Roflumilast is used in the prevention of lung attacks in severe COPD. It is a long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4).Reference standards of Roflumilast API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object ( [pname] => 3-O-Decyclopropyl Roflumilast [catalogue_number] => PA 18 15520 [category_ids] => ,80,71,75,81,78,70,82, [chemical_name] => [weight] => 349.12 [form] => C13H8Cl2F2N2O3 [cas] => 1391052-76-8 [pslug] => 1391052-76-8-3-o-decyclopropyl-roflumilast-pa1815520 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 15520
CAS :
Molecular Formula : C13H8Cl2F2N2O3
Molecular Weight : 349.12
stdClass Object ( [pname] => Roflumilast Carboxylic Acid Impurity [catalogue_number] => PA 18 15540 [category_ids] => ,80,75,70, [chemical_name] => [weight] => 258.22 [form] => C12H12F2O4 [cas] => 162401-62-9 [pslug] => 162401-62-9-roflumilast-carboxylic-acid-impurity-pa1815540 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 15540
Molecular Formula : C12H12F2O4
Molecular Weight : 258.22
stdClass Object ( [pname] => 4-Amino-3,5-dichloropyridine [catalogue_number] => PA 18 15550 [category_ids] => ,79,80,71,78,70,82, [chemical_name] => [weight] => 163 [form] => C5H4Cl2N2 [cas] => 22889-78-7 [pslug] => 22889-78-7-4-amino-3-5-dichloropyridine-pa1815550 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 15550
Molecular Formula : C5H4Cl2N2
Molecular Weight : 163
stdClass Object ( [pname] => 3,4-Di(cyclopropylmethoxy) Roflumilast [catalogue_number] => PA 18 15570 [category_ids] => ,80,71,75,81,78,70,82, [chemical_name] => [weight] => 407.29 [form] => C20H20Cl2N2O3 [cas] => 1391052-24-6 [pslug] => 1391052-24-6-3-4-di-cyclopropylmethoxy-roflumilast-pa1815570 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 15570
Molecular Formula : C20H20Cl2N2O3
Molecular Weight : 407.29
stdClass Object ( [pname] => 4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast [catalogue_number] => PA 18 15580 [category_ids] => ,80,71,75,81,78,70,82, [chemical_name] => [weight] => 403.21 [form] => C17H14Cl2F2N2O3 [cas] => 162401-43-6 [pslug] => 162401-43-6-4-cyclopropylmethoxy-3-difluoromethoxy-roflumilast-pa1815580 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 15580
Molecular Formula : C17H14Cl2F2N2O3
Molecular Weight : 403.21
stdClass Object ( [pname] => 3,4-bis(Difluoromethoxy) Roflumilast [catalogue_number] => PA 18 15590 [category_ids] => ,80,71,75,81,78,70,82, [chemical_name] => [weight] => 399.12 [form] => C14H8Cl2F4N2O3 [cas] => 162401-30-1 [pslug] => 162401-30-1-3-4-bis-difluoromethoxy-roflumilast-pa1815590 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 15590
Molecular Formula : C14H8Cl2F4N2O3
Molecular Weight : 399.12
stdClass Object ( [pname] => 3-Cyclobutyl-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide [catalogue_number] => PA 18 15610 [category_ids] => ,80,71,75,81,78,70,82, [chemical_name] => [weight] => 387.21 [form] => C17H14Cl2F2N2O2 [cas] => NA [pslug] => 3-cyclobutyl-n-3-5-dichloropyridin-4-yl-4-difluoromethoxy-benzamide-pa1815610 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 15610
Molecular Formula : C17H14Cl2F2N2O2
Molecular Weight : 387.21
stdClass Object ( [pname] => 4-(Cyclopropylmethoxy)-3-(difluoromethoxy) benzoic Acid [catalogue_number] => PA 18 15640 [category_ids] => 75,80,70 [chemical_name] => [weight] => 258.22 [form] => C12H12F2O4 [cas] => 162401-69-6 [pslug] => 162401-69-6-4-cyclopropylmethoxy-3-difluoromethoxy-benzoic-acid-pa1815640 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 15640
stdClass Object ( [pname] => 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic-d4 Acid [catalogue_number] => PA STI 023650 [category_ids] => ,80,75,70,98, [chemical_name] => [weight] => 262.24 [form] => C12H8D4F2O4 [cas] => 1794816-96-8 [pslug] => 1794816-96-8-3-cyclopropylmethoxy-4-difluoromethoxybenzoic-d4-acid-pasti023650 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA STI 023650
Molecular Formula : C12H8D4F2O4
Molecular Weight : 262.24
stdClass Object ( [pname] => 4-Amino-2,6-dichloropyridine [catalogue_number] => PA 18 15680 [category_ids] => ,79,80,71,85,83, [chemical_name] => [weight] => 163 [form] => C5H4Cl2N2 [cas] => 2587-02-2 [pslug] => 2587-02-2-4-amino-2-6-dichloropyridine-pa1815680 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 15680
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