bosutinib
Bosutinib is used to treat chronic myeloid leukaemia that has an abnormal chromosome called the Philadelphia chromosome. It is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity.. Reference standards of Bosutinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
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[pname] => Bosutinib - API Standards
[catalogue_number] => PA 02 92000
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[weight] => 530.45
[form] => C26H29Cl2N5O3
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Bosutinib - API Standards
Catalogue No.:PA 02 92000
Molecular Formula : C26H29Cl2N5O3
Molecular Weight : 530.45
stdClass Object
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[pname] => 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-propoxyquinoline-3-carbonitrile
[catalogue_number] => PA 02 0921010
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[weight] => 432.3
[form] => C21H19Cl2N3O3
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4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-propoxyquinoline-3-carbonitrile
stdClass Object
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[pname] => Bosutinib Desmethyl Impurity
[catalogue_number] => PA 02 0921012
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[weight] => 516.42
[form] => C25H27Cl2N5O3
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Bosutinib Desmethyl Impurity
Catalogue No.:PA 02 0921012
Molecular Formula : C25H27Cl2N5O3
Molecular Weight : 516.42
stdClass Object
(
[pname] => Bosutinib Regio Isomer Impurity
[catalogue_number] => PA 02 0921027
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[weight] => 530.45
[form] => C26H29Cl2N5O3
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Bosutinib Regio Isomer Impurity
Catalogue No.:PA 02 0921027
Molecular Formula : C26H29Cl2N5O3
Molecular Weight : 530.45
stdClass Object
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[catalogue_number] => PA 02 0921014
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[weight] => 374.87
[form] => C19H23ClN4O2
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4-Chloro-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
Catalogue No.:PA 02 0921014
Molecular Formula : C19H23ClN4O2
Molecular Weight : 374.87
stdClass Object
(
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[catalogue_number] => PA 02 0921015
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[weight] => 390.22
[form] => C18H13Cl2N3O3
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4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-hydroxy-6-methoxy-3-quinolinecarbonitrile
Catalogue No.:PA 02 0921015
Molecular Formula : C18H13Cl2N3O3
Molecular Weight : 390.22
stdClass Object
(
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[catalogue_number] => PA 02 0921016
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[weight] => 404.25
[form] => C19H15Cl2N3O3
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4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6,7-dimethoxy-3-quinolinecarbonitrile
Catalogue No.:PA 02 0921016
Molecular Formula : C19H15Cl2N3O3
Molecular Weight : 404.25
stdClass Object
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[catalogue_number] => PA 02 0921018
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[weight] => 466.74
[form] => C21H18Cl3N3O3
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7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyanilino)-6-methoxyquinoline-3-carbonitrile
Catalogue No.:PA 02 0921018
Molecular Formula : C21H18Cl3N3O3
Molecular Weight : 466.74
stdClass Object
(
[pname] => 4-((3,5-Dichloro-4-methoxyphenyl)amino)-6-methoxy-7-(3-(1-methylpiperidin-4-yl)propoxy)quinoline-3-carbonitrile
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[weight] => 529.46
[form] => C27H30Cl2N4O3
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4-((3,5-Dichloro-4-methoxyphenyl)amino)-6-methoxy-7-(3-(1-methylpiperidin-4-yl)propoxy)quinoline-3-carbonitrile
Catalogue No.:PA 02 92510
Molecular Formula : C27H30Cl2N4O3
Molecular Weight : 529.46
stdClass Object
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[pname] => 2-Cyano-N-(2,4-Dichloro-5-Methoxyphenyl)Acetamide
