Displaying 70 results for quetiapine

Quetiapine - API

Quetiapine


  • Catalogue No.:PA 17 02000

  • CAS : 111974-69-7

  • Molecular Formula : C21H25N3O2S

  • Molecular Weight : 383.51

Quetiapine - Impurity A

Quetiapine Acetate


  • Catalogue No.:PA 17 02010

  • CAS : 844639-07-2

  • Molecular Formula : C23H27N3O3S

  • Molecular Weight : 425.54

Quetiapine - Impurity B

11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine Dihydrochloride


  • Catalogue No.:PA 17 02020

  • CAS : 111974-74-4

  • Molecular Formula : C17H19Cl2N3S

  • Molecular Weight : 368.32

Quetiapine - Impurity C

2-[2-[4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl]ethoxy]ethyl [4-(dibenzo[b,f][1, 4]thiazepin-11-yl)piperazin-1-yl]acetate


  • Catalogue No.:PA 17 02030

  • CAS : 1798840-31-9

  • Molecular Formula : C40H42N6O3S2

  • Molecular Weight : 718.93

Quetiapine - Impurity D

Quetiapine Dimer Impurity


  • Catalogue No.:PA 17 02040

  • CAS : 945668-94-0

  • Molecular Formula : C30H24N4S2

  • Molecular Weight : 504.67

Quetiapine - Impurity E

Quetiapine bis-Ether


  • Catalogue No.:PA 17 02050

  • CAS : 1371638-05-9

  • Molecular Formula : C40H44N6O2S2

  • Molecular Weight : 704.95

Quetiapine - Impurity F

[2-[(2-aminophenyl)sulfanyl]phenyl][4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]methanone


  • Catalogue No.:PA 17 02060

  • CAS : 848814-27-7

  • Molecular Formula : C21H27N3O3S

  • Molecular Weight : 401.52

Quetiapine - Impurity G

Quetiapine Lactam


  • Catalogue No.:PA 17 02070

  • CAS : 3159-07-7

  • Molecular Formula : C13H9NOS

  • Molecular Weight : 227.28

Quetiapine - Impurity H

Quetiapine N-Oxide


  • Catalogue No.:PA 17 02080

  • CAS : 1076199-40-0

  • Molecular Formula : C21H25N3O3S

  • Molecular Weight : 399.51

Quetiapine - Impurity I

2-[4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl]ethanol


  • Catalogue No.:PA 17 02090

  • CAS : 329216-67-3

  • Molecular Formula : C19H21N3OS

  • Molecular Weight : 339.46

Quetiapine - Impurity J

2-[2-[2-[2-[4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethanol


  • Catalogue No.:PA 17 02100

  • CAS : 1356906-17-6

  • Molecular Formula : C25H33N3O4S

  • Molecular Weight : 471.61

Quetiapine - Impurity K

N-(2-((2-(4-(2-(2-Hydroxyethoxy)ethyl)piperazine-1-carbonyl)phenyl)thio)phenyl)acetamide


  • Catalogue No.:PA 17 02110

  • CAS : 1371638-10-6

  • Molecular Formula : C23H29N3O4S

  • Molecular Weight : 443.56

Quetiapine - Impurity L

9-Chloro Quetiapine


  • Catalogue No.:PA 17 02120

  • CAS : 1371638-11-7

  • Molecular Formula : C21H24ClN3O2S

  • Molecular Weight : 417.95

Quetiapine - Impurity N

2-(2-(4-(2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethyl)piperazin-1-yl)ethoxy)ethanol


  • Catalogue No.:PA 17 02140

  • CAS : 1800291-86-4

  • Molecular Formula : C29H41N5O3S

  • Molecular Weight : 539.73

Quetiapine - Impurity O

Quetiapine O-Trityl Impurity


  • Catalogue No.:PA 17 02150

  • CAS : 844639-06-1

  • Molecular Formula : C40H39N3O2S

  • Molecular Weight : 625.82

Quetiapine - Impurity P

Quetiapine N-Ethyl Impurity


  • Catalogue No.:PA 17 02160

  • CAS : 1011758-03-4

  • Molecular Formula : C19H21N3S

  • Molecular Weight : 323.46

Quetiapine - Impurity P (Dihydrochloride Salt)

