rosuvastatin acid and its Impurities
Rosuvastatin Acid used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. It is sold under the trade name Crestor. It is available as a generic medication.Reference standards of Rosuvastatin Acid API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Rosuvastatin Acid - Impurity A (Calcium Salt)
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl (2-hydroxy-2-methylpropylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy- 6-heptenoic Acid Calcium Salt
Catalogue No.:PA 18 20010
CAS :
1714147-47-3
Molecular Formula : C25H33FN3O7S•1/2Ca
Molecular Weight : 558.65
Rosuvastatin Acid - Impurity A (Sodium Salt)
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-2-[[(2-hydroxy-2-methylpropyl)sulfonyl](methyl)amino]-6-(1-methylethyl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic Acid sodium
Catalogue No.:PA 18 20011
CAS :
1714147-50-8
Molecular Formula : C25H33FN3NaO7S
Molecular Weight : 561.60
Rosuvastatin Acid - Impurity B (Sodium Salt)
(3RS,5RS,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl (methyl sulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic Acid Sodium Salt
Catalogue No.:PA 18 20020
CAS :
1007871-86-4
Molecular Formula : C22H27FN3NaO6S
Molecular Weight : 503.52
Rosuvastatin Acid - Impurity B (Freebase)
(3RS,5RS,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic Acid
Catalogue No.:PA 18 20021
CAS :
1007912-86-8
Molecular Formula : C22H28FN3O6S
Molecular Weight : 481.54
Rosuvastatin Acid - Impurity D (Freebase)
N-[4-(4-Fluorophenyl)-5-[(E)-2-[(2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethenyl]-6- (1-methylethyl)pyrimidin-2-yl]-N-methylmethanesulfonamide
Catalogue No.:PA 18 20040
CAS :
503610-43-3
Molecular Formula : C22H26FN3O5S
Molecular Weight : 463.52
Rosuvastatin Acid - Impurity F
1,1-Dimethylethyl [(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]ethenyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
Catalogue No.:PA 18 20060
CAS :
289042-12-2
Molecular Formula : C29H40FN3O6S
Molecular Weight : 577.71
Rosuvastatin Acid - Impurity C (Sodium Salt)
(3R,6E)-7-[4-(4-Fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoic Acid Sodium
Catalogue No.:PA 18 0200032
CAS :
1620823-61-1
Molecular Formula : C22H26FN3NaO6S
Molecular Weight : 502.51
Rosuvastatin Acid - Impurity G (Calcium Salt)
(3S,5R,6E)-7-[4-(4-Fluorophenyl)-2-[N-methylmethane-sulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic Acid Calcium
Catalogue No.:PA 18 0200071
CAS :
2414245-11-5
Molecular Formula : C44H54CaF2N6O12S2
Molecular Weight : 1001.14
Sodium (S,2E,6E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-hydroxyhepta-2,6-dienoate
Sodium (S,2E,6E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-hydroxyhepta-2,6-dienoate
Catalogue No.:PA 18 0201046
CAS :
NA
Molecular Formula : C22H25FN3NaO5S
Molecular Weight : 485.51
Rosuvastatin Acid - Impurity E
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-2-[[[2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-2-hydroxyethyl]sulfonyl](methyl)-amino]-6-(1-methylethyl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic Acid
Catalogue No.:PA 18 20050
CAS :
2226413-61-0
Molecular Formula : C38H46F2N6O9S2
Molecular Weight : 832.93
Rosuvastatin Acid - Impurity E (Calcium Salt)
Calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-2-{2-[4-(4-fluorophenyl)-6-isopropyl-2-(Nmethylmethylsulfonamido)pyrimidin-5-yl]-2-hydroxy-N-methylethylsulfonamido}-6-isopropylpyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate Salt (1:2)
Catalogue No.:PA 18 20051
CAS :
NA
Molecular Formula : C76H90CaF4N12O18S4
Molecular Weight : 1703.93
Rosuvastatin Acid - Impurity J
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-2-[[[(E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]ethenyl]sulfonyl](methyl)amino]-6-(1-methylethyl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic Acid
Catalogue No.:PA 18 20100
CAS :
2226413-62-1
Molecular Formula : C38H44F2N6O8S2
Molecular Weight : 814.92
Rosuvastatin Acid - Impurity J (Sodium Salt)
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-2-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-N-methylethene-1-sulfonamido]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic Acid Sodium
Catalogue No.:PA 18 0200101
CAS :
NA
Molecular Formula : C38H44F2N6NaO8S2
Molecular Weight : 837.91
tert-Butyl (E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dioxohept-6-enoate
tert-Butyl (E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dioxohept-6-enoate
Catalogue No.:PA 18 0201042
CAS :
1005003-78-0
Molecular Formula : C26H32FN3O6S
Molecular Weight : 533.62
tert-Butyl 2-((4R,6S)-6-((E)-2-(4-isopropyl-2-(N-methylmethylsulfonamido)-6-phenylpyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