[catalogue_number] => PA 02 92680
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[weight] => 259.09
[form] => C10H8Cl2N2O2
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2-Cyano-N-(2,4-Dichloro-5-Methoxyphenyl)Acetamide
Catalogue No.:PA 02 92680
Molecular Formula : C10H8Cl2N2O2
Molecular Weight : 259.09
stdClass Object
(
[pname] => Methyl 2-amino-4-(3-chloropropoxy)-5-methoxybenzoate
[catalogue_number] => PA 02 0921000
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[weight] => 273.71
[form] => C12H16ClNO4
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Methyl 2-amino-4-(3-chloropropoxy)-5-methoxybenzoate
Catalogue No.:PA 02 0921000
Molecular Formula : C12H16ClNO4
Molecular Weight : 273.71
stdClass Object
(
[pname] => 2-(3-Bromopropoxy)-1-methoxy-4-nitrobenzene
[catalogue_number] => PA 02 0921001
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[weight] => 290.11
[form] => C10H12BrNO4
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2-(3-Bromopropoxy)-1-methoxy-4-nitrobenzene
Catalogue No.:PA 02 0921001
Molecular Formula : C10H12BrNO4
Molecular Weight : 290.11
stdClass Object
(
[pname] => 2-Cyano-N-(2,4-dichlorophenyl)acetamide
[catalogue_number] => PA 02 0921002
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[weight] => 229.06
[form] => C9H6Cl2N2O
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2-Cyano-N-(2,4-dichlorophenyl)acetamide
Catalogue No.:PA 02 0921002
Molecular Formula : C9H6Cl2N2O
Molecular Weight : 229.06
stdClass Object
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[pname] => 2-Cyano-N-(3,5-dichloro-4-methoxyphenyl)-acetamide
[catalogue_number] => PA 02 0921003
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[weight] => 259.09
[form] => C10H8Cl2N2O2
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2-Cyano-N-(3,5-dichloro-4-methoxyphenyl)-acetamide
Catalogue No.:PA 02 0921003
Molecular Formula : C10H8Cl2N2O2
Molecular Weight : 259.09
stdClass Object
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[catalogue_number] => PA 02 0921004
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[weight] => 234.08
[form] => C9H9Cl2NO2
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N-(2,4-Dichloro-5-methoxyphenyl)acetamide
Catalogue No.:PA 02 0921004
Molecular Formula : C9H9Cl2NO2
Molecular Weight : 234.08
stdClass Object
(
[pname] => N-(4-chloro-3-methoxyphenyl)-2-cyanoacetamide
[catalogue_number] => PA 02 0921005
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[weight] => 224.64
[form] => C10H9ClN2O2
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N-(4-chloro-3-methoxyphenyl)-2-cyanoacetamide
Catalogue No.:PA 02 0921005
Molecular Formula : C10H9ClN2O2
Molecular Weight : 224.64
stdClass Object
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[catalogue_number] => PA 02 0921006
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[weight] => 502.4
[form] => C24H25Cl2N5O3
[cas] => 2468737-94-0
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4-((2,4-Dichloro-5-hydroxyphenyl)amino)-6-hydroxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
stdClass Object
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[pname] => N-(2-Chloro-5-methoxyphenyl)-2-cyanoacetamide
[catalogue_number] => PA 02 0921007
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[weight] => 224.64
[form] => C10H9ClN2O2
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N-(2-Chloro-5-methoxyphenyl)-2-cyanoacetamide
Catalogue No.:PA 02 0921007
Molecular Formula : C10H9ClN2O2
Molecular Weight : 224.64
stdClass Object
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[pname] => Bosutinib Dimer Impurity
[catalogue_number] => PA 02 0921008
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[chemical_name] =>
[weight] => 960.74
[form] => C47H46Cl4N8O6
[cas] => NA
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Catalogue No.:PA 02 0921008
Molecular Formula : C47H46Cl4N8O6
Molecular Weight : 960.74
stdClass Object
(
[pname] => 2-Cyano-N-(2,4-dichloro-5-methoxy phenyl)-3-{4-methoxy-3-[3-(4-methyl piperazin-1-yl)-propoxy]- phenylamino} acrylamide
[catalogue_number] => PA 02 0921009
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[weight] => 548.47
[form] => C26H31Cl2N5O4
