| Catalogue number: | PA STI 053890 |
| Chemical name: | Isoniazid-d4 |
CAS Number: |
774596-24-6 |
| Category: | amines,aromatics,stable isotopes,pharmaceutical standards,intermediates,Fine Chemicals |
| Synonyms: | 4-(Pyridine-d4)carboxylic Acid Hydrazide; Isonicotinic Acid-d4 Hydrazide; 4-(Hydrazinocarbonyl)pyridine-d4; 4-(Pyridine-d4)carbonylhydrazine; 4-(Pyridine-d4)carboxylic Hydrazide; 4-(Pyridyl-d4)carbonylhydrazide; 5015 R.P.-d4; Armazid-d4; Armazide-d4; Atcotibine-d4; Isonizide-d4; Isotebezid-d4; Isozide-d4; Robisellin-d4; Sauterazid-d4; Zidon-d4; Zozide-d4; Tubazid-d4; 4-Pyridine-2,3,5,6-d4-carboxylic acid, hydrazide; |
| Molecular form: | C6H3D4N3O |
| Appearance: | White to Off-White Solid |
| Mol. Weight: | 141.16 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Labelled Isoniazid. Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic). |
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