Raltegravir-impurities | Pharmaffiliates

raltegravir

An antiretroviral drug used for the treatment of HIV infections.Raltegravir works by targeting integrase, an HIV enzyme. Raltegravir is first in a novel class of antiretroviral drugs known as integrase inhibitors and it was produced by Merck & Co.Reference standards of Raltegravir API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Raltegravir - API Standards 
    [catalogue_number] => PA 18 57000
    [category_ids] => ,79,80,71,81,78,70,82,
    [chemical_name] => 
    [weight] => 444.42
    [form] => C20H21FN6O5
    [cas] => 518048-05-0
    [pslug] => 518048-05-0-raltegravir-api-pa1857000
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PA 18 57000

Raltegravir - API Standards


  • Catalogue No.:PA 18 57000

  • CAS :

    518048-05-0

  • Molecular Formula : C20H21FN6O5

  • Molecular Weight : 444.42

stdClass Object
(
    [pname] => N-(4-Fluorobenzyl)-5-methoxy-2-(2-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}propan-2-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide
    [catalogue_number] => PA 18 04510
    [category_ids] => ,79,80,71,81,78,70,82,
    [chemical_name] => 
    [weight] => 444.42
    [form] => C20H21FN6O5
    [cas] => NA
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PA 18 04510

N-(4-Fluorobenzyl)-5-methoxy-2-(2-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}propan-2-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide


  • Catalogue No.:PA 18 04510

  • CAS :

    NA

  • Molecular Formula : C20H21FN6O5

  • Molecular Weight : 444.42

stdClass Object
(
    [pname] => Raltegravir β-D-Glucuronide
    [catalogue_number] => PA 18 04520
    [category_ids] => ,95,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 620.54
    [form] => C26H29FN6O11
    [cas] => 952654-62-5
    [pslug] => 952654-62-5-raltegravir-beta-d-glucuronide-pa1804520
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PA 18 04520

Raltegravir β-D-Glucuronide


  • Catalogue No.:PA 18 04520

  • CAS :

    952654-62-5

  • Molecular Formula : C26H29FN6O11

  • Molecular Weight : 620.54

stdClass Object
(
    [pname] => Raltegravir β-D-Glucuronide Methyl Ester
    [catalogue_number] => PA 18 04530
    [category_ids] => ,95,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 634.57
    [form] => C27H31FN6O11
    [cas] => NA
    [pslug] => raltegravir-beta-d-glucuronide-methyl-ester-pa1804530
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PA 18 04530

Raltegravir β-D-Glucuronide Methyl Ester


  • Catalogue No.:PA 18 04530

  • CAS :

    NA

  • Molecular Formula : C27H31FN6O11

  • Molecular Weight : 634.57

stdClass Object
(
    [pname] => Raltegravir 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester
    [catalogue_number] => PA 18 04540
    [category_ids] => ,95,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 760.68
    [form] => C33H37FN6O14
    [cas] => NA
    [pslug] => raltegravir-2-3-4-tri-o-acetyl-beta-d-glucuronide-methyl-ester-pa1804540
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PA 18 04540

Raltegravir 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester


  • Catalogue No.:PA 18 04540

  • CAS :

    NA

  • Molecular Formula : C33H37FN6O14

  • Molecular Weight : 760.68

stdClass Object
(
    [pname] => Raltegravir-d3 Potassium Salt
    [catalogue_number] => PA STI 077050
    [category_ids] => ,81,98,78,70,82,
    [chemical_name] => 
    [weight] => 485.53
    [form] => C20H17D3FKN6O5
    [cas] => 1246816-98-7
    [pslug] => 1246816-98-7-raltegravir-d3-potassium-salt-pasti077050
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PA STI 077050

Raltegravir-d3 Potassium Salt


  • Catalogue No.:PA STI 077050

  • CAS :

    1246816-98-7

  • Molecular Formula : C20H17D3FKN6O5

  • Molecular Weight : 485.53

stdClass Object
(
    [pname] => Raltegravir-3H
    [catalogue_number] => PA STI 077060
    [category_ids] => ,81,98,78,70,82,
    [chemical_name] => 
    [weight] => 444.42
    [form] => C20H21FN6O5
    [cas] => NA
    [pslug] => raltegravir-3h-pasti077060
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PA STI 077060

