| Catalogue number: | PA STI 043480 |
| Chemical name: | FTY720-d4 Hydrochloride |
CAS Number: |
1346604-90-7 |
| Category: | aromatics,enzyme inhibitors,metabolites,impurities,pharmaceutical standards,intermediates,fine chemicals,stable isotopes |
| Synonyms: | 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol-d4 Hydrochloride; Fingolimod-d4 Hydrochloride; |
| Molecular form: | C19H30D4ClNO2 |
| Appearance: | White Solid |
| Mol. Weight: | 347.96 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | A labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). |
| BTM: | NA |
FTY720-d4 Hydrochloride
FTY720-d4 Hydrochloride
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