Displaying 140 results for nicotine

Nicotine - API

Nicotine


  • Catalogue No.:PA 14 21000

  • CAS : 54-11-5

  • Molecular Formula : C10H14N2

  • Molecular Weight : 162.23

Nicotine - Impurity A

Anatabine


  • Catalogue No.:PA 14 21010

  • CAS : 581-49-7

  • Molecular Formula : C10H12N2

  • Molecular Weight : 160.22

Nicotine - Impurity B

β-Nicotyrine


  • Catalogue No.:PA 14 21020

  • CAS : 487-19-4

  • Molecular Formula : C10H10N2

  • Molecular Weight : 158.21

Nicotine - Impurity C

Cotinine


  • Catalogue No.:PA 14 21030

  • CAS : 486-56-6

  • Molecular Formula : C10H12N2O

  • Molecular Weight : 176.22

Nicotine - Impurity D

Myosmine


  • Catalogue No.:PA 14 21040

  • CAS : 532-12-7

  • Molecular Formula : C9H10N2

  • Molecular Weight : 146.19

Nicotine - Impurity E

Nicotine N-Oxide


  • Catalogue No.:PA 14 21050

  • CAS : NA

  • Molecular Formula : C10H14N2O

  • Molecular Weight : 178.24

Nicotine - Impurity F

Nornicotine


  • Catalogue No.:PA 14 21060

  • CAS : 494-97-3

  • Molecular Formula : C9H12N2

  • Molecular Weight : 148.20

Nicotine - Impurity G

Anabasine


  • Catalogue No.:PA 14 21070

  • CAS : 494-52-0

  • Molecular Formula : C10H14N2

  • Molecular Weight : 162.23

Nicotine - In house impurity

Nicotine Salicylate


  • Catalogue No.:PA 14 21510

  • CAS : 29790-52-1

  • Molecular Formula : C17H20N2O3

  • Molecular Weight : 300.35

Nicotine - In house impurity

6-(Acetoxymethyl)-4-methoxy-5-methyl Nicotinic Acid Methyl Ester


  • Catalogue No.:PA 14 21520

  • CAS : 1329633-58-0

  • Molecular Formula : C12H15NO5

  • Molecular Weight : 0.00

Nicotine - In house impurity

2-Amino Nicotinic Acid


  • Catalogue No.:PA 14 21530

  • CAS : 5345-47-1

  • Molecular Formula : C6H6N2O2

  • Molecular Weight : 138.12

Nicotine - In house impurity

6-Amino Nicotinic Acid


  • Catalogue No.:PA 14 21540

  • CAS : 3167-49-5

  • Molecular Formula : C6H6N2O2

  • Molecular Weight : 138.12

Nicotine - In house impurity

6-Bromo Nicotinic Acid


  • Catalogue No.:PA 14 21550

  • CAS : 6311-35-9

  • Molecular Formula : C6H4BrNO2

  • Molecular Weight : 202.01

Nicotine - In house impurity

6-Bromo Nicotinic Acid Ethyl Ester


  • Catalogue No.:PA 14 21560

  • CAS : 132334-98-6

  • Molecular Formula : C8H8BrNO2

  • Molecular Weight : 230.06

Nicotine - In house impurity

2-(Carboxymethylamino) Nicotinic Acid


  • Catalogue No.:PA 14 21570

  • CAS : 1057318-86-1

  • Molecular Formula : C8H8N2O4

  • Molecular Weight : 196.16

Nicotine - In house impurity

2-(Carboxymethylamino) Nicotinic Acid Diethyl Ester


  • Catalogue No.:PA 14 21580

  • CAS : 1178176-00-5

  • Molecular Formula : C12H16N2O4

  • Molecular Weight : 252.27

Nicotine - In house impurity

2-Chloro-5,6-dimethyl Nicotinic Acid


  • Catalogue No.:PA 14 21590

  • CAS : 120003-75-0

  • Molecular Formula : C8H8ClNO2

  • Molecular Weight : 185.61

Nicotine - In house impurity

2-Chloro-5,6-dimethyl-4-methoxy Nicotinic Acid Methyl Ester


  • Catalogue No.:PA 14 21600

  • CAS : 1329833-74-0

  • Molecular Formula : C10H12ClNO3

  • Molecular Weight : 229.66

Nicotine - In house impurity

6-Chloro-4-methoxy Nicotinic Acid


  • Catalogue No.:PA 14 21610

  • CAS : 716362-10-6

  • Molecular Formula : C7H6ClNO3

  • Molecular Weight : 187.58

Nicotine - In house impurity

6-(Chloromethyl)-4-methoxy-5-methyl Nicotinic Acid Methyl Ester


  • Catalogue No.:PA 14 21620

  • CAS : 120003-81-8

  • Molecular Formula : C10H12ClNO3

  • Molecular Weight : 229.66

Nicotine - In house impurity

5,6-Dimethyl-4-methoxy Nicotinic Acid Methyl Ester


  • Catalogue No.:PA 14 21630

  • CAS : 1314982-27-8

  • Molecular Formula : C10H13NO3

  • Molecular Weight : 195.22

Nicotine - In house impurity

5,6-Dimethyl-4-methoxy Nicotinic Acid Methyl Ester 1-Oxide


  • Catalogue No.:PA 14 21640

  • CAS : 12519762-02-3

  • Molecular Formula : C10H13NO4

  • Molecular Weight : 211.21

Nicotine - In house impurity

