Displaying 80 results for progesterone

Progesterone - API

Progesterone


  • Catalogue No.:PA 16 52000

  • CAS : 57-83-0

  • Molecular Formula : C21H30O2

  • Molecular Weight : 314.46

Progesterone - Impurity A

Pregna-4,14-diene-3,20-dione


  • Catalogue No.:PA 16 52010

  • CAS : 24377-08-0

  • Molecular Formula : C21H28O2

  • Molecular Weight : 312.45

Progesterone - Impurity B

(20S)-20-Hydroxypregn-4-en-3-one


  • Catalogue No.:PA 16 52020

  • CAS : 145-14-2

  • Molecular Formula : C21H32O2

  • Molecular Weight : 316.48

Progesterone - Impurity C

20β-Dihydroprogesterone


  • Catalogue No.:PA 16 52030

  • CAS : 145-15-3

  • Molecular Formula : C21H32O2

  • Molecular Weight : 316.48

Progesterone - Impurity D

(20S)-3-Oxopregn-4-en-20-yl Acetate


  • Catalogue No.:PA 16 52040

  • CAS : 5035-09-6

  • Molecular Formula : C23H34O3

  • Molecular Weight : 358.51

Progesterone - Impurity E

20-Dihydroprogesterone Acetate


  • Catalogue No.:PA 16 52050

  • CAS : 5062-62-4

  • Molecular Formula : C23H34O3

  • Molecular Weight : 358.51

Progesterone - Impurity F

21-(Cyclohex-1-enyl)pregn-4-ene-3,20-dione


  • Catalogue No.:PA 16 52060

  • CAS : NA

  • Molecular Formula : C27H38O2

  • Molecular Weight : 394.59

Progesterone - Impurity G

21-(Cyclohexylidene)pregn-4-ene-3,20-dione


  • Catalogue No.:PA 16 52070

  • CAS : NA

  • Molecular Formula : C27H38O2

  • Molecular Weight : 394.59

Progesterone - Impurity H

Δ6-Progesterone


  • Catalogue No.:PA 16 52080

  • CAS : 1162-56-7

  • Molecular Formula : C21H28O2

  • Molecular Weight : 312.40

Progesterone - Impurity I

(20S)-20-Formylpregn-4-en-3-one


  • Catalogue No.:PA 16 52090

  • CAS : 3986-89-8

  • Molecular Formula : C22H32O2

  • Molecular Weight : 328.49

Progesterone - Impurity J

Pregna-1,4-diene-3,20-dione


  • Catalogue No.:PA 16 52100

  • CAS : NA

  • Molecular Formula : C21H28O2

  • Molecular Weight : 312.45

Progesterone - Impurity K

Pregna-4,9(11)-diene-3,20-dione


  • Catalogue No.:PA 16 52110

  • CAS : NA

  • Molecular Formula : C21H28O2

  • Molecular Weight : 312.45

Progesterone - Impurity L

20-Methylidene-3-oxopregn-4-en-21-al


  • Catalogue No.:PA 16 52120

  • CAS : NA

  • Molecular Formula : C22H30O2

  • Molecular Weight : 326.47

Progesterone - Impurity M

(17α)-Pregn-4-ene-3,20-dione


  • Catalogue No.:PA 16 52130

  • CAS : 2000-66-0

  • Molecular Formula : C21H30O2

  • Molecular Weight : 314.46

Progesterone - In house impurity

11α-Hydroxy Progesterone


  • Catalogue No.:PA 16 52510

  • CAS : 80-75-1

  • Molecular Formula : C21H30O3

  • Molecular Weight : 330.46

Progesterone - In house impurity

11-Ketoprogesterone


  • Catalogue No.:PA 16 52520

  • CAS : 516-15-4

  • Molecular Formula : C21H28O3

  • Molecular Weight : 328.45

Progesterone - In house impurity

Δ6-Acetoxyprogesterone


  • Catalogue No.:PA 16 52530

  • CAS : 425-51-4

  • Molecular Formula : C23H30O4

  • Molecular Weight : 370.48

Progesterone - In house impurity

6-Bromo-Δ6-chloro-acetoxyprogesterone


  • Catalogue No.:PA 16 52540

  • CAS : 15251-04-4

  • Molecular Formula : C23H29BrO4

  • Molecular Weight : 449.38

Progesterone - In house impurity

6α-Chloro-17-acetoxy Progesterone


  • Catalogue No.:PA 16 52550

