solifenacin
A muscarinic receptor antagonist drug used for treating contraction of overactive bladder such as incontinence, urinary frequency, and urgency. Solifenacin is a competitive cholinergic receptor antagonist, selective for the M3 receptor subtype. It was manufactured and marketed by Astellas, GlaxoSmithKline and Teva Pharmaceutical Industries. Reference standards of Solifenacin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
Catalogue No.:PA 19 50510
Molecular Formula : C15H15N
Molecular Weight : 209.29
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Solifenacin (R,S)-Isomer Hydrochloride Salt
Catalogue No.:PA 19 50530
Molecular Formula : C23H27ClN2O2
Molecular Weight : 398.93
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1-Phenyl-3,4-dihydroisoquinoline
Catalogue No.:PA 19 50580
Molecular Formula : C15H13N
Molecular Weight : 207.27
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1-Phenyl-1,2,3,4-tetrahydroisoquinoline
Catalogue No.:PA 19 50780
Molecular Formula : C15H15N
Molecular Weight : 209.29
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3,4-Dihydro-1-phenylisoquinoline Hydrochloride
Catalogue No.:PA 19 50790
Molecular Formula : C15H14ClN
Molecular Weight : 243.73
stdClass Object
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Solifenacin - API Standards
Catalogue No.:PA 19 2090000
Molecular Formula : C23H26N2O2
Molecular Weight : 362.47
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Solifenacin (R,R)-Isomer Succinate Salt
Catalogue No.:PA 19 50520
Molecular Formula : C27H32N2O6
Molecular Weight : 480.55
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Solifenacin (S,S)-Isomer Hydrochloride Salt
Catalogue No.:PA 19 50540
Molecular Formula : C23H27ClN2O2
Molecular Weight : 398.93
stdClass Object
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[pname] => (R)-(-)-3-Quinuclidinol
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Catalogue No.:PA 19 50550
Molecular Formula : C7H13NO
Molecular Weight : 127.18
stdClass Object
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Ethyl (S)-1-Phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate
Catalogue No.:PA 19 50560
Molecular Formula : C18H19NO2
Molecular Weight : 281.35
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Catalogue No.:PA 19 50640
Molecular Formula : C7H13NO
Molecular Weight : 127.18
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(S)-1-Phenyl-3,4-dihydroisoquinoline-2(1H)-Carboxylic Acid
stdClass Object
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(R)-Quinuclidin-3-yl 2-benzoylphenethylcarbamate
Catalogue No.:PA 19 50660
Molecular Formula : C23H26N2O3
Molecular Weight : 378.46
stdClass Object
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(R)-Quinuclidin-3-yl-[2-(2-Benzoyl phenyl)ethyl]carbamate Succinate
Catalogue No.:PA 19 50670
Molecular Formula : C27H32N2O7
Molecular Weight : 496.55
stdClass Object
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(S)-Phenyl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
Catalogue No.:PA 19 50680
Molecular Formula : C22H19NO2
Molecular Weight : 329.39
stdClass Object
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[pname] => Solifenacin Succinate Impurity S1
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Solifenacin Succinate Impurity S1
Catalogue No.:PA 19 50690
Molecular Formula : C23H27N2O3+
Molecular Weight : 379.47
stdClass Object
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[pname] => (1R,3R,4R)-3-((4-Hydroxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)oxy)quinuclidine 1-oxide
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[weight] => 394.46
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(1R,3R,4R)-3-((4-Hydroxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)oxy)quinuclidine 1-oxide
Catalogue No.:PA 19 50700
Molecular Formula : C23H26N2O4
Molecular Weight : 394.46
stdClass Object
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Solifenacin cis-Hydroxy Impurity
Catalogue No.:PA 19 50710
Molecular Formula : C23H26N2O3
Molecular Weight : 378.46
stdClass Object
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[pname] => 1,2-Dihydro-1-phenylisoquinoline
[catalogue_number] => PA 19 50720
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[weight] => 207.27
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1,2-Dihydro-1-phenylisoquinoline
Catalogue No.:PA 19 50720
Molecular Formula : C15H13N
Molecular Weight : 207.27
stdClass Object
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Trans-4-Hydroxy Solifenacin (Mixture of Diastereomers)
Catalogue No.:PA 19 50730
Molecular Formula : C23H26N2O3
Molecular Weight : 378.46
stdClass Object
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[weight] => 399.49
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cis-Hydroxy Solifenacin-d5 N-Oxide
(Mixture of Diastereomers)
Catalogue No.:PA STI 051630
Molecular Formula : C23H21D5N2O4
Molecular Weight : 399.49
stdClass Object
(
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[weight] => 403.96
[form] => C23H22D5ClN2O2
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Solifenacin-d5 Hydrochloride
Catalogue No.:PA STI 079630
Molecular Formula : C23H22D5ClN2O2
Molecular Weight : 403.96
stdClass Object
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(1S,3S-)Solifenacin Hydrochloride-d5
Catalogue No.:PA STI 079640
Molecular Formula : C23H22D5ClN2O2
Molecular Weight : 403.96
stdClass Object
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(1R,3S-)Solifenacin-d5 Hydrochloride
Catalogue No.:PA STI 079650
Molecular Formula : C23H22D5ClN2O2
Molecular Weight : 403.96
stdClass Object
(
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[catalogue_number] => PA 19 50740
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[weight] => 378.47
[form] => C23H26N2O3
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(1S)-1-Phenyl-2-((((R)-quinuclidin-3-yl)oxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline 2-oxide
Catalogue No.:PA 19 50740
Molecular Formula : C23H26N2O3
Molecular Weight : 378.47