[cas] => 846023-56-1
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2-Cyano-N-(2,4-dichloro-5-methoxy phenyl)-3-{4-methoxy-3-[3-(4-methyl piperazin-1-yl)-propoxy]- phenylamino} acrylamide
Catalogue No.:PA 02 0921009
Molecular Formula : C26H31Cl2N5O4
Molecular Weight : 548.47
stdClass Object
(
[pname] => 7,7'-((Piperazine-1,4-diylbis(propane-3,1-diyl))bis(oxy))bis(4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile)
[catalogue_number] => PA 02 0921011
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[weight] => 946.71
[form] => C46H44Cl4N8O6
[cas] => 2095306-26-4
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7,7'-((Piperazine-1,4-diylbis(propane-3,1-diyl))bis(oxy))bis(4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile)
Catalogue No.:PA 02 0921011
Molecular Formula : C46H44Cl4N8O6
Molecular Weight : 946.71
stdClass Object
(
[pname] => Bosutinib N-Oxide
[catalogue_number] => PA 02 0921013
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 546.45
[form] => C26H29Cl2N5O4
[cas] => 2468737-96-2
[pslug] => 2468737-96-2-bosutinib-n-oxide-pa020921013
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Catalogue No.:PA 02 0921013
Molecular Formula : C26H29Cl2N5O4
Molecular Weight : 546.45
stdClass Object
(
[pname] => N-Desmethylpiperazine Hydroxy Bosutinib
[catalogue_number] => PA 02 0921017
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 448.3
[form] => C21H19Cl2N3O4
[cas] => 2724727-55-1
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N-Desmethylpiperazine Hydroxy Bosutinib
stdClass Object
(
[pname] => Methyl 4-(3-chloropropoxy)-3-methoxybenzoate
[catalogue_number] => PA 02 0921019
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 258.7
[form] => C12H15ClO4
[cas] => 111627-40-8
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Methyl 4-(3-chloropropoxy)-3-methoxybenzoate
stdClass Object
(
[pname] => 2-Bromo-4-(3-chloropropoxy)-5-methoxybenzoic Acid
[catalogue_number] => PA 02 0921022
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 323.57
[form] => C11H12BrClO4
[cas] => 1910109-73-7
[pslug] => 1910109-73-7-2-bromo-4-3-chloropropoxy-5-methoxybenzoic-acid-pa020921022
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2-Bromo-4-(3-chloropropoxy)-5-methoxybenzoic Acid
Catalogue No.:PA 02 0921022
Molecular Formula : C11H12BrClO4
Molecular Weight : 323.57
stdClass Object
(
[pname] => Ethyl (Z)-3-(2-bromo-4-(3-chloropropoxy)-5-methoxyphenyl)-2-cyano-3-hydroxyacrylate
[catalogue_number] => PA 02 0921023
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[chemical_name] =>
[weight] => 418.67
[form] => C16H17BrClNO5
[cas] => 1910109-74-8
[pslug] => 1910109-74-8-ethyl-z-3-2-bromo-4-3-chloropropoxy-5-methoxyphenyl-2-cyano-3-hydroxyacrylate-pa020921023
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Ethyl (Z)-3-(2-bromo-4-(3-chloropropoxy)-5-methoxyphenyl)-2-cyano-3-hydroxyacrylate
Catalogue No.:PA 02 0921023
Molecular Formula : C16H17BrClNO5
Molecular Weight : 418.67
stdClass Object
(
[pname] => (E)-3-(2-Bromo-4-(3-chloropropoxy)-5-methoxyphenyl)-3-hydroxyacrylonitrile
[catalogue_number] => PA 02 0921024
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[chemical_name] =>
[weight] => 346.61
[form] => C13H13BrClNO3
[cas] => NA
[pslug] => e-3-2-bromo-4-3-chloropropoxy-5-methoxyphenyl-3-hydroxyacrylonitrile-pa020921024
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(E)-3-(2-Bromo-4-(3-chloropropoxy)-5-methoxyphenyl)-3-hydroxyacrylonitrile
Catalogue No.:PA 02 0921024
Molecular Formula : C13H13BrClNO3
Molecular Weight : 346.61
stdClass Object
(
[pname] => (E)-3-Amino-2-(2-bromo-4-(3-chloropropoxy)-5-methoxybenzoyl)acrylonitrile
[catalogue_number] => PA 02 0921025
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[chemical_name] =>
[weight] => 373.63
[form] => C14H14BrClN2O3
[cas] => 1910109-76-0
[pslug] => 1910109-76-0-e-3-amino-2-2-bromo-4-3-chloropropoxy-5-methoxybenzoyl-acrylonitrile-pa020921025
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(E)-3-Amino-2-(2-bromo-4-(3-chloropropoxy)-5-methoxybenzoyl)acrylonitrile
Catalogue No.:PA 02 0921025
Molecular Formula : C14H14BrClN2O3
Molecular Weight : 373.63
stdClass Object
(
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[catalogue_number] => PA 02 0921026
