Trametinib may be used alone or in combination with another medication to treat a type of skin cancer. It is a MEK inhibitor drug with anti-cancer activity.Reference standards of Trametinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Trametinib
Catalogue No.:PA 47 14000
CAS :
Molecular Formula : C26H23FIN5O4
Molecular Weight : 615.39
N-(3-(5-((4-Bromo-2-fluorophenyl)amino)-3-cyclopropyl-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Catalogue No.:PA 47 14510
Molecular Formula : C26H23BrFN5O4
Molecular Weight : 568.39
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 47 14520
Molecular Formula : C14H13FIN3O2
Molecular Weight : 401.17
Trametinib-d4
Catalogue No.:PA STI 084082
Molecular Formula : C26H19D4FIN5O4
Molecular Weight : 619.42
Trametinib Dimethyl Sulfoxide
Catalogue No.:PA 47 0141000
Molecular Formula : C28H29FIN5O5S
Molecular Weight : 693.53
1-(3-Aminophenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141001
Molecular Formula : C24H21FIN5O3
Molecular Weight : 573.37
1-(3-Amino-4-hydroxyphenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141002
Molecular Formula : C24H21FIN5O4
Molecular Weight : 589.37
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione
Catalogue No.:PA 47 0141005
Molecular Formula : C18H15FIN3O4
Molecular Weight : 483.24
N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)amino)phenyl)acetamide
Catalogue No.:PA 47 0141004
Molecular Weight : 615.4
Desiodo Trametinib
Catalogue No.:PA 47 0141003
Molecular Formula : C26H24FN5O4
Molecular Weight : 489.51
N-Cyclopropyl-2-((2-fluoro-4-iodophenyl)amino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
Catalogue No.:PA 47 0141006
Molecular Formula : C17H17FIN3O3
Molecular Weight : 457.24
N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Catalogue No.:PA 47 0141007
Molecular Formula : C26H23FIN5O5
Molecular Weight : 631.4
N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroperoxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Catalogue No.:PA 47 0141008
Molecular Formula : C26H23FIN5O6
Molecular Weight : 647.4
3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-1-(3-nitrophenyl)pyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141009
Molecular Formula : C24H19FIN5O5
Molecular Weight : 603.35
N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)(nitroso)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Catalogue No.:PA 47 0141010
Molecular Formula : C26H22FIN6O5
Molecular Weight : 644.4
N-(1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N-methylnitrous amide
Catalogue No.:PA 47 0141011
Molecular Formula : C14H12FIN4O3
Molecular Weight : 430.18
N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)(nitroso)amino)phenyl)acetamide
Catalogue No.:PA 47 0141012
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