Displaying 45 results for olmesartan medoxomil

Olmesartan Medoxomil - API

Olmesartan Medoxomil


  • Catalogue No.:PA 15 26000

  • CAS : 144689-63-4

  • Molecular Formula : C29H30N6O6

  • Molecular Weight : 558.59

Olmesartan Medoxomil - In house impurity

cis-4,5-Dichloro-4,5-dimethyl-1,3-dioxolan-2-one


  • Catalogue No.:PA 15 26510

  • CAS : 129482-56-0

  • Molecular Formula : C5H6Cl2O3

  • Molecular Weight : 185.00

Olmesartan Medoxomil - In house impurity

trans-4,5-Dichloro-4,5-dimethyl-1,3-dioxolan-2-one


  • Catalogue No.:PA 15 26520

  • CAS : 116857-05-7

  • Molecular Formula : C5H6Cl2O3

  • Molecular Weight : 185.01

Olmesartan Medoxomil - In house impurity

4,5-Bis(chloromethyl)-1,3-dioxol-2-one


  • Catalogue No.:PA 15 26530

  • CAS : 1443544-27-1

  • Molecular Formula : C5H4Cl2O3

  • Molecular Weight : 182.99

Olmesartan Medoxomil - In house impurity

4-(1-Methoxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic Acid Ethyl Ester


  • Catalogue No.:PA 15 26540

  • CAS : 1092980-84-1

  • Molecular Formula : C13H22N2O3

  • Molecular Weight : 254.33

Olmesartan Medoxomil - In house impurity

Ethyl 4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate


  • Catalogue No.:PA 15 26550

  • CAS : 172875-53-5

  • Molecular Formula : C13H22N2O3

  • Molecular Weight : 254.33

Olmesartan Medoxomil - In house impurity

4-(1-Hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic Acid


  • Catalogue No.:PA 15 26560

  • CAS : 144690-04-0

  • Molecular Formula : C10H16N2O3

  • Molecular Weight : 212.25

Olmesartan Medoxomil - In house impurity

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-4-carboxylate


  • Catalogue No.:PA 15 26570

  • CAS : 144978-05-2

  • Molecular Formula : C15H20N2O6

  • Molecular Weight : 324.33

Olmesartan Medoxomil - In house impurity

N-1 Trityl Olmesartan Medoxomil


  • Catalogue No.:PA 15 26580

  • CAS : 144690-92-6

  • Molecular Formula : C48H44N6O6

  • Molecular Weight : 800.90

Olmesartan Medoxomil - In house impurity

Ethyl Olmesartan Medoxomil


  • Catalogue No.:PA 15 26590

  • CAS : 1378863-74-1

  • Molecular Formula : C30H32N6O6

  • Molecular Weight : 572.61

Olmesartan Medoxomil - In house impurity

4,5-bis-(Chloromethyl)-1,3-dioxolan-2-one


  • Catalogue No.:PA 15 26600

  • CAS : 1487-64-5

  • Molecular Formula : C5H6Cl2O3

  • Molecular Weight : 185.01

Olmesartan Medoxomil - In house impurity

4,5-bis(Chloromethyl)-1,3-diazolan-2-one


  • Catalogue No.:PA 15 26610

  • CAS : NA

  • Molecular Formula : C5H8Cl2N2O

  • Molecular Weight : 183.04

Olmesartan Medoxomil - In house impurity

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxybutan-2-yl)-2-propyl-1-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate


