| Catalogue number: | PA 27 07050 |
| Chemical name: | Belumosudil |
CAS Number: |
911417-87-3 |
| Similar Products: | |
| Category: | aromatics,antiviral agents,pharmaceutical standards,intermediates,Fine Chemicals |
| Synonyms: | 2-[3-[4-(1H-Indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)acetamide; 2-[3-[4-(1H-Indazol-5-ylamino)quinazolin-2-yl]phenoxy]-N-propan-2-ylacetamide; 2-{3-[4-(1H-indazol-5-ylamino)quinazolin-2-yl]phenoxy}-N-(propan-2-yl)acetamide; |
| Molecular form: | C26H24N6O2 |
| Appearance: | Off-White to Pale Yellow Solid |
| Mol. Weight: | 452.52 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | KD 025 is an inhibitor of Rho-associated protein kinase II (ROCK-II), a serine/threonine kinase that regulates the formation of actin stress fibers and focal adhesions, smooth muscle contraction, and gene expression (1, 2). KD025 has been shown to reduce infarct volume after transient middle cerebral artery occlusion (2).FDA has approved belumosudil (Rezurock) for the treatment of chronic graft-versus-host disease (GVHD). |
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