Axitinib-Impurities | Pharmaffiliates

axitinib

Axitinib is an indazole derivative. It is most commonly marketed under the name Inlyta® and is available in oral formulations._x000D_ Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3).7. Reference standards of Axitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

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    [pname] => Axitinib - API Standards 
    [catalogue_number] => PA 28 45000
    [category_ids] => ,80,81,78,70,82,117,
    [chemical_name] => 
    [weight] => 386.47
    [form] => C22H18N4OS
    [cas] => 319460-85-0
    [pslug] => 319460-85-0-axitinib-api-pa2845000
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PA 28 45000

Axitinib - API Standards


  • Catalogue No.:PA 28 45000

  • CAS :

    319460-85-0

  • Molecular Formula : C22H18N4OS

  • Molecular Weight : 386.47

stdClass Object
(
    [pname] => (Z)-Axitinib
    [catalogue_number] => PA 28 45510
    [category_ids] => ,80,81,78,70,82,117,
    [chemical_name] => 
    [weight] => 386.47
    [form] => C22H18N4OS
    [cas] => 885126-40-9
    [pslug] => 885126-40-9-z-axitinib-pa2845510
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PA 28 45510

(Z)-Axitinib


  • Catalogue No.:PA 28 45510

  • CAS :

    885126-40-9

  • Molecular Formula : C22H18N4OS

  • Molecular Weight : 386.47

stdClass Object
(
    [pname] => Axitinib Sulfoxide
    [catalogue_number] => PA 28 45540
    [category_ids] => ,80,81,78,70,82,117,
    [chemical_name] => 
    [weight] => 402.47
    [form] => C22H18N4O2S
    [cas] => 1347304-18-0
    [pslug] => 1347304-18-0-axitinib-sulfoxide-pa2845540
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PA 28 45540

Axitinib Sulfoxide


  • Catalogue No.:PA 28 45540

  • CAS :

    1347304-18-0

  • Molecular Formula : C22H18N4O2S

  • Molecular Weight : 402.47

stdClass Object
(
    [pname] => (E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
    [catalogue_number] => PA 28 45550
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 491.61
    [form] => C29H25N5OS
    [cas] => 1443118-72-6
    [pslug] => 1443118-72-6-e-n-methyl-2-1-2-pyridin-2-yl-ethyl-3-2-pyridin-2-yl-vinyl-1h-indazol-6-yl-thio-benzamide-pa2845550
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PA 28 45550

(E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide


  • Catalogue No.:PA 28 45550

  • CAS :

    1443118-72-6

  • Molecular Formula : C29H25N5OS

  • Molecular Weight : 491.61

stdClass Object
(
    [pname] => Axitinib N-Glucuronide
    [catalogue_number] => PA 28 45560
    [category_ids] => ,70,78,80,81,82,88,95,
    [chemical_name] => 
    [weight] => 562.59
    [form] => C28H26N4O7S
    [cas] => NA
    [pslug] => axitinib-n-glucuronide-pa2845560
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PA 28 45560

Axitinib N-Glucuronide


  • Catalogue No.:PA 28 45560

  • CAS :

    NA

  • Molecular Formula : C28H26N4O7S

  • Molecular Weight : 562.59

stdClass Object
(
    [pname] => Axitinib Sulfone Impurity
    [catalogue_number] => PA 28 45570
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 418.47
    [form] => C22H18N4O3S
    [cas] => 1348536-59-3
    [pslug] => 1348536-59-3-axitinib-sulfone-impurity-pa2845570
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PA 28 45570

Axitinib Sulfone Impurity


  • Catalogue No.:PA 28 45570

  • CAS :

    1348536-59-3

  • Molecular Formula : C22H18N4O3S

  • Molecular Weight : 418.47

stdClass Object
(
    [pname] => 2-(1H-Indazol-6-ylsulfanyl)-N-methylbenzamide
    [catalogue_number] => PA 28 45580
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 283.34
    [form] => C15H13N3OS
    [cas] => 944835-85-2
    [pslug] => 944835-85-2-2-1h-indazol-6-ylsulfanyl-n-methylbenzamide-pa2845580
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PA 28 45580

2-(1H-Indazol-6-ylsulfanyl)-N-methylbenzamide


  • Catalogue No.:PA 28 45580

  • CAS :

    944835-85-2

  • Molecular Formula : C15H13N3OS

  • Molecular Weight : 283.34

stdClass Object
(
    [pname] => 2-((3-Iodo-2H-indazol-6-yl)thio)-N-methylbenzamide
    [catalogue_number] => PA 28 45590
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 409.24
    [form] => C15H12IN3OS
    [cas] => 885126-34-1
    [pslug] => 885126-34-1-2-3-iodo-2h-indazol-6-yl-thio-n-methylbenzamide-pa2845590
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PA 28 45590

2-((3-Iodo-2H-indazol-6-yl)thio)-N-methylbenzamide


  • Catalogue No.:PA 28 45590

  • CAS :

    885126-34-1

  • Molecular Formula : C15H12IN3OS

  • Molecular Weight : 409.24

stdClass Object
(
    [pname] => Dehydro Axitinib
    [catalogue_number] => PA 28 45600
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 388.49
    [form] => C22H20N4OS
    [cas] => 2749797-54-2
    [pslug] => 2749797-54-2-dehydro-axitinib-pa2845600
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PA 28 45600