2,4-Dichloro-5,6-dimethyl Nicotinic Acid Ethyl Ester 1-Oxide


  • Catalogue No.:PA 14 21650

  • CAS : 1329488-60-9

  • Molecular Formula : C10H11Cl2NO3

  • Molecular Weight : 264.11

Nicotine - In house impurity

2,4-Dihydroxy-5,6-dimethyl Nicotinic Acid Ethyl Ester


  • Catalogue No.:PA 14 21660

  • CAS : 77629-51-7

  • Molecular Formula : C10H13NO4

  • Molecular Weight : 211.21

Nicotine - In house impurity

Ethyl Nicotinate


  • Catalogue No.:PA 14 21670

  • CAS : 614-18-6

  • Molecular Formula : C8H9NO2

  • Molecular Weight : 151.16

Nicotine - In house impurity

5-Ethynyl Nicotine


  • Catalogue No.:PA 14 21680

  • CAS : 179120-92-4

  • Molecular Formula : C12H14N2

  • Molecular Weight : 186.25

Nicotine - In house impurity

5-Formyl Nicotinic Acid Methyl Ester


  • Catalogue No.:PA 14 21690

  • CAS : 6221-06-3

  • Molecular Formula : C8H7NO3

  • Molecular Weight : 165.15

Nicotine - In house impurity

6-(Hydroxymethyl)-4-methoxy-5-methyl Nicotinic Acid Methyl Ester


  • Catalogue No.:PA 14 21700

  • CAS : 1251762-18-1

  • Molecular Formula : C10H13NO4

  • Molecular Weight : 211.21

Nicotine - In house impurity

6-Hydroxy Nicotinic Acid


  • Catalogue No.:PA 14 21710

  • CAS : 5006-66-6

  • Molecular Formula : C6H5NO3

  • Molecular Weight : 139.11

Nicotine - In house impurity

5-Hydroxy Nicotinic Acid


  • Catalogue No.:PA 14 21720

  • CAS : 27828-71-3

  • Molecular Formula : C6H5NO3

  • Molecular Weight : 139.11

Nicotine - In house impurity

2-Hydroxy Nicotinic Acid


  • Catalogue No.:PA 14 21730

  • CAS : 609-71-2

  • Molecular Formula : C6H5NO3

  • Molecular Weight : 139.11

Nicotine - In house impurity

2-Methyl Nicotinic Acid


  • Catalogue No.:PA 14 21740

  • CAS : 3222-56-8

  • Molecular Formula : C7H7NO2

  • Molecular Weight : 137.14

Nicotine - In house impurity

Nicotine Bitartrate Dihydrate


  • Catalogue No.:PA 14 21750

  • CAS : 6019-06-3

  • Molecular Formula : C18H30N2O14

  • Molecular Weight : 498.44

Nicotine - In house impurity

(1'S,2'S)-Nicotine 1'-Oxide


  • Catalogue No.:PA 14 21760

  • CAS : 51095-86-4

  • Molecular Formula : C10H14N2O

  • Molecular Weight : 178.23

Nicotine - In house impurity

(R,S)-Anatabine


  • Catalogue No.:PA 14 21770

  • CAS : 2743-90-0

  • Molecular Formula : C10H12N2

  • Molecular Weight : 160.21

Nicotine - In house impurity

(R,S)-Anabasine


  • Catalogue No.:PA 14 21780

  • CAS : 13078-04-1

  • Molecular Formula : C10H14N2

  • Molecular Weight : 162.23

Nicotine - In house impurity

(RS)-Nornicotine


  • Catalogue No.:PA 14 21790

  • CAS : 5746-86-1

  • Molecular Formula : C9H12N2

  • Molecular Weight : 148.20

Nicotine - In house impurity

Dibromo Cotinine Hydrobromide Perbromide


  • Catalogue No.:PA 14 21800

  • CAS : NA

  • Molecular Formula : C10H11Br5N2O

  • Molecular Weight : 574.73

Nicotine - In house impurity

Trans-3'-Hydroxy Cotinine


  • Catalogue No.:PA 14 21810

  • CAS : 34834-67-8

  • Molecular Formula : C10H12N2O2

  • Molecular Weight : 192.21

Nicotine - In house impurity

Demethylcotinine


  • Catalogue No.:PA 14 21820

  • CAS : 5980-06-3

  • Molecular Formula : C9H10N2O

  • Molecular Weight : 162.19

Nicotine - In house impurity

(R,S)-Norcotinine


  • Catalogue No.:PA 14 21830

  • CAS : 17708-87-1

  • Molecular Formula : C9H10N2O

  • Molecular Weight : 162.19

Nicotine - In house impurity

(S)-Cotinine N-Oxide


  • Catalogue No.:PA 14 21840

  • CAS : 36508-80-2

  • Molecular Formula : C10H12N2O2

  • Molecular Weight : 192.21

Nicotine - In house impurity

N-Methyl--oxo-3-pyridinebutanamide


  • Catalogue No.:PA 14 21850

  • CAS : 713-05-3

  • Molecular Formula : C10H12N2O2

  • Molecular Weight : 192.21

Nicotine - In house impurity

5-Hydroxy-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one


  • Catalogue No.:PA 14 21860

  • CAS : 75919-05-0

  • Molecular Formula : C10H12N2O2

  • Molecular Weight : 192.21

Nicotine - In house impurity

