitrophenyl)acetamide

N-(4-Fluoro-2-methoxy-5-nitrophenyl)acetamide

  • Catalogue No.:PA 15 0511031

  • CAS :

    1823445-36-8

  • Molecular Formula : C9H9FN2O4

  • Molecular Weight : 228.18

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