Lubiprostone-impurities | Pharmaffiliates

lubiprostone

Lubiprostone used in the management of idiopathic chronic constipation. It is sold under the trade name Amitiza. Reference standards of Lubiprostone API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Lubiprostone - API Standards 
    [catalogue_number] => PA 12 87000
    [category_ids] => ,69,78,70,82,
    [chemical_name] => 
    [weight] => 390.46
    [form] => C20H32F2O5
    [cas] => 136790-76-6
    [pslug] => 136790-76-6-lubiprostone-api-pa1287000
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PA 12 87000

Lubiprostone - API Standards


  • Catalogue No.:PA 12 87000

  • CAS :

    136790-76-6

  • Molecular Formula : C20H32F2O5

  • Molecular Weight : 390.46

stdClass Object
(
    [pname] => 7-((2S,4aS,5S,7aS)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic Acid
    [catalogue_number] => PA 12 87510
    [category_ids] => ,78,70,82,80,92,89,
    [chemical_name] => 
    [weight] => 390.46
    [form] => C20H32F2O5
    [cas] => 2743427-14-5
    [pslug] => 2743427-14-5-7-2s-4as-5s-7as-2-1-1-difluoropentyl-2-hydroxy-6-oxooctahydrocyclopenta-b-pyran-5-yl-heptanoic-acid-pa1287510
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PA 12 87510

7-((2S,4aS,5S,7aS)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic Acid


  • Catalogue No.:PA 12 87510

  • CAS :

    2743427-14-5

  • Molecular Formula : C20H32F2O5

  • Molecular Weight : 390.46

stdClass Object
(
    [pname] => Lubiprostone (Mixture of Tautomeric Isomers)
    [catalogue_number] => PA 12 87520
    [category_ids] => ,78,70,82,80,92,89,
    [chemical_name] => 
    [weight] => 780.94
    [form] => C40H64F4O10
    [cas] => 333963-40-9(ring-closed),136790-76-6(ring-opened)
    [pslug] => 333963-40-9-ring-closed-136790-76-6-ring-opened-lubiprostone-mixture-of-tautomeric-isomers-pa1287520
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PA 12 87520

Lubiprostone (Mixture of Tautomeric Isomers)


  • Catalogue No.:PA 12 87520

  • CAS :

    333963-40-9(ring-closed),136790-76-6(ring-opened)

  • Molecular Formula : C40H64F4O10

  • Molecular Weight : 780.94

stdClass Object
(
    [pname] => 7-((1S,2R,5R,8S)-2-(1,1-Difluoropentyl)-2,8-dihydroxy-7-oxobicyclo[3.2.1]octan-6-yl)heptanoic Acid
    [catalogue_number] => PA 12 87540
    [category_ids] => ,78,70,82,
    [chemical_name] => 
    [weight] => 390.46
    [form] => C20H32F2O5
    [cas] => NA
    [pslug] => 7-1s-2r-5r-8s-2-1-1-difluoropentyl-2-8-dihydroxy-7-oxobicyclo-3-2-1-octan-6-yl-heptanoic-acid-pa1287540
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PA 12 87540

7-((1S,2R,5R,8S)-2-(1,1-Difluoropentyl)-2,8-dihydroxy-7-oxobicyclo[3.2.1]octan-6-yl)heptanoic Acid


  • Catalogue No.:PA 12 87540

  • CAS :

    NA

  • Molecular Formula : C20H32F2O5

  • Molecular Weight : 390.46

stdClass Object
(
    [pname] => 15-Hydroxy Lubiprostone Dicyclohexylammonium Salt-d7
    [catalogue_number] => PA STI 049600
    [category_ids] => ,69,74,98,78,70,82,
    [chemical_name] => 
    [weight] => 580.84
    [form] => C32H50D7F2NO5
    [cas] => NA
    [pslug] => 15-hydroxy-lubiprostone-dicyclohexylammonium-salt-d7-pasti049600
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PA STI 049600

15-Hydroxy Lubiprostone Dicyclohexylammonium Salt-d7


  • Catalogue No.:PA STI 049600

  • CAS :