(R)-5-Hydroxy-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one


  • Catalogue No.:PA 14 21870

  • CAS : 61192-50-5

  • Molecular Formula : C10H12N2O2

  • Molecular Weight : 192.21

Nicotine - In house impurity

5'-Hydroxynorcotinine


  • Catalogue No.:PA 14 21880

  • CAS : 118995-82-7

  • Molecular Formula : C9H10N2O2

  • Molecular Weight : 178.19

Nicotine - In house impurity

4-Oxo-4-(3-pyridyl)-butanamide


  • Catalogue No.:PA 14 21890

  • CAS : 61192-49-2

  • Molecular Formula : C9H10N2O2

  • Molecular Weight : 178.19

Nicotine - In house impurity

4-Oxo-4-pyridin-3-yl-butyric Acid


  • Catalogue No.:PA 14 21900

  • CAS : 4192-31-8

  • Molecular Formula : C9H9NO3

  • Molecular Weight : 179.17

Nicotine - In house impurity

4-Hydroxy-4-(pyridin-3-yl)butanoic Acid


  • Catalogue No.:PA 14 21910

  • CAS : 15569-97-8

  • Molecular Formula : C9H11NO3

  • Molecular Weight : 181.19

Nicotine - In house impurity

4-(Methylamino)-1-(pyridin-3-yl)butan-1-one


  • Catalogue No.:PA 14 21920

  • CAS : 2055-23-4

  • Molecular Formula : C10H14N2O

  • Molecular Weight : 178.23

Nicotine - In house impurity

Dihydro Nicotyrine


  • Catalogue No.:PA 14 21930

  • CAS : 525-74-6

  • Molecular Formula : C10H12N2

  • Molecular Weight : 160.22

Nicotine - In house impurity

(S)-1-Methylnicotinium Iodide


  • Catalogue No.:PA 14 21940

  • CAS : 21446-46-8

  • Molecular Formula : C11H17IN2

  • Molecular Weight : 304.17

Nicotine - In house impurity

(S)-1-Methyl-3-(1-methyl-5-oxopyrrolidin-2-yl)pyridin-1-ium iodide


  • Catalogue No.:PA 14 21950

  • CAS : 33952-07-7

  • Molecular Formula : C11H15IN2O

  • Molecular Weight : 318.15

Nicotine - In house impurity

1-Methyl-5-(pyridin-3-yl)-3,4-dihydro-2H-pyrrol-1-ium


  • Catalogue No.:PA 14 21960

  • CAS : 75043-32-2

  • Molecular Formula : C10H13N2

  • Molecular Weight : 161.22

Nicotine - In house impurity

1-Isopropenyl-2,2,4,4-tetramethyl-6-(2,2,4-trimethyl-pentyl-1-)-cyclohexane


  • Catalogue No.:PA 14 21970

  • CAS : NA

  • Molecular Formula : C21H40

  • Molecular Weight : 292.54

Nicotine - In house impurity

R-(+)-Nicotine


  • Catalogue No.:PA 14 21980

  • CAS : 25162-00-9

  • Molecular Formula : C10H14N2

  • Molecular Weight : 162.23

5-Methylnicotine-d3

5-Methylnicotine-d3


  • Catalogue No.:PA STI 062910

  • CAS : 1190016-33-1

  • Molecular Formula : C11H13D3N2

  • Molecular Weight : 179.28

3-Methyl Isonicotinic Acid-d6

3-Methyl Isonicotinic Acid-d6


  • Catalogue No.:PA STI 062920

  • CAS : 1346599-31-2

  • Molecular Formula : C7HD6NO2

  • Molecular Weight : 143.17

(R,S)-1-Methyl-3-nicotinoylpyrrolidone-d3

(R,S)-1-Methyl-3-nicotinoylpyrrolidone-d3


  • Catalogue No.:PA STI 062930

  • CAS : 86270-95-3

  • Molecular Formula : C11H9D3N2O2

  • Molecular Weight : 207.24

(R,S)-1-Methyl-3-nicotinoylpyrrolidone-d4

(R,S)-1-Methyl-3-nicotinoylpyrrolidone-d4


  • Catalogue No.:PA STI 062940

  • CAS : 764661-22-5

  • Molecular Formula : C11H8D4N2O2

  • Molecular Weight : 208.25

1-Methyl-3-(3'-pyridylcarbonyl-1,2',3',4',5',6'-13C6-pyrrolidinone

1-Methyl-3-(3'-pyridylcarbonyl-1,2',3',4',5',6'-13C6-pyrrolidinone


  • Catalogue No.:PA STI 063570

  • CAS : 1189492-36-1

  • Molecular Formula : C513C6H12N2O2

  • Molecular Weight : 210.18

N-Methyl-D3-pyrrolidine

N-Methyl-D3-pyrrolidine


  • Catalogue No.:PA STI 063740

  • CAS : 77422-30-1

  • Molecular Formula : C5H8D3N

  • Molecular Weight : 88.17

(2R)-1-Methyl-2-phenylpyrrolidine-D3

(2R)-1-Methyl-2-phenylpyrrolidine-D3


  • Catalogue No.:PA STI 064340

  • CAS : NA

  • Molecular Formula : C11H12D3N

  • Molecular Weight : 164.26

Anabaseine-d4


  • Catalogue No.:PA STI 007710

  • CAS : 1020719-05-4

  • Molecular Formula : C10H8D4N2

  • Molecular Weight : 164.24

(R,S)-Anabasine-2,4,5,6-d4


  • Catalogue No.:PA STI 007720

  • CAS : 1020719-08-7

  • Molecular Formula : C10H10D4N2

  • Molecular Weight : 166.26

(R,S)-Anatabine-2,4,5,6-d4 (Major)