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[chemical_name] =>
[weight] => 292.72
[form] => C14H13ClN2O3
[cas] => 214470-66-3
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7-(3-Chloropropoxy)-4-hydroxy-6-methoxyquinoline-3-carbonitrile
Catalogue No.:PA 02 0921026
Molecular Formula : C14H13ClN2O3
Molecular Weight : 292.72
stdClass Object
(
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[catalogue_number] => PA 02 0921021
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 303.7
[form] => C12H14ClNO6
[cas] => 214470-57-2
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Methyl 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoate
stdClass Object
(
[pname] => Methyl (E)-4-(3-chloropropoxy)-2-((2-cyanovinyl)amino)-5-methoxybenzoate
[catalogue_number] => PA 02 0921020
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 324.76
[form] => C15H17ClN2O4
[cas] => 1248588-02-4
[pslug] => 1248588-02-4-methyl-e-4-3-chloropropoxy-2-2-cyanovinyl-amino-5-methoxybenzoate-pa020921020
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Methyl (E)-4-(3-chloropropoxy)-2-((2-cyanovinyl)amino)-5-methoxybenzoate
Catalogue No.:PA 02 0921020
Molecular Formula : C15H17ClN2O4
Molecular Weight : 324.76
stdClass Object
(
[pname] => 7,7'-(Propane-1,3-diylbis(oxy))bis(4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile)
[catalogue_number] => PA 02 0921028
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 820.51
[form] => C39H30Cl4N6O6
[cas] => 2095306-27-5
[pslug] => 2095306-27-5-7-7-propane-1-3-diylbis-oxy-bis-4-2-4-dichloro-5-methoxyphenyl-amino-6-methoxyquinoline-3-carbonitrile-pa020921028
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7,7'-(Propane-1,3-diylbis(oxy))bis(4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile)
Catalogue No.:PA 02 0921028
Molecular Formula : C39H30Cl4N6O6
Molecular Weight : 820.51
stdClass Object
(
[pname] => 1,3-bis(2-Methoxy-5-nitrophenoxy)propane
[catalogue_number] => PA 02 0921029
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 378.34
[form] => C17H18N2O8
[cas] => 2095306-22-0
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1,3-bis(2-Methoxy-5-nitrophenoxy)propane
Catalogue No.:PA 02 0921029
Molecular Formula : C17H18N2O8
Molecular Weight : 378.34
stdClass Object
(
[pname] => 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-nitrosopiperazin-1-yl)propoxy)quinoline-3-carbonitrile
[catalogue_number] => PA 02 0921030
[category_ids] => ,70,71,78,80,81,82,162,
[chemical_name] =>
[weight] => 545.42
[form] => C25H26Cl2N6O4
[cas] => NA
[pslug] => 4-2-4-dichloro-5-methoxyphenyl-amino-6-methoxy-7-3-4-nitrosopiperazin-1-yl-propoxy-quinoline-3-carbonitrile-pa020921030
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4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-nitrosopiperazin-1-yl)propoxy)quinoline-3-carbonitrile
Catalogue No.:PA 02 0921030
Molecular Formula : C25H26Cl2N6O4
Molecular Weight : 545.42
stdClass Object
(
[pname] => 7-(3-Chloropropoxy)-4-((2,4-dichloro-5-hydroxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile
[catalogue_number] => PAI 02 092001
[category_ids] => ,70,
[chemical_name] =>
[weight] => 452.72
[form] => C20H16Cl3N3O3
[cas] => NA
[pslug] => 7-3-chloropropoxy-4-2-4-dichloro-5-hydroxyphenyl-amino-6-methoxyquinoline-3-carbonitrile-pai02092001
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7-(3-Chloropropoxy)-4-((2,4-dichloro-5-hydroxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile
Catalogue No.:PAI 02 092001
Molecular Formula : C20H16Cl3N3O3
Molecular Weight : 452.72
stdClass Object
(
[pname] => tert-Butyl 4-(3-((3-cyano-4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinolin-7-yl)oxy)propyl)piperazine-1-carboxylate
[catalogue_number] => PAI 02 092002
[category_ids] => ,70,
[chemical_name] =>
[weight] => 616.54
[form] => C30H35Cl2N5O5
[cas] => 1613270-82-8
[pslug] => 1613270-82-8-tert-butyl-4-3-3-cyano-4-2-4-dichloro-5-methoxyphenyl-amino-6-methoxyquinolin-7-yl-oxy-propyl-piperazine-1-carboxylate-pai02092002
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tert-Butyl 4-(3-((3-cyano-4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinolin-7-yl)oxy)propyl)piperazine-1-carboxylate
