cabazitaxel
Cabazitaxel was developed by Sanofi-Aventis and was approved by the U.S. FDA for the treatment of hormone-refractory prostate cancer on June 17, 2010. It is a semi-synthetic derivative of a natural taxoid. It is a microtubule inhibitor, and the fourth taxane to be approved as a cancer therapy.. Reference standards of Cabazitaxel API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
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Cabazitaxel - API Standards
Catalogue No.:PA 03 01000
Molecular Formula : C45H57NO14
Molecular Weight : 835.93
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Catalogue No.:PA 03 01510
Molecular Formula : C40H49NO12
Molecular Weight : 735.82
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10-Deacetyl-7,10-dimethoxy-Baccatin III
Catalogue No.:PA 03 01520
Molecular Formula : C31H40O10
Molecular Weight : 572.64
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De-boc Cabazitaxel Formate
Catalogue No.:PA 03 0011030
Molecular Formula : C41H51NO14
Molecular Weight : 781.85
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Cabazitaxel N-formyl Impurity
Catalogue No.:PA 03 01530
Molecular Formula : C41H49NO13
Molecular Weight : 763.83
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10-Deacetyl-7,10,13-trimethyl Baccatin III
Catalogue No.:PA 03 01540
Molecular Formula : C32H42O10
Molecular Weight : 586.67
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Catalogue No.:PA 03 01550
Molecular Formula : C45H57NO14
Molecular Weight : 835.93
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Cabazitaxel Di Boc Impurity
Catalogue No.:PA 03 01560
Molecular Formula : C50H67NO16
Molecular Weight : 938.06
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(4S,5S)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid
Catalogue No.:PA 03 01590
Molecular Formula : C22H25NO6
Molecular Weight : 399.44
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(4R,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid
Catalogue No.:PA 03 01600
Molecular Formula : C22H25NO6
Molecular Weight : 399.44
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(4R,5S)-2,2-Dimethyl-4-phenyl-3,5-oxazolidinedicarboxylic Acid 3-(1,1-Dimethylethyl) Ester
Catalogue No.:PA 03 01610
Molecular Formula : C17H23NO5
Molecular Weight : 321.37
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(4S,5S)-2,2-Dimethyl-4-phenyl-3,5-oxazolidinedicarboxylic Acid 3-(1,1-Dimethylethyl) Ester
Catalogue No.:PA 03 01630
Molecular Formula : C17H23NO5
Molecular Weight : 321.37
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Catalogue No.:PA STI 016870
Molecular Formula : C45H51D6NO14
Molecular Weight : 841.97
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(2'S, 3'R)-Cabazitaxel-D6
Catalogue No.:PA STI 016880
Molecular Formula : C45H51D6NO14
Molecular Weight : 841.97
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4-Deacetyl-4-propionyl Cabazitaxel-D6
Catalogue No.:PA STI 024550
Molecular Formula : C46H53D6NO14
Molecular Weight : 856.00
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Catalogue No.:PA 03 01640
Molecular Formula : C44H55NO14
Molecular Weight : 821.92
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10-Methoxy-10-deacetylbaccatin III
Catalogue No.:PA 03 01650
Molecular Formula : C30H38O10
Molecular Weight : 558.62
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10-Deacetyl-7-methyl Baccatin III
Catalogue No.:PA 03 01660
Molecular Formula : C30H38O10
Molecular Weight : 558.62
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4,10-Desdiacetyl-7,10-dimethyl-4-propionyl Baccatin III
Catalogue No.:PA 03 01670
Molecular Formula : C32H42O10
Molecular Weight : 586.68
stdClass Object
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Catalogue No.:PA 03 01680
Molecular Formula : C53H63NO15
Molecular Weight : 954.08
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Catalogue No.:PA 03 01690
Molecular Formula : C46H59NO14
Molecular Weight : 849.97
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Catalogue No.:PA 04 97670
Molecular Formula : C58H72N2O18
Molecular Weight : 1085.21
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Catalogue No.:PA 03 0010030
Molecular Formula : C46H59NO14
Molecular Weight : 1085.21
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[pslug] => cabazitaxel-impurity-d-pa030010040
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Catalogue No.:PA 03 0010040
Molecular Formula : C58H72N2O18
Molecular Weight : 1085.21
stdClass Object
(
[pname] => Cabazitaxel - Impurity E
[catalogue_number] => PA 03 0010050
[category_ids] => ,69,70,78,80,81,82,
[chemical_name] =>
[weight] => 1085.21
[form] => C58H72N2O18
[cas] => NA
[pslug] => cabazitaxel-impurity-e-pa030010050
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Catalogue No.:PA 03 0010050
Molecular Formula : C58H72N2O18
Molecular Weight : 1085.21
stdClass Object
(
[pname] => Cabazitaxel - Impurity H
[catalogue_number] => PA 03 0010080
[category_ids] => ,69,70,78,80,81,82,
[chemical_name] =>
[weight] => 954.08
[form] => C53H63NO15
[cas] => NA
[pslug] => cabazitaxel-impurity-h-pa030010080
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Catalogue No.:PA 03 0010080
Molecular Formula : C53H63NO15
Molecular Weight : 954.08
stdClass Object
(
[pname] => Cabazitaxel - Impurity F
[catalogue_number] => PA 03 0010060
[category_ids] => ,69,70,78,80,81,82,
[chemical_name] =>
[weight] => 954.08
[form] => C53H63NO15
[cas] => NA
[pslug] => cabazitaxel-impurity-f-pa030010060
[latest_product] => 0
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Catalogue No.:PA 03 0010060
Molecular Formula : C53H63NO15
Molecular Weight : 954.08
stdClass Object
(
[pname] => rel-(4R,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid
[catalogue_number] => PA 03 0011031
[category_ids] => ,82,81,80,78,70,69,
[chemical_name] =>
[weight] => 399.44
[form] => C22H25NO6
[cas] => 2983453-05-8
[pslug] => 2983453-05-8-rel-4r-5r-3-tert-butoxycarbonyl-2-4-methoxyphenyl-4-phenyloxazolidine-5-carboxylic-acid-pa030011031
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rel-(4R,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid
Catalogue No.:PA 03 0011031
Molecular Formula : C22H25NO6
Molecular Weight : 399.44
stdClass Object
(
[pname] => Cabazitaxel N-3
[catalogue_number] => PA 03 0011032
[category_ids] => ,82,81,80,78,69,
[chemical_name] =>
[weight] => 1276.8
[form] => C57H61Cl6NO19
[cas] => 859498-31-0
[pslug] => 859498-31-0-cabazitaxel-n-3-pa030011032
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Catalogue No.:PA 03 0011032
Molecular Formula : C57H61Cl6NO19
Molecular Weight : 1276.8