  • Catalogue No.:PA STI 007830

  • CAS : 1020719-11-2

  • Molecular Formula : C10H8D4N2

  • Molecular Weight : 164.24

(R,S)-Anatabine-2,4,5,6-d4


  • Catalogue No.:PA STI 007840

  • CAS : 1020719-11-2

  • Molecular Formula : C10H8D4N2

  • Molecular Weight : 164.24

2-(tert-Butylamino)-3',5'-dichloropropiophenone-d6 Hydrochloride


  • Catalogue No.:PA STI 016060

  • CAS : NA

  • Molecular Formula : C13H12D6Cl3NO

  • Molecular Weight : 316.68

rac-Cotinine-d3


  • Catalogue No.:PA STI 022580

  • CAS : 110952-70-0

  • Molecular Formula : C10H9D3N2O

  • Molecular Weight : 179.22

rac-Cotinine-d3


  • Catalogue No.:PA STI 022590

  • CAS : 110952-70-0

  • Molecular Formula : C10H9D3N2O

  • Molecular Weight : 179.23

rac-Cotinine-13C,d3


  • Catalogue No.:PA STI 022600

  • CAS : 1215842-75-3

  • Molecular Formula : C913CH9D3N2O

  • Molecular Weight : 180.23

Cotinine-d3 N-β-D-Glucuronide see C725180


  • Catalogue No.:PA STI 022610

  • CAS : NA

  • Molecular Formula : C16H17D3N2O7

  • Molecular Weight : 355.36

Cotinine-d3 N-β-D-Glucuronide


  • Catalogue No.:PA STI 022620

  • CAS : NA

  • Molecular Formula : C16H17D3N2O7

  • Molecular Weight : 355.36

(R,S)-Cotinine-d3 N-Oxide


  • Catalogue No.:PA STI 022630

  • CAS : 1215561-37-7

  • Molecular Formula : C10H9D3N2O2

  • Molecular Weight : 195.23

Dihydro Nicotyrine-d3


  • Catalogue No.:PA STI 032480

  • CAS : 1246818-62-1

  • Molecular Formula : C10H9D3N2

  • Molecular Weight : 163.23

trans-3'-Hydroxy Cotinine-d3


  • Catalogue No.:PA STI 048350

  • CAS : 159956-78-2

  • Molecular Formula : C10H9D3N2O2

  • Molecular Weight : 195.23

rac-trans-3'-Hydroxy Cotinine-d3 O-β-D-Glucuronide (mixture of diastereomers)


  • Catalogue No.:PA STI 048360

  • CAS : NA

  • Molecular Formula : C16H17D3N2O8

  • Molecular Weight : 371.36

3-trans-Hydroxy Norcotinine-13C4 (2 : 1 = trans : cis)


  • Catalogue No.:PA STI 050490

  • CAS : NA

  • Molecular Formula : C513C4H10N2O2

  • Molecular Weight : 182.16

Isonicotinic Acid-d4


  • Catalogue No.:PA STI 053920

  • CAS : 53907-55-4

  • Molecular Formula : C6HD4NO2

  • Molecular Weight : 127.13

rac 4-Hydroxy-4-(3-pyridyl)butanoic-d3 Acid Dicyclohexylamine Salt (d3 Major)


  • Catalogue No.:PA STI 051370

  • CAS : NA

  • Molecular Formula : C21H31D3N2O3

  • Molecular Weight : 365.52

Isonicotinamide-d4


  • Catalogue No.:PA STI 053900

  • CAS : 1219799-40-2

  • Molecular Formula : C6H2D4N2O

  • Molecular Weight : 126.15

Isonicotine-d3


  • Catalogue No.:PA STI 053910

  • CAS : 1346601-08-8

  • Molecular Formula : C10H11D3N2

  • Molecular Weight : 165.25

rac-Cotinine-d3 (1.0 mg/mL in Methanol)


  • Catalogue No.:PA STI 055360

  • CAS : 110952-70-0

  • Molecular Formula : C10H9D3N2O

  • Molecular Weight : 179.23

(RS)-Nornicotine-d4 (100 ug/mL in Methanol)


  • Catalogue No.:PA STI 055370

  • CAS : 66148-18-3

  • Molecular Formula : C9H8D4N2

  • Molecular Weight : 152.23

rac N'-Nitrosonornicotine-d4 (1.0 mg/mL in Acetonitrile)


  • Catalogue No.:PA STI 055420

  • CAS : 66148-19-4

  • Molecular Formula : C9H7D4N3O

  • Molecular Weight : 181.23

(R,S)-N-Nitroso Anabasine-d4 (0.1 mg/mL in Methanol)


  • Catalogue No.:PA STI 055450

  • CAS : 1020719-68-9

  • Molecular Formula : C10H9D4N3O

  • Molecular Weight : 195.25

(R,S)-N-Nitroso Anatabine-2,4,5,6-d4 (0.1 mg/mL in Methanol)


  • Catalogue No.:PA STI 055460

  • CAS : 1020719-69-0

  • Molecular Formula : C10H7D4N3O

  • Molecular Weight : 193.24

3-(4-Methylaminobutyryl)pyridine-1,2',3',4',5',6'-13C6, Dihydrochloride


  • Catalogue No.:PA STI 060230

  • CAS : 1246819-72-6

  • Molecular Formula : C413C6H16Cl2N2O

  • Molecular Weight : 257.11

4-(Methylamino)-1-(3-pyridyl)-1-butanol-1,2',3',4',5',6'-13C6


  • Catalogue No.:PA STI 060330

  • CAS : 1216991-24-0

  • Molecular Formula : C413C6H16N2O

  • Molecular Weight : 186.20

4-(Methylamino)-1-(3-pyridyl)-1-butanol-d3


  • Catalogue No.:PA STI 060340

  • CAS : 1189642-32-7

  • Molecular Formula : C10H13D3N2O

  • Molecular Weight : 183.27

4-(Methylamino)-1-(3-pyridyl-d4)-1-butanone Dihydrochloride


  • Catalogue No.:PA STI 060350

  • CAS : 764661-23-6_x0000_

  • Molecular Formula : C10H12D4Cl2N2O

  • Molecular Weight : 255.18

5-Methylcotinine-d3


  • Catalogue No.:PA STI 060870

  • CAS : 1217003-12-7

  • Molecular Formula : C11H11D3N2O

  • Molecular Weight : 193.26

N-(4-Methoxybenzyl)cotinine-d4


  • Catalogue No.:PA STI 059190

  • CAS : 1020719-59-8

  • Molecular Formula : C17H14D4N2O2

  • Molecular Weight : 286.36

Nicotelline-d8


  • Catalogue No.:PA STI 067410

  • CAS : 1469367-99-4

  • Molecular Formula : C15H3D8N3

  • Molecular Weight : 241.32

rac-Nicotine-1,2',3',4',5',6'-13C6 (Solution in Methanol -0.025% w/v)


