Methotrexate-impurities | Pharmaffiliates

methotrexate

An antimetabolite of the antifolate type, Methotrexate is an chemotherapy drug and used for treating autoimmune diseases like psoriasis, rheumatoid arthritis. It causes life threatening side effects. Reference standards of Methotrexate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

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(
    [pname] => Methotrexate - Impurity A (Hydrochloride Salt)
    [catalogue_number] => PA 13 0280011
    [category_ids] => ,78,75,76,82,
    [chemical_name] => 
    [weight] => 228.64
    [form] => C7H9ClN6O
    [cas] => 73978-41-3
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PA 13 0280011

Methotrexate - Impurity A (Hydrochloride Salt)


  • Catalogue No.:PA 13 0280011

  • CAS :

    73978-41-3

  • Molecular Formula : C7H9ClN6O

  • Molecular Weight : 228.64

stdClass Object
(
    [pname] => 7-Methylpteridine-2,4-diamine
    [catalogue_number] => PA 13 0281010
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 176.18
    [form] => C7H8N6
    [cas] => 4215-07-0
    [pslug] => 4215-07-0-7-methylpteridine-2-4-diamine-pa130281010
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PA 13 0281010

7-Methylpteridine-2,4-diamine


  • Catalogue No.:PA 13 0281010

  • CAS :

    4215-07-0

  • Molecular Formula : C7H8N6

  • Molecular Weight : 176.18

20% OFF
stdClass Object
(
    [pname] => Methotrexate - Impurity B (Hydrate Salt)
    [catalogue_number] => PA 13 0280021
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 458.44
    [form] => C19H22N8O6
    [cas] => 1217459-90-9
    [pslug] => 1217459-90-9-methotrexate-impurity-b-hydrate-salt-pa130280021
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    [offers_product_id] => 2836
    [offers_product_code] => PA 13 0280021
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PA 13 0280021

Methotrexate - Impurity B (Hydrate Salt)


  • Catalogue No.:PA 13 0280021

  • CAS :

    1217459-90-9

  • Molecular Formula : C19H22N8O6

  • Molecular Weight : 458.44

stdClass Object
(
    [pname] => 7-Hydroxy Methotrexate-d3
    [catalogue_number] => PA STI 049680
    [category_ids] => ,98,76,78,70,82,
    [chemical_name] => 
    [weight] => 473.46
    [form] => C20H19D3N8O6
    [cas] => 432545-62-5
    [pslug] => 432545-62-5-7-hydroxy-methotrexate-d3-pasti049680
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PA STI 049680

7-Hydroxy Methotrexate-d3


  • Catalogue No.:PA STI 049680

  • CAS :

    432545-62-5

  • Molecular Formula : C20H19D3N8O6

  • Molecular Weight : 473.46

stdClass Object
(
    [pname] => Methotrexate - Impurity K
    [catalogue_number] => PA 13 28110
    [category_ids] => 75,76,97
    [chemical_name] => 
    [weight] => 266.25
    [form] => C12H14N2O5
    [cas] => 4271-30-1
    [pslug] => 4271-30-1-methotrexate-impurity-k-pa1328110
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PA 13 28110

Methotrexate - Impurity K


  • Catalogue No.:PA 13 28110

  • CAS :

    4271-30-1

  • Molecular Formula : C12H14N2O5

  • Molecular Weight : 266.25

stdClass Object
(
    [pname] => 10-Deazaaminopterin
    [catalogue_number] => PA 13 0281000
    [category_ids] => ,75,76,123,81,70,78,82,
    [chemical_name] => 
    [weight] => 439.43
    [form] => C20H21N7O5
    [cas] => 52454-37-2
    [pslug] => 52454-37-2-10-deazaaminopterin-pa130281000
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PA 13 0281000

10-Deazaaminopterin


  • Catalogue No.:PA 13 0281000

  • CAS :

    52454-37-2

  • Molecular Formula : C20H21N7O5

  • Molecular Weight : 439.43

stdClass Object
(
    [pname] => 7-Cyanomethotrexate Dimethyl Ester
    [catalogue_number] => PA 13 0281001
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 507.51
    [form] => C23H25N9O5
    [cas] => 112163-39-0
    [pslug] => 112163-39-0-7-cyanomethotrexate-dimethyl-ester-pa130281001
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PA 13 0281001

7-Cyanomethotrexate Dimethyl Ester


  • Catalogue No.:PA 13 0281001

  • CAS :

    112163-39-0

  • Molecular Formula : C23H25N9O5

  • Molecular Weight : 507.51

stdClass Object
(
    [pname] => Methotrexate-d3 Dimethyl Ester
    [catalogue_number] => PA 13 0281002
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 485.52
    [form] => C22H23D3N8O5
    [cas] => 432545-60-3
    [pslug] => 432545-60-3-methotrexate-d3-dimethyl-ester-pa130281002
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PA 13 0281002