  • Catalogue No.:PA 15 26620

  • CAS : NA

  • Molecular Formula : C49H46N6O6

  • Molecular Weight : 814.93

Olmesartan Medoxomil - In house impurity

4,5-Bis(hydroxymethyl)-1,3-dioxol-2-one


  • Catalogue No.:PA 15 26630

  • CAS : NA

  • Molecular Formula : C5H6O5

  • Molecular Weight : 146.10

Olmesartan Medoxomil - In house impurity

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-4-carboxylate


  • Catalogue No.:PA 15 26640

  • CAS : NA

  • Molecular Formula : C29H30N6O6

  • Molecular Weight : 558.59

Olmesartan Medoxomil - In house impurity

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4-carboxylate


  • Catalogue No.:PA 15 26650

  • CAS : NA

  • Molecular Formula : C48H44N6O6

  • Molecular Weight : 800.90

Olmesartan Medoxomil - In house impurity

Ethyl 5-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4-carboxylate


  • Catalogue No.:PA 15 26660

  • CAS : NA

  • Molecular Formula : C45H44N6O3

  • Molecular Weight : 716.87

Olmesartan Medoxomil - In house impurity

Olmesartan Medoxomil Methyl Ether


  • Catalogue No.:PA 15 26670

  • CAS : 896419-17-3

  • Molecular Formula : C30H32N6O6

  • Molecular Weight : 572.61

Olmesartan Medoxomil - In house impurity

3,6-Dihydro-6,6-dimethyl-2-propyl-3-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-4H-furo[3,4-d]imidazol-4-one


  • Catalogue No.:PA 15 26680

  • CAS : 1048948-15-7

  • Molecular Formula : C43H38N6O2

  • Molecular Weight : 670.80

Olmesartan Medoxomil - In house impurity

1-(4-(2-Hydroxypropan-2-yl)-2-propyl-1H-imidazol-5-yl)ethanone


  • Catalogue No.:PA 15 26690

  • CAS : NA

  • Molecular Formula : C11H18N2O2

  • Molecular Weight : 210.27

Olmesartan Medoxomil - In house impurity

Ethyl 4-(prop-1-en-2-yl)-2-propyl-1H-imidazole-5-carboxylate


  • Catalogue No.:PA 15 26700

  • CAS : 157356-73-5

  • Molecular Formula : C12H18N2O2

  • Molecular Weight : 222.28

Olmesartan Medoxomil - In house impurity

5-(4'-((4-(2-Hydroxypropan-2-yl)-5-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-2-propyl-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-1H-tetrazole 4-oxide


  • Catalogue No.:PA 15 26710

  • CAS : NA

  • Molecular Formula : C29H30N6O7

  • Molecular Weight : 574.58

Ethyl Olmesartan Medoxomil-d4


  • Catalogue No.:PA STI 039850

  • CAS : NA

  • Molecular Formula : C30H28D4N6O6

  • Molecular Weight : 576.64

Olmesartan-d4 Medoxomil


  • Catalogue No.:PA STI 070080

  • CAS : 1127298-55-8

  • Molecular Formula : C29H26D4N6O6

  • Molecular Weight : 562.61

Olmesartan-d6 Acid


  • Catalogue No.:PA STI 070090

  • CAS : 1185144-74-4

  • Molecular Formula : C24H20D6N6O3

  • Molecular Weight : 452.54

Olmesartan Medoxomil-d6


  • Catalogue No.:PA STI 070100

  • CAS : 1127298-67-2

  • Molecular Formula : C29H24D6N6O6

  • Molecular Weight : 564.62

Olmesartan-d4 Acid


  • Catalogue No.:PA STI 070110

  • CAS : 1420880-41-6

  • Molecular Formula : C24H22D4N6O3

  • Molecular Weight : 450.53

Trityl Olmesartan-d6 Medoxomil


  • Catalogue No.:PA STI 085870

  • CAS : NA

  • Molecular Formula : C48H38D6N6O6

  • Molecular Weight : 806.94

N-Trityl Olmesartan-d6 Ethyl Ester


  • Catalogue No.:PA STI 085880

  • CAS : NA

  • Molecular Formula : C45H38D6N6O3

  • Molecular Weight : 722.91

N-Trityl Olmesartan-d4 Ethyl Ester


  • Catalogue No.:PA STI 085890

  • CAS : NA

  • Molecular Formula : C45H40D4N6O3

  • Molecular Weight : 720.89

Olmesartan Medoxomil - In house impurity

Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-4,5-dihydro-1H-imidazole-5-carboxylate


