Sacubitril-impurities | Pharmaffiliates

sacubitril

An antihypertensive drug, Sacubitril is used in combination with valsartan for the treatment of heart ailments. A prodrug of sacubitrilat which is an inhibitor of enzyme neprilysin, which aids the degradation of blood pressure-lowering peptides, atrial and brain natriuretic peptide.Reference standards of Sacubitril API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Sacubitrilat
    [catalogue_number] => PA 19 66580
    [category_ids] => 70,75,78,79,80,82
    [chemical_name] => 
    [weight] => 383.44
    [form] => C22H25NO5
    [cas] => 149709-44-4
    [pslug] => 149709-44-4-sacubitrilat-pa1966580
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PA 19 66580

Sacubitrilat


  • Catalogue No.:PA 19 66580

  • CAS :

    149709-44-4

  • Molecular Formula : C22H25NO5

  • Molecular Weight : 383.44

stdClass Object
(
    [pname] => (R,E)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpent-2-enoic Acid
    [catalogue_number] => PA 19 66590
    [category_ids] => ,80,75,70,82,78,79,
    [chemical_name] => 
    [weight] => 381.42
    [form] => C22H23NO5
    [cas] => NA
    [pslug] => r-e-5-1-1-biphenyl-4-yl-4-3-carboxypropanamido-2-methylpent-2-enoic-acid-pa1966590
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PA 19 66590

(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpent-2-enoic Acid


  • Catalogue No.:PA 19 66590

  • CAS :

    NA

  • Molecular Formula : C22H23NO5

  • Molecular Weight : 381.42

stdClass Object
(
    [pname] => Sacubitril mixture with Valsartan - API Standards
    [catalogue_number] => PA 19 66600
    [category_ids] => 80,79,71,82,78,75,70
    [chemical_name] => 
    [weight] => 847.01
    [form] => C48H58N6O8
    [cas] => NA
    [pslug] => sacubitril-mixture-with-valsartan-pa1966600
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PA 19 66600

Sacubitril mixture with Valsartan - API Standards


  • Catalogue No.:PA 19 66600

  • CAS :

    NA

  • Molecular Formula : C48H58N6O8

  • Molecular Weight : 847.01

stdClass Object
(
    [pname] => Sacubitril Calcium - API Standards 
    [catalogue_number] => PA 19 66610
    [category_ids] => ,80,75,70,82,78,79,71,
    [chemical_name] => 
    [weight] => 430.52
    [form] => C24H28NO5 ·0.5Ca
    [cas] => 1369773-39-6
    [pslug] => 1369773-39-6-sacubitril-calcium-pa1966610
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PA 19 66610

Sacubitril Calcium - API Standards


  • Catalogue No.:PA 19 66610

  • CAS :

    1369773-39-6

  • Molecular Formula : C24H28NO5 ·0.5Ca

  • Molecular Weight : 430.52

stdClass Object
(
    [pname] => Sacubitril (3R,5S)-Pyrrolidinone Impurity
    [catalogue_number] => PA 19 66620
    [category_ids] => 82,80,79,78,75,70
    [chemical_name] => 
    [weight] => 265.35
    [form] => C18H19NO
    [cas] => 1038924-70-7
    [pslug] => 1038924-70-7-sacubitril-3r-5s-pyrrolidinone-impurity-pa1966620
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PA 19 66620

Sacubitril (3R,5S)-Pyrrolidinone Impurity


  • Catalogue No.:PA 19 66620

  • CAS :

    1038924-70-7

  • Molecular Formula : C18H19NO

  • Molecular Weight : 265.35

stdClass Object
(
    [pname] => (R,E)-5-([1,1-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic Acid
    [catalogue_number] => PA 19 66630
    [category_ids] => ,80,75,70,82,78,79,
    [chemical_name] => 
    [weight] => 379.5
    [form] => C24H29NO3
    [cas] => 1012341-48-8
    [pslug] => 1012341-48-8-r-e-5-1-1-biphenyl-4-yl-4-tert-butoxycarbonyl-amino-2-methylpent-2-enoic-acid-pa1966630
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PA 19 66630

(R,E)-5-([1,1-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic Acid


  • Catalogue No.:PA 19 66630

  • CAS :

    1012341-48-8

  • Molecular Formula : C24H29NO3

  • Molecular Weight : 379.5

stdClass Object
(
    [pname] => (R,E)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate
    [catalogue_number] => PA 19 66640
    [category_ids] => 80,79,70,82,78,75
    [chemical_name] => 
    [weight] => 409.53
    [form] => C25H31NO4
    [cas] => 1817838-91-7
    [pslug] => 1817838-91-7-r-e-ethyl-5-1-1-biphenyl-4-yl-4-tert-butoxycarbonyl-amino-2-methylpent-2-enoate-pa1966640
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PA 19 66640

(R,E)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate


  • Catalogue No.:PA 19 66640

  • CAS :

    1817838-91-7

  • Molecular Formula : C25H31NO4

  • Molecular Weight : 409.53

stdClass Object
(
    [pname] => Methyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride
    [catalogue_number] => PA 19 66650
    [category_ids] => ,80,75,70,82,78,79,
    [chemical_name] => 
    [weight] => 333.86
    [form] => C19H24ClNO2
    [cas] => 1933501-50-8
    [pslug] => 1933501-50-8-methyl-2r-4s-5-1-1-biphenyl-4-yl-4-amino-2-methylpentanoate-hydrochloride-pa1966650
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PA 19 66650

Methyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride


  • Catalogue No.:PA 19 66650

  • CAS :

