sofosbuvir
A recently approved nucleotide analog used in the treatment of hepatitis. Sofosbuvir works by inhibiting the hepatitis C NS5B protein. It is a a prodrug of its active antiviral agent GS-461203 Reference standards of Sofosbuvir API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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Sofosbuvir - API Standards
Catalogue No.:PA 19 51000
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.45
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(R)-Sofosbuvir Pentafluorophenoxy Analogue
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[form] => C13H19FN3O9P
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Sofosbuvir Metabolite GS-566500
Catalogue No.:PA 19 51520
Molecular Formula : C13H19FN3O9P
Molecular Weight : 411.28
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1-((2R,3R,4R,5R)-3-Chloro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 19 51660
Molecular Formula : C10H13ClN2O5
Molecular Weight : 276.67
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(1R,2S)-1-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-3-ethoxy-2-fluoro-2-methyl-3-oxopropyl Sulfate
Catalogue No.:PA 19 51670
Molecular Formula : C11H19FO8S
Molecular Weight : 330.33
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(4S,5R)-Ethyl 5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-methyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide
Catalogue No.:PA 19 51680
Molecular Formula : C11H18O8S
Molecular Weight : 310.32
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(2S,3R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate
Catalogue No.:PA 19 51690
Molecular Formula : C11H20O6
Molecular Weight : 248.27
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(S,E)-Ethyl 3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylacrylate
Catalogue No.:PA 19 51700
Molecular Formula : C11H18O4
Molecular Weight : 214.26
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(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde
Catalogue No.:PA 19 51710
Molecular Formula : C6H10O3
Molecular Weight : 130.14
stdClass Object
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[pname] => Mixture of (Pentafluorophenol, Sofosbuvir-14-ethyl impurity, Sofosbuvir-14, And n-Propyl Sofosbuvir-14)
[catalogue_number] => PA 19 51720
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Mixture of (Pentafluorophenol, Sofosbuvir-14-ethyl impurity, Sofosbuvir-14, And n-Propyl Sofosbuvir-14)
Catalogue No.:PA 19 51720
Molecular Formula : C59H50F20N3O16P3
Molecular Weight : 1529.93
stdClass Object
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[pname] => Mixture of (Sofosbuvir-14 And L-Rp-Sofosbuvir-14)
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Mixture of (Sofosbuvir-14 And L-Rp-Sofosbuvir-14)
Catalogue No.:PA 19 51730
Molecular Formula : C36H34F10N2O10P2
Molecular Weight : 906.59
stdClass Object
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[pname] => Mixture of (Pentafluorophenol, Sofosbuvir, Rp-Sofosbuvir, n-Propyl Sofosbuvir)
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Mixture of (Pentafluorophenol, Sofosbuvir, Rp-Sofosbuvir, n-Propyl Sofosbuvir)
Catalogue No.:PA 19 51740
Molecular Formula : C72H88F8N9O28P3
Molecular Weight : 1772.42
stdClass Object
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Catalogue No.:PA 19 51770
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.45
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Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 19 51790
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.45
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[pname] => (R)-Isopropyl 2-(((R)-(((2R,3R,4R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
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(R)-Isopropyl 2-(((R)-(((2R,3R,4R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
Catalogue No.:PA 19 51800
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.45
stdClass Object
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Catalogue No.:PA 19 51820
Molecular Formula : C22H29ClN3O9P
Molecular Weight : 545.91
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[weight] => 798.69
[form] => C34H45FN4O13P2
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Sofosbuvir 3',5'-Bis-(S)-phosphate
Catalogue No.:PA 19 51830
Molecular Formula : C34H45FN4O13P2
Molecular Weight : 798.69
stdClass Object
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[pname] => Sofosbuvir 5'-Desphosphate 3'-O-[(S)-Phosphate]
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Sofosbuvir 5'-Desphosphate 3'-O-[(S)-Phosphate]