Quetiapine N-Ethyl Dihydrochloride Impurity


  • Catalogue No.:PA 17 02161

  • CAS : NA

  • Molecular Formula : C19H23Cl2N3S

  • Molecular Weight : 396.38

Quetiapine - Impurity Q

4-(Dibenzo[b,f][1,4]thiazepin-11-yl)-1,1-bis[2-(2-hydroxyethoxy)ethyl]piperazin-1-ium


  • Catalogue No.:PA 17 02170

  • CAS : NA

  • Molecular Formula : C25H34N3O4S

  • Molecular Weight : 472.62

Quetiapine - Impurity R

Fumaric Acid Monoethyl Ester


  • Catalogue No.:PA 17 02180

  • CAS : 2459-05-4

  • Molecular Formula : C6H8O4

  • Molecular Weight : 144.13

Quetiapine - Impurity S

Quetiapine Sulfoxide


  • Catalogue No.:PA 17 02190

  • CAS : 329216-63-9

  • Molecular Formula : C21H25N3O3S

  • Molecular Weight : 399.51

Quetiapine - Impurity T

Quetiapine Morpholine Impurity


  • Catalogue No.:PA 17 02200

  • CAS : 5747-46-6

  • Molecular Formula : C17H16N2OS

  • Molecular Weight : 296.39

Quetiapine - Impurity U

Dibenzo[b,f][1,4]thiazepin-11-amine


  • Catalogue No.:PA 17 02210

  • CAS : 5786-26-5

  • Molecular Formula : C13H10N2S

  • Molecular Weight : 226.30

Quetiapine - Impurity V

2-(2-(4-Phenanthridin-6-yl)piperazin-1-yl)ethoxy)ethanol


  • Catalogue No.:PA 17 02220

  • CAS : NA

  • Molecular Formula : C21H25N3O2

  • Molecular Weight : 351.44

Quetiapine - Impurity W

11-(2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethoxy) dibenzo[b,f][1,4]thiazepine