  • Catalogue No.:PA STI 067470

  • CAS : 1189715-49-8

  • Molecular Formula : C413C6H14N2

  • Molecular Weight : 168.19

rac-Nicotine-3',3'-d2


  • Catalogue No.:PA STI 067480

  • CAS : NA

  • Molecular Formula : C10H12D2N2

  • Molecular Weight : 164.24

rac-Nicotine-2',3',3'-d3


  • Catalogue No.:PA STI 067490

  • CAS : 1189681-48-8

  • Molecular Formula : C10H11D3N2

  • Molecular Weight : 165.25

rac-Nicotine-13CD3


  • Catalogue No.:PA STI 067500

  • CAS : 909014-86-4

  • Molecular Formula : C913CH11D3N2

  • Molecular Weight : 166.24

rac-Nicotine-d3


  • Catalogue No.:PA STI 067510

  • CAS : 69980-24-1

  • Molecular Formula : C10H11D3N2

  • Molecular Weight : 165.26

rac-Nicotine-d4


  • Catalogue No.:PA STI 067520

  • CAS : 350818-69-8

  • Molecular Formula : C10H10D4N2

  • Molecular Weight : 166.26

(S)-(-)-Nicotine-d4


  • Catalogue No.:PA STI 067530

  • CAS : 284685-07-0

  • Molecular Formula : C10H10D4N2

  • Molecular Weight : 166.26

Nicotine-d3 N-(4-Deoxy-4,5-didehydro)-β-D-glucuronide


  • Catalogue No.:PA STI 067540

  • CAS : NA

  • Molecular Formula : C16H17D3N2O5

  • Molecular Weight : 323.36

Nicotine-d3 N-β-D-Glucuronide


  • Catalogue No.:PA STI 067550

  • CAS : 329002-74-6_x0000_

  • Molecular Formula : C16H19D3N2O6

  • Molecular Weight : 341.37

rac-trans-Nicotine-1'-oxide-d3


  • Catalogue No.:PA STI 067560

  • CAS : NA

  • Molecular Formula : C10H11D3N2O

  • Molecular Weight : 181.25

(R,S)-N-Nitroso Anabasine-d4


  • Catalogue No.:PA STI 068360

  • CAS : 1020719-68-9

  • Molecular Formula : C10H9D4N3O

  • Molecular Weight : 195.25

N-Nitrosoanabasine-13C6


  • Catalogue No.:PA STI 068370

  • CAS : NA

  • Molecular Formula : C413C6H13N3O

  • Molecular Weight : 197.19

(R,S)-N2-Nitroso-Anabasine-d4 N'-β-D-Glucuronide


  • Catalogue No.:PA STI 068380

  • CAS : NA

  • Molecular Formula : C16H17D4N3O7

  • Molecular Weight : 371.38

rac N'-Nitrosonornicotine-d4


  • Catalogue No.:PA STI 068660

  • CAS : 66148-19-4

  • Molecular Formula : C9H7D4N3O

  • Molecular Weight : 181.23

(R,S)-Norcotinine-pyridyl-d4


  • Catalogue No.:PA STI 068920

  • CAS : 1020719-70-3

  • Molecular Formula : C9H6D4N2O

  • Molecular Weight : 166.21

(R,S)-Nornicotine-d4


  • Catalogue No.:PA STI 069290

  • CAS : 66148-18-3

  • Molecular Formula : C9H8D4N2

  • Molecular Weight : 152.23

3-Picoline-d6 1-Oxide


  • Catalogue No.:PA STI 073670

  • CAS : NA

  • Molecular Formula : C6HD6NO

  • Molecular Weight : 115.16

3-Pyridine-d4-acetic Acid


  • Catalogue No.:PA STI 076290

  • CAS : 1035439-74-7

  • Molecular Formula : C7H3D4NO2

  • Molecular Weight : 141.16

rac 5-(3-Pyridyl)tetrahydro-2-furanone-d3


  • Catalogue No.:PA STI 076380

  • CAS : NA

  • Molecular Formula : C9H6D3NO2

  • Molecular Weight : 166.19

3-Buten-1-amine

3-Buten-1-amine


  • Catalogue No.:PAI 14 005510

  • CAS : NA

  • Molecular Formula : C4H9N

  • Molecular Weight : 71.12

Nicotine - Impurity D (Fumarate Salt)

Myosmine Fumarate


  • Catalogue No.:PA 14 21041

  • CAS : NA

  • Molecular Formula : C13H14N2O4

  • Molecular Weight : 262.27

Nicotine - Impurity E (Oxalate Salt)