    NA

  • Molecular Formula : C32H50D7F2NO5

  • Molecular Weight : 580.84

stdClass Object
(
    [pname] => 15-Hydroxy Lubiprostone Phenylmethyl Ester-d7 (Mixture of Diastereomers)
    [catalogue_number] => PA STI 049610
    [category_ids] => ,69,74,98,78,70,82,
    [chemical_name] => 
    [weight] => 489.64
    [form] => C27H33D7F2O5
    [cas] => 1346597-35-0
    [pslug] => 1346597-35-0-15-hydroxy-lubiprostone-phenylmethyl-ester-d7-mixture-of-diastereomers-pasti049610
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PA STI 049610

15-Hydroxy Lubiprostone Phenylmethyl Ester-d7 (Mixture of Diastereomers)


  • Catalogue No.:PA STI 049610

  • CAS :

    1346597-35-0

  • Molecular Formula : C27H33D7F2O5

  • Molecular Weight : 489.64

stdClass Object
(
    [pname] => Lubiprostone-d9
    [catalogue_number] => PA STI 057250
    [category_ids] => ,69,98,78,70,82,
    [chemical_name] => 
    [weight] => 399.52
    [form] => C20H23D9F2O5
    [cas] => 1134188-25-2
    [pslug] => 1134188-25-2-lubiprostone-d9-pasti057250
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PA STI 057250

Lubiprostone-d9


  • Catalogue No.:PA STI 057250

  • CAS :

    1134188-25-2

  • Molecular Formula : C20H23D9F2O5

  • Molecular Weight : 399.52

stdClass Object
(
    [pname] => Lubiprostone-d7
    [catalogue_number] => PA STI 057260
    [category_ids] => ,69,98,78,70,82,
    [chemical_name] => 
    [weight] => 397.51
    [form] => C20H25D7F2O5
    [cas] => 1217675-13-2
    [pslug] => 1217675-13-2-lubiprostone-d7-pasti057260
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PA STI 057260

Lubiprostone-d7


  • Catalogue No.:PA STI 057260

  • CAS :

    1217675-13-2

  • Molecular Formula : C20H25D7F2O5

  • Molecular Weight : 397.51

stdClass Object
(
    [pname] => 11-O-Tetrahydropyranyl-15-O-tert-butyldimethylsilyl-lubiprostone-d7 Phenylmethyl Ester
    [catalogue_number] => PA STI 082200
    [category_ids] => ,69,74,78,70,82,98,
    [chemical_name] => 
    [weight] => 688.02
    [form] => C38H55D7F2O6Si
    [cas] => 1346597-45-2
    [pslug] => 1346597-45-2-11-o-tetrahydropyranyl-15-o-tert-butyldimethylsilyl-lubiprostone-d7-phenylmethyl-ester-pasti082200
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PA STI 082200

11-O-Tetrahydropyranyl-15-O-tert-butyldimethylsilyl-lubiprostone-d7 Phenylmethyl Ester


  • Catalogue No.:PA STI 082200

  • CAS :

    1346597-45-2

  • Molecular Formula : C38H55D7F2O6Si

  • Molecular Weight : 688.02

stdClass Object
(
    [pname] => O-Tetrahydropyranyl Lubiprostone-d7
    [catalogue_number] => PA STI 082230
    [category_ids] => ,78,70,82,98,
    [chemical_name] => 
    [weight] => 481.62
    [form] => C25H33D7F2O6
    [cas] => 1246812-24-7
    [pslug] => 1246812-24-7-o-tetrahydropyranyl-lubiprostone-d7-pasti082230
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PA STI 082230

O-Tetrahydropyranyl Lubiprostone-d7


  • Catalogue No.:PA STI 082230

  • CAS :

    1246812-24-7

  • Molecular Formula : C25H33D7F2O6

  • Molecular Weight : 481.62

stdClass Object
(
    [pname] => 15-Hydroxy Lubiprostone
    [catalogue_number] => PA 12 87560
    [category_ids] => ,69,74,78,70,82,
    [chemical_name] => 
    [weight] => 392.48
    [form] => C20H34F2O5
    [cas] => 475992-30-4
    [pslug] => 475992-30-4-15-hydroxy-lubiprostone-pa1287560
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PA 12 87560

15-Hydroxy Lubiprostone


  • Catalogue No.:PA 12 87560

  • CAS :