Methotrexate-d3 Dimethyl Ester


  • Catalogue No.:PA 13 0281002

  • CAS :

    432545-60-3

  • Molecular Formula : C22H23D3N8O5

  • Molecular Weight : 485.52

stdClass Object
(
    [pname] => 7-Hydroxy Methotrexate
    [catalogue_number] => PA 13 0281003
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 470.45
    [form] => C20H22N8O6
    [cas] => 5939-37-7
    [pslug] => 5939-37-7-7-hydroxy-methotrexate-pa130281003
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PA 13 0281003

7-Hydroxy Methotrexate


  • Catalogue No.:PA 13 0281003

  • CAS :

    5939-37-7

  • Molecular Formula : C20H22N8O6

  • Molecular Weight : 470.45

stdClass Object
(
    [pname] => (2,4-Diaminopteridin-7-yl)methanol
    [catalogue_number] => PA 13 0281004
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 192.18
    [form] => C7H8N6O
    [cas] => 881-33-4
    [pslug] => 881-33-4-2-4-diaminopteridin-7-yl-methanol-pa130281004
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PA 13 0281004

(2,4-Diaminopteridin-7-yl)methanol


  • Catalogue No.:PA 13 0281004

  • CAS :

    881-33-4

  • Molecular Formula : C7H8N6O

  • Molecular Weight : 192.18

stdClass Object
(
    [pname] => 2,4-Diaminopteridine
    [catalogue_number] => PA 13 0281005
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 162.16
    [form] => C6H6N6
    [cas] => 1127-93-1
    [pslug] => 1127-93-1-2-4-diaminopteridine-pa130281005
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PA 13 0281005

2,4-Diaminopteridine


  • Catalogue No.:PA 13 0281005

  • CAS :

    1127-93-1

  • Molecular Formula : C6H6N6

  • Molecular Weight : 162.16

stdClass Object
(
    [pname] => 6-Methylpteridine-2,4-diamine
    [catalogue_number] => PA 13 0281006
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 176.18
    [form] => C7H8N6
    [cas] => 708-74-7
    [pslug] => 708-74-7-6-methylpteridine-2-4-diamine-pa130281006
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PA 13 0281006

6-Methylpteridine-2,4-diamine


  • Catalogue No.:PA 13 0281006

  • CAS :

    708-74-7

  • Molecular Formula : C7H8N6

  • Molecular Weight : 176.18

stdClass Object
(
    [pname] => (4-Chlorobenzoyl)-L-glutamic Acid
    [catalogue_number] => PA 13 0281007
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 285.68
    [form] => C12H12ClNO5
    [cas] => 57444-70-9
    [pslug] => 57444-70-9-4-chlorobenzoyl-l-glutamic-acid-pa130281007
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PA 13 0281007

(4-Chlorobenzoyl)-L-glutamic Acid


  • Catalogue No.:PA 13 0281007

  • CAS :

    57444-70-9

  • Molecular Formula : C12H12ClNO5

  • Molecular Weight : 285.68

stdClass Object
(
    [pname] => Methotrexate System Suitability Mixture
    [catalogue_number] => PA 13 0281008
    [category_ids] => ,80,71,76,75,93,78,70,82,
    [chemical_name] => 
    [weight] => NA
    [form] => NA
    [cas] => NA
    [pslug] => methotrexate-system-suitability-mixture-pa130281008
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PA 13 0281008

Methotrexate System Suitability Mixture


  • Catalogue No.:PA 13 0281008

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

stdClass Object
(
    [pname] => Aminopterin-α-hyrazide
    [catalogue_number] => PA 13 0281009
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 454.45
    [form] => C19H22N10O4
    [cas] => 118359-33-4
    [pslug] => 118359-33-4-aminopterin-alpha-hyrazide-pa130281009
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PA 13 0281009

Aminopterin-α-hyrazide


  • Catalogue No.:PA 13 0281009

  • CAS :

    118359-33-4

  • Molecular Formula : C19H22N10O4

  • Molecular Weight : 454.45

stdClass Object
(
    [pname] => Methotrexate - Impurity E (Freebase)
    [catalogue_number] => PA 13 0280051
    [category_ids] => 82,78,76,75,70
    [chemical_name] => 
    [weight] => 325.33
    [form] => C15H15N7O2
    [cas] => 19741-14-1
    [pslug] => 19741-14-1-methotrexate-impurity-e-freebase-pa130280051
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PA 13 0280051

Methotrexate - Impurity E (Freebase)


  • Catalogue No.:PA 13 0280051

  • CAS :