  • CAS : 2477-73-8

  • Molecular Formula : C23H31ClO4

  • Molecular Weight : 406.94

Progesterone - In house impurity

6β-Chloro-17-acetoxy Progesterone


  • Catalogue No.:PA 16 52560

  • CAS : 2658-74-4

  • Molecular Formula : C23H31ClO4

  • Molecular Weight : 406.94

Progesterone - In house impurity

Hydromadinone Acetate


  • Catalogue No.:PA 16 52570

  • CAS : 33125-90-5

  • Molecular Formula : C23H31ClO4

  • Molecular Weight : 406.94

Progesterone - In house impurity

6α-Hydroxy Progesterone


  • Catalogue No.:PA 16 52580

  • CAS : 604-20-6

  • Molecular Formula : C21H30O3

  • Molecular Weight : 330.46

Progesterone - In house impurity

6β-Hydroxy Progesterone


  • Catalogue No.:PA 16 52590

  • CAS : 604-19-3

  • Molecular Formula : C21H30O3

  • Molecular Weight : 330.46

Progesterone - In house impurity

Progesterone 6-Oxo Impurity


  • Catalogue No.:PA 16 52600

  • CAS : 2243-08-5

  • Molecular Formula : C21H28O3

  • Molecular Weight : 328.45

Progesterone - In house impurity

(3β,20S)-Pregn-5-ene-3,17,20-triol Sulfate


  • Catalogue No.:PA 16 52610

  • CAS : 4080-06-2

  • Molecular Formula : C21H34O6S

  • Molecular Weight : 414.56

Progesterone - In house impurity

5α-Pregnan-3β,20β-diol-20-sulphate


  • Catalogue No.:PA 16 52620

  • CAS : NA

  • Molecular Formula : C21H36O5S

  • Molecular Weight : 400.57

Progesterone - In house impurity

5α-Pregnan-3β,20β-diol-3-sulphate Sodium


  • Catalogue No.:PA 16 52630

  • CAS : NA

  • Molecular Formula : C21H35NaO5S

  • Molecular Weight : 422.55

Progesterone - In house impurity

20α-Dihydroprognenolone Sulfate


  • Catalogue No.:PA 16 52640

  • CAS : 26838-20-0

  • Molecular Formula : C21H34O5S

  • Molecular Weight : 398.56

Progesterone - In house impurity

Pregnanetriol 3α-O-β-D-Glucuronide


  • Catalogue No.:PA 16 52650

  • CAS : 74915-85-8

  • Molecular Formula : C27H44O9

  • Molecular Weight : 512.63

Progesterone - In house impurity

11-Dehydroprogesterone


  • Catalogue No.:PA 16 52660

  • CAS : 2625-60-7

  • Molecular Formula : C21H28O2

  • Molecular Weight : 312.45

Progesterone - In house impurity

(10R,13S,17R)-17-Acetyl-17-hydroxy-10,13-dimethyl-6-methylene-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one


  • Catalogue No.:PA 16 52670

  • CAS : NA

  • Molecular Formula : C22H28O3

  • Molecular Weight : 340.46

Progesterone - In house impurity

17α-Hydroxy Progesterone


  • Catalogue No.:PA 16 52680

  • CAS : 68-96-2

  • Molecular Formula : C21H30O3

  • Molecular Weight : 330.46

Progesterone - In house impurity

17α-Hydroxyprogesterone Valerate


  • Catalogue No.:PA 16 52690

  • CAS : 6677-15-2

  • Molecular Formula : C26H38O4

  • Molecular Weight : 414.58

Progesterone - In house impurity

(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl hex-5-enoate


  • Catalogue No.:PA 16 52700

  • CAS : NA

  • Molecular Formula : C27H38O4

  • Molecular Weight : 426.59

Progesterone - In house impurity

17α-Hydroxyprogesterone Heptanoate


  • Catalogue No.:PA 16 52710

  • CAS : 4596-16-1

  • Molecular Formula : C28H42O4

  • Molecular Weight : 442.63

Progesterone - In house impurity

(8R,9S,10R,13S,14S,17R)-17-Acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl 2,2,2-trifluoroacetate


