rapamycin
Rapamycin is also known as Sirolimus which is a naturally occurring triene macrolide antibiotic , used to prevent organ transplant rejection and for the treatment of lymphangioleiomyomatosis (LAM). Rapamycin was also initially used as anti fungal agent. It works by inhibiting the activation of T cells and B cells by reducing the production of interleukin-2.Reference standards of Rapamycin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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Rapamycin - API Standards
Catalogue No.:PA 18 26000
Molecular Formula : C51H79NO13
Molecular Weight : 914.17
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Catalogue No.:PA 18 26510
Molecular Formula : C51H79NO15
Molecular Weight : 946.17
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Catalogue No.:PA 18 26530
Molecular Formula : C50H77NO13
Molecular Weight : 900.17
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Catalogue No.:PA 18 26550
Molecular Formula : C51H79NO13
Molecular Weight : 914.17
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Catalogue No.:PA 18 26560
Molecular Formula : C50H77NO13
Molecular Weight : 900.15
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Catalogue No.:PA 18 26570
Molecular Formula : C50H77NO13
Molecular Weight : 900.15
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Catalogue No.:PA 18 26580
Molecular Formula : C50H77NO13
Molecular Weight : 900.15
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Catalogue No.:PA 18 26590
Molecular Formula : C51H77NO13
Molecular Weight : 912.16
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Molecular Formula : C51H79NO13
Molecular Weight : 914.17
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Catalogue No.:PA 18 26610
Molecular Formula : C50H77NO12
Molecular Weight : 884.15
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(19E/Z)-seco-[4-O-[2-Hydroxy(ethyl)-d4]] Rapamycin Sodium Salt
Catalogue No.:PA STI 047640
Molecular Formula : C53H78D4NNaO14
Molecular Weight : 984.23
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Catalogue No.:PA 18 26640
Molecular Formula : C51H79NO13
Molecular Weight : 914.19
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Catalogue No.:PA 18 26650
Molecular Formula : C50H77NO13
Molecular Weight : 900.16
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Catalogue No.:PA 18 0261000
Molecular Formula : C51H78NNaO13
Molecular Weight : 936.17
stdClass Object
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7-O-Demethyl-7-O-ethyl-Rapamycin
Catalogue No.:PA 18 0261001
Molecular Formula : C52H81NO13
Molecular Weight : 928.21
stdClass Object
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42-O-[2-[[Hydroxy[2-(trimethylammonio)ethoxy]phosphinyl]oxy]ethyl] Rapamycin Inner Salt
Catalogue No.:PA 18 0261002
Molecular Formula : C58H95N2O17P
Molecular Weight : 1123.37
stdClass Object
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Catalogue No.:PA 18 0261004
Molecular Formula : C50H77NO13
Molecular Weight : 900.15
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Catalogue No.:PA 18 0261006
Molecular Formula : C24H15F3N4O
Molecular Weight : 432.41
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Catalogue No.:PA 18 0261007
Molecular Formula : C15H15N7O
Molecular Weight : 309.33
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Catalogue No.:PA 18 0261008
Molecular Formula : C50H77NO13
Molecular Weight : 900.16
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Rapamycin, 36-demethyl-36-ethyl