  • Catalogue No.:PA 17 02230

  • CAS : 1800608-95-0

  • Molecular Formula : C34H32N4O2S2

  • Molecular Weight : 592.77

Quetiapine - In house impurity

Quetiapine Hemifumarate


  • Catalogue No.:PA 17 02510

  • CAS : 111974-72-2

  • Molecular Formula : C46H54N6O8S2

  • Molecular Weight : 883.10

Quetiapine - In house impurity

1-[2-(2-Hydroxyethoxy)ethyl]piperazine


  • Catalogue No.:PA 17 02520

  • CAS : 13349-82-1

  • Molecular Formula : C8H18N2O2

  • Molecular Weight : 174.24

Quetiapine - In house impurity

11-Chloro-dibenzo[b,f][1,4]thiazepine


  • Catalogue No.:PA 17 02530

  • CAS : 13745-86-3

  • Molecular Formula : C13H8ClNS

  • Molecular Weight : 245.73

Quetiapine - In house impurity

Quetiapine Hydroxy Impurity Dihydrochloride Salt


  • Catalogue No.:PA 17 02540

  • CAS : 329218-14-6

  • Molecular Formula : C19H23Cl2N3OS

  • Molecular Weight : 412.38

Quetiapine - In house impurity

Quetiapine Sulfone


  • Catalogue No.:PA 17 02550

  • CAS : 329216-65-1

  • Molecular Formula : C21H25N3O4S

  • Molecular Weight : 415.51

Quetiapine - In house impurity

7-Hydroxy-N-des{[2-(2-hydroxy)ethoxy]ethyl} Quetiapine Dihydrochloride


  • Catalogue No.:PA 17 02560

  • CAS : 232597-73-8

  • Molecular Formula : C17H19Cl2N3OS

  • Molecular Weight : 384.32

Quetiapine - In house impurity

7-Hydroxy Quetiapine


  • Catalogue No.:PA 17 02570

  • CAS : 139079-39-3

  • Molecular Formula : C21H25N3O3S

  • Molecular Weight : 399.51

Quetiapine - In house impurity

7-Hydroxy Quetiapine S-Oxide


  • Catalogue No.:PA 17 02580

  • CAS : 1185170-04-0

  • Molecular Formula : C21H25N3O4S

  • Molecular Weight : 415.51

Quetiapine - In house impurity

2-(2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethoxy)ethanol


  • Catalogue No.:PA 17 02590

  • CAS : 329216-69-5

  • Molecular Formula : C23H29N3O3S

  • Molecular Weight : 427.56

7-Benzyloxy-N-des[[2-(2-hydroxy)ethoxy]ethyl] Quetiapine-d8


  • Catalogue No.:PA STI 011850

  • CAS : 1185177-12-1

  • Molecular Formula : C24H15D8N3OS

  • Molecular Weight : 409.57

9-Chloro Quetiapine-D8


  • Catalogue No.:PA STI 019650

  • CAS : NA

  • Molecular Formula : C21H16D8ClN3O2S

  • Molecular Weight : 426.00

N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine-d8


  • Catalogue No.:PA STI 027060

  • CAS : 1189866-35-0

  • Molecular Formula : C17H9D8N3S

  • Molecular Weight : 303.45

2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl-d8)ethoxy)ethyl Acetate


  • Catalogue No.:PA STI 029720

  • CAS : NA

  • Molecular Formula : C23H19D8N3O3S

  • Molecular Weight : 433.59

2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl-d8)ethoxy)ethanol


  • Catalogue No.:PA STI 029730

  • CAS : NA

  • Molecular Formula : C21H19D8N3O3S

  • Molecular Weight : 409.57

Di(2-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl))-2-propoxyethyl Propionate-d8


  • Catalogue No.:PA STI 029740

  • CAS : NA

  • Molecular Formula : C40H34D8N6O3S2

  • Molecular Weight : 726.98

2-[2-[2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethoxy]ethoxy]-ethanol-d8 Fumarate


  • Catalogue No.:PA STI 029880

  • CAS : NA

  • Molecular Formula : C29H29D8N3O8S

  • Molecular Weight : 595.73

2-[2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethoxy]ethanol-d8 Fumarate


  • Catalogue No.:PA STI 029890

  • CAS : NA

  • Molecular Formula : C27H25D8N3O7S

  • Molecular Weight : 551.68

O-Dibenzo[b,f][1,4]thiazepinyl Quetiapine-D8


  • Catalogue No.:PA STI 037960

  • CAS : NA

  • Molecular Formula : C34H24D8N4O2S

  • Molecular Weight : 600.82

Ethyl Quetiapine-d5


  • Catalogue No.:PA STI 040130

  • CAS : NA

  • Molecular Formula : C23H24D5N3O2S

  • Molecular Weight : 416.59

7-Hydroxy-N-des{[2-(2-hydroxy)ethoxy]ethyl} Quetiapine-d8 Dihydrochloride


  • Catalogue No.:PA STI 048510

  • CAS : 1246819-53-3

  • Molecular Formula : C17H11D8Cl2N3OS

  • Molecular Weight : 392.37

N-(2-((2-(4-(2-(2-Hydroxyethoxy)ethyl)piperazine-d8--1-carbonyl)phenyl)thio)phenyl)acetamide