  • Catalogue No.:PA 16 52720

  • CAS : 560-10-1

  • Molecular Formula : C23H29F3O4

  • Molecular Weight : 426.47

Progesterone - In house impurity

(8R,9S,10R,13S,14S)-4'-Butyl-3',10,13-trimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione


  • Catalogue No.:PA 16 52730

  • CAS : NA

  • Molecular Formula : C27H38O3

  • Molecular Weight : 410.59

Progesterone - In house impurity

16α,17α-Epoxyprogesterone


  • Catalogue No.:PA 16 52740

  • CAS : 1097-51-4

  • Molecular Formula : C21H28O3

  • Molecular Weight : 328.45

Progesterone - In house impurity

1-((17R)-17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl)ethanone


  • Catalogue No.:PA 16 52750

  • CAS : NA

  • Molecular Formula : C23H34O4

  • Molecular Weight : 374.51

Progesterone - In house impurity

(17R)-17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]-17-carbonitrile


  • Catalogue No.:PA 16 52760

  • CAS : NA

  • Molecular Formula : C22H31NO3

  • Molecular Weight : 357.49

Progesterone - In house impurity

17-Acetyl-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diyl Diacetate


  • Catalogue No.:PA 16 52770

  • CAS : NA

  • Molecular Formula : C25H34O5

  • Molecular Weight : 414.53

Progesterone - In house impurity

(9S,10R,13S,14S)-10,13-Dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione


  • Catalogue No.:PA 16 52780

  • CAS : NA

  • Molecular Formula : C19H26O2

  • Molecular Weight : 286.41

Progesterone - In house impurity

Pregnanediol 3α-O-β-D-Glucuronide


  • Catalogue No.:PA 16 52790

  • CAS : 1852-49-9

  • Molecular Formula : C27H44O8

  • Molecular Weight : 496.63

Progesterone - In house impurity

16-Dehydropregnolone


  • Catalogue No.:PA 16 52800

  • CAS : 1162-53-4

  • Molecular Formula : C21H30O2

  • Molecular Weight : 314.46

Progesterone - In house impurity

(20S)​-3-​Oxo-pregna-​1,​4-​diene-​20-​carboxaldehyde


  • Catalogue No.:PA 16 52810

  • CAS : 81201-82-3

  • Molecular Formula : C22H30O2

  • Molecular Weight : 326.47

Progesterone - In house impurity

(8R,9S,10R,13S,14S,17R)-17-Acetyl-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diyl Dihexanoate


  • Catalogue No.:PA 16 52820

  • CAS : NA

  • Molecular Formula : C33H52O5

  • Molecular Weight : 528.76

3β-Cholic Acid-d5


  • Catalogue No.:PA STI 021300

  • CAS : NA

  • Molecular Formula : C24H35D5O5

  • Molecular Weight : 413.60

3β,21-Dihydroxy-5α-pregnan-20-one-d4


  • Catalogue No.:PA STI 033010

  • CAS : NA

  • Molecular Formula : C21H30D4O3

  • Molecular Weight : 338.52

(5β,17α)-Dihydroxy-6α-(methyl-d3)-pregnane-3,20-dione-3,20-bis(ethyleneketal)


  • Catalogue No.:PA STI 032910

  • CAS : NA

  • Molecular Formula : C26H37D3O5

  • Molecular Weight : 435.61

(17aα)-Hydroxy-6α,17a-dimethyl-D-homoandrost-4-ene-3,17-dione 17-Acetate-d3


  • Catalogue No.:PA STI 048660

  • CAS : NA

  • Molecular Formula : C24H31D3O4

  • Molecular Weight : 389.54

17α-Hydroxy Progesterone-d8


  • Catalogue No.:PA STI 051030

  • CAS : 850023-80-2

  • Molecular Formula : C21H22D8O3

  • Molecular Weight : 338.51

Medroxy Progesterone.