    475992-30-4

  • Molecular Formula : C20H34F2O5

  • Molecular Weight : 392.48

stdClass Object
(
    [pname] => 7-((1R,2R,3R)-3-(Benzyloxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic Acid
    [catalogue_number] => PA 12 0871000
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 480.58
    [form] => C27H38F2O5
    [cas] => NA
    [pslug] => -7-1r-2r-3r-3-benzyloxy-2-4-4-difluoro-3-oxooctyl-5-oxocyclopentyl-heptanoic-acid-pa120871000
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PA 12 0871000

7-((1R,2R,3R)-3-(Benzyloxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic Acid


  • Catalogue No.:PA 12 0871000

  • CAS :

    NA

  • Molecular Formula : C27H38F2O5

  • Molecular Weight : 480.58

stdClass Object
(
    [pname] => 7-((1R,2S)-2-(4,4-Difluoro-3-oxooctyl)-5-oxocyclopent-3-en-1-yl)heptanoic Acid
    [catalogue_number] => PA 12 0871001
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 372.45
    [form] => C20H30F2O4
    [cas] => 2196182-47-3
    [pslug] => 2196182-47-3-7-1r-2s-2-4-4-difluoro-3-oxooctyl-5-oxocyclopent-3-en-1-yl-heptanoic-acid-pa120871001
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PA 12 0871001

7-((1R,2S)-2-(4,4-Difluoro-3-oxooctyl)-5-oxocyclopent-3-en-1-yl)heptanoic Acid


  • Catalogue No.:PA 12 0871001

  • CAS :

    2196182-47-3

  • Molecular Formula : C20H30F2O4

  • Molecular Weight : 372.45

stdClass Object
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    [pname] => 7-((2R,4aR,5S,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic Acid
    [catalogue_number] => PA 12 0871002
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 390.47
    [form] => C20H32F2O5
    [cas] => 1263283-38-0
    [pslug] => 1263283-38-0-7-2r-4ar-5s-7ar-2-1-1-difluoropentyl-2-hydroxy-6-oxooctahydrocyclopenta-b-pyran-5-yl-heptanoic-acid-pa120871002
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PA 12 0871002

7-((2R,4aR,5S,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic Acid


  • Catalogue No.:PA 12 0871002

  • CAS :

    1263283-38-0

  • Molecular Formula : C20H32F2O5

  • Molecular Weight : 390.47

stdClass Object
(
    [pname] => 7-(3-(1,1-difluoropentyl)-3-hydroxy-4-oxo-1,2,3,3a,4,6a-hexahydropentalen-3a-yl)heptanoic acid
    [catalogue_number] => PA 12 0871003
    [category_ids] => 76,75,70,78,82
    [chemical_name] => 
    [weight] => 372.45
    [form] => C20H30F2O4
    [cas] => NA
    [pslug] => 7-3-1-1-difluoropentyl-3-hydroxy-4-oxo-1-2-3-3a-4-6a-hexahydropentalen-3a-yl-heptanoic-acid-pa120871003
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PA 12 0871003

7-(3-(1,1-difluoropentyl)-3-hydroxy-4-oxo-1,2,3,3a,4,6a-hexahydropentalen-3a-yl)heptanoic acid


  • Catalogue No.:PA 12 0871003

  • CAS :

    NA

  • Molecular Formula : C20H30F2O4

  • Molecular Weight : 372.45

stdClass Object
(
    [pname] => 7-(2-(1,1-Difluoropentyl)-2,8-dihydroxy-7-oxobicyclo[3.2.1]octan-6-yl)heptanoic acid
    [catalogue_number] => PA 12 0871004
    [category_ids] => 82,78,70,75,76
    [chemical_name] => 
    [weight] => 390.47
    [form] => C20H32F2O5
    [cas] => NA
    [pslug] => 7-2-1-1-difluoropentyl-2-8-dihydroxy-7-oxobicyclo-3-2-1-octan-6-yl-heptanoic-acid-pa120871004
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PA 12 0871004

7-(2-(1,1-Difluoropentyl)-2,8-dihydroxy-7-oxobicyclo[3.2.1]octan-6-yl)heptanoic acid


  • Catalogue No.:PA 12 0871004

  • CAS :