  • Catalogue No.:PA STI 048760

  • CAS : NA

  • Molecular Formula : C23H21D8N3O4S

  • Molecular Weight : 451.61

7-Hydroxy Quetiapine-d8


  • Catalogue No.:PA STI 051420

  • CAS : 1185098-57-0

  • Molecular Formula : C21H17D8N3O3S

  • Molecular Weight : 407.56

11-(1-Piperazinyl-d8)-dibenzo[b,f][1,4]thiazepin-7-ol


  • Catalogue No.:PA STI 073950

  • CAS : 1246819-53-3

  • Molecular Formula : C17H9D8N3OS

  • Molecular Weight : 319.45

Quetiapine Dimer Impurity-d8


  • Catalogue No.:PA STI 076560

  • CAS : NA

  • Molecular Formula : C30H16D8N4S2

  • Molecular Weight : 512.72

Quetiapine Carboxylate-d4


  • Catalogue No.:PA STI 076570

  • CAS : NA

  • Molecular Formula : C22H21D4N3O4S

  • Molecular Weight : 431.54

Quetiapine-d8 Fumarate


  • Catalogue No.:PA STI 076580

  • CAS : 1185247-12-4

  • Molecular Formula : C25H21D8N3O6S

  • Molecular Weight : 507.63

Quetiapine-d4 Fumarate


  • Catalogue No.:PA STI 076590

  • CAS : 1331636-50-0

  • Molecular Formula : C25H25D4N3O6S

  • Molecular Weight : 503.60

Quetiapine Hydroxy Impurity-d8


  • Catalogue No.:PA STI 076600

  • CAS : 1246820-78-9

  • Molecular Formula : C19H13D8N3OS

  • Molecular Weight : 347.50

Quetiapine Sulfoxide-d8


  • Catalogue No.:PA STI 076610

  • CAS : 1330238-38-4

  • Molecular Formula : C21H17D8N3O3S

  • Molecular Weight : 407.56

O-Triphenylmethoxy Quetiapine-D8


  • Catalogue No.:PA STI 085600

  • CAS : NA

  • Molecular Formula : C40H31D8N3O2S

  • Molecular Weight : 633.87

11-(4-(2-(2-Chloroethoxy)ethyl)piperazin-1-yl)dibenzo[b,f][1,4]thiazepine

11-(4-(2-(2-Chloroethoxy)ethyl)piperazin-1-yl)dibenzo[b,f][1,4]thiazepine


  • Catalogue No.:PAI 17 001000

  • CAS : NA

  • Molecular Formula : C21H24ClN3OS

  • Molecular Weight : 401.95

2-(2-(2-(2-Chloroethoxy)ethoxy)ethoxy)ethanol

2-(2-(2-(2-Chloroethoxy)ethoxy)ethoxy)ethanol


  • Catalogue No.:PAI 17 001010

  • CAS : 5197-66-0

  • Molecular Formula : C8H17ClO4

  • Molecular Weight : 212.67

2,2,3,3-Tetramethyl-4,7,10,13-tetraoxa-3-silapentadecan-15-ol

2,2,3,3-Tetramethyl-4,7,10,13-tetraoxa-3-silapentadecan-15-ol


  • Catalogue No.:PAI 17 001020

  • CAS : 134179-40-1

  • Molecular Formula : C14H32O5Si

  • Molecular Weight : 308.49

15-Bromo-2,2,3,3-tetramethyl-4,7,10,13-tetraoxa-3-silapentadecane

15-Bromo-2,2,3,3-tetramethyl-4,7,10,13-tetraoxa-3-silapentadecane


  • Catalogue No.:PAI 17 001030

  • CAS : NA

  • Molecular Formula : C14H31BrO4Si

  • Molecular Weight : 371.38

11-(4-(2,2,3,3-Tetramethyl-4,7,10,13-tetraoxa-3-silapentadecan-15-yl)piperazin-1-yl)dibenzo[b,f][1,4]thiazepine

11-(4-(2,2,3,3-Tetramethyl-4,7,10,13-tetraoxa-3-silapentadecan-15-yl)piperazin-1-yl)dibenzo[b,f][1,4]thiazepine