    1933501-50-8

  • Molecular Formula : C19H24ClNO2

  • Molecular Weight : 333.86

stdClass Object
(
    [pname] => (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
    [catalogue_number] => PA 19 66660
    [category_ids] => ,80,75,70,82,78,79,
    [chemical_name] => 
    [weight] => 347.88
    [form] => C20H26ClNO2
    [cas] => 149690-12-0
    [pslug] => 149690-12-0-2r-4s-4-amino-5-biphenyl-4-yl-2-methylpentanoic-acid-ethyl-ester-hydrochloride-pa1966660
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PA 19 66660

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride


  • Catalogue No.:PA 19 66660

  • CAS :

    149690-12-0

  • Molecular Formula : C20H26ClNO2

  • Molecular Weight : 347.88

stdClass Object
(
    [pname] => Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate
    [catalogue_number] => PA 19 66670
    [category_ids] => 82,80,79,78,75,70
    [chemical_name] => 
    [weight] => 411.54
    [form] => C25H33NO4
    [cas] => 149709-60-4
    [pslug] => 149709-60-4-ethyl-2r-4s-5-1-1-biphenyl-4-yl-4-tert-butoxycarbonyl-amino-2-methylpentanoate-pa1966670
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PA 19 66670

Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate


  • Catalogue No.:PA 19 66670

  • CAS :

    149709-60-4

  • Molecular Formula : C25H33NO4

  • Molecular Weight : 411.54

stdClass Object
(
    [pname] => (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoic Acid Hydrochloride
    [catalogue_number] => PA 19 66680
    [category_ids] => ,80,75,70,82,78,79,
    [chemical_name] => 
    [weight] => 319.83
    [form] => C18H22ClNO2
    [cas] => 1038924-71-8
    [pslug] => 1038924-71-8-2r-4s-5-1-1-biphenyl-4-yl-4-amino-2-methylpentanoic-acid-hydrochloride-pa1966680
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PA 19 66680

(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoic Acid Hydrochloride


  • Catalogue No.:PA 19 66680

  • CAS :

    1038924-71-8

  • Molecular Formula : C18H22ClNO2

  • Molecular Weight : 319.83

stdClass Object
(
    [pname] => Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-acetamido-2-methylpentanoate
    [catalogue_number] => PA 19 66690
    [category_ids] => ,80,75,70,82,78,79,
    [chemical_name] => 
    [weight] => 353.46
    [form] => C22H27NO3
    [cas] => NA
    [pslug] => ethyl-2r-4s-5-1-1-biphenyl-4-yl-4-acetamido-2-methylpentanoate-pa1966690
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PA 19 66690

Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-acetamido-2-methylpentanoate


  • Catalogue No.:PA 19 66690

  • CAS :

    NA

  • Molecular Formula : C22H27NO3

  • Molecular Weight : 353.46

stdClass Object
(
    [pname] => 2,5-Dioxopyrrolidine Sacubitril
    [catalogue_number] => PA 19 66700
    [category_ids] => ,80,75,70,82,78,79,
    [chemical_name] => 
    [weight] => 393.48
    [form] => C24H27NO4
    [cas] => 1038924-97-8
    [pslug] => 1038924-97-8-2-5-dioxopyrrolidine-sacubitril-pa1966700
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PA 19 66700

2,5-Dioxopyrrolidine Sacubitril


  • Catalogue No.:PA 19 66700

  • CAS :

    1038924-97-8

  • Molecular Formula : C24H27NO4

  • Molecular Weight : 393.48

stdClass Object
(
    [pname] => ((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-butyl Ester
    [catalogue_number] => PA 19 66710
    [category_ids] => ,80,75,70,82,78,79,
    [chemical_name] => 
    [weight] => 325.41
    [form] => C20H23NO3
    [cas] => 149709-58-0
    [pslug] => 149709-58-0-r-2-biphenyl-4-yl-1-formylethyl-carbamic-acid-t-butyl-ester-pa1966710
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PA 19 66710

((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-butyl Ester


  • Catalogue No.:PA 19 66710

  • CAS :

    149709-58-0

  • Molecular Formula : C20H23NO3

  • Molecular Weight : 325.41

stdClass Object
(
    [pname] => (R)-tert-Butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
    [catalogue_number] => PA 19 66720
    [category_ids] => 82,80,79,78,75,70
    [chemical_name] => 
    [weight] => 327.42
    [form] => C20H25NO3
    [cas] => 1426129-50-1
    [pslug] => 1426129-50-1-r-tert-butyl-1-1-1-biphenyl-4-yl-3-hydroxypropan-2-yl-carbamate-pa1966720
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PA 19 66720

(R)-tert-Butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate


  • Catalogue No.:PA 19 66720

  • CAS :

    1426129-50-1

  • Molecular Formula : C20H25NO3

  • Molecular Weight : 327.42

stdClass Object
(
    [pname] => Ethyl (R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate
    [catalogue_number] => PA 19 0661046
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    [weight] => 409.53
    [form] => C25H31NO4
    [cas] => 149709-59-1
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PA 19 0661046

Ethyl (R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate


  • Catalogue No.:PA 19 0661046

  • CAS :

    149709-59-1

  • Molecular Formula : C25H31NO4

  • Molecular Weight : 409.53

stdClass Object
(
    [pname] => Ethyl (S,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate
    [catalogue_number] => PA 19 0661056
    [category_ids] => ,80,79,70,82,78,75,
    [chemical_name] => 
    [weight] => 409.53
    [form] => C25H31NO4
    [cas] => 2131788-25-3
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PA 19 0661056

Ethyl (S,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate


  • Catalogue No.:PA 19 0661056

  • CAS :

    2131788-25-3

  • Molecular Formula : C25H31NO4

  • Molecular Weight : 409.53