cabazitaxel
Cabazitaxel was developed by Sanofi-Aventis and was approved by the U.S. FDA for the treatment of hormone-refractory prostate cancer on June 17, 2010. It is a semi-synthetic derivative of a natural taxoid. It is a microtubule inhibitor, and the fourth taxane to be approved as a cancer therapy.. Reference standards of Cabazitaxel API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
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Cabazitaxel - API Standards
Catalogue No.:PA 03 01000
Molecular Formula : C45H57NO14
Molecular Weight : 835.93
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Catalogue No.:PA 03 01510
Molecular Formula : C40H49NO12
Molecular Weight : 735.82
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10-Deacetyl-7,10-dimethoxy-Baccatin III
Catalogue No.:PA 03 01520
Molecular Formula : C31H40O10
Molecular Weight : 572.64
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De-boc Cabazitaxel Hydrochloride
Catalogue No.:PA 03 0011029
Molecular Formula : C40H50ClNO12
Molecular Weight : 772.29
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De-boc Cabazitaxel Formate
Catalogue No.:PA 03 0011030
Molecular Formula : C41H51NO14
Molecular Weight : 781.85
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Cabazitaxel N-formyl Impurity
Catalogue No.:PA 03 01530
Molecular Formula : C41H49NO13
Molecular Weight : 763.83
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10-Deacetyl-7,10,13-trimethyl Baccatin III
Catalogue No.:PA 03 01540
Molecular Formula : C32H42O10
Molecular Weight : 586.67
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Catalogue No.:PA 03 01550
Molecular Formula : C45H57NO14
Molecular Weight : 835.93
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Cabazitaxel Di Boc Impurity
Catalogue No.:PA 03 01560
Molecular Formula : C50H67NO16
Molecular Weight : 938.06
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2-Debenzoyl-2-tigloyl 10-Deacetyl Baccatin III
Catalogue No.:PA 03 01580
Molecular Formula : C27H38O10
Molecular Weight : 522.58
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(4S,5S)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid
Catalogue No.:PA 03 01590
Molecular Formula : C22H25NO6
Molecular Weight : 399.44
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(4R,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid
Catalogue No.:PA 03 01600
Molecular Formula : C22H25NO6
Molecular Weight : 399.44
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Catalogue No.:PA STI 016870
Molecular Formula : C45H51D6NO14
Molecular Weight : 841.97
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(2'S, 3'R)-Cabazitaxel-D6
Catalogue No.:PA STI 016880
Molecular Formula : C45H51D6NO14
Molecular Weight : 841.97
stdClass Object
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4-Deacetyl-4-propionyl Cabazitaxel-D6
Catalogue No.:PA STI 024550
Molecular Formula : C46H53D6NO14
Molecular Weight : 856.00
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Catalogue No.:PA 03 01640
Molecular Formula : C44H55NO14
Molecular Weight : 821.92
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10-Methoxy-10-deacetylbaccatin III
Catalogue No.:PA 03 01650
Molecular Formula : C30H38O10
Molecular Weight : 558.62
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10-Deacetyl-7-methyl Baccatin III
Catalogue No.:PA 03 01660
Molecular Formula : C30H38O10
Molecular Weight : 558.62
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4,10-Desdiacetyl-7,10-dimethyl-4-propionyl Baccatin III
Catalogue No.:PA 03 01670
Molecular Formula : C32H42O10
Molecular Weight : 586.68
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Catalogue No.:PA 03 01680
Molecular Formula : C53H63NO15
Molecular Weight : 954.08
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Catalogue No.:PA 03 01690
Molecular Formula : C46H59NO14
Molecular Weight : 849.97
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Catalogue No.:PA 04 97670
Molecular Formula : C58H72N2O18
Molecular Weight : 1085.21
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(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-3-phenyl-2-((triethylsilyl)oxy)propanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Benzoate
Catalogue No.:PA 03 01700
Molecular Formula : C51H71NO14Si
Molecular Weight : 950.21
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Catalogue No.:PA 03 01710
Molecular Formula : C43H59NO14
Molecular Weight : 813.94