    NA

  • Molecular Formula : C20H32F2O5

  • Molecular Weight : 390.47

stdClass Object
(
    [pname] => (3aR,4R,5R,6aS)-2-oxo-5-((Tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-4-carbaldehyde
    [catalogue_number] => PA 12 0871005
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 254.28
    [form] => C13H18O5
    [cas] => 32233-41-3
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PA 12 0871005

(3aR,4R,5R,6aS)-2-oxo-5-((Tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-4-carbaldehyde


  • Catalogue No.:PA 12 0871005

  • CAS :

    32233-41-3

  • Molecular Formula : C13H18O5

  • Molecular Weight : 254.28

stdClass Object
(
    [pname] => (3AR,4S,5R,6aS)-4-(Hydroxymethyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one
    [catalogue_number] => PA 12 0871006
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 256.3
    [form] => C13H20O5
    [cas] => 69222-61-3
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PA 12 0871006

(3AR,4S,5R,6aS)-4-(Hydroxymethyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one


  • Catalogue No.:PA 12 0871006

  • CAS :

    69222-61-3

  • Molecular Formula : C13H20O5

  • Molecular Weight : 256.3

stdClass Object
(
    [pname] => (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
    [catalogue_number] => PA 12 0871009
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 172.18
    [form] => C8H12O4
    [cas] => 54423-47-1
    [pslug] => 54423-47-1-3ar-4s-5r-6as-5-hydroxy-4-hydroxymethyl-3-3a-4-5-6-6a-hexahydrocyclopenta-b-furan-2-one-pa120871009
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PA 12 0871009

(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one


  • Catalogue No.:PA 12 0871009

  • CAS :

    54423-47-1

  • Molecular Formula : C8H12O4

  • Molecular Weight : 172.18

stdClass Object
(
    [pname] => 7-((1R,2R,3S)-2-(4,4-difluoro-3-oxooctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic acid
    [catalogue_number] => PA 12 0871007
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 390.47
    [form] => C20H32F2O5
    [cas] => NA
    [pslug] => 7-1r-2r-3s-2-4-4-difluoro-3-oxooctyl-3-hydroxy-5-oxocyclopentyl-heptanoic-acid-pa120871007
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PA 12 0871007

7-((1R,2R,3S)-2-(4,4-difluoro-3-oxooctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic acid


  • Catalogue No.:PA 12 0871007

  • CAS :

    NA

  • Molecular Formula : C20H32F2O5

  • Molecular Weight : 390.47

stdClass Object
(
    [pname] => 7-((1R,2R,3R)-2-(4,4-difluoro-3-hydroxyoctyl-6,6,7,7,8,8,8-d7)-3-hydroxy-5-oxocyclopentyl)heptanoic acid
    [catalogue_number] => PA STI 088979
    [category_ids] => ,98,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 399.53
    [form] =>  C20H27D7F2O5
    [cas] => 1217511-55-1
    [pslug] => 1217511-55-1-7-1r-2r-3r-2-4-4-difluoro-3-hydroxyoctyl-6-6-7-7-8-8-8-d7-3-hydroxy-5-oxocyclopentyl-heptanoic-acid-pasti088979
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PA STI 088979

7-((1R,2R,3R)-2-(4,4-difluoro-3-hydroxyoctyl-6,6,7,7,8,8,8-d7)-3-hydroxy-5-oxocyclopentyl)heptanoic acid


  • Catalogue No.:PA STI 088979

  • CAS :

    1217511-55-1

  • Molecular Formula : C20H27D7F2O5

  • Molecular Weight : 399.53

stdClass Object
(
    [pname] => 7-((1R,2R,3R)-2-(4,4-Difluoro-3-hydroxyoctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic-3,3,4,4-d4 acid
    [catalogue_number] => PA STI 088977
    [category_ids] => ,98,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 396.51
    [form] => C20H30D4F2O5
    [cas] => NA
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PA STI 088977

7-((1R,2R,3R)-2-(4,4-Difluoro-3-hydroxyoctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic-3,3,4,4-d4 acid


  • Catalogue No.:PA STI 088977

  • CAS :