Oxynicotine Oxalate


  • Catalogue No.:PA 14 21051

  • CAS : NA

  • Molecular Formula : C12H16N2O5

  • Molecular Weight : 268.27

Nicotine - In house impurity

(S)-N-Nitroso Anabasine


  • Catalogue No.:PA 14 21515

  • CAS : 1133-64-8

  • Molecular Formula : C10H13N3O

  • Molecular Weight : 191.23

Nicotine - In house impurity

(S)-N-Nitroso Anatabine


  • Catalogue No.:PA 14 21990

  • CAS : 71267-22-6

  • Molecular Formula : C10H11N3O

  • Molecular Weight : 189.22

Nicotine - In house impurity

rac-trans 3’-Acetylthiomethyl Nicotine


  • Catalogue No.:PA 14 21525

  • CAS : 1217716-10-3

  • Molecular Formula : C13H18N2OS

  • Molecular Weight : 250.36

Nicotine - reference spectrum (N0590000)


  • Catalogue No.:PA EP-N0590000

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotine ditartrate (N0590200)


  • Catalogue No.:PA EP-N0590200

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotinic acid (N0700000)


  • Catalogue No.:PA EP-N0700000

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotine for system suitability (Y0001023)


  • Catalogue No.:PA EP-Y0001023

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotinic acid impurity mixture (Y0001268)


  • Catalogue No.:PA EP-Y0001268

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotine ditartrate dihydrate (Y0001425)


  • Catalogue No.:PA EP-Y0001425

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotine Bitartrate Dihydrate (1463304)


  • Catalogue No.:PA USP-1463304

  • CAS : 6019-06-3

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotine Related Compound A (1,2,3,6-tetrahydro-2,3'-bipyridine) (1463326)


  • Catalogue No.:PA USP-1463326

  • CAS : 2743-90-0

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotine Related Compound B (3-(1-methyl-1H-pyrrol-2-yl)pyridine) (1463337)


  • Catalogue No.:PA USP-1463337

  • CAS : 487-19-4

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotine Related Compound C ((S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one) (1463348)


  • Catalogue No.:PA USP-1463348

  • CAS : 486-56-6

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotine Related Compound D (3-(4,5-dihydro-3H-pyrrol-2-yl)pyridine fumarate) (1463359)


  • Catalogue No.:PA USP-1463359

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotine Related Compound E ((1RS,2S)-1-methyl-2-(pyridin-3-yl)pyrrolidine 1-oxide oxalate) (1463360)


  • Catalogue No.:PA USP-1463360

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotine Related Compound F (3-(pyrrolidin-2-yl)pyridine) (1463371)


  • Catalogue No.:PA USP-1463371

  • CAS : 5746-86-1

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotine Related Compound G ((S)-3-(piperidin-2-yl)pyridine) (1463382)


  • Catalogue No.:PA USP-1463382

  • CAS : 494-52-0

  • Molecular Formula :

  • Molecular Weight : 0.00

nicotine ditartrate dihydrate (821RB)


  • Catalogue No.:PA BP-821RB

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

nicotine impurity standard (822RB)


  • Catalogue No.:PA BP-822RB

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Nicotine - In house impurity

5-Triisopropylsilyl-ethynyl (S)-(-)-Nicotine


  • Catalogue No.:PA 14 21535

  • CAS : 916046-39-4

  • Molecular Formula : C21H34N2Si

  • Molecular Weight : 342.59

Nicotine - In house impurity

(+/-)-2-Methylnicotine


  • Catalogue No.:PA 14 21545

  • CAS : 64114-31-4

  • Molecular Formula : C11H16N2

  • Molecular Weight : 176.26

Nicotine - In house impurity

Nicotine N-β-D-Glucuronide


  • Catalogue No.:PA 14 21555

  • CAS : 153536-53-9

  • Molecular Formula : C16H22N2O6

  • Molecular Weight : 338.36

Diethyl N,N-(3’-Pyridylmethylene)bis(carbamate)

Diethyl N,N-(3’-Pyridylmethylene)bis(carbamate)


  • Catalogue No.:PAI 14 005520

  • CAS : 2744-17-4

  • Molecular Formula : C12H17N3O4

  • Molecular Weight : 267.29

Ethyl 3,6-dihydro-[2,3'-bipyridine]-1(2H)-carboxylate

Ethyl 3,6-dihydro-[2,3'-bipyridine]-1(2H)-carboxylate


  • Catalogue No.:PAI 14 005530

  • CAS : NA

  • Molecular Formula : C13H16N2O2

  • Molecular Weight : 232.28

Whoops! There was an error.
UnexpectedValueException
The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied UnexpectedValueException thrown with message "The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied" Stacktrace: #10 UnexpectedValueException in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php:107 #9 Monolog\Handler\StreamHandler:write in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Handler/AbstractProcessingHandler.php:37 #8 Monolog\Handler\AbstractProcessingHandler:handle in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Logger.php:337 #7 Monolog\Logger:addRecord in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Logger.php:616 #6 Monolog\Logger:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php:179 #5 Illuminate\Log\Logger:writeLog in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php:90 #4 Illuminate\Log\Logger:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/LogManager.php:524 #3 Illuminate\Log\LogManager:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Exceptions/Handler.php:113 #2 Illuminate\Foundation\Exceptions\Handler:report in /home/pharmaaffiliates/public_html/app/Exceptions/Handler.php:43 #1 App\Exceptions\Handler:report in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Bootstrap/HandleExceptions.php:81 #0 Illuminate\Foundation\Bootstrap\HandleExceptions:handleException in [internal]:0
10
UnexpectedValueException
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StreamHandler.php
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9
Monolog
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StreamHandler
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monolog
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Handler
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AbstractProcessingHandler.php
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8
Monolog
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Handler
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AbstractProcessingHandler
handle
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vendor
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monolog
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src
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Monolog
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Logger.php
337
7
Monolog
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Logger
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monolog
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Monolog
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Logger.php
616
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Logger
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Log
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Logger.php
179
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Illuminate
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Log
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Logger
writeLog
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vendor
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laravel
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framework
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src
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Illuminate
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Log
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Logger.php
90
4
Illuminate
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Log
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Logger
error
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laravel
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framework
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src
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Illuminate
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Log
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LogManager.php
524
3
Illuminate
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Log
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LogManager
error
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vendor
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laravel
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framework
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src
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Illuminate
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Foundation
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Exceptions
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Handler.php
113
2
Illuminate
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Foundation
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Exceptions
\
Handler
report
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app
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Exceptions
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Handler.php
43
1
App
\
Exceptions
\
Handler
report
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vendor
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laravel
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framework
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src
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Illuminate
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Foundation
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Bootstrap
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HandleExceptions.php
81
0
Illuminate
\
Foundation
\
Bootstrap
\
HandleExceptions
handleException
[internal]
0
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StreamHandler.php
    /**
     * {@inheritdoc}
     */
    protected function write(array $record)
    {
        if (!is_resource($this->stream)) {
            if (null === $this->url || '' === $this->url) {
                throw new \LogicException('Missing stream url, the stream can not be opened. This may be caused by a premature call to close().');
            }
            $this->createDir();
            $this->errorMessage = null;
            set_error_handler(array($this, 'customErrorHandler'));
            $this->stream = fopen($this->url, 'a');
            if ($this->filePermission !== null) {
                @chmod($this->url, $this->filePermission);
            }
            restore_error_handler();
            if (!is_resource($this->stream)) {
                $this->stream = null;
                throw new \UnexpectedValueException(sprintf('The stream or file "%s" could not be opened: '.$this->errorMessage, $this->url));
            }
        }
 