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(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Benzoate compound with Propan-2-ol (1:1)
Catalogue No.:PA 03 01720
Molecular Formula : C48H65NO15
Molecular Weight : 896.04
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Catalogue No.:PA STI 016881
Molecular Formula : C45H48D9NO14
Molecular Weight : 845.00
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N',O'-(4-Methoxybenzylidene)cabazitaxel
Catalogue No.:PA 03 0011000
Molecular Formula : C53H63NO15
Molecular Weight : 954.08
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(2aR,4S,4aS,6R,8S,9aS,10S,10aR,10bS)-10b-Acetoxy-8-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-9a-(2-hydroxypropan-2-yl)-4,6-dimethoxy-4a,7-dimethyl-5-oxo-2a,3,4,4a,5,6,8,9,9a,10,10a,10b-dodecahydro-1H-azuleno[5',6':3,4]benzo[1,2-b]oxet-10-yl benzoate;
Catalogue No.:PA 03 0011001
Molecular Formula : C45H57NO14
Molecular Weight : 835.94
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Cabazitaxel Impurity (DeTroc-oxazolidine)
Catalogue No.:PA 03 0011002
Molecular Formula : C46H57NO14
Molecular Weight : 847.96
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(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxotetradecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Catalogue No.:PA 03 0011003
Molecular Formula : C45H59NO14
Molecular Weight : 837.96
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(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-(N-(tert-butoxycarbonyl)pivalamido)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Catalogue No.:PA 03 0011005
Molecular Formula : C50H65NO15
Molecular Weight : 920.06
stdClass Object
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(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2S,3R)-3-((tert-butoxycarbonyl)amino)-2-((2-methoxypropan-2-yl)oxy)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Catalogue No.:PA 03 0011006
Molecular Formula : C49H65NO15
Molecular Weight : 908.05
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(3R,4S)-3-((2-methoxypropan-2-yl)oxy)-4-phenylazetidin-2-one
Catalogue No.:PA 03 0011007
Molecular Formula : C13H17NO3
Molecular Weight : 235.28
stdClass Object
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(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-((2-methoxypropan-2-yl)oxy)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Catalogue No.:PA 03 0011008
Molecular Formula : C49H65NO15
Molecular Weight : 908.05
stdClass Object
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(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-4,6,9,11-tetramethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Catalogue No.:PA 03 0011009
Molecular Formula : C33H44O10
Molecular Weight : 600.71
stdClass Object
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(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxotetradecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Catalogue No.:PA 03 0011010
Molecular Formula : C31H42O10
Molecular Weight : 574.67
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(4R,5S)-rel-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-Oxazolidinecarboxylic Acid
Catalogue No.:PA 03 0011011
Molecular Formula : C24H21NO5
Molecular Weight : 403.43
stdClass Object
(
[pname] => (4S,5S)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid
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[weight] => 403.43
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(4S,5S)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid
Catalogue No.:PA 03 0011012
Molecular Formula : C24H21NO5
Molecular Weight : 403.43
stdClass Object
(
[pname] => (2S,4S,5S)-3-(Tert-butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid
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(2S,4S,5S)-3-(Tert-butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid
Catalogue No.:PA 03 0011013
Molecular Formula : C22H25NO6
Molecular Weight : 399.44
stdClass Object
(
[pname] => (4R,5R)-3-Benzoyl-2-(4-anisyl)-4-phenyl-5-oxazolidinecarboxylic acid
[catalogue_number] => PA 03 0011014
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[weight] => 403.43
[form] => C24H21NO5
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(4R,5R)-3-Benzoyl-2-(4-anisyl)-4-phenyl-5-oxazolidinecarboxylic acid
Catalogue No.:PA 03 0011014
Molecular Formula : C24H21NO5
Molecular Weight : 403.43
stdClass Object
(
[pname] => (3S,4S)-3-Hydroxy-4-phenylazetidin-2-one