  • Catalogue No.:PA STI 057960

  • CAS : 520-85-4

  • Molecular Formula : C22H32O3

  • Molecular Weight : 344.49

Medroxy Progesterone-d3


  • Catalogue No.:PA STI 057970

  • CAS : 162462-69-3_x0000_

  • Molecular Formula : C22H29D3O3

  • Molecular Weight : 347.51

Medroxy Progesterone-d3 17-O-β-D-Glucuronide


  • Catalogue No.:PA STI 057980

  • CAS : NA

  • Molecular Formula : C28H37D3O9

  • Molecular Weight : 523.63

Medroxy Progesterone-d6 17-Acetate


  • Catalogue No.:PA STI 057990

  • CAS : NA

  • Molecular Formula : C24H28D6O4

  • Molecular Weight : 392.56

6-epi-Medroxy Progesterone-d3 17-Acetate


  • Catalogue No.:PA STI 058000

  • CAS : NA

  • Molecular Formula : C24H31D3O4

  • Molecular Weight : 389.54

5β-Pregnane-3α,20α-diol-d5


  • Catalogue No.:PA STI 074710

  • CAS : NA

  • Molecular Formula : C21H31D5O2

  • Molecular Weight : 325.54

4-Pregnen-20α-ol-3-one-d4


  • Catalogue No.:PA STI 074750

  • CAS : NA

  • Molecular Formula : C21H28D4O2

  • Molecular Weight : 320.50

Progesterone-d9


  • Catalogue No.:PA STI 074970

  • CAS : 15775-74-3

  • Molecular Formula : C21H21D9O2

  • Molecular Weight : 323.52

3α,5α-Tetrahydronorethisterone-d5


  • Catalogue No.:PA STI 082150

  • CAS : 122605-87-2

  • Molecular Formula : C20H25D5O2

  • Molecular Weight : 307.48

3β,5α-Tetrahydronorethisterone-d5


  • Catalogue No.:PA STI 082160

  • CAS : 122605-89-4

  • Molecular Formula : C20H25D5O2

  • Molecular Weight : 307.48

(8S,9S,10R,13S,14S,17S)-17-Acetyl-16-bromo-10,13-dimethyl-4,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

(8S,9S,10R,13S,14S,17S)-17-Acetyl-16-bromo-10,13-dimethyl-4,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one


  • Catalogue No.:PAI 16 015010

  • CAS : NA

  • Molecular Formula : C21H29BrO2

  • Molecular Weight : 393.36

Progesterone - In house impurity

Androstane Spin Label


  • Catalogue No.:PA 16 52830

  • CAS : 25521-33-9

  • Molecular Formula : C23H38NO3

  • Molecular Weight : 376.56

Progesterone - In house impurity

17-(Acetyloxy)-3-ethoxy-pregna-3,5-dien-20-one


  • Catalogue No.:PA 16 52840

  • CAS : 16319-93-0

  • Molecular Formula : C25H36O4

  • Molecular Weight : 400.55

Progesterone - In house impurity

17-Acetyloxy-pregna-1,4-diene-3,20-dione


  • Catalogue No.:PA 16 52850

  • CAS : 2668-74-8

  • Molecular Formula : C23H30O4

  • Molecular Weight : 370.48

Progesterone - In house impurity

(11β)-11-(Acetyloxy)-20-hydroxy-3-oxo-pregna-4,17(20)-dien-21-al


  • Catalogue No.:PA 16 52860

  • CAS : 1089670-72-3

  • Molecular Formula : C23H30O5

  • Molecular Weight : 386.48

Progesterone - In house impurity

(3β)-3-(Acetyloxy)pregna-5,14,16-trien-20-one


  • Catalogue No.:PA 16 52870

  • CAS : 2453-93-2

  • Molecular Formula : C23H30O3

  • Molecular Weight : 354.48

Progesterone (ICRS0400)