    19741-14-1

  • Molecular Formula : C15H15N7O2

  • Molecular Weight : 325.33

stdClass Object
(
    [pname] => Diethyl (4-(methylamino)benzoyl)-L-glutamate
    [catalogue_number] => PA 13 0281011
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 336.39
    [form] => C17H24N2O5
    [cas] => 2378-95-2
    [pslug] => 2378-95-2-diethyl-4-methylamino-benzoyl-l-glutamate-pa130281011
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PA 13 0281011

Diethyl (4-(methylamino)benzoyl)-L-glutamate


  • Catalogue No.:PA 13 0281011

  • CAS :

    2378-95-2

  • Molecular Formula : C17H24N2O5

  • Molecular Weight : 336.39

stdClass Object
(
    [pname] => Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)-N-nitrosobenzamido)-2-methylpentanedioate
    [catalogue_number] => PA 13 0281012
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 541.44
    [form] => C21H21N9Na2O6
    [cas] => NA
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PA 13 0281012

Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)-N-nitrosobenzamido)-2-methylpentanedioate


  • Catalogue No.:PA 13 0281012

  • CAS :

    NA

  • Molecular Formula : C21H21N9Na2O6

  • Molecular Weight : 541.44

stdClass Object
(
    [pname] => (4-(((2,4-Diaminopteridin-6-yl)methyl)(nitroso)amino)benzoyl)-L-glutamic Acid
    [catalogue_number] => PA 13 0281013
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 469.42
    [form] => C19H19N9O6
    [cas] => NA
    [pslug] => 4-2-4-diaminopteridin-6-yl-methyl-nitroso-amino-benzoyl-l-glutamic-acid-pa130281013
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PA 13 0281013

(4-(((2,4-Diaminopteridin-6-yl)methyl)(nitroso)amino)benzoyl)-L-glutamic Acid


  • Catalogue No.:PA 13 0281013

  • CAS :

    NA

  • Molecular Formula : C19H19N9O6

  • Molecular Weight : 469.42

stdClass Object
(
    [pname] => N-(4-(Methylamino)benzoyl)-N-nitroso-L-glutamic Acid
    [catalogue_number] => PA 13 0281014
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 309.28
    [form] => C13H15N3O6
    [cas] => NA
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PA 13 0281014

N-(4-(Methylamino)benzoyl)-N-nitroso-L-glutamic Acid


  • Catalogue No.:PA 13 0281014

  • CAS :

    NA

  • Molecular Formula : C13H15N3O6

  • Molecular Weight : 309.28

stdClass Object
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    [pname] => (4-(Methyl(nitroso)amino)benzoyl)-L-glutamic Acid
    [catalogue_number] => PA 13 0281015
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 309.28
    [form] => C13H15N3O6
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PA 13 0281015

(4-(Methyl(nitroso)amino)benzoyl)-L-glutamic Acid


  • Catalogue No.:PA 13 0281015

  • CAS :

    NA

  • Molecular Formula : C13H15N3O6

  • Molecular Weight : 309.28

stdClass Object
(
    [pname] => N-(4-(Methyl(nitroso)amino)benzoyl)-N-nitroso-L-glutamic Acid
    [catalogue_number] => PA 13 0281016
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 338.28
    [form] => C13H14N4O7
    [cas] => NA
    [pslug] => n-4-methyl-nitroso-amino-benzoyl-n-nitroso-l-glutamic-acid-pa130281016
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PA 13 0281016

N-(4-(Methyl(nitroso)amino)benzoyl)-N-nitroso-L-glutamic Acid


  • Catalogue No.:PA 13 0281016

  • CAS :

    NA

  • Molecular Formula : C13H14N4O7

  • Molecular Weight : 338.28

stdClass Object
(
    [pname] => Diethyl (3-(methylamino)benzoyl)-L-glutamate
    [catalogue_number] => PA 13 0281030
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 336.39
    [form] => C17H24N2O5
    [cas] => 2820151-35-5
    [pslug] => 2820151-35-5-diethyl-3-methylamino-benzoyl-l-glutamate-pa130281030
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PA 13 0281030

Diethyl (3-(methylamino)benzoyl)-L-glutamate


  • Catalogue No.:PA 13 0281030

  • CAS :

    2820151-35-5

  • Molecular Formula : C17H24N2O5

  • Molecular Weight : 336.39

stdClass Object
(
    [pname] => Diethyl (2-(methylamino)benzoyl)-L-glutamate
    [catalogue_number] => PA 13 0281031
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 336.39
    [form] => C17H24N2O5
    [cas] => 1029980-84-4
    [pslug] => 1029980-84-4-diethyl-2-methylamino-benzoyl-l-glutamate-pa130281031
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PA 13 0281031

Diethyl (2-(methylamino)benzoyl)-L-glutamate


  • Catalogue No.:PA 13 0281031

  • CAS :

    1029980-84-4

  • Molecular Formula : C17H24N2O5

  • Molecular Weight : 336.39