[catalogue_number] => PA 03 0011015
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[chemical_name] =>
[weight] => 163.18
[form] => C9H9NO2
[cas] => 146924-92-7
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(3S,4S)-3-Hydroxy-4-phenylazetidin-2-one
Catalogue No.:PA 03 0011015
Molecular Formula : C9H9NO2
Molecular Weight : 163.18
stdClass Object
(
[pname] => (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(Benzoyloxy)-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4-methoxy-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate
[catalogue_number] => PA 03 0011016
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[weight] => 863.95
[form] => C46H57NO15
[cas] => 174674-15-8
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(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(Benzoyloxy)-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4-methoxy-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate
Catalogue No.:PA 03 0011016
Molecular Formula : C46H57NO15
Molecular Weight : 863.95
stdClass Object
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[weight] => 399.44
[form] => C22H25NO6
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(2R,4S,5R)-3-(Tert-butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid
Catalogue No.:PA 03 0011017
Molecular Formula : C22H25NO6
Molecular Weight : 399.44
stdClass Object
(
[pname] => Sodium (4S,5R)-2-(2,4-dimethoxyphenyl)-3-((2-nitrophenyl)thio)-4-phenyloxazolidine-5-carboxylate
[catalogue_number] => PA 03 0011018
[category_ids] => 82,78,76,75,70
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[weight] => 504.49
[form] => C24H21N2NaO7S
[cas] => 614748-67-3
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Sodium (4S,5R)-2-(2,4-dimethoxyphenyl)-3-((2-nitrophenyl)thio)-4-phenyloxazolidine-5-carboxylate
Catalogue No.:PA 03 0011018
Molecular Formula : C24H21N2NaO7S
Molecular Weight : 504.49
stdClass Object
(
[pname] => 3-(tert-Butyl) 5-methyl (2R,4S,5R)-2-(4-methoxyphenyl)-4-phenyloxazolidine-3,5-dicarboxylate
[catalogue_number] => PA 03 0011019
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[chemical_name] =>
[weight] => 413.47
[form] => C23H27NO6
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3-(tert-Butyl) 5-methyl (2R,4S,5R)-2-(4-methoxyphenyl)-4-phenyloxazolidine-3,5-dicarboxylate
Catalogue No.:PA 03 0011019
Molecular Formula : C23H27NO6
Molecular Weight : 413.47
stdClass Object
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[pname] => Tigloyl Cabazitaxel (2-debenzoyl-2-tigloyl-cabazitaxel
[catalogue_number] => PA 03 0011020
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[weight] => 813.94
[form] => C43H59NO14
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Tigloyl Cabazitaxel (2-debenzoyl-2-tigloyl-cabazitaxel
Catalogue No.:PA 03 0011020
Molecular Formula : C43H59NO14
Molecular Weight : 813.94
stdClass Object
(
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[weight] => 572.65
[form] => C31H40O10
[cas] => NA
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(9S,12bS)-12b-Acetoxy-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Catalogue No.:PA 03 0011021
Molecular Formula : C31H40O10
Molecular Weight : 572.65
stdClass Object
(
[pname] => (9S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
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[weight] => 835.94
[form] => C45H57NO14
[cas] => NA
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(9S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Catalogue No.:PA 03 0011022
Molecular Formula : C45H57NO14
Molecular Weight : 835.94
stdClass Object
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[pname] => Cabazitaxel Monohydrate
[catalogue_number] => PA 03 0011023
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[chemical_name] =>
[weight] => 853.96
[form] => C45H59NO15
[cas] => 1613316-39-4
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Catalogue No.:PA 03 0011023
Molecular Formula : C45H59NO15
Molecular Weight : 853.96
stdClass Object
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[pname] => (4R)-10-Deacetyl-7,10-dimethoxy-Baccatin III
[catalogue_number] => PA 03 0011024
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[weight] => 572.65
[form] => C31H40O10
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(4R)-10-Deacetyl-7,10-dimethoxy-Baccatin III
Catalogue No.:PA 03 0011024
Molecular Formula : C31H40O10
