levothyroxine
A synthetic form of thyroid hormone, Thyroxine. Levothyroxine is used in the treatment of thyroid hormone deficiency and certain types of thyroid tumors. It is a levorotatory enantiomer of Thyroxine. Reference standards of Levothyroxine API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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Levothyroxine - API Standards
Catalogue No.:PA 12 15000
Molecular Formula : C15H11I4NO4
Molecular Weight : 776.87
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Levothyroxine - Impurity A
Catalogue No.:PA 12 15010
Molecular Formula : C15H12I3NO4
Molecular Weight : 650.97
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Levothyroxine - Impurity C
Catalogue No.:PA 12 15030
Molecular Formula : C14H9I3O4
Molecular Weight : 621.93
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Levothyroxine - Impurity D
Catalogue No.:PA 12 15040
Molecular Formula : C14H8I4O4
Molecular Weight : 747.83
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Monochlorotriiodothyronine
Catalogue No.:PA 12 15590
Molecular Formula : C15H11ClI3NO4
Molecular Weight : 685.42
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Catalogue No.:PA 12 15670
Molecular Formula : C16H11I4NO5
Molecular Weight : 804.88
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Catalogue No.:PA 12 15680
Molecular Formula : C17H13I4NO5
Molecular Weight : 818.91
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Levothyroxine Acetamide Impurity
Catalogue No.:PA 12 15690
Molecular Formula : C14H9I4NO3
Molecular Weight : 746.84
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2-(4-(4-Hydroxyphenoxy)-3,5-diiodophenyl)acetic Acid
Catalogue No.:PA 12 15740
Molecular Formula : C14H10I2O4
Molecular Weight : 496.04
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Levothyroxine - Impurity B
Catalogue No.:PA 12 15020
Molecular Formula : C15H11ClI3NO4
Molecular Weight : 685.42
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Levothyroxine - Impurity F
Catalogue No.:PA 12 15060
Molecular Formula : C21H13I6NO5
Molecular Weight : 1120.76
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Levothyroxine - Impurity I
Catalogue No.:PA 12 15090
Molecular Formula : C13H6I4O3
Molecular Weight : 717.80
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Catalogue No.:PA 12 15510
Molecular Formula : C15H10I4NNaO4
Molecular Weight : 798.85
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Levothyroxine Ethyl Ester
Catalogue No.:PA 12 15520
Molecular Formula : C17H15I4NO4
Molecular Weight : 804.92
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Levothyroxine Methyl Ester
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Levothyroxine N-Methylamide
Catalogue No.:PA 12 15540
Molecular Formula : C16H14I4N2O3
Molecular Weight : 789.91
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O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-hydroxy-L-tyrosine
Catalogue No.:PA 12 15550
Molecular Formula : C15H11I4NO5
Molecular Weight : 792.87
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Catalogue No.:PA 12 15560
Molecular Formula : C15H13I4NO2
Molecular Weight : 746.89
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2-Acetamido-3-(4-acetoxy-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PA 12 15570
Molecular Formula : C13H13I2NO5
Molecular Weight : 517.05
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Catalogue No.:PA 12 15580
Molecular Formula : C15H11I4NO5
Molecular Weight : 792.87
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Catalogue No.:PA 12 15600
Molecular Formula : C15H11I4NO4
Molecular Weight : 776.87
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(S)-2-Amino-3-(4-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PA 12 15610
Molecular Formula : C21H14I5NO5
Molecular Weight : 994.86
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2-Hydroxy-2-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-N-methylacetamide
Catalogue No.:PA 12 15620
Molecular Formula : C15H11I4NO4
Molecular Weight : 776.87
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(S)-2-Amino-3-(4-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenoxy)-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PA 12 15630
Molecular Formula : C21H14I5NO5
Molecular Weight : 994.86
stdClass Object
(
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[catalogue_number] => PA 12 15640
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[chemical_name] =>
[weight] => 746.84
[form] => C14H9I4NO3