  • Catalogue No.:PA ICRS-ICRS0400

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Progesterone (IPRS/115/14)


  • Catalogue No.:PA IP-IPRS 115 14

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Progesterone (JP 0192)


  • Catalogue No.:PA JP-JP 0192

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Progesterone (P3300000)


  • Catalogue No.:PA EP-P3300000

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Progesterone for system suitability (Y0001665)


  • Catalogue No.:PA EP-Y0001665

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Progesterone for peak identification (Y0001666)


  • Catalogue No.:PA EP-Y0001666

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Progesterone for impurity H identification (Y0001667)


  • Catalogue No.:PA EP-Y0001667

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Progesterone (1568007)


  • Catalogue No.:PA USP-1568007

  • CAS : 57-83-0

  • Molecular Formula :

  • Molecular Weight : 0.00

progesterone (449RB)


  • Catalogue No.:PA BP-449RB

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Progesterone - In house impurity

5,6-Tribromo-3β-hydroxy-16-pregnen-20-one Acetate


  • Catalogue No.:PA 16 52880

  • CAS : 883880-57-7

  • Molecular Formula : C23H31Br3O3

  • Molecular Weight : 595.20

Progesterone - In house impurity

11β,17α,21-Tris(acetyloxy)pregn-4-ene-3,20-dione


  • Catalogue No.:PA 16 52890

  • CAS : 3517-51-9

  • Molecular Formula : C27H36O8

  • Molecular Weight : 488.57

Progesterone - In house impurity

17α-Acetyloxy-11β-methyl-19-norprogesterone


  • Catalogue No.:PA 16 52900

  • CAS : 25092-41-5

  • Molecular Formula : C23H32O4

  • Molecular Weight : 372.50

(8S,9S,10R,13R,14S)-17-((2R,5S,E)-5-Ethyl-6-methylhept-3-en-2-yl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

(8S,9S,10R,13R,14S)-17-((2R,5S,E)-5-Ethyl-6-methylhept-3-en-2-yl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one


  • Catalogue No.:PAI 16 015020

  • CAS : NA

  • Molecular Formula : C29H46O

  • Molecular Weight : 410.69

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     */
Arguments
  1. "The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied"
    
/
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/
pharmaaffiliates
/
public_html
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Handler
/
AbstractProcessingHandler.php
 *
 * @author Jordi Boggiano <j.boggiano@seld.be>
 * @author Christophe Coevoet <stof@notk.org>
 */
abstract class AbstractProcessingHandler extends AbstractHandler
{
    /**
     * {@inheritdoc}
     */
    public function handle(array $record)
    {
        if (!$this->isHandling($record)) {
            return false;
        }
 
        $record = $this->processRecord($record);
 
        $record['formatted'] = $this->getFormatter()->format($record);
 
        $this->write($record);
 
        return false === $this->bubble;
    }
 
    /**
     * Writes the record down to the log of the implementing handler
     *
     * @param  array $record
     * @return void
     */
    abstract protected function write(array $record);
 
    /**
     * Processes a record.
     *
     * @param  array $record
     * @return array
     */
    protected function processRecord(array $record)
    {
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571598620 {#33
        date: 2019-10-20 19:10:20.278981 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 19:10:20] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6IkU2dHc...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6IkU2dHc...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('ZZy1JLtyKyIEpaD...', 'eyJpdiI6IkU2dHc...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
/
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pharmaaffiliates
/
public_html
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Logger.php
            $ts = new \DateTime(null, static::$timezone);
        }
        $ts->setTimezone(static::$timezone);
 