        if ($this->useLocking) {
            // ignoring errors here, there's not much we can do about them
            flock($this->stream, LOCK_EX);
        }
 
        $this->streamWrite($this->stream, $record);
 
        if ($this->useLocking) {
            flock($this->stream, LOCK_UN);
        }
    }
 
    /**
     * Write to stream
     * @param resource $stream
     * @param array $record
     */
Arguments
  1. "The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied"
    
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AbstractProcessingHandler.php
 *
 * @author Jordi Boggiano <j.boggiano@seld.be>
 * @author Christophe Coevoet <stof@notk.org>
 */
abstract class AbstractProcessingHandler extends AbstractHandler
{
    /**
     * {@inheritdoc}
     */
    public function handle(array $record)
    {
        if (!$this->isHandling($record)) {
            return false;
        }
 
        $record = $this->processRecord($record);
 
        $record['formatted'] = $this->getFormatter()->format($record);
 
        $this->write($record);
 
        return false === $this->bubble;
    }
 
    /**
     * Writes the record down to the log of the implementing handler
     *
     * @param  array $record
     * @return void
     */
    abstract protected function write(array $record);
 
    /**
     * Processes a record.
     *
     * @param  array $record
     * @return array
     */
    protected function processRecord(array $record)
    {
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571596991 {#33
        date: 2019-10-20 18:43:11.632608 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 18:43:11] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6InM5Z28...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6InM5Z28...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('7p8qRksrcHaAC3C...', 'eyJpdiI6InM5Z28...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
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Logger.php
            $ts = new \DateTime(null, static::$timezone);
        }
        $ts->setTimezone(static::$timezone);
 
        $record = array(
            'message' => (string) $message,
            'context' => $context,
            'level' => $level,
            'level_name' => $levelName,
            'channel' => $this->name,
            'datetime' => $ts,
            'extra' => array(),
        );
 
        foreach ($this->processors as $processor) {
            $record = call_user_func($processor, $record);
        }
 
        while ($handler = current($this->handlers)) {
            if (true === $handler->handle($record)) {
                break;
            }
 
            next($this->handlers);
        }
 
        return true;
    }
 
    /**
     * Adds a log record at the DEBUG level.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function addDebug($message, array $context = array())
    {
        return $this->addRecord(static::DEBUG, $message, $context);
    }
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571596991 {#33
        date: 2019-10-20 18:43:11.632608 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 18:43:11] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6InM5Z28...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6InM5Z28...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('7p8qRksrcHaAC3C...', 'eyJpdiI6InM5Z28...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
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Logger.php
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function err($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the ERROR level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function error($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function crit($message, array $context = array())
    {
        return $this->addRecord(static::CRITICAL, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
Arguments
  1. 400
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
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Logger.php
     * @return void
     */
    public function write($level, $message, array $context = [])
    {
        $this->writeLog($level, $message, $context);
    }
 
    /**
     * Write a message to the log.
     *
     * @param  string  $level
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    protected function writeLog($level, $message, $context)
    {
        $this->fireLogEvent($level, $message = $this->formatMessage($message), $context);
 
        $this->logger->{$level}($message, $context);
    }
 
    /**
     * Register a new callback handler for when a log event is triggered.
     *
     * @param  \Closure  $callback
     * @return void
     *
     * @throws \RuntimeException
     */
    public function listen(Closure $callback)
    {
        if (! isset($this->dispatcher)) {
            throw new RuntimeException('Events dispatcher has not been set.');
        }
 
        $this->dispatcher->listen(MessageLogged::class, $callback);
    }
 
    /**
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
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Logger.php
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function critical($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log an error message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function error($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a warning message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function warning($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a notice to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
Arguments
  1. "error"
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
LogManager.php
     *
     * @return void
     */
    public function critical($message, array $context = [])
    {
        return $this->driver()->critical($message, $context);
    }
 
    /**
     * Runtime errors that do not require immediate action but should typically
     * be logged and monitored.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function error($message, array $context = [])
    {
        return $this->driver()->error($message, $context);
    }
 
    /**
     * Exceptional occurrences that are not errors.
     *
     * Example: Use of deprecated APIs, poor use of an API, undesirable things
     * that are not necessarily wrong.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function warning($message, array $context = [])
    {
        return $this->driver()->warning($message, $context);
    }
 