Raltegravir-3H


  • Catalogue No.:PA STI 077060

  • CAS :

    NA

  • Molecular Formula : C20H21FN6O5

  • Molecular Weight : 444.42

stdClass Object
(
    [pname] => Raltegravir-13C6 Potassium Salt
    [catalogue_number] => PA STI 077070
    [category_ids] => ,81,98,78,70,82,
    [chemical_name] => 
    [weight] => 488.46
    [form] => C1413C6H20FKN6O5
    [cas] => 1391053-33-0
    [pslug] => 1391053-33-0-raltegravir-13c6-potassium-salt-pasti077070
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PA STI 077070

Raltegravir-13C6 Potassium Salt


  • Catalogue No.:PA STI 077070

  • CAS :

    1391053-33-0

  • Molecular Formula : C1413C6H20FKN6O5

  • Molecular Weight : 488.46

stdClass Object
(
    [pname] => Raltegravir-d3 β-D-Glucuronide
    [catalogue_number] => PA STI 077080
    [category_ids] => ,95,98,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 623.56
    [form] => C26H26D3FN6O11
    [cas] => NA
    [pslug] => raltegravir-d3-beta-d-glucuronide-pasti077080
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PA STI 077080

Raltegravir-d3 β-D-Glucuronide


  • Catalogue No.:PA STI 077080

  • CAS :

    NA

  • Molecular Formula : C26H26D3FN6O11

  • Molecular Weight : 623.56

stdClass Object
(
    [pname] => Raltegravir β-D-Glucuronide Methyl Ester-d3
    [catalogue_number] => PA STI 077090
    [category_ids] => ,95,98,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 637.59
    [form] => C27H28D3FN6O11
    [cas] => NA
    [pslug] => raltegravir-beta-d-glucuronide-methyl-ester-d3-pasti077090
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PA STI 077090

Raltegravir β-D-Glucuronide Methyl Ester-d3


  • Catalogue No.:PA STI 077090

  • CAS :

    NA

  • Molecular Formula : C27H28D3FN6O11

  • Molecular Weight : 637.59

stdClass Object
(
    [pname] => Raltegravir 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester-d3
    [catalogue_number] => PA STI 077100
    [category_ids] => ,95,98,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 763.7
    [form] => C33H34D3FN6O14
    [cas] => NA
    [pslug] => raltegravir-2-3-4-tri-o-acetyl-beta-d-glucuronide-methyl-ester-d3-pasti077100
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PA STI 077100

Raltegravir 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester-d3


  • Catalogue No.:PA STI 077100

  • CAS :

    NA

  • Molecular Formula : C33H34D3FN6O14

  • Molecular Weight : 763.7

stdClass Object
(
    [pname] => 2-(2-Aminopropan-2-yl)-4-((3-fluorobenzyl)carbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl Pivalate
    [catalogue_number] => PA 18 04550
    [category_ids] => ,78,70,82,
    [chemical_name] => 
    [weight] => 418.47
    [form] => C21H27FN4O4
    [cas] => NA
    [pslug] => 2-2-aminopropan-2-yl-4-3-fluorobenzyl-carbamoyl-1-methyl-6-oxo-1-6-dihydropyrimidin-5-yl-pivalate-pa1804550
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PA 18 04550

2-(2-Aminopropan-2-yl)-4-((3-fluorobenzyl)carbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl Pivalate


  • Catalogue No.:PA 18 04550

  • CAS :

    NA

  • Molecular Formula : C21H27FN4O4

  • Molecular Weight : 418.47

stdClass Object
(
    [pname] => 4-((4-fluorobenzyl)carbamoyl)-1-methyl-2-(2-(methylamino)propan-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl Pivalate
    [catalogue_number] => PA 18 04560
    [category_ids] => ,78,70,82,
    [chemical_name] => 
    [weight] => 432.5
    [form] => C22H29FN4O4
    [cas] => NA
    [pslug] => 4-4-fluorobenzyl-carbamoyl-1-methyl-2-2-methylamino-propan-2-yl-6-oxo-1-6-dihydropyrimidin-5-yl-pivalate-pa1804560
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PA 18 04560