Dehydro Axitinib


  • Catalogue No.:PA 28 45600

  • CAS :

    2749797-54-2

  • Molecular Formula : C22H20N4OS

  • Molecular Weight : 388.49

stdClass Object
(
    [pname] => (E)-2-((3-(2-(Pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzoic Acid
    [catalogue_number] => PA 28 45610
    [category_ids] => 88,82,81,80,78,70
    [chemical_name] => 
    [weight] => 373.43
    [form] => C21H15N3O2S
    [cas] => 319462-34-5
    [pslug] => 319462-34-5-e-2-3-2-pyridin-2-yl-vinyl-1h-indazol-6-yl-thio-benzoic-acid-pa2845610
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PA 28 45610

(E)-2-((3-(2-(Pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzoic Acid


  • Catalogue No.:PA 28 45610

  • CAS :

    319462-34-5

  • Molecular Formula : C21H15N3O2S

  • Molecular Weight : 373.43

stdClass Object
(
    [pname] => Axitinib Amide Impurity
    [catalogue_number] => PA 28 45620
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 372.44
    [form] => C21H16N4OS
    [cas] => 319462-41-4
    [pslug] => 319462-41-4-axitinib-amide-impurity-pa2845620
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PA 28 45620

Axitinib Amide Impurity


  • Catalogue No.:PA 28 45620

  • CAS :

    319462-41-4

  • Molecular Formula : C21H16N4OS

  • Molecular Weight : 372.44

stdClass Object
(
    [pname] => Axitinib N-Acetyl impurity
    [catalogue_number] => PA 28 45630
    [category_ids] => 88,82,81,80,78,70
    [chemical_name] => 
    [weight] => 428.51
    [form] => C24H20N4O2S
    [cas] => 1639137-80-6
    [pslug] => 1639137-80-6-axitinib-n-acetyl-impurity-pa2845630
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PA 28 45630

Axitinib N-Acetyl impurity


  • Catalogue No.:PA 28 45630

  • CAS :

    1639137-80-6

  • Molecular Formula : C24H20N4O2S

  • Molecular Weight : 428.51

stdClass Object
(
    [pname] => Axitinib-d3
    [catalogue_number] => PA STI 009300
    [category_ids] => ,80,81,78,70,82,117,98,
    [chemical_name] => 
    [weight] => 389.49
    [form] => C22H15D3N4OS
    [cas] => 1126623-89-9
    [pslug] => 1126623-89-9-axitinib-d3-pasti009300
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PA STI 009300

Axitinib-d3


  • Catalogue No.:PA STI 009300

  • CAS :

    1126623-89-9

  • Molecular Formula : C22H15D3N4OS

  • Molecular Weight : 389.49

stdClass Object
(
    [pname] => N-Methyl-2-sulfanylbenzamide
    [catalogue_number] => PA 28 45730
    [category_ids] => ,80,81,78,70,82,
    [chemical_name] => 
    [weight] => 167.23
    [form] => C8H9NOS
    [cas] => 20054-45-9
    [pslug] => 20054-45-9-n-methyl-2-sulfanylbenzamide-pa2845730
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PA 28 45730

N-Methyl-2-sulfanylbenzamide


  • Catalogue No.:PA 28 45730

  • CAS :

    20054-45-9

  • Molecular Formula : C8H9NOS

  • Molecular Weight : 167.23

stdClass Object
(
    [pname] => N-Nitroso Axitinib
    [catalogue_number] => PA 28 0451019
    [category_ids] => ,70,78,80,81,82,162,
    [chemical_name] => 
    [weight] => 415.47
    [form] => C22H17N5O2S
    [cas] => NA
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PA 28 0451019

N-Nitroso Axitinib


  • Catalogue No.:PA 28 0451019

  • CAS :

    NA

  • Molecular Formula : C22H17N5O2S

  • Molecular Weight : 415.47

stdClass Object
(
    [pname] => 2-[(2-Carbamoylphenyl)disulfanyl]benzamide
    [catalogue_number] => PA 28 0451020
    [category_ids] => ,80,81,78,70,82,117,
    [chemical_name] => 
    [weight] => 304.38
    [form] => C14H12N2O2S2
    [cas] => 2527-57-3
    [pslug] => 2527-57-3-2-2-carbamoylphenyl-disulfanyl-benzamide-pa280451020
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PA 28 0451020

2-[(2-Carbamoylphenyl)disulfanyl]benzamide


  • Catalogue No.:PA 28 0451020

  • CAS :

    2527-57-3

  • Molecular Formula : C14H12N2O2S2

  • Molecular Weight : 304.38

stdClass Object
(
    [pname] => (E)-6-Nitro-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
    [catalogue_number] => PA 28 0451024
    [category_ids] => ,80,81,78,70,82,
    [chemical_name] => 
    [weight] => 350.38
    [form] => C19H18N4O3
    [cas] => 886230-75-7
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PA 28 0451024

(E)-6-Nitro-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole


  • Catalogue No.:PA 28 0451024

  • CAS :

    886230-75-7

  • Molecular Formula : C19H18N4O3

  • Molecular Weight : 350.38