  • Catalogue No.:PAI 17 001040

  • CAS : NA

  • Molecular Formula : C31H47N3O4SSi

  • Molecular Weight : 585.87

Quetiapine - In house impurity

4-(Dibenzo[b,f][1,4]thiazepin-11-yl)-1-(2-(2-hydroxyethoxy)ethyl)-1-(2-hydroxyethyl)piperazin-1-ium Bromide


  • Catalogue No.:PA 17 02600

  • CAS : NA

  • Molecular Formula : C23H30BrN3O3S

  • Molecular Weight : 508.48

Quetiapine Fumarate (IPRS/60/11)


  • Catalogue No.:PA IP-IPRS 60 11

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Quetiapine Fumarate (JP 0198)


  • Catalogue No.:PA JP-JP 0198

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Quetiapine for system suitability (Y0001419)


  • Catalogue No.:PA EP-Y0001419

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Quetiapine Fumarate (1592704)


  • Catalogue No.:PA USP-1592704

  • CAS : 111974-72-2

  • Molecular Formula :

  • Molecular Weight : 0.00

Quetiapine System Suitability (Mixture contains Quetiapine Fumarate and about 1% each of Quetiapine (1592715)


  • Catalogue No.:PA USP-1592715

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Quetiapine Related Compound B (11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine dihydrochloride) (1592737)


  • Catalogue No.:PA USP-1592737

  • CAS : 111974-74-4

  • Molecular Formula :

  • Molecular Weight : 0.00

Quetiapine Related Compound G (Dibenzo[b,f][1,4]thiazepin-11(10H)-one) (1592781)


  • Catalogue No.:PA USP-1592781

  • CAS : 3159-07-7

  • Molecular Formula :

  • Molecular Weight : 0.00

Quetiapine Related Compound H (4-(Dibenzo[b,f][1,4]thiazepin-11-yl)-1-[2-(2-hydroxyethoxy)ethyl]pip (1592792)


  • Catalogue No.:PA USP-1592792

  • CAS : 1076199-40-0

  • Molecular Formula :

  • Molecular Weight : 0.00

Quetiapine - Impurity B (Freebase)

11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine


  • Catalogue No.:PA 17 02021

  • CAS : 5747-48-8

  • Molecular Formula : C17H17N3S

  • Molecular Weight : 295.40

Quetiapine - Impurity U (Hydrochloride Salt)

Dibenzo[b,f][1,4]thiazepin-11-amine Hydrochloride


  • Catalogue No.:PA 17 02211

  • CAS : 1176987-11-3

  • Molecular Formula : C13H11ClN2S

  • Molecular Weight : 262.76

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  1. "The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied"
    
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AbstractProcessingHandler.php
 *
 * @author Jordi Boggiano <j.boggiano@seld.be>
 * @author Christophe Coevoet <stof@notk.org>
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abstract class AbstractProcessingHandler extends AbstractHandler
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Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
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          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571602593 {#33
        date: 2019-10-20 20:16:33.295449 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 20:16:33] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6ImJtWjB...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6ImJtWjB...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('PcYzAXFGxfXjGjj...', 'eyJpdiI6ImJtWjB...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Logger.php
            $ts = new \DateTime(null, static::$timezone);
        }
        $ts->setTimezone(static::$timezone);
 