Molecular Weight : 572.65
stdClass Object
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[weight] => 399.44
[form] => C22H25NO6
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(2S,4R,5S)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid
Catalogue No.:PA 03 0011025
Molecular Formula : C22H25NO6
Molecular Weight : 399.44
stdClass Object
(
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[weight] => 1085.21
[form] => C58H72N2O18
[cas] => NA
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(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-6-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4-methoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Benzoate
Catalogue No.:PA 03 0011026
Molecular Formula : C58H72N2O18
Molecular Weight : 1085.21
stdClass Object
(
[pname] => (2S,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid
[catalogue_number] => PA 03 0011027
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[weight] => 399.44
[form] => C22H25NO6
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(2S,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid
Catalogue No.:PA 03 0011027
Molecular Formula : C22H25NO6
Molecular Weight : 399.44
stdClass Object
(
[pname] => Cabazitaxel - Impurity C
[catalogue_number] => PA 03 0010030
[category_ids] => ,69,70,78,80,81,82,
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[weight] => 1085.21
[form] => C46H59NO14
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Catalogue No.:PA 03 0010030
Molecular Formula : C46H59NO14
Molecular Weight : 1085.21
stdClass Object
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Catalogue No.:PA 03 0010040
Molecular Formula : C58H72N2O18
Molecular Weight : 1085.21
stdClass Object
(
[pname] => Cabazitaxel - Impurity E
[catalogue_number] => PA 03 0010050
[category_ids] => ,69,70,78,80,81,82,
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Catalogue No.:PA 03 0010050
Molecular Formula : C58H72N2O18
Molecular Weight : 1085.21
stdClass Object
(
[pname] => Cabazitaxel - Impurity H
[catalogue_number] => PA 03 0010080
[category_ids] => ,69,70,78,80,81,82,
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[weight] => 954.08
[form] => C53H63NO15
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Catalogue No.:PA 03 0010080
Molecular Formula : C53H63NO15
Molecular Weight : 954.08
stdClass Object
(
[pname] => Cabazitaxel - Impurity F
[catalogue_number] => PA 03 0010060
[category_ids] => ,69,70,78,80,81,82,
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[weight] => 954.08
[form] => C53H63NO15
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Catalogue No.:PA 03 0010060
Molecular Formula : C53H63NO15
Molecular Weight : 954.08
stdClass Object
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[pname] => (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-9-((triethylsilyl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
[catalogue_number] => PA 03 0011028
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 686.91
[form] => C37H54O10Si
[cas] => 1396601-24-3
[pslug] => 1396601-24-3-2ar-4s-4as-6r-9s-11s-12s-12ar-12bs-12b-acetoxy-11-hydroxy-4-6-dimethoxy-4a-8-13-13-tetramethyl-5-oxo-9-triethylsilyl-oxy-2a-3-4-4a-5-6-9-10-11-12-12a-12b-dodecahydro-1h-7-11-methanocyclodeca-3-4-benzo-1-2-b-oxet-12-yl-benzoate-pa030011028
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(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-9-((triethylsilyl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Catalogue No.:PA 03 0011028
Molecular Formula : C37H54O10Si
Molecular Weight : 686.91
stdClass Object
(
[pname] => rel-(4R,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid
[catalogue_number] => PA 03 0011031
[category_ids] => ,82,81,80,78,70,69,
[chemical_name] =>
[weight] => 399.44
[form] => C22H25NO6
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rel-(4R,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid
Catalogue No.:PA 03 0011031
Molecular Formula : C22H25NO6
Molecular Weight : 399.44
stdClass Object
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[pname] => Cabazitaxel N-3
[catalogue_number] => PA 03 0011032
[category_ids] => ,82,81,80,78,69,
[chemical_name] =>
[weight] => 1276.8
[form] => C57H61Cl6NO19
[cas] => 859498-31-0
[pslug] => 859498-31-0-cabazitaxel-n-3-pa030011032
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Catalogue No.:PA 03 0011032
Molecular Formula : C57H61Cl6NO19
Molecular Weight : 1276.8