stdClass Object
(
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[catalogue_number] => PA 19 50750
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(R)-Quinuclidin-3-yl (1S)-4-hydroxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
Catalogue No.:PA 19 50750
Molecular Formula : C23H26N2O3
Molecular Weight : 378.47
stdClass Object
(
[pname] => (1S,3R,4S)-Quinuclidin-3-yl Benzylcarbamate
[catalogue_number] => PA 19 50760
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[chemical_name] =>
[weight] => 260.34
[form] => C15H20N2O2
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(1S,3R,4S)-Quinuclidin-3-yl Benzylcarbamate
Catalogue No.:PA 19 50760
Molecular Formula : C15H20N2O2
Molecular Weight : 260.34
stdClass Object
(
[pname] => (R)-3-(((S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)oxy)quinuclidine 1-oxide Fumarate
[catalogue_number] => PA 19 50770
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[chemical_name] =>
[weight] => 494.54
[form] => C27H30N2O7
[cas] => NA
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(R)-3-(((S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)oxy)quinuclidine 1-oxide Fumarate
Catalogue No.:PA 19 50770
Molecular Formula : C27H30N2O7
Molecular Weight : 494.54
stdClass Object
(
[pname] => (1S,3′R)-Solifenacin-d7 HCl (quinuclidinyl-d7)
[catalogue_number] => PA STI 088429
[category_ids] => ,98,78,70,82,
[chemical_name] =>
[weight] => 405.97
[form] => C23H20D7ClN2O2
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(1S,3′R)-Solifenacin-d7 HCl (quinuclidinyl-d7)
Catalogue No.:PA STI 088429
Molecular Formula : C23H20D7ClN2O2
Molecular Weight : 405.97
stdClass Object
(
[pname] => 4R-Hydroxy Solifenacin
[catalogue_number] => PA 19 0501000
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 378.47
[form] => C23H26N2O3
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Catalogue No.:PA 19 0501000
Molecular Formula : C23H26N2O3
Molecular Weight : 378.47
stdClass Object
(
[pname] => (1S,3R,4S)-Quinuclidin-3-yl (1S,4R)-4-hydroxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
[catalogue_number] => PA 19 0501001
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(1S,3R,4S)-Quinuclidin-3-yl (1S,4R)-4-hydroxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
Catalogue No.:PA 19 0501001
Molecular Formula : C23H26N2O3
Molecular Weight : 378.47
stdClass Object
(
[pname] => Solifenacin Identification Mixture A
[catalogue_number] => PA 19 0501004
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Solifenacin Identification Mixture A
stdClass Object
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[pname] => Solifenacin Identification Mixture B
[catalogue_number] => PA 19 0501003
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Solifenacin Identification Mixture B
stdClass Object
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[pname] => Methyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
[catalogue_number] => PA 19 0501006
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 267.33
[form] => C17H17NO2
[cas] => 1251905-45-9
[pslug] => 1251905-45-9-methyl-s-1-phenyl-3-4-dihydroisoquinoline-2-1h-carboxylate-pa190501006
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Methyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
Catalogue No.:PA 19 0501006
Molecular Formula : C17H17NO2
Molecular Weight : 267.33
stdClass Object
(
[pname] => Ethyl (R)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
[catalogue_number] => PA 19 0501007
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[chemical_name] =>
[weight] => 281.36
[form] => C18H19NO2
[cas] => 180468-41-1
[pslug] => 180468-41-1-ethyl-r-1-phenyl-3-4-dihydroisoquinoline-2-1h-carboxylate-pa190501007
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Ethyl (R)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
Catalogue No.:PA 19 0501007
Molecular Formula : C18H19NO2
Molecular Weight : 281.36
stdClass Object
(
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[catalogue_number] => PA 19 0501008
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[weight] => 378.47
[form] => C23H26N2O3
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(R)-Quinuclidin-3-yl (S)-1-hydroxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
Catalogue No.:PA 19 0501008
Molecular Formula : C23H26N2O3
Molecular Weight : 378.47
stdClass Object
(
[pname] => Solifenacin Succinate (IPRS/82/19) - from IPC
[catalogue_number] => PA IPRS 82 19
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[weight] => NA
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Solifenacin Succinate (IPRS/82/19) - from IPC
stdClass Object
(
[pname] => Quinuclidin-3-one
[catalogue_number] => PA 19 0501009
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 125.17
[form] => C7H11NO
[cas] => 3731-38-2
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Catalogue No.:PA 19 0501009
Molecular Formula : C7H11NO
Molecular Weight : 125.17
stdClass Object
(
[pname] => Solifenacin Nitrophenyl Ester Impurity
[catalogue_number] => PA 19 0501011
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 374.4
[form] => C22H18N2O4
[cas] => 1229227-22-8
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Solifenacin Nitrophenyl Ester Impurity
stdClass Object
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[catalogue_number] => PA 19 2091000
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 390.53
[form] => C25H30N2O2
[cas] => 2407763-27-1
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(2R,3R)-2-Ethylquinuclidin-3-yl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
Catalogue No.:PA 19 2091000
Molecular Formula : C25H30N2O2
Molecular Weight : 390.53
stdClass Object
(
[pname] => 2-Nitroso-1-phenyl-1,2,3,4-tetrahydroisoquinoline
[catalogue_number] => PA 19 2091001
[category_ids] => ,70,75,76,78,82,162,
[chemical_name] =>
[weight] => 238.29
[form] => C15H14N2O
[cas] => 2659259-64-8
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2-Nitroso-1-phenyl-1,2,3,4-tetrahydroisoquinoline
Catalogue No.:PA 19 2091001
Molecular Formula : C15H14N2O
Molecular Weight : 238.29