        $record = array(
            'message' => (string) $message,
            'context' => $context,
            'level' => $level,
            'level_name' => $levelName,
            'channel' => $this->name,
            'datetime' => $ts,
            'extra' => array(),
        );
 
        foreach ($this->processors as $processor) {
            $record = call_user_func($processor, $record);
        }
 
        while ($handler = current($this->handlers)) {
            if (true === $handler->handle($record)) {
                break;
            }
 
            next($this->handlers);
        }
 
        return true;
    }
 
    /**
     * Adds a log record at the DEBUG level.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function addDebug($message, array $context = array())
    {
        return $this->addRecord(static::DEBUG, $message, $context);
    }
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571598620 {#33
        date: 2019-10-20 19:10:20.278981 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 19:10:20] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6IkU2dHc...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6IkU2dHc...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('ZZy1JLtyKyIEpaD...', 'eyJpdiI6IkU2dHc...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
/
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pharmaaffiliates
/
public_html
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Logger.php
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function err($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the ERROR level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function error($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function crit($message, array $context = array())
    {
        return $this->addRecord(static::CRITICAL, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
Arguments
  1. 400
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
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/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
Logger.php
     * @return void
     */
    public function write($level, $message, array $context = [])
    {
        $this->writeLog($level, $message, $context);
    }
 
    /**
     * Write a message to the log.
     *
     * @param  string  $level
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    protected function writeLog($level, $message, $context)
    {
        $this->fireLogEvent($level, $message = $this->formatMessage($message), $context);
 
        $this->logger->{$level}($message, $context);
    }
 
    /**
     * Register a new callback handler for when a log event is triggered.
     *
     * @param  \Closure  $callback
     * @return void
     *
     * @throws \RuntimeException
     */
    public function listen(Closure $callback)
    {
        if (! isset($this->dispatcher)) {
            throw new RuntimeException('Events dispatcher has not been set.');
        }
 
        $this->dispatcher->listen(MessageLogged::class, $callback);
    }
 
    /**
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
Logger.php
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function critical($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log an error message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function error($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a warning message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function warning($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a notice to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
Arguments
  1. "error"
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
LogManager.php
     *
     * @return void
     */
    public function critical($message, array $context = [])
    {
        return $this->driver()->critical($message, $context);
    }
 
    /**
     * Runtime errors that do not require immediate action but should typically
     * be logged and monitored.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function error($message, array $context = [])
    {
        return $this->driver()->error($message, $context);
    }
 
    /**
     * Exceptional occurrences that are not errors.
     *
     * Example: Use of deprecated APIs, poor use of an API, undesirable things
     * that are not necessarily wrong.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function warning($message, array $context = [])
    {
        return $this->driver()->warning($message, $context);
    }
 
    /**
     * Normal but significant events.
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
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public_html
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vendor
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laravel
/
framework
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src
/
Illuminate
/
Foundation
/
Exceptions
/
Handler.php
     */
    public function report(Exception $e)
    {
        if ($this->shouldntReport($e)) {
            return;
        }
 
        if (method_exists($e, 'report')) {
            return $e->report();
        }
 
        try {
            $logger = $this->container->make(LoggerInterface::class);
        } catch (Exception $ex) {
            throw $e;
        }
 
        $logger->error(
            $e->getMessage(),
            array_merge($this->context(), ['exception' => $e]
        ));
    }
 
    /**
     * Determine if the exception should be reported.
     *
     * @param  \Exception  $e
     * @return bool
     */
    public function shouldReport(Exception $e)
    {
        return ! $this->shouldntReport($e);
    }
 
    /**
     * Determine if the exception is in the "do not report" list.
     *
     * @param  \Exception  $e
     * @return bool
     */
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
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pharmaaffiliates
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public_html
/
app
/
Exceptions
/
Handler.php
        \Illuminate\Auth\AuthenticationException::class,
        \Illuminate\Auth\Access\AuthorizationException::class,
        \Symfony\Component\HttpKernel\Exception\HttpException::class,
        \Illuminate\Database\Eloquent\ModelNotFoundException::class,
        \Illuminate\Session\TokenMismatchException::class,
        \Illuminate\Validation\ValidationException::class,
    ];
 
    /**
     * Report or log an exception.
     *
     * This is a great spot to send exceptions to Sentry, Bugsnag, etc.
     *
     * @param \Exception $exception
     *
     * @return void
     */
    public function report(Exception $exception)
    {
        parent::report($exception);
    }
 