Catalogue No.:PA 19 51840
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.45
stdClass Object
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[form] => C16H18FN2O8P
[cas] => 1859162-80-3
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((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methyl Phenyl Hydrogen Phosphate
Catalogue No.:PA 19 51850
Molecular Formula : C16H18FN2O8P
Molecular Weight : 416.29
stdClass Object
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[pname] => Sofosbuvir α-Isomer
[catalogue_number] => PA 19 51860
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Catalogue No.:PA 19 51860
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.45
stdClass Object
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[pname] => (2R,3S,4S,5S)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
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[form] => C31H26FN3O7
[cas] => NA
[pslug] => 2r-3s-4s-5s-5-4-benzamido-2-oxopyrimidin-1-2h-yl-2-benzoyloxy-methyl-4-fluoro-4-methyltetrahydrofuran-3-yl-benzoate-pa1951870
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(2R,3S,4S,5S)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
Catalogue No.:PA 19 51870
Molecular Formula : C31H26FN3O7
Molecular Weight : 571.55
stdClass Object
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[pname] => (S)-Isopropyl 2-(((S)-(((2S,3S,4S,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
[catalogue_number] => PA 19 51880
[category_ids] => ,71,75,85,83,78,70,82,72,
[chemical_name] =>
[weight] => 529.45
[form] => C22H29FN3O9P
[cas] => NA
[pslug] => s-isopropyl-2-s-2s-3s-4s-5s-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methoxy-phenoxy-phosphoryl-amino-propanoate-pa1951880
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(S)-Isopropyl 2-(((S)-(((2S,3S,4S,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
Catalogue No.:PA 19 51880
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.45
stdClass Object
(
[pname] => (R)-Isopropyl 2-(((R)-(((2S,3S,4S,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
[catalogue_number] => PA 19 51890
[category_ids] => ,71,75,85,83,78,70,82,72,
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[weight] => 529.45
[form] => C22H29FN3O9P
[cas] => NA
[pslug] => r-isopropyl-2-r-2s-3s-4s-5s-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methoxy-phenoxy-phosphoryl-amino-propanoate-pa1951890
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(R)-Isopropyl 2-(((R)-(((2S,3S,4S,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
Catalogue No.:PA 19 51890
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.45
stdClass Object
(
[pname] => Isopropyl ((((3S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate
[catalogue_number] => PA 19 0511018
[category_ids] => ,80,77,79,71,98,85,83,78,70,82,
[chemical_name] =>
[weight] => 529.46
[form] => C22H29FN3O9P
[cas] => 2766447-19-0
[pslug] => 2766447-19-0-isopropyl-3s-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methoxy-phenoxy-phosphoryl-d-alaninate-pa190511018
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Isopropyl ((((3S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate
Catalogue No.:PA 19 0511018
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.46
stdClass Object
(
[pname] => Isopropyl ((S)-(((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
[catalogue_number] => PA 19 0511019
[category_ids] => ,80,77,79,71,98,85,83,78,70,82,
[chemical_name] =>
[weight] => 528.47
[form] => C22H30FN4O8P
[cas] => 1334513-10-8
[pslug] => 1334513-10-8-isopropyl-s-2r-3r-4r-5r-5-4-amino-2-oxopyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methoxy-phenoxy-phosphoryl-l-alaninate-pa190511019
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Isopropyl ((S)-(((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 19 0511019
Molecular Formula : C22H30FN4O8P
Molecular Weight : 528.47
stdClass Object
(
[pname] => Isopropyl ((S)-((S)-1-((2S,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)-L-alaninate
[catalogue_number] => PA 19 0511020
[category_ids] => ,80,77,79,71,98,85,83,78,70,82,
[chemical_name] =>
[weight] => 541.49
[form] => C23H32N3O10P
[cas] => 2500766-09-4
[pslug] => 2500766-09-4-isopropyl-s-s-1-2s-3r-4r-5r-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-3-4-dihydroxy-4-methyltetrahydrofuran-2-yl-ethoxy-phenoxy-phosphoryl-l-alaninate-pa190511020
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Isopropyl ((S)-((S)-1-((2S,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 19 0511020
Molecular Formula : C23H32N3O10P
Molecular Weight : 541.49