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4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodo-N-methylbenzamide
Catalogue No.:PA 12 15640
Molecular Formula : C14H9I4NO3
Molecular Weight : 746.84
stdClass Object
(
[pname] => 3,4-Bis(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-1H-pyrrole-2-carboxylic acid
[catalogue_number] => PA 12 15650
[category_ids] => ,79,80,78,70,82,71,
[chemical_name] =>
[weight] => 1486.65
[form] => C29H13I8NO6
[cas] => 2088032-81-7
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3,4-Bis(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-1H-pyrrole-2-carboxylic acid
Catalogue No.:PA 12 15650
Molecular Formula : C29H13I8NO6
Molecular Weight : 1486.65
stdClass Object
(
[pname] => Levothyroxine Lactose Adduct
[catalogue_number] => PA 12 15660
[category_ids] => ,70,78,79,80,82,91,
[chemical_name] =>
[weight] => 1101.15
[form] => C27H31I4NO14
[cas] => NA
[pslug] => levothyroxine-lactose-adduct-pa1215660
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Levothyroxine Lactose Adduct
Catalogue No.:PA 12 15660
Molecular Formula : C27H31I4NO14
Molecular Weight : 1101.15
stdClass Object
(
[pname] => 3,5,3',5'-Tetraiodo Thyromandelic Acid
[catalogue_number] => PA 12 15700
[category_ids] => 82,80,78,75,74,70
[chemical_name] =>
[weight] => 763.83
[form] => C14H8I4O5
[cas] => 93647-48-4
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3,5,3',5'-Tetraiodo Thyromandelic Acid
Catalogue No.:PA 12 15700
Molecular Formula : C14H8I4O5
Molecular Weight : 763.83
stdClass Object
(
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[catalogue_number] => PA 12 15710
[category_ids] => ,97,80,78,70,82,
[chemical_name] =>
[weight] => 776.87
[form] => C15H11I4NO4
[cas] => 51-49-0
[pslug] => 51-49-0-levothyroxine-d-isomer-pa1215710
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Catalogue No.:PA 12 15710
Molecular Formula : C15H11I4NO4
Molecular Weight : 776.87
stdClass Object
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[chemical_name] =>
[weight] => 777.85
[form] => C15H10I4O5
[cas] => 7069-47-8
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3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]lactic Acid
Catalogue No.:PA 12 15720
Molecular Formula : C15H10I4O5
Molecular Weight : 777.85
stdClass Object
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[chemical_name] =>
[weight] => 525.08
[form] => C15H13I2NO4
[cas] => 5563-89-3
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2-Amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PA 12 15730
Molecular Formula : C15H13I2NO4
Molecular Weight : 525.08
stdClass Object
(
[pname] => Di(p-Anisyl)iodonium Bromide
[catalogue_number] => PA 12 15820
[category_ids] => ,80,81,84,
[chemical_name] =>
[weight] => 421.07
[form] => C14H14BrIO2
[cas] => 19231-06-2
[pslug] => 19231-06-2-di-p-anisyl-iodonium-bromide-pa1215820
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Di(p-Anisyl)iodonium Bromide
Catalogue No.:PA 12 15820
Molecular Formula : C14H14BrIO2
Molecular Weight : 421.07
stdClass Object
(
[pname] => N-(Trifluoroacetyl)-L-thyroxine Methyl Ester
[catalogue_number] => PA 12 15860
[category_ids] => ,80,95,76,75,78,70,82,
[chemical_name] =>
[weight] => 886.9
[form] => C18H12F3I4NO5
[cas] => 906325-95-9
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N-(Trifluoroacetyl)-L-thyroxine Methyl Ester
stdClass Object
(
[pname] => 3,3’,5-Triiodo Thyroacetic Acid n-Butyl Ester
[catalogue_number] => PA 12 15880
[category_ids] => ,80,74,75,78,70,82,
[chemical_name] =>
[weight] => 678.04
[form] => C18H17I3O4
[cas] => 1797030-15-9
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3,3’,5-Triiodo Thyroacetic Acid n-Butyl Ester
Catalogue No.:PA 12 15880
Molecular Formula : C18H17I3O4
Molecular Weight : 678.04
stdClass Object
(
[pname] => 3,3’,5-Triiodo-L-thyronine 4’-O-Sulfate
[catalogue_number] => PA 12 15900
[category_ids] => ,97,80,76,75,78,70,82,88,
[chemical_name] =>
[weight] => 731.04
[form] => C15H12I3NO7S
[cas] => 31135-55-4
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3,3’,5-Triiodo-L-thyronine 4’-O-Sulfate
Catalogue No.:PA 12 15900
Molecular Formula : C15H12I3NO7S
Molecular Weight : 731.04
stdClass Object
(
[pname] => Methyl L-tyrosinate,
[catalogue_number] => PAI 12 008190
[category_ids] => ,71,79,80,78,70,82,
[chemical_name] =>
[weight] => 195.22
[form] => C10H13NO3
[cas] => NA
[pslug] => -methyl-l-tyrosinate-pai12008190
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Catalogue No.:PAI 12 008190
Molecular Formula : C10H13NO3