    /**
     * Render an exception into an HTTP response.
     *
     * @param \Illuminate\Http\Request $request
     * @param \Exception               $exception
     *
     * @return \Illuminate\Http\Response
     */
    public function render($request, Exception $exception)
    {
        //dd($exception);
        if (strpos($request->url(), '/api/') !== false) {
            \Log::debug('API Request Exception - '.$request->url().' - '.$exception->getMessage().(!empty($request->all()) ? ' - '.json_encode($request->except(['password'])) : ''));
 
            if ($exception instanceof AuthorizationException) {
                return $this->setStatusCode(403)->respondWithError($exception->getMessage());
            }
 
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
/
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pharmaaffiliates
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public_html
/
vendor
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laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Bootstrap
/
HandleExceptions.php
    }
 
    /**
     * Handle an uncaught exception from the application.
     *
     * Note: Most exceptions can be handled via the try / catch block in
     * the HTTP and Console kernels. But, fatal error exceptions must
     * be handled differently since they are not normal exceptions.
     *
     * @param  \Throwable  $e
     * @return void
     */
    public function handleException($e)
    {
        if (! $e instanceof Exception) {
            $e = new FatalThrowableError($e);
        }
 
        try {
            $this->getExceptionHandler()->report($e);
        } catch (Exception $e) {
            //
        }
 
        if ($this->app->runningInConsole()) {
            $this->renderForConsole($e);
        } else {
            $this->renderHttpResponse($e);
        }
    }
 
    /**
     * Render an exception to the console.
     *
     * @param  \Exception  $e
     * @return void
     */
    protected function renderForConsole(Exception $e)
    {
        $this->getExceptionHandler()->renderForConsole(new ConsoleOutput, $e);
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
[internal]
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/ZZy1JLtyKyIEpaDenRLffdix0obpEla0lF93OCYO): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    

Environment & details:

empty
empty
empty
empty
empty
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
HTTP_ACCEPT
"text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8"
HTTP_ACCEPT_ENCODING
"gzip"
HTTP_ACCEPT_LANGUAGE
"en-US,en;q=0.5"
HTTP_CONNECTION
"Keep-Alive"
HTTP_HOST
"www.pharmaffiliates.com"
HTTP_USER_AGENT
"CCBot/2.0 (https://commoncrawl.org/faq/)"
HTTP_IF_MODIFIED_SINCE
"Wed, 17 Jul 2019 03:34:25 PDT"
DOCUMENT_ROOT
"/home/pharmaaffiliates/public_html"
REMOTE_ADDR
"3.228.24.192"
REMOTE_PORT
"32886"
SERVER_ADDR
"172.105.43.57"
SERVER_NAME
"www.pharmaffiliates.com"
SERVER_ADMIN
"webmaster@pharmaffiliates.com"
SERVER_PORT
"443"
REQUEST_URI
"/en/parentapi/progesterone"
REDIRECT_URL
"/en/parentapi/progesterone"
HTTPS
"on"
REDIRECT_STATUS
"200"
SSL_PROTOCOL
"TLSv1.2"
SSL_SESSION_ID
"b7ded83bf3fb51da2a5c018796c2ff32d70b1a19bd185794b82a6b327e49bcb7"
SSL_CIPHER
"ECDHE-RSA-AES256-GCM-SHA384"
SSL_CIPHER_USEKEYSIZE
"256"
SSL_CIPHER_ALGKEYSIZE
"256"
SCRIPT_FILENAME
"/home/pharmaaffiliates/public_html/index.php"
QUERY_STRING
""
SCRIPT_URI
"https://www.pharmaffiliates.com/en/parentapi/progesterone"
SCRIPT_URL
"/en/parentapi/progesterone"
SCRIPT_NAME
"/index.php"
SERVER_PROTOCOL
"HTTP/1.1"
SERVER_SOFTWARE
"LiteSpeed"
REQUEST_METHOD
"GET"
X-LSCACHE
"on"
PHP_SELF
"/index.php"
REQUEST_TIME_FLOAT
1571598620.0064
REQUEST_TIME
1571598620
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
0. Whoops\Handler\PrettyPageHandler