Sofosbuvir-impurities | Pharmaffiliates

sofosbuvir

A recently approved nucleotide analog used in the treatment of hepatitis. Sofosbuvir works by inhibiting the hepatitis C NS5B protein. It is a a prodrug of its active antiviral agent GS-461203 Reference standards of Sofosbuvir API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

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(
    [pname] => Sofosbuvir - API Standards 
    [catalogue_number] => PA 19 51000
    [category_ids] => ,80,77,79,71,98,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 529.45
    [form] => C22H29FN3O9P
    [cas] => 1190307-88-0
    [pslug] => 1190307-88-0-sofosbuvir-api-pa1951000
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PA 19 51000

Sofosbuvir - API Standards


  • Catalogue No.:PA 19 51000

  • CAS :

    1190307-88-0

  • Molecular Formula : C22H29FN3O9P

  • Molecular Weight : 529.45

stdClass Object
(
    [pname] => Sofosbuvir Metabolite GS-566500
    [catalogue_number] => PA 19 51520
    [category_ids] => ,80,77,79,71,98,76,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 411.28
    [form] => C13H19FN3O9P
    [cas] => 1233335-78-8
    [pslug] => 1233335-78-8-sofosbuvir-metabolite-gs-566500-pa1951520
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PA 19 51520

Sofosbuvir Metabolite GS-566500


  • Catalogue No.:PA 19 51520

  • CAS :

    1233335-78-8

  • Molecular Formula : C13H19FN3O9P

  • Molecular Weight : 411.28

stdClass Object
(
    [pname] => ((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methyl dihydrogen Phosphate
    [catalogue_number] => PA 19 51530
    [category_ids] => 85,83,82,80,79,78,77,76,71,70
    [chemical_name] => 
    [weight] => 340.2
    [form] => C10H14FN2O8P
    [cas] => 1015073-43-4
    [pslug] => 1015073-43-4-2r-3r-4r-5r-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methyl-dihydrogen-phosphate-pa1951530
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PA 19 51530

((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methyl dihydrogen Phosphate


  • Catalogue No.:PA 19 51530

  • CAS :

    1015073-43-4

  • Molecular Formula : C10H14FN2O8P

  • Molecular Weight : 340.2

stdClass Object
(
    [pname] => 1-((2R,3R,4R,5R)-3-Chloro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
    [catalogue_number] => PA 19 51660
    [category_ids] => ,77,79,71,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 276.67
    [form] => C10H13ClN2O5
    [cas] => 1496551-72-4
    [pslug] => 1496551-72-4-1-2r-3r-4r-5r-3-chloro-4-hydroxy-5-hydroxymethyl-3-methyltetrahydrofuran-2-yl-pyrimidine-2-4-1h-3h-dione-pa1951660
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PA 19 51660

1-((2R,3R,4R,5R)-3-Chloro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione


  • Catalogue No.:PA 19 51660

  • CAS :

    1496551-72-4

  • Molecular Formula : C10H13ClN2O5

  • Molecular Weight : 276.67

stdClass Object
(
    [pname] => Sofosbuvir (R)-Phosphate
    [catalogue_number] => PA 19 51770
    [category_ids] => ,71,75,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 529.45
    [form] => C22H29FN3O9P
    [cas] => 1190308-01-0
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PA 19 51770

Sofosbuvir (R)-Phosphate


  • Catalogue No.:PA 19 51770

  • CAS :

    1190308-01-0

  • Molecular Formula : C22H29FN3O9P

  • Molecular Weight : 529.45

stdClass Object
(
    [pname] => D-Alanine Sofosbuvir
    [catalogue_number] => PA 19 51780
    [category_ids] => 85,83,82,78,75,71,70
    [chemical_name] => 
    [weight] => 529.45
    [form] => C22H29FN3O9P
    [cas] => 1064684-71-4
    [pslug] => 1064684-71-4-d-alanine-sofosbuvir-pa1951780
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PA 19 51780

D-Alanine Sofosbuvir


  • Catalogue No.:PA 19 51780

  • CAS :

    1064684-71-4

  • Molecular Formula : C22H29FN3O9P

  • Molecular Weight : 529.45

stdClass Object
(
    [pname] => Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
    [catalogue_number] => PA 19 51790
    [category_ids] => ,71,75,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 529.45
    [form] => C22H29FN3O9P
    [cas] => NA
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PA 19 51790

Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate


  • Catalogue No.:PA 19 51790

  • CAS :

    NA

  • Molecular Formula : C22H29FN3O9P

  • Molecular Weight : 529.45

stdClass Object
(
    [pname] => (R)-Isopropyl 2-(((R)-(((2R,3R,4R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
    [catalogue_number] => PA 19 51800
    [category_ids] => ,71,75,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 529.45
    [form] => C22H29FN3O9P
    [cas] => 1496552-16-9
    [pslug] => 1496552-16-9-r-isopropyl-2-r-2r-3r-4r-5s-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methoxy-phenoxy-phosphoryl-amino-propanoate-pa1951800
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PA 19 51800

(R)-Isopropyl 2-(((R)-(((2R,3R,4R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate


  • Catalogue No.:PA 19 51800

  • CAS :

    1496552-16-9

  • Molecular Formula : C22H29FN3O9P

  • Molecular Weight : 529.45

stdClass Object
(
    [pname] => (R)-Sofosbuvir Pentafluorophenoxy Analogue 
    [catalogue_number] => PA 19 51810
    [category_ids] => ,71,75,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 453.3
    [form] => C18H17F5NO5P
    [cas] => 1334513-02-8
    [pslug] => 1334513-02-8-r-sofosbuvir-pentafluorophenoxy-analogue-pa1951810
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PA 19 51810

(R)-Sofosbuvir Pentafluorophenoxy Analogue


  • Catalogue No.:PA 19 51810

  • CAS :

    1334513-02-8

  • Molecular Formula : C18H17F5NO5P

  • Molecular Weight : 453.3

stdClass Object
(
    [pname] => Chloro Sofosbuvir
    [catalogue_number] => PA 19 51820
    [category_ids] => ,79,80,71,76,75,85,83,78,70,82,72,
    [chemical_name] => 
    [weight] => 545.91
    [form] => C22H29ClN3O9P
    [cas] => 1496552-51-2
    [pslug] => 1496552-51-2-chloro-sofosbuvir-pa1951820
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PA 19 51820

Chloro Sofosbuvir


  • Catalogue No.:PA 19 51820

  • CAS :

    1496552-51-2

  • Molecular Formula : C22H29ClN3O9P

  • Molecular Weight : 545.91

stdClass Object
(
    [pname] => Sofosbuvir 3',5'-Bis-(S)-phosphate
    [catalogue_number] => PA 19 51830
    [category_ids] => ,71,75,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 798.69
    [form] => C34H45FN4O13P2
    [cas] => 1337482-17-3
    [pslug] => 1337482-17-3-sofosbuvir-3-5-bis-s-phosphate-pa1951830
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PA 19 51830

Sofosbuvir 3',5'-Bis-(S)-phosphate


  • Catalogue No.:PA 19 51830

  • CAS :

    1337482-17-3

  • Molecular Formula : C34H45FN4O13P2

  • Molecular Weight : 798.69

stdClass Object
(
    [pname] => Sofosbuvir 5'-Desphosphate 3'-O-[(S)-Phosphate]
    [catalogue_number] => PA 19 51840
    [category_ids] => ,71,75,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 529.45
    [form] => C22H29FN3O9P
    [cas] => 1337482-15-1
    [pslug] => 1337482-15-1-sofosbuvir-5-desphosphate-3-o-s-phosphate-pa1951840
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PA 19 51840

Sofosbuvir 5'-Desphosphate 3'-O-[(S)-Phosphate]


  • Catalogue No.:PA 19 51840

  • CAS :

    1337482-15-1

  • Molecular Formula : C22H29FN3O9P

  • Molecular Weight : 529.45

stdClass Object
(
    [pname] => ((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methyl Phenyl Hydrogen Phosphate
    [catalogue_number] => PA 19 51850
    [category_ids] => ,71,75,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 416.29
    [form] => C16H18FN2O8P
    [cas] => 1859162-80-3
    [pslug] => 1859162-80-3-2r-3r-4r-5r-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methyl-phenyl-hydrogen-phosphate-pa1951850
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PA 19 51850