4-((4-fluorobenzyl)carbamoyl)-1-methyl-2-(2-(methylamino)propan-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl Pivalate


  • Catalogue No.:PA 18 04560

  • CAS :

    NA

  • Molecular Formula : C22H29FN4O4

  • Molecular Weight : 432.5

stdClass Object
(
    [pname] => (Z)-N-(2-((2-(4-((4-Fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)amino)-2-oxoacetyl)acetohydrazonic Acid
    [catalogue_number] => PA 18 04580
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 462.44
    [form] => C20H23FN6O6
    [cas] => 2525279-50-7
    [pslug] => 2525279-50-7-z-n-2-2-4-4-fluorobenzyl-carbamoyl-5-hydroxy-1-methyl-6-oxo-1-6-dihydropyrimidin-2-yl-propan-2-yl-amino-2-oxoacetyl-acetohydrazonic-acid-pa1804580
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PA 18 04580

(Z)-N-(2-((2-(4-((4-Fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)amino)-2-oxoacetyl)acetohydrazonic Acid


  • Catalogue No.:PA 18 04580

  • CAS :

    2525279-50-7

  • Molecular Formula : C20H23FN6O6

  • Molecular Weight : 462.44

stdClass Object
(
    [pname] => Deoxadiazole Oxalamide Raltegravir
    [catalogue_number] => PA 18 04590
    [category_ids] => ,78,70,82,
    [chemical_name] => 
    [weight] => 405.39
    [form] => C18H20FN5O5
    [cas] => 1193687-86-3
    [pslug] => 1193687-86-3-deoxadiazole-oxalamide-raltegravir-pa1804590
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PA 18 04590

Deoxadiazole Oxalamide Raltegravir


  • Catalogue No.:PA 18 04590

  • CAS :

    1193687-86-3

  • Molecular Formula : C18H20FN5O5

  • Molecular Weight : 405.39

stdClass Object
(
    [pname] => N-(2-(5-Hydroxy-4-((4-methoxybenzyl)carbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide
    [catalogue_number] => PA 18 04600
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 456.46
    [form] => C21H24N6O6
    [cas] => 2249903-70-4
    [pslug] => 2249903-70-4-n-2-5-hydroxy-4-4-methoxybenzyl-carbamoyl-1-methyl-6-oxo-1-6-dihydropyrimidin-2-yl-propan-2-yl-5-methyl-1-3-4-oxadiazole-2-carboxamide-pa1804600
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PA 18 04600

N-(2-(5-Hydroxy-4-((4-methoxybenzyl)carbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide


  • Catalogue No.:PA 18 04600

  • CAS :

    2249903-70-4

  • Molecular Formula : C21H24N6O6

  • Molecular Weight : 456.46

stdClass Object
(
    [pname] => Ethyl 2-[[1-[4-[[[(4-fluorophenyl)methyl]amino]carbonyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-pyrimidinyl]-1-methylethyl]amino]-2-oxoacetate
    [catalogue_number] => PA 18 04610
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 434.42
    [form] => C20H23FN4O6
    [cas] => 1193687-88-5
    [pslug] => 1193687-88-5-ethyl-2-1-4-4-fluorophenyl-methyl-amino-carbonyl-1-6-dihydro-5-hydroxy-1-methyl-6-oxo-2-pyrimidinyl-1-methylethyl-amino-2-oxoacetate-pa1804610
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PA 18 04610

Ethyl 2-[[1-[4-[[[(4-fluorophenyl)methyl]amino]carbonyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-pyrimidinyl]-1-methylethyl]amino]-2-oxoacetate


  • Catalogue No.:PA 18 04610

  • CAS :

    1193687-88-5

  • Molecular Formula : C20H23FN4O6

  • Molecular Weight : 434.42

stdClass Object
(
    [pname] => N-(2-(4-((4-Fluorobenzyl)carbamoyl)-5-hydroxy-6-methoxypyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide
    [catalogue_number] => PA 18 04620
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 444.42
    [form] => C20H21FN6O5
    [cas] => 1370588-48-9
    [pslug] => 1370588-48-9-n-2-4-4-fluorobenzyl-carbamoyl-5-hydroxy-6-methoxypyrimidin-2-yl-propan-2-yl-5-methyl-1-3-4-oxadiazole-2-carboxamide-pa1804620
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PA 18 04620