  • Catalogue No.:PA 15 26720

  • CAS : 1219207-91-6

  • Molecular Formula : C12H22N2O3

  • Molecular Weight : 242.32

Olmesartan Medoxomil - In house impurity

Dehydro Olmesartan-2-trityl Medoxomil


  • Catalogue No.:PA 15 26730

  • CAS : 1391052-99-5

  • Molecular Formula : C48H42N6O5

  • Molecular Weight : 782.90

Olmesartan Medoxomil - In house impurity

Potassium 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-1,2,3-triazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate


  • Catalogue No.:PA 15 26740

  • CAS : NA

  • Molecular Formula : C44H40KN5O3

  • Molecular Weight : 725.93

Olmesartan Medoxomil - In house impurity

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxybutan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate


  • Catalogue No.:PA 15 26750

  • CAS : 1378863-72-9

  • Molecular Formula : C49H46N6O6

  • Molecular Weight : 814.94

Olmesartan Medoxomil (IPRS/107/15)


  • Catalogue No.:PA IP-IPRS 107 15

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Olmesartan medoxomil (Y0001405)


  • Catalogue No.:PA EP-Y0001405

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Olmesartan medoxomil for system suitability (Y0001424)


  • Catalogue No.:PA EP-Y0001424

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

olmesartan medoxomil (1173RB)


  • Catalogue No.:PA BP-1173RB

  • CAS : NA

  • Molecular Formula :

  • Molecular Weight : 0.00

Olmesartan Medoxomil (1478367)


  • Catalogue No.:PA USP-1478367

  • CAS : 144689-63-4

  • Molecular Formula :

  • Molecular Weight : 0.00

Olmesartan Medoxomil Related Compound A (1-{[2'-(1H-Tetrazol-5-yl)biphenyl-4-yl]methyl}-4,4-dimethy (1478378)


  • Catalogue No.:PA USP-1478378

  • CAS : 849206-43-5

  • Molecular Formula :

  • Molecular Weight : 0.00

Olmesartan Medoxomil - In house impurity

Ethyl 4-(2-hydroxybutan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate


  • Catalogue No.:PA 15 26770

  • CAS : NA

  • Molecular Formula : C46H46N6O3

  • Molecular Weight : 730.91

Olmesartan Medoxomil - In house impurity

Ethyl 2-ethyl-4-(2-hydroxypropan-2-yl)-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate


  • Catalogue No.:PA 15 26780

  • CAS : NA

  • Molecular Formula : C44H42N6O3

  • Molecular Weight : 702.86

Olmesartan Medoxomil - In house impurity

Ethyl 4-(2-hydroxypropan-2-yl)-2-(2-hydroxypropyl)-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate


  • Catalogue No.:PA 15 26790

  • CAS : NA

  • Molecular Formula : C45H44N6O4

  • Molecular Weight : 732.89

Olmesartan Medoxomil - In house impurity

N2-Trityl Olmesartan Acid


  • Catalogue No.:PA 15 26760

  • CAS : 752179-89-8

  • Molecular Formula : C43H40N6O3

  • Molecular Weight : 688.82

Olmesartan Medoxomil - In house impurity

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethyl-4-(2-hydroxypropan-2-yl)-1-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate


  • Catalogue No.:PA 15 26800

  • CAS : NA

  • Molecular Formula : C47H42N6O6

  • Molecular Weight : 786.89

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UnexpectedValueException
The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied UnexpectedValueException thrown with message "The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied" Stacktrace: #10 UnexpectedValueException in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php:107 #9 Monolog\Handler\StreamHandler:write in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Handler/AbstractProcessingHandler.php:37 #8 Monolog\Handler\AbstractProcessingHandler:handle in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Logger.php:337 #7 Monolog\Logger:addRecord in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Logger.php:616 #6 Monolog\Logger:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php:179 #5 Illuminate\Log\Logger:writeLog in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php:90 #4 Illuminate\Log\Logger:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/LogManager.php:524 #3 Illuminate\Log\LogManager:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Exceptions/Handler.php:113 #2 Illuminate\Foundation\Exceptions\Handler:report in /home/pharmaaffiliates/public_html/app/Exceptions/Handler.php:43 #1 App\Exceptions\Handler:report in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Bootstrap/HandleExceptions.php:81 #0 Illuminate\Foundation\Bootstrap\HandleExceptions:handleException in [internal]:0
10
UnexpectedValueException
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StreamHandler.php
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AbstractProcessingHandler.php
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AbstractProcessingHandler
handle
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vendor
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monolog
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Logger.php
337
7
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Logger
addRecord
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monolog
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Logger.php
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Logger.php
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src
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Illuminate
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Logger.php
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4
Illuminate
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error
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src
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Illuminate
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LogManager.php
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framework
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src
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Illuminate
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Foundation
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Exceptions
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Handler.php
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Exceptions
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Handler
report
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Exceptions
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Handler.php
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Bootstrap
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HandleExceptions.php
81
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Illuminate
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Foundation
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Bootstrap
\
HandleExceptions
handleException
[internal]
0
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StreamHandler.php
    /**
     * {@inheritdoc}
     */
    protected function write(array $record)
    {
        if (!is_resource($this->stream)) {
            if (null === $this->url || '' === $this->url) {
                throw new \LogicException('Missing stream url, the stream can not be opened. This may be caused by a premature call to close().');
            }
            $this->createDir();
            $this->errorMessage = null;
            set_error_handler(array($this, 'customErrorHandler'));
            $this->stream = fopen($this->url, 'a');
            if ($this->filePermission !== null) {
                @chmod($this->url, $this->filePermission);
            }
            restore_error_handler();
            if (!is_resource($this->stream)) {
                $this->stream = null;
                throw new \UnexpectedValueException(sprintf('The stream or file "%s" could not be opened: '.$this->errorMessage, $this->url));
            }
        }
 
        if ($this->useLocking) {
            // ignoring errors here, there's not much we can do about them
            flock($this->stream, LOCK_EX);
        }
 
        $this->streamWrite($this->stream, $record);
 
        if ($this->useLocking) {
            flock($this->stream, LOCK_UN);
        }
    }
 
    /**
     * Write to stream
     * @param resource $stream
     * @param array $record
     */
Arguments
  1. "The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied"
    
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home
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pharmaaffiliates
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public_html
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Monolog
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Handler
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AbstractProcessingHandler.php
 *
 * @author Jordi Boggiano <j.boggiano@seld.be>
 * @author Christophe Coevoet <stof@notk.org>
 */
abstract class AbstractProcessingHandler extends AbstractHandler
{
    /**
     * {@inheritdoc}
     */
    public function handle(array $record)
    {
        if (!$this->isHandling($record)) {
            return false;
        }
 
        $record = $this->processRecord($record);
 
        $record['formatted'] = $this->getFormatter()->format($record);
 
        $this->write($record);
 
        return false === $this->bubble;
    }
 
    /**
     * Writes the record down to the log of the implementing handler
     *
     * @param  array $record
     * @return void
     */
    abstract protected function write(array $record);
 
    /**
     * Processes a record.
     *
     * @param  array $record
     * @return array
     */
    protected function processRecord(array $record)
    {
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571599058 {#33
        date: 2019-10-20 19:17:38.677290 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 19:17:38] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6IktjMEh...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6IktjMEh...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('jWjNBwanc6ZO7sY...', 'eyJpdiI6IktjMEh...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
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Logger.php
            $ts = new \DateTime(null, static::$timezone);
        }
        $ts->setTimezone(static::$timezone);
 