        $record = array(
            'message' => (string) $message,
            'context' => $context,
            'level' => $level,
            'level_name' => $levelName,
            'channel' => $this->name,
            'datetime' => $ts,
            'extra' => array(),
        );
 
        foreach ($this->processors as $processor) {
            $record = call_user_func($processor, $record);
        }
 
        while ($handler = current($this->handlers)) {
            if (true === $handler->handle($record)) {
                break;
            }
 
            next($this->handlers);
        }
 
        return true;
    }
 
    /**
     * Adds a log record at the DEBUG level.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function addDebug($message, array $context = array())
    {
        return $this->addRecord(static::DEBUG, $message, $context);
    }
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571602593 {#33
        date: 2019-10-20 20:16:33.295449 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 20:16:33] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6ImJtWjB...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6ImJtWjB...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('PcYzAXFGxfXjGjj...', 'eyJpdiI6ImJtWjB...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Logger.php
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function err($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the ERROR level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function error($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function crit($message, array $context = array())
    {
        return $this->addRecord(static::CRITICAL, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
Arguments
  1. 400
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
Logger.php
     * @return void
     */
    public function write($level, $message, array $context = [])
    {
        $this->writeLog($level, $message, $context);
    }
 
    /**
     * Write a message to the log.
     *
     * @param  string  $level
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    protected function writeLog($level, $message, $context)
    {
        $this->fireLogEvent($level, $message = $this->formatMessage($message), $context);
 
        $this->logger->{$level}($message, $context);
    }
 
    /**
     * Register a new callback handler for when a log event is triggered.
     *
     * @param  \Closure  $callback
     * @return void
     *
     * @throws \RuntimeException
     */
    public function listen(Closure $callback)
    {
        if (! isset($this->dispatcher)) {
            throw new RuntimeException('Events dispatcher has not been set.');
        }
 
        $this->dispatcher->listen(MessageLogged::class, $callback);
    }
 
    /**
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
Logger.php
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function critical($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log an error message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function error($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a warning message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function warning($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a notice to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
Arguments
  1. "error"
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
LogManager.php
     *
     * @return void
     */
    public function critical($message, array $context = [])
    {
        return $this->driver()->critical($message, $context);
    }
 
    /**
     * Runtime errors that do not require immediate action but should typically
     * be logged and monitored.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function error($message, array $context = [])
    {
        return $this->driver()->error($message, $context);
    }
 
    /**
     * Exceptional occurrences that are not errors.
     *
     * Example: Use of deprecated APIs, poor use of an API, undesirable things
     * that are not necessarily wrong.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function warning($message, array $context = [])
    {
        return $this->driver()->warning($message, $context);
    }
 
    /**
     * Normal but significant events.
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Exceptions
/
Handler.php
     */
    public function report(Exception $e)
    {
        if ($this->shouldntReport($e)) {
            return;
        }
 
        if (method_exists($e, 'report')) {
            return $e->report();
        }
 
        try {
            $logger = $this->container->make(LoggerInterface::class);
        } catch (Exception $ex) {
            throw $e;
        }
 
        $logger->error(
            $e->getMessage(),
            array_merge($this->context(), ['exception' => $e]
        ));
    }
 
    /**
     * Determine if the exception should be reported.
     *
     * @param  \Exception  $e
     * @return bool
     */
    public function shouldReport(Exception $e)
    {
        return ! $this->shouldntReport($e);
    }
 
    /**
     * Determine if the exception is in the "do not report" list.
     *
     * @param  \Exception  $e
     * @return bool
     */
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
app
/
Exceptions
/
Handler.php
        \Illuminate\Auth\AuthenticationException::class,
        \Illuminate\Auth\Access\AuthorizationException::class,
        \Symfony\Component\HttpKernel\Exception\HttpException::class,
        \Illuminate\Database\Eloquent\ModelNotFoundException::class,
        \Illuminate\Session\TokenMismatchException::class,
        \Illuminate\Validation\ValidationException::class,
    ];
 
    /**
     * Report or log an exception.
     *
     * This is a great spot to send exceptions to Sentry, Bugsnag, etc.
     *
     * @param \Exception $exception
     *
     * @return void
     */
    public function report(Exception $exception)
    {
        parent::report($exception);
    }
 