N-(2-(4-((4-Fluorobenzyl)carbamoyl)-5-hydroxy-6-methoxypyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide


  • Catalogue No.:PA 18 04620

  • CAS :

    1370588-48-9

  • Molecular Formula : C20H21FN6O5

  • Molecular Weight : 444.42

stdClass Object
(
    [pname] => Ethyl N-(2-((2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)amino)-2-oxoacetyl)acetohydrazonate
    [catalogue_number] => PA 18 04630
    [category_ids] => ,79,80,71,78,70,82,89,75,
    [chemical_name] => 
    [weight] => 490.49
    [form] => C22H27FN6O6
    [cas] => NA
    [pslug] => ethyl-n-2-2-4-4-fluorobenzyl-carbamoyl-5-hydroxy-1-methyl-6-oxo-1-6-dihydropyrimidin-2-yl-propan-2-yl-amino-2-oxoacetyl-acetohydrazonate-pa1804630
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PA 18 04630

Ethyl N-(2-((2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)amino)-2-oxoacetyl)acetohydrazonate


  • Catalogue No.:PA 18 04630

  • CAS :

    NA

  • Molecular Formula : C22H27FN6O6

  • Molecular Weight : 490.49

stdClass Object
(
    [pname] => 5-Methyl-1,3,4-oxadiazole-2-carboxylic Acid
    [catalogue_number] => PA 18 04570
    [category_ids] => ,71,78,70,82,
    [chemical_name] => 
    [weight] => 128.09
    [form] => C4H4N2O3
    [cas] => 518048-06-1
    [pslug] => 518048-06-1-5-methyl-1-3-4-oxadiazole-2-carboxylic-acid-pa1804570
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PA 18 04570

5-Methyl-1,3,4-oxadiazole-2-carboxylic Acid


  • Catalogue No.:PA 18 04570

  • CAS :

    518048-06-1

  • Molecular Formula : C4H4N2O3

  • Molecular Weight : 128.09

stdClass Object
(
    [pname] => 2-Methyl-2-(5-methyl-1,3,4-oxadiazole-2-carboxamido)propanoic Acid
    [catalogue_number] => PA 18 04640
    [category_ids] => ,79,80,71,81,78,70,82,
    [chemical_name] => 
    [weight] => 213.19
    [form] => C8H11N3O4
    [cas] => NA
    [pslug] => 2-methyl-2-5-methyl-1-3-4-oxadiazole-2-carboxamido-propanoic-acid-pa1804640
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PA 18 04640

2-Methyl-2-(5-methyl-1,3,4-oxadiazole-2-carboxamido)propanoic Acid


  • Catalogue No.:PA 18 04640

  • CAS :

    NA

  • Molecular Formula : C8H11N3O4

  • Molecular Weight : 213.19

stdClass Object
(
    [pname] => Raltegravir Mixture of G & F
    [catalogue_number] => PA 18 04650
    [category_ids] => ,79,80,71,81,78,70,82,
    [chemical_name] => 
    [weight] => 490.48
    [form] => C22H27FN6O6
    [cas] => NA
    [pslug] => raltegravir-mixture-of-g-and-f-pa1804650
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PA 18 04650

Raltegravir Mixture of G & F


  • Catalogue No.:PA 18 04650

  • CAS :

    NA

  • Molecular Formula : C22H27FN6O6

  • Molecular Weight : 490.48

stdClass Object
(
    [pname] => Raltegravir Oxidative Impurity
    [catalogue_number] => PA 18 0571000
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 197.17
    [form] => C9H8FNO3
    [cas] => 864244-64-4
    [pslug] => 864244-64-4-raltegravir-oxidative-impurity-pa180571000
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PA 18 0571000

Raltegravir Oxidative Impurity


  • Catalogue No.:PA 18 0571000

  • CAS :

    864244-64-4

  • Molecular Formula : C9H8FNO3

  • Molecular Weight : 197.17

stdClass Object
(
    [pname] => Raltegravir 13CD3
    [catalogue_number] => PA STI 089016
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 448.43
    [form] => C1913CH18D3FN6O5
    [cas] => NA
    [pslug] => raltegravir-13cd3-pasti089016
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PA STI 089016