    /**
     * Normal but significant events.
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Exceptions
/
Handler.php
     */
    public function report(Exception $e)
    {
        if ($this->shouldntReport($e)) {
            return;
        }
 
        if (method_exists($e, 'report')) {
            return $e->report();
        }
 
        try {
            $logger = $this->container->make(LoggerInterface::class);
        } catch (Exception $ex) {
            throw $e;
        }
 
        $logger->error(
            $e->getMessage(),
            array_merge($this->context(), ['exception' => $e]
        ));
    }
 
    /**
     * Determine if the exception should be reported.
     *
     * @param  \Exception  $e
     * @return bool
     */
    public function shouldReport(Exception $e)
    {
        return ! $this->shouldntReport($e);
    }
 
    /**
     * Determine if the exception is in the "do not report" list.
     *
     * @param  \Exception  $e
     * @return bool
     */
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
app
/
Exceptions
/
Handler.php
        \Illuminate\Auth\AuthenticationException::class,
        \Illuminate\Auth\Access\AuthorizationException::class,
        \Symfony\Component\HttpKernel\Exception\HttpException::class,
        \Illuminate\Database\Eloquent\ModelNotFoundException::class,
        \Illuminate\Session\TokenMismatchException::class,
        \Illuminate\Validation\ValidationException::class,
    ];
 
    /**
     * Report or log an exception.
     *
     * This is a great spot to send exceptions to Sentry, Bugsnag, etc.
     *
     * @param \Exception $exception
     *
     * @return void
     */
    public function report(Exception $exception)
    {
        parent::report($exception);
    }
 
    /**
     * Render an exception into an HTTP response.
     *
     * @param \Illuminate\Http\Request $request
     * @param \Exception               $exception
     *
     * @return \Illuminate\Http\Response
     */
    public function render($request, Exception $exception)
    {
        //dd($exception);
        if (strpos($request->url(), '/api/') !== false) {
            \Log::debug('API Request Exception - '.$request->url().' - '.$exception->getMessage().(!empty($request->all()) ? ' - '.json_encode($request->except(['password'])) : ''));
 
            if ($exception instanceof AuthorizationException) {
                return $this->setStatusCode(403)->respondWithError($exception->getMessage());
            }
 
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Bootstrap
/
HandleExceptions.php
    }
 
    /**
     * Handle an uncaught exception from the application.
     *
     * Note: Most exceptions can be handled via the try / catch block in
     * the HTTP and Console kernels. But, fatal error exceptions must
     * be handled differently since they are not normal exceptions.
     *
     * @param  \Throwable  $e
     * @return void
     */
    public function handleException($e)
    {
        if (! $e instanceof Exception) {
            $e = new FatalThrowableError($e);
        }
 
        try {
            $this->getExceptionHandler()->report($e);
        } catch (Exception $e) {
            //
        }
 
        if ($this->app->runningInConsole()) {
            $this->renderForConsole($e);
        } else {
            $this->renderHttpResponse($e);
        }
    }
 
    /**
     * Render an exception to the console.
     *
     * @param  \Exception  $e
     * @return void
     */
    protected function renderForConsole(Exception $e)
    {
        $this->getExceptionHandler()->renderForConsole(new ConsoleOutput, $e);
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
[internal]
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/7p8qRksrcHaAC3CNTJPqc17fFCmRyUPjo8gxxltR): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    

Environment & details:

empty
empty
empty
empty
empty
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
HTTP_ACCEPT
"text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8"
HTTP_ACCEPT_ENCODING
"gzip"
HTTP_ACCEPT_LANGUAGE
"en-US,en;q=0.5"
HTTP_CONNECTION
"Keep-Alive"
HTTP_HOST
"www.pharmaffiliates.com"
HTTP_USER_AGENT
"CCBot/2.0 (https://commoncrawl.org/faq/)"
HTTP_IF_MODIFIED_SINCE
"Wed, 17 Jul 2019 01:19:54 PDT"
DOCUMENT_ROOT
"/home/pharmaaffiliates/public_html"
REMOTE_ADDR
"3.228.24.192"
REMOTE_PORT
"48738"
SERVER_ADDR
"172.105.43.57"
SERVER_NAME
"www.pharmaffiliates.com"
SERVER_ADMIN
"webmaster@pharmaffiliates.com"
SERVER_PORT
"443"
REQUEST_URI
"/en/parentapi/nicotine"
REDIRECT_URL
"/en/parentapi/nicotine"
HTTPS
"on"
REDIRECT_STATUS
"200"
SSL_PROTOCOL
"TLSv1.2"
SSL_SESSION_ID
"cac5324101e05d6197758ec434674ffa35e8874cbe6d113c20a8e745592626bb"
SSL_CIPHER
"ECDHE-RSA-AES256-GCM-SHA384"
SSL_CIPHER_USEKEYSIZE
"256"
SSL_CIPHER_ALGKEYSIZE
"256"
SCRIPT_FILENAME
"/home/pharmaaffiliates/public_html/index.php"
QUERY_STRING
""
SCRIPT_URI
"https://www.pharmaffiliates.com/en/parentapi/nicotine"
SCRIPT_URL
"/en/parentapi/nicotine"
SCRIPT_NAME
"/index.php"
SERVER_PROTOCOL
"HTTP/1.1"
SERVER_SOFTWARE
"LiteSpeed"
REQUEST_METHOD
"GET"
X-LSCACHE
"on"
PHP_SELF
"/index.php"
REQUEST_TIME_FLOAT
1571596991.3523
REQUEST_TIME
1571596991
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
0. Whoops\Handler\PrettyPageHandler