        $record = array(
            'message' => (string) $message,
            'context' => $context,
            'level' => $level,
            'level_name' => $levelName,
            'channel' => $this->name,
            'datetime' => $ts,
            'extra' => array(),
        );
 
        foreach ($this->processors as $processor) {
            $record = call_user_func($processor, $record);
        }
 
        while ($handler = current($this->handlers)) {
            if (true === $handler->handle($record)) {
                break;
            }
 
            next($this->handlers);
        }
 
        return true;
    }
 
    /**
     * Adds a log record at the DEBUG level.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function addDebug($message, array $context = array())
    {
        return $this->addRecord(static::DEBUG, $message, $context);
    }
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571599058 {#33
        date: 2019-10-20 19:17:38.677290 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 19:17:38] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6IktjMEh...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6IktjMEh...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('jWjNBwanc6ZO7sY...', 'eyJpdiI6IktjMEh...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Logger.php
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function err($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the ERROR level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function error($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function crit($message, array $context = array())
    {
        return $this->addRecord(static::CRITICAL, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
Arguments
  1. 400
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
Logger.php
     * @return void
     */
    public function write($level, $message, array $context = [])
    {
        $this->writeLog($level, $message, $context);
    }
 
    /**
     * Write a message to the log.
     *
     * @param  string  $level
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    protected function writeLog($level, $message, $context)
    {
        $this->fireLogEvent($level, $message = $this->formatMessage($message), $context);
 
        $this->logger->{$level}($message, $context);
    }
 
    /**
     * Register a new callback handler for when a log event is triggered.
     *
     * @param  \Closure  $callback
     * @return void
     *
     * @throws \RuntimeException
     */
    public function listen(Closure $callback)
    {
        if (! isset($this->dispatcher)) {
            throw new RuntimeException('Events dispatcher has not been set.');
        }
 
        $this->dispatcher->listen(MessageLogged::class, $callback);
    }
 
    /**
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
Logger.php
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function critical($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log an error message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function error($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a warning message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function warning($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a notice to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
Arguments
  1. "error"
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
LogManager.php
     *
     * @return void
     */
    public function critical($message, array $context = [])
    {
        return $this->driver()->critical($message, $context);
    }
 
    /**
     * Runtime errors that do not require immediate action but should typically
     * be logged and monitored.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function error($message, array $context = [])
    {
        return $this->driver()->error($message, $context);
    }
 
    /**
     * Exceptional occurrences that are not errors.
     *
     * Example: Use of deprecated APIs, poor use of an API, undesirable things
     * that are not necessarily wrong.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function warning($message, array $context = [])
    {
        return $this->driver()->warning($message, $context);
    }
 
    /**
     * Normal but significant events.
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Exceptions
/
Handler.php
     */
    public function report(Exception $e)
    {
        if ($this->shouldntReport($e)) {
            return;
        }
 
        if (method_exists($e, 'report')) {
            return $e->report();
        }
 
        try {
            $logger = $this->container->make(LoggerInterface::class);
        } catch (Exception $ex) {
            throw $e;
        }
 
        $logger->error(
            $e->getMessage(),
            array_merge($this->context(), ['exception' => $e]
        ));
    }
 
    /**
     * Determine if the exception should be reported.
     *
     * @param  \Exception  $e
     * @return bool
     */
    public function shouldReport(Exception $e)
    {
        return ! $this->shouldntReport($e);
    }
 
    /**
     * Determine if the exception is in the "do not report" list.
     *
     * @param  \Exception  $e
     * @return bool
     */
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
app
/
Exceptions
/
Handler.php
        \Illuminate\Auth\AuthenticationException::class,
        \Illuminate\Auth\Access\AuthorizationException::class,
        \Symfony\Component\HttpKernel\Exception\HttpException::class,
        \Illuminate\Database\Eloquent\ModelNotFoundException::class,
        \Illuminate\Session\TokenMismatchException::class,
        \Illuminate\Validation\ValidationException::class,
    ];
 
    /**
     * Report or log an exception.
     *
     * This is a great spot to send exceptions to Sentry, Bugsnag, etc.
     *
     * @param \Exception $exception
     *
     * @return void
     */
    public function report(Exception $exception)
    {
        parent::report($exception);
    }
 