Raltegravir 13CD3


  • Catalogue No.:PA STI 089016

  • CAS :

    NA

  • Molecular Formula : C1913CH18D3FN6O5

  • Molecular Weight : 448.43

stdClass Object
(
    [pname] => Methyl 2-((2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)amino)-2-oxoacetate
    [catalogue_number] => PA 18 0571001
    [category_ids] => ,79,80,71,81,78,70,82,
    [chemical_name] => 
    [weight] => 420.4
    [form] => C19H21FN4O6
    [cas] => 518048-04-9
    [pslug] => 518048-04-9-methyl-2-2-4-4-fluorobenzyl-carbamoyl-5-hydroxy-1-methyl-6-oxo-1-6-dihydropyrimidin-2-yl-propan-2-yl-amino-2-oxoacetate-pa180571001
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PA 18 0571001

Methyl 2-((2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)amino)-2-oxoacetate


  • Catalogue No.:PA 18 0571001

  • CAS :

    518048-04-9

  • Molecular Formula : C19H21FN4O6

  • Molecular Weight : 420.4

stdClass Object
(
    [pname] => N-(1-Amino-2-methyl-1-oxopropan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide
    [catalogue_number] => PA 18 0571002
    [category_ids] => ,79,80,71,81,78,82,
    [chemical_name] => 
    [weight] => 212.21
    [form] => C8H12N4O3
    [cas] => NA
    [pslug] => n-1-amino-2-methyl-1-oxopropan-2-yl-5-methyl-1-3-4-oxadiazole-2-carboxamide-pa180571002
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PA 18 0571002

N-(1-Amino-2-methyl-1-oxopropan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide


  • Catalogue No.:PA 18 0571002

  • CAS :

    NA

  • Molecular Formula : C8H12N4O3

  • Molecular Weight : 212.21

stdClass Object
(
    [pname] => Methyl 2-(2-(((benzyloxy)carbonyl)amino)propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate
    [catalogue_number] => PA 18 0571003
    [category_ids] => ,79,80,71,81,78,70,82,
    [chemical_name] => 
    [weight] => 361.35
    [form] => C17H19N3O6
    [cas] => 519032-08-7
    [pslug] => 519032-08-7-methyl-2-2-benzyloxy-carbonyl-amino-propan-2-yl-5-hydroxy-6-oxo-1-6-dihydropyrimidine-4-carboxylate-pa180571003
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PA 18 0571003

Methyl 2-(2-(((benzyloxy)carbonyl)amino)propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate


  • Catalogue No.:PA 18 0571003

  • CAS :

    519032-08-7

  • Molecular Formula : C17H19N3O6

  • Molecular Weight : 361.35

stdClass Object
(
    [pname] => 2-(4-((3-Fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl benzylcarbamate
    [catalogue_number] => PA 18 0571004
    [category_ids] => ,79,80,71,81,78,70,82,
    [chemical_name] => 
    [weight] => 468.49
    [form] => C24H25FN4O5
    [cas] => NA
    [pslug] => 2-4-3-fluorobenzyl-carbamoyl-5-hydroxy-1-methyl-6-oxo-1-6-dihydropyrimidin-2-yl-propan-2-yl-benzylcarbamate-pa180571004
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PA 18 0571004

2-(4-((3-Fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl benzylcarbamate


  • Catalogue No.:PA 18 0571004

  • CAS :

    NA

  • Molecular Formula : C24H25FN4O5

  • Molecular Weight : 468.49

stdClass Object
(
    [pname] => Benzyl (2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)carbamate
    [catalogue_number] => PA 18 0571005
    [category_ids] => ,79,80,71,81,78,70,82,
    [chemical_name] => 
    [weight] => 454.46
    [form] => C23H23FN4O5
    [cas] => 519028-33-2
    [pslug] => 519028-33-2-benzyl-2-4-4-fluorobenzyl-carbamoyl-5-hydroxy-6-oxo-1-6-dihydropyrimidin-2-yl-propan-2-yl-carbamate-pa180571005
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PA 18 0571005

Benzyl (2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)carbamate


  • Catalogue No.:PA 18 0571005

  • CAS :

    519028-33-2

  • Molecular Formula : C23H23FN4O5

  • Molecular Weight : 454.46