tert-Butyl 2-((4R,6S)-6-((E)-2-(4-isopropyl-2-(N-methylmethylsulfonamido)-6-phenylpyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
Catalogue No.:PA 18 0201043
CAS :
NA
Molecular Formula : C29H41N3O6S
Molecular Weight : 559.72
N-(4-(4-Fluorophenyl)-5-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
N-(4-(4-Fluorophenyl)-5-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
Catalogue No.:PAI 18 013078
CAS :
1254070-72-8
Molecular Formula : C22H28FN3O5S
Molecular Weight : 465.54
Methyl (3R,5R)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyheptanoate
Methyl (3R,5R)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyheptanoate
Catalogue No.:PAI 18 013079
CAS :
NA
Molecular Formula : C23H32FN3O6S
Molecular Weight : 497.58
Methyl (E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dioxohept-6-enoate
Methyl (E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dioxohept-6-enoate
Catalogue No.:PAI 18 013080
CAS :
NA
Molecular Formula : C23H26FN3O6S
Molecular Weight : 491.53
Methyl (E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
Methyl (E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
Catalogue No.:PAI 18 013086
CAS :
890028-68-9
Molecular Formula : C23H30FN3O6S
Molecular Weight : 495.57
((4-(4-Fluorophenyl)-6-isopropyl-2-(methylsulfonamido)pyrimidin-5-yl)methyl)triphenylphosphonium Bromide
((4-(4-Fluorophenyl)-6-isopropyl-2-(methylsulfonamido)pyrimidin-5-yl)methyl)triphenylphosphonium Bromide
Catalogue No.:PAI 18 013092
CAS :
NA
Molecular Formula : C33H32BrFN3O2PS
Molecular Weight : 664.57
Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dioxoheptanoate
Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dioxoheptanoate
Catalogue No.:PAI 18 013093
CAS :
NA
Molecular Formula : C23H28FN3O6S
Molecular Weight : 493.55
Methyl (R)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxoheptanoate
Methyl (R)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxoheptanoate
Catalogue No.:PAI 18 013094
CAS :
NA
Molecular Formula : C23H30FN3O6S
Molecular Weight : 495.57
((4-(4-Fluorophenyl)-2-((2-(6-(4-fluorophenyl)-4-isopropyl-1-methyl-2-(N-methylmethylsulfonamido)-1,6-dihydropyrimidin-5-yl)-2-hydroxyethyl)sulfonamido)-6-isopropylpyrimidin-5-yl)methyl)triphenylphosphonium Bromide
((4-(4-Fluorophenyl)-2-((2-(6-(4-fluorophenyl)-4-isopropyl-1-methyl-2-(N-methylmethylsulfonamido)-1,6-dihydropyrimidin-5-yl)-2-hydroxyethyl)sulfonamido)-6-isopropylpyrimidin-5-yl)methyl)triphenylphosphonium Bromide
Catalogue No.:PAI 18 013097
CAS :
NA
Molecular Formula : C50H54BrF2N6O5PS2
Molecular Weight : 1032.01
tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2-((2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-2-hydroxy-N-methylethyl)sulfonamido)-6-isopropylpyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2-((2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-2-hydroxy-N-methylethyl)sulfonamido)-6-isopropylpyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
Catalogue No.:PAI 18 013098
CAS :
NA
Molecular Formula : C45H58F2N6O9S2
Molecular Weight : 929.11
tert-Butyl 2-((4S,6R)-2,2-dimethyl-6-((triphenyl-l5-phosphaneylidene)methyl)-1,3-dioxan-4-yl)acetate
tert-Butyl 2-((4S,6R)-2,2-dimethyl-6-((triphenyl-l5-phosphaneylidene)methyl)-1,3-dioxan-4-yl)acetate
Catalogue No.:PAI 18 013103
CAS :
NA
Molecular Formula : C31H37O4P
Molecular Weight : 504.61
2-((4R,6S)-6-((E)-2-(4-Isopropyl-2-(N-methylmethylsulfonamido)-6-(4-(methylthio)phenyl)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic Acid
2-((4R,6S)-6-((E)-2-(4-Isopropyl-2-(N-methylmethylsulfonamido)-6-(4-(methylthio)phenyl)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic Acid
Catalogue No.:PAI 18 013106
CAS :
NA
Molecular Formula : C26H35N3O6S2
Molecular Weight : 549.7
2-((4R,6S)-6-((E)-2-(4-Isopropyl-2-(N-methylmethylsulfonamido)-6-phenylpyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic Acid
2-((4R,6S)-6-((E)-2-(4-Isopropyl-2-(N-methylmethylsulfonamido)-6-phenylpyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic Acid
Catalogue No.:PAI 18 013107
CAS :
NA
Molecular Formula : C25H33N3O6S
Molecular Weight : 503.61
tert-Butyl 2-((4R,6S)-6-((Z)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
tert-Butyl 2-((4R,6S)-6-((Z)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
Catalogue No.:PA 18 0201049
CAS :
1821422-50-7
Molecular Formula : C29H40FN3O6S
Molecular Weight : 577.71
tert-Butyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-methoxyhept-6-enoate
tert-Butyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-methoxyhept-6-enoate
Catalogue No.:PA 18 0201050
CAS :
NA
Molecular Formula : C27H38FN3O6S
Molecular Weight : 551.67