    /**
     * Render an exception into an HTTP response.
     *
     * @param \Illuminate\Http\Request $request
     * @param \Exception               $exception
     *
     * @return \Illuminate\Http\Response
     */
    public function render($request, Exception $exception)
    {
        //dd($exception);
        if (strpos($request->url(), '/api/') !== false) {
            \Log::debug('API Request Exception - '.$request->url().' - '.$exception->getMessage().(!empty($request->all()) ? ' - '.json_encode($request->except(['password'])) : ''));
 
            if ($exception instanceof AuthorizationException) {
                return $this->setStatusCode(403)->respondWithError($exception->getMessage());
            }
 
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Bootstrap
/
HandleExceptions.php
    }
 
    /**
     * Handle an uncaught exception from the application.
     *
     * Note: Most exceptions can be handled via the try / catch block in
     * the HTTP and Console kernels. But, fatal error exceptions must
     * be handled differently since they are not normal exceptions.
     *
     * @param  \Throwable  $e
     * @return void
     */
    public function handleException($e)
    {
        if (! $e instanceof Exception) {
            $e = new FatalThrowableError($e);
        }
 
        try {
            $this->getExceptionHandler()->report($e);
        } catch (Exception $e) {
            //
        }
 
        if ($this->app->runningInConsole()) {
            $this->renderForConsole($e);
        } else {
            $this->renderHttpResponse($e);
        }
    }
 
    /**
     * Render an exception to the console.
     *
     * @param  \Exception  $e
     * @return void
     */
    protected function renderForConsole(Exception $e)
    {
        $this->getExceptionHandler()->renderForConsole(new ConsoleOutput, $e);
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
[internal]
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/PcYzAXFGxfXjGjj9MoJOHPokubu0uTIKpjvV03lt): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    

Environment & details:

empty
empty
empty
empty
empty
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
HTTP_ACCEPT
"text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8"
HTTP_ACCEPT_ENCODING
"gzip"
HTTP_ACCEPT_LANGUAGE
"en-US,en;q=0.5"
HTTP_CONNECTION
"Keep-Alive"
HTTP_HOST
"www.pharmaffiliates.com"
HTTP_USER_AGENT
"CCBot/2.0 (https://commoncrawl.org/faq/)"
HTTP_IF_MODIFIED_SINCE
"Tue, 16 Jul 2019 08:02:08 PDT"
DOCUMENT_ROOT
"/home/pharmaaffiliates/public_html"
REMOTE_ADDR
"3.228.24.192"
REMOTE_PORT
"37928"
SERVER_ADDR
"172.105.43.57"
SERVER_NAME
"www.pharmaffiliates.com"
SERVER_ADMIN
"webmaster@pharmaffiliates.com"
SERVER_PORT
"443"
REQUEST_URI
"/en/parentapi/quetiapine"
REDIRECT_URL
"/en/parentapi/quetiapine"
HTTPS
"on"
REDIRECT_STATUS
"200"
SSL_PROTOCOL
"TLSv1.2"
SSL_SESSION_ID
"3b37a759022e45b9093a61e80395889159c4a4f4b28c11eb7768b5ed44ce0756"
SSL_CIPHER
"ECDHE-RSA-AES256-GCM-SHA384"
SSL_CIPHER_USEKEYSIZE
"256"
SSL_CIPHER_ALGKEYSIZE
"256"
SCRIPT_FILENAME
"/home/pharmaaffiliates/public_html/index.php"
QUERY_STRING
""
SCRIPT_URI
"https://www.pharmaffiliates.com/en/parentapi/quetiapine"
SCRIPT_URL
"/en/parentapi/quetiapine"
SCRIPT_NAME
"/index.php"
SERVER_PROTOCOL
"HTTP/1.1"
SERVER_SOFTWARE
"LiteSpeed"
REQUEST_METHOD
"GET"
X-LSCACHE
"on"
PHP_SELF
"/index.php"
REQUEST_TIME_FLOAT
1571602593.0024
REQUEST_TIME
1571602593
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
0. Whoops\Handler\PrettyPageHandler