    /**
     * Render an exception into an HTTP response.
     *
     * @param \Illuminate\Http\Request $request
     * @param \Exception               $exception
     *
     * @return \Illuminate\Http\Response
     */
    public function render($request, Exception $exception)
    {
        //dd($exception);
        if (strpos($request->url(), '/api/') !== false) {
            \Log::debug('API Request Exception - '.$request->url().' - '.$exception->getMessage().(!empty($request->all()) ? ' - '.json_encode($request->except(['password'])) : ''));
 
            if ($exception instanceof AuthorizationException) {
                return $this->setStatusCode(403)->respondWithError($exception->getMessage());
            }
 
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Bootstrap
/
HandleExceptions.php
    }
 
    /**
     * Handle an uncaught exception from the application.
     *
     * Note: Most exceptions can be handled via the try / catch block in
     * the HTTP and Console kernels. But, fatal error exceptions must
     * be handled differently since they are not normal exceptions.
     *
     * @param  \Throwable  $e
     * @return void
     */
    public function handleException($e)
    {
        if (! $e instanceof Exception) {
            $e = new FatalThrowableError($e);
        }
 
        try {
            $this->getExceptionHandler()->report($e);
        } catch (Exception $e) {
            //
        }
 
        if ($this->app->runningInConsole()) {
            $this->renderForConsole($e);
        } else {
            $this->renderHttpResponse($e);
        }
    }
 
    /**
     * Render an exception to the console.
     *
     * @param  \Exception  $e
     * @return void
     */
    protected function renderForConsole(Exception $e)
    {
        $this->getExceptionHandler()->renderForConsole(new ConsoleOutput, $e);
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
[internal]
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/jWjNBwanc6ZO7sYow7I3QcSSrsCubR8rz7pqmQto): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    

Environment & details:

empty
empty
empty
empty
empty
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
HTTP_ACCEPT
"text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8"
HTTP_ACCEPT_ENCODING
"gzip"
HTTP_ACCEPT_LANGUAGE
"en-US,en;q=0.5"
HTTP_CONNECTION
"Keep-Alive"
HTTP_HOST
"www.pharmaffiliates.com"
HTTP_USER_AGENT
"CCBot/2.0 (https://commoncrawl.org/faq/)"
HTTP_IF_MODIFIED_SINCE
"Tue, 16 Jul 2019 07:23:46 PDT"
DOCUMENT_ROOT
"/home/pharmaaffiliates/public_html"
REMOTE_ADDR
"3.228.24.192"
REMOTE_PORT
"33762"
SERVER_ADDR
"172.105.43.57"
SERVER_NAME
"www.pharmaffiliates.com"
SERVER_ADMIN
"webmaster@pharmaffiliates.com"
SERVER_PORT
"443"
REQUEST_URI
"/en/parentapi/olmesartan-medoxomil"
REDIRECT_URL
"/en/parentapi/olmesartan-medoxomil"
HTTPS
"on"
REDIRECT_STATUS
"200"
SSL_PROTOCOL
"TLSv1.2"
SSL_SESSION_ID
"853ebfcf32fba41c4ef0f888986329cbd17a44602196dc8addfd880a27ca164f"
SSL_CIPHER
"ECDHE-RSA-AES256-GCM-SHA384"
SSL_CIPHER_USEKEYSIZE
"256"
SSL_CIPHER_ALGKEYSIZE
"256"
SCRIPT_FILENAME
"/home/pharmaaffiliates/public_html/index.php"
QUERY_STRING
""
SCRIPT_URI
"https://www.pharmaffiliates.com/en/parentapi/olmesartan-medoxomil"
SCRIPT_URL
"/en/parentapi/olmesartan-medoxomil"
SCRIPT_NAME
"/index.php"
SERVER_PROTOCOL
"HTTP/1.1"
SERVER_SOFTWARE
"LiteSpeed"
REQUEST_METHOD
"GET"
X-LSCACHE
"on"
PHP_SELF
"/index.php"
REQUEST_TIME_FLOAT
1571599058.4163
REQUEST_TIME
1571599058
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
0. Whoops\Handler\PrettyPageHandler