    NA

  • Molecular Formula : C20H30D4F2O5

  • Molecular Weight : 396.51

stdClass Object
(
    [pname] => 7-((1S,2R,3R)-2-(4,4-Difluoro-3-oxooctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic acid
    [catalogue_number] => PA 12 0871008
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 390.47
    [form] => C20H32F2O5
    [cas] => NA
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PA 12 0871008

7-((1S,2R,3R)-2-(4,4-Difluoro-3-oxooctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic acid


  • Catalogue No.:PA 12 0871008

  • CAS :

    NA

  • Molecular Formula : C20H32F2O5

  • Molecular Weight : 390.47

stdClass Object
(
    [pname] => Lubiprostone hemiketal
    [catalogue_number] => PA 12 0871010
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 390.47
    [form] => C20H32F2O5
    [cas] => 333963-40-9
    [pslug] => 333963-40-9-lubiprostone-hemiketal-pa120871010
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PA 12 0871010

Lubiprostone hemiketal


  • Catalogue No.:PA 12 0871010

  • CAS :

    333963-40-9

  • Molecular Formula : C20H32F2O5

  • Molecular Weight : 390.47

stdClass Object
(
    [pname] => O-Tetrahydropyranyl Lubiprostone
    [catalogue_number] => PA 12 0871011
    [category_ids] => ,69,78,70,82,
    [chemical_name] => 
    [weight] => 474.59
    [form] => C25H40F2O6
    [cas] => 876068-08-5
    [pslug] => 876068-08-5-o-tetrahydropyranyl-lubiprostone-pa120871011
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PA 12 0871011

O-Tetrahydropyranyl Lubiprostone


  • Catalogue No.:PA 12 0871011

  • CAS :

    876068-08-5

  • Molecular Formula : C25H40F2O6

  • Molecular Weight : 474.59

stdClass Object
(
    [pname] => Cyclohexylmethyl 7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoate
    [catalogue_number] => PA 12 0871012
    [category_ids] => ,69,78,70,82,
    [chemical_name] => 
    [weight] => 486.64
    [form] => C27H44F2O5
    [cas] => NA
    [pslug] => cyclohexylmethyl-7-2r-4ar-5r-7ar-2-1-1-difluoropentyl-2-hydroxy-6-oxooctahydrocyclopenta-b-pyran-5-yl-heptanoate-pa120871012
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PA 12 0871012

Cyclohexylmethyl 7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoate


  • Catalogue No.:PA 12 0871012

  • CAS :

    NA

  • Molecular Formula : C27H44F2O5

  • Molecular Weight : 486.64

stdClass Object
(
    [pname] => Benzyl (Z)-7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)hept-5-enoate
    [catalogue_number] => PA 12 0871013
    [category_ids] => ,69,78,70,82,
    [chemical_name] => 
    [weight] => 478.58
    [form] => C27H36F2O5
    [cas] => 1447733-80-3
    [pslug] => 1447733-80-3-benzyl-z-7-2r-4ar-5r-7ar-2-1-1-difluoropentyl-2-hydroxy-6-oxooctahydrocyclopenta-b-pyran-5-yl-hept-5-enoate-pa120871013
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PA 12 0871013

Benzyl (Z)-7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)hept-5-enoate


  • Catalogue No.:PA 12 0871013

  • CAS :

    1447733-80-3

  • Molecular Formula : C27H36F2O5

  • Molecular Weight : 478.58

stdClass Object
(
    [pname] => 7-((1R,2R)-2-(4,4-Difluoro-3-oxooctyl)-5-oxocyclopent-3-en-1-yl)heptanamide
    [catalogue_number] => PA 12 0871014
    [category_ids] => ,69,78,70,82,
    [chemical_name] => 
    [weight] => 371.47
    [form] => C20H31F2NO3
    [cas] => NA
    [pslug] => 7-1r-2r-2-4-4-difluoro-3-oxooctyl-5-oxocyclopent-3-en-1-yl-heptanamide-pa120871014
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PA 12 0871014

7-((1R,2R)-2-(4,4-Difluoro-3-oxooctyl)-5-oxocyclopent-3-en-1-yl)heptanamide


  • Catalogue No.:PA 12 0871014

  • CAS :

    NA

  • Molecular Formula : C20H31F2NO3

  • Molecular Weight : 371.47