((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methyl Phenyl Hydrogen Phosphate


  • Catalogue No.:PA 19 51850

  • CAS :

    1859162-80-3

  • Molecular Formula : C16H18FN2O8P

  • Molecular Weight : 416.29

stdClass Object
(
    [pname] => Sofosbuvir α-Isomer
    [catalogue_number] => PA 19 51860
    [category_ids] => ,71,75,85,83,78,70,82,72,
    [chemical_name] => 
    [weight] => 529.45
    [form] => C22H29FN3O9P
    [cas] => NA
    [pslug] => sofosbuvir-alpha-isomer-pa1951860
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PA 19 51860

Sofosbuvir α-Isomer


  • Catalogue No.:PA 19 51860

  • CAS :

    NA

  • Molecular Formula : C22H29FN3O9P

  • Molecular Weight : 529.45

stdClass Object
(
    [pname] => (2R,3S,4S,5S)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
    [catalogue_number] => PA 19 51870
    [category_ids] => ,71,75,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 571.55
    [form] => C31H26FN3O7
    [cas] => NA
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PA 19 51870

(2R,3S,4S,5S)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate


  • Catalogue No.:PA 19 51870

  • CAS :

    NA

  • Molecular Formula : C31H26FN3O7

  • Molecular Weight : 571.55

stdClass Object
(
    [pname] => (S)-Isopropyl 2-(((S)-(((2S,3S,4S,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
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PA 19 51880

(S)-Isopropyl 2-(((S)-(((2S,3S,4S,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate


  • Catalogue No.:PA 19 51880

  • CAS :

    NA

  • Molecular Formula : C22H29FN3O9P

  • Molecular Weight : 529.45

stdClass Object
(
    [pname] => (R)-Isopropyl 2-(((R)-(((2S,3S,4S,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
    [catalogue_number] => PA 19 51890
    [category_ids] => ,71,75,85,83,78,70,82,72,
    [chemical_name] => 
    [weight] => 529.45
    [form] => C22H29FN3O9P
    [cas] => NA
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PA 19 51890

(R)-Isopropyl 2-(((R)-(((2S,3S,4S,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate


  • Catalogue No.:PA 19 51890

  • CAS :

    NA

  • Molecular Formula : C22H29FN3O9P

  • Molecular Weight : 529.45

stdClass Object
(
    [pname] => Isopropyl ((((3S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate
    [catalogue_number] => PA 19 0511018
    [category_ids] => ,80,77,79,71,98,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 529.46
    [form] => C22H29FN3O9P
    [cas] => 2766447-19-0
    [pslug] => 2766447-19-0-isopropyl-3s-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methoxy-phenoxy-phosphoryl-d-alaninate-pa190511018
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PA 19 0511018

Isopropyl ((((3S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate


  • Catalogue No.:PA 19 0511018

  • CAS :

    2766447-19-0

  • Molecular Formula : C22H29FN3O9P

  • Molecular Weight : 529.46

stdClass Object
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    [pname] => Isopropyl ((S)-(((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
    [catalogue_number] => PA 19 0511019
    [category_ids] => ,80,77,79,71,98,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 528.47
    [form] => C22H30FN4O8P
    [cas] => 1334513-10-8
    [pslug] => 1334513-10-8-isopropyl-s-2r-3r-4r-5r-5-4-amino-2-oxopyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methoxy-phenoxy-phosphoryl-l-alaninate-pa190511019
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PA 19 0511019

Isopropyl ((S)-(((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate


  • Catalogue No.:PA 19 0511019

  • CAS :

    1334513-10-8

  • Molecular Formula : C22H30FN4O8P

  • Molecular Weight : 528.47

stdClass Object
(
    [pname] => Isopropyl ((S)-((S)-1-((2S,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)-L-alaninate
    [catalogue_number] => PA 19 0511020
    [category_ids] => ,80,77,79,71,98,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 541.49
    [form] => C23H32N3O10P
    [cas] => 2500766-09-4
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PA 19 0511020

Isopropyl ((S)-((S)-1-((2S,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)-L-alaninate


  • Catalogue No.:PA 19 0511020

  • CAS :

    2500766-09-4

  • Molecular Formula : C23H32N3O10P

  • Molecular Weight : 541.49