Catalogue No.:PAI 02 092002
Molecular Formula : C30H35Cl2N5O5
Molecular Weight : 616.54
stdClass Object
(
[pname] => 2,4-Dichloro-N-(4-chlorobutyl)-5-methoxyaniline
[catalogue_number] => PAI 02 092003
[category_ids] => ,70,
[chemical_name] =>
[weight] => 282.59
[form] => C11H14Cl3NO
[cas] => NA
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2,4-Dichloro-N-(4-chlorobutyl)-5-methoxyaniline
Catalogue No.:PAI 02 092003
Molecular Formula : C11H14Cl3NO
Molecular Weight : 282.59
stdClass Object
(
[pname] => 4-((3-Bromopropyl)(2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
[catalogue_number] => PAI 02 092004
[category_ids] => ,70,
[chemical_name] =>
[weight] => 651.43
[form] => C29H34BrCl2N5O3
[cas] => NA
[pslug] => 4-3-bromopropyl-2-4-dichloro-5-methoxyphenyl-amino-6-methoxy-7-3-4-methylpiperazin-1-yl-propoxy-quinoline-3-carbonitrile-pai02092004
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4-((3-Bromopropyl)(2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
Catalogue No.:PAI 02 092004
Molecular Formula : C29H34BrCl2N5O3
Molecular Weight : 651.43
stdClass Object
(
[pname] => 5-Chloro-7-(3-hydroxypropoxy)-6-methoxyquinoline-3-carbonitrile
[catalogue_number] => PAI 02 092005
[category_ids] => ,70,
[chemical_name] =>
[weight] => 292.72
[form] => C14H13ClN2O3
[cas] => NA
[pslug] => 5-chloro-7-3-hydroxypropoxy-6-methoxyquinoline-3-carbonitrile-pai02092005
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5-Chloro-7-(3-hydroxypropoxy)-6-methoxyquinoline-3-carbonitrile
Catalogue No.:PAI 02 092005
Molecular Formula : C14H13ClN2O3
Molecular Weight : 292.72
stdClass Object
(
[pname] => 4-Chloro-6,7-dimethoxyquinoline-3-carbonitrile
[catalogue_number] => PAI 02 092006
[category_ids] => ,70,
[chemical_name] =>
[weight] => 248.67
[form] => C12H9ClN2O2
[cas] => 214470-55-0
[pslug] => 214470-55-0-4-chloro-6-7-dimethoxyquinoline-3-carbonitrile-pai02092006
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4-Chloro-6,7-dimethoxyquinoline-3-carbonitrile
Catalogue No.:PAI 02 092006
Molecular Formula : C12H9ClN2O2
Molecular Weight : 248.67
stdClass Object
(
[pname] => 4-Chloro-6-methoxy-7-propoxyquinoline-3-carbonitrile
[catalogue_number] => PAI 02 092007
[category_ids] => ,70,
[chemical_name] =>
[weight] => 276.72
[form] => C14H13ClN2O2
[cas] => NA
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4-Chloro-6-methoxy-7-propoxyquinoline-3-carbonitrile
Catalogue No.:PAI 02 092007
Molecular Formula : C14H13ClN2O2
Molecular Weight : 276.72
stdClass Object
(
[pname] => 4-Chloro-7-(3-hydroxypropoxy)-6-methoxyquinoline-3-carbonitrile
[catalogue_number] => PAI 02 092008
[category_ids] => ,70,
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[weight] => 292.72
[form] => C14H13ClN2O3
[cas] => 2760140-40-5
[pslug] => 2760140-40-5-4-chloro-7-3-hydroxypropoxy-6-methoxyquinoline-3-carbonitrile-pai02092008
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4-Chloro-7-(3-hydroxypropoxy)-6-methoxyquinoline-3-carbonitrile
Catalogue No.:PAI 02 092008
Molecular Formula : C14H13ClN2O3
Molecular Weight : 292.72
stdClass Object
(
[pname] => 7,7'-(Propane-1,3-diylbis(oxy))bis(4-chloro-6-methoxyquinoline-3-carbonitrile)
[catalogue_number] => PAI 02 092009
[category_ids] => ,70,
[chemical_name] =>
[weight] => 509.34
[form] => C25H18Cl2N4O4
[cas] => NA
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7,7'-(Propane-1,3-diylbis(oxy))bis(4-chloro-6-methoxyquinoline-3-carbonitrile)
Catalogue No.:PAI 02 092009
Molecular Formula : C25H18Cl2N4O4
Molecular Weight : 509.34
stdClass Object
(
[pname] => 4-((2,4-Dichloro-5-methoxyphenyl)amino)-7-(3-((2,4-dichloro-5-methoxyphenyl)amino)propoxy)-6-methoxyquinoline-3-carbonitrile
[catalogue_number] => PAI 02 092010
[category_ids] => ,70,
[chemical_name] =>
[weight] => 622.32
[form] => C28H24Cl4N4O4
[cas] => NA
[pslug] => 4-2-4-dichloro-5-methoxyphenyl-amino-7-3-2-4-dichloro-5-methoxyphenyl-amino-propoxy-6-methoxyquinoline-3-carbonitrile-pai02092010
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4-((2,4-Dichloro-5-methoxyphenyl)amino)-7-(3-((2,4-dichloro-5-methoxyphenyl)amino)propoxy)-6-methoxyquinoline-3-carbonitrile
Catalogue No.:PAI 02 092010
Molecular Formula : C28H24Cl4N4O4
Molecular Weight : 622.32