Molecular Weight : 195.22
stdClass Object
(
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[catalogue_number] => PAI 12 008200
[category_ids] => ,71,79,80,78,70,82,
[chemical_name] =>
[weight] => 229.66
[form] => C10H12ClNO3
[cas] => NA
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Methyl (S)-2-amino-3-(3-chloro-4-hydroxyphenyl)propanoate,
Catalogue No.:PAI 12 008200
Molecular Formula : C10H12ClNO3
Molecular Weight : 229.66
stdClass Object
(
[pname] => Methyl (S)-2-amino-3-(3-chloro-4-hydroxy-5-iodophenyl)propanoate,
[catalogue_number] => PAI 12 008210
[category_ids] => ,71,79,80,78,70,82,
[chemical_name] =>
[weight] => 355.56
[form] => C10H11ClINO3
[cas] => NA
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Methyl (S)-2-amino-3-(3-chloro-4-hydroxy-5-iodophenyl)propanoate,
Catalogue No.:PAI 12 008210
Molecular Formula : C10H11ClINO3
Molecular Weight : 355.56
stdClass Object
(
[pname] => Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-4-hydroxy-5-iodophenyl)propanoate,
[catalogue_number] => PAI 12 008220
[category_ids] => ,71,79,80,78,70,82,
[chemical_name] =>
[weight] => 455.67
[form] => C15H19ClINO5
[cas] => NA
[pslug] => -methyl-s-2-tert-butoxycarbonyl-amino-3-3-chloro-4-hydroxy-5-iodophenyl-propanoate-pai12008220
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Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-4-hydroxy-5-iodophenyl)propanoate,
Catalogue No.:PAI 12 008220
Molecular Formula : C15H19ClINO5
Molecular Weight : 455.67
stdClass Object
(
[pname] => Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-iodo-4-(4-methoxyphenoxy)phenyl)propanoate,
[catalogue_number] => PAI 12 008230
[category_ids] => ,71,79,80,78,70,82,
[chemical_name] =>
[weight] => 561.81
[form] => C22H25ClINO6
[cas] => NA
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Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-iodo-4-(4-methoxyphenoxy)phenyl)propanoate,
Catalogue No.:PAI 12 008230
Molecular Formula : C22H25ClINO6
Molecular Weight : 561.81
stdClass Object
(
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[catalogue_number] => PAI 12 008240
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[chemical_name] =>
[weight] => 433.63
[form] => C15H13ClINO4
[cas] => NA
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(S)-2-amino-3-(3-chloro-4-(4-hydroxyphenoxy)-5-iodophenyl)propanoic acid,
Catalogue No.:PAI 12 008240
Molecular Formula : C15H13ClINO4
Molecular Weight : 433.63
stdClass Object
(
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Levothyroxine Peak Identification Mixture
stdClass Object
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[catalogue_number] => PA 12 0151005
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[chemical_name] =>
[weight] => 447.4
[form] => C20H21N3O9
[cas] => 83290-90-8
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Ethyl (S)-2-acetamido-3-(4-(4-methoxyphenoxy)-3,5-dinitrophenyl)propanoate
stdClass Object
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[catalogue_number] => PA 12 0151006
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[chemical_name] =>
[weight] => 387.44
[form] => C20H25N3O5
[cas] => 440667-78-7
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Ethyl (S)-2-acetamido-3-(3,5-diamino-4-(4-methoxyphenoxy)phenyl)propanoate
Catalogue No.:PA 12 0151006
Molecular Formula : C20H25N3O5
Molecular Weight : 387.44
stdClass Object
(
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[catalogue_number] => PA 12 0151007
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[weight] => 609.2
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Ethyl (S)-2-acetamido-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoate
stdClass Object
(
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[catalogue_number] => PA 12 0151008
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[chemical_name] =>
[weight] => 313.22
[form] => C11H11N3O8
[cas] => 20767-00-4
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(S)-2-Acetamido-3-(4-hydroxy-3,5-dinitrophenyl)propanoic Acid
Catalogue No.:PA 12 0151008
Molecular Formula : C11H11N3O8
Molecular Weight : 313.22
stdClass Object
(
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[catalogue_number] => PA 12 0151009
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[weight] => 341.28
[form] => C13H15N3O8
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Ethyl (S)-2-acetamido-3-(4-hydroxy-3,5-dinitrophenyl)propanoate
Catalogue No.:PA 12 0151009
Molecular Formula : C13H15N3O8
Molecular Weight : 341.28