Catalogue No.:PA 18 0261010
Molecular Formula : C52H81NO13
Molecular Weight : 928.21
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Catalogue No.:PA 18 0261009
Molecular Formula : C51H77NO13
Molecular Weight : 912.17
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stdClass Object
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[pname] => (9aS)-3-Hydroxy-3-((2R,3R,6S)-2-hydroxy-6-((2S,3E,5E,7E,9S,11R,13S,14R,15E)-14-hydroxy-2,13-dimethoxy-3,9,11,15-tetramethyl-12,17-dioxooctadeca-3,5,7,15-tetraen-1-yl)-3-methyltetrahydro-2H-pyran-2-yl)tetrahydropyrido[2,1-c][1,4]oxazine-1,4(3H,6H)-dione
[catalogue_number] => PA 18 0261012
[category_ids] => ,82,81,78,71,70,69,
[chemical_name] =>
[weight] => 703.87
[form] => C38H57NO11
[cas] => NA
[pslug] => 9as-3-hydroxy-3-2r-3r-6s-2-hydroxy-6-2s-3e-5e-7e-9s-11r-13s-14r-15e-14-hydroxy-2-13-dimethoxy-3-9-11-15-tetramethyl-12-17-dioxooctadeca-3-5-7-15-tetraen-1-yl-3-methyltetrahydro-2h-pyran-2-yl-tetrahydropyrido-2-1-c-1-4-oxazine-1-4-3h-6h-dione-pa180261012
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(9aS)-3-Hydroxy-3-((2R,3R,6S)-2-hydroxy-6-((2S,3E,5E,7E,9S,11R,13S,14R,15E)-14-hydroxy-2,13-dimethoxy-3,9,11,15-tetramethyl-12,17-dioxooctadeca-3,5,7,15-tetraen-1-yl)-3-methyltetrahydro-2H-pyran-2-yl)tetrahydropyrido[2,1-c][1,4]oxazine-1,4(3H,6H)-dione
Catalogue No.:PA 18 0261012
Molecular Formula : C38H57NO11
Molecular Weight : 703.87
stdClass Object
(
[pname] => Sirolimus-31,42-Diester Impurity
[catalogue_number] => PA 18 0261013
[category_ids] => ,82,78,70,69,
[chemical_name] =>
[weight] => 1146.42
[form] => C61H95NO19
[cas] => NA
[pslug] => sirolimus-31-42-diester-impurity-pa180261013
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Sirolimus-31,42-Diester Impurity
Catalogue No.:PA 18 0261013
Molecular Formula : C61H95NO19
Molecular Weight : 1146.42
stdClass Object
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[pname] => (7R)-Rapamycin
[catalogue_number] => PA 18 0261014
[category_ids] => ,75,78,70,82,
[chemical_name] =>
[weight] => 914.19
[form] => C51H79NO13
[cas] => 157182-37-1
[pslug] => 157182-37-1-7r-rapamycin-pa180261014
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Catalogue No.:PA 18 0261014
Molecular Formula : C51H79NO13
Molecular Weight : 914.19
stdClass Object
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[pname] => (3R,9aS)-3-Hydroxy-3-((2R,3R,6S)-2-hydroxy-6-((2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19E,21R)-14-hydroxy-22-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl)-3-methyltetrahydro-2H-pyran-2-yl)tetrahydropyrido[2,1-c][1,4]oxazine-1,4(3H,6H)-dione
[catalogue_number] => PA 18 0261015
[category_ids] => ,82,81,78,71,70,69,
[chemical_name] =>
[weight] => 914.19
[form] => C51H79NO13
[cas] => NA
[pslug] => 3r-9as-3-hydroxy-3-2r-3r-6s-2-hydroxy-6-2s-3e-5e-7e-9s-11r-13r-14r-15e-17r-19e-21r-14-hydroxy-22-1s-3r-4r-4-hydroxy-3-methoxycyclohexyl-2-13-dimethoxy-3-9-11-15-17-21-hexamethyl-12-18-dioxodocosa-3-5-7-15-19-pentaen-1-yl-3-methyltetrahydro-2h-pyran-2-yl-tetrahydropyrido-2-1-c-1-4-oxazine-1-4-3h-6h-dione-pa180261015
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(3R,9aS)-3-Hydroxy-3-((2R,3R,6S)-2-hydroxy-6-((2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19E,21R)-14-hydroxy-22-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl)-3-methyltetrahydro-2H-pyran-2-yl)tetrahydropyrido[2,1-c][1,4]oxazine-1,4(3H,6H)-dione
Catalogue No.:PA 18 0261015
Molecular Formula : C51H79NO13
Molecular Weight : 914.19