Afatinib-Impurities | Pharmaffiliates

afatinib

afatinib is a protein kinase inhibitor, it is used for the treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It is also known as Gilotrif and Giotrif. Reference standards of Afatinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
    [catalogue_number] => PA 28 02550
    [category_ids] => ,89,79,80,71,78,
    [chemical_name] => 
    [weight] => 374.8
    [form] => C18H16ClFN4O2
    [cas] => 314771-76-1
    [pslug] => 314771-76-1-s-n4-3-chloro-4-fluorophenyl-7-tetrahydrofuran-3-yl-oxy-quinazoline-4-6-diamine-pa2802550
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02550

(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine


  • Catalogue No.:PA 28 02550

  • CAS :

    314771-76-1

  • Molecular Formula : C18H16ClFN4O2

  • Molecular Weight : 374.8

stdClass Object
(
    [pname] => (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide
    [catalogue_number] => PA 28 02560
    [category_ids] => ,89,79,80,71,78,
    [chemical_name] => 
    [weight] => 402.81
    [form] => C19H16ClFN4O3
    [cas] => 2223677-60-7
    [pslug] => 2223677-60-7-s-n-4-3-chloro-4-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-formamide-pa2802560
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02560

(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide


  • Catalogue No.:PA 28 02560

  • CAS :

    2223677-60-7

  • Molecular Formula : C19H16ClFN4O3

  • Molecular Weight : 402.81

stdClass Object
(
    [pname] => (S)-N-(((4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methylene)-N-methylmethanaminium
    [catalogue_number] => PA 28 02570
    [category_ids] => ,89,79,80,71,78,
    [chemical_name] => 
    [weight] => 430.88
    [form] => C21H22ClFN5O2
    [cas] => NA
    [pslug] => s-n-4-3-chloro-4-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-amino-methylene-n-methylmethanaminium-pa2802570
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02570

(S)-N-(((4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methylene)-N-methylmethanaminium


  • Catalogue No.:PA 28 02570

  • CAS :

    NA

  • Molecular Formula : C21H22ClFN5O2

  • Molecular Weight : 430.88

stdClass Object
(
    [pname] => (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
    [catalogue_number] => PA 28 02590
    [category_ids] => ,89,79,80,71,78,
    [chemical_name] => 
    [weight] => 503.95
    [form] => C24H27ClFN5O4
    [cas] => NA
    [pslug] => s-n-4-3-chloro-4-fluorophenyl-amino-7-s-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-4-dimethylamino-3-hydroxybutanamide-pa2802590
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02590

(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide


  • Catalogue No.:PA 28 02590

  • CAS :

    NA

  • Molecular Formula : C24H27ClFN5O4

  • Molecular Weight : 503.95

stdClass Object
(
    [pname] => (R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
    [catalogue_number] => PA 28 02600
    [category_ids] => ,89,79,80,71,78,
    [chemical_name] => 
    [weight] => 503.95
    [form] => C24H27ClFN5O4
    [cas] => NA
    [pslug] => r-n-4-3-chloro-4-fluorophenyl-amino-7-s-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-4-dimethylamino-3-hydroxybutanamide-pa2802600
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02600

(R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide


  • Catalogue No.:PA 28 02600

  • CAS :

    NA

  • Molecular Formula : C24H27ClFN5O4

  • Molecular Weight : 503.95

stdClass Object
(
    [pname] => (S,E)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
    [catalogue_number] => PA 28 02610
    [category_ids] => ,89,79,80,71,78,
    [chemical_name] => 
    [weight] => 485.94
    [form] => C24H25ClFN5O3
    [cas] => 2475094-87-0
    [pslug] => 2475094-87-0-s-e-n-4-4-chloro-3-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-4-dimethylamino-but-2-enamide-pa2802610
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02610

(S,E)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide


  • Catalogue No.:PA 28 02610

  • CAS :

    2475094-87-0

  • Molecular Formula : C24H25ClFN5O3

  • Molecular Weight : 485.94

stdClass Object
(
    [pname] => (S,E)-4-(Dimethylamino)-N-(4-((4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
    [catalogue_number] => PA 28 02620
    [category_ids] => ,89,79,80,71,78,
    [chemical_name] => 
    [weight] => 451.49
    [form] => C24H26FN5O3
    [cas] => 2413212-25-4
    [pslug] => 2413212-25-4-s-e-4-dimethylamino-n-4-4-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-but-2-enamide-pa2802620
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02620

(S,E)-4-(Dimethylamino)-N-(4-((4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide


  • Catalogue No.:PA 28 02620

  • CAS :

    2413212-25-4

  • Molecular Formula : C24H26FN5O3

  • Molecular Weight : 451.49

stdClass Object
(
    [pname] => (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(methylamino)but-2-enamide
    [catalogue_number] => PA 28 02710
    [category_ids] => ,89,79,80,71,78,
    [chemical_name] => 
    [weight] => 471.91
    [form] => C23H23ClFN5O3
    [cas] => 2413212-13-0
    [pslug] => 2413212-13-0-s-e-n-4-3-chloro-4-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-4-methylamino-but-2-enamide-pa2802710
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02710

(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(methylamino)but-2-enamide


  • Catalogue No.:PA 28 02710

  • CAS :

    2413212-13-0

  • Molecular Formula : C23H23ClFN5O3

  • Molecular Weight : 471.91

stdClass Object
(
    [pname] => (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
    [catalogue_number] => PA 28 02730
    [category_ids] => 78,89,80,79
    [chemical_name] => 
    [weight] => 443.9
    [form] => C22H23ClFN5O2
    [cas] => 2085843-51-0
    [pslug] => 2085843-51-0-e-n-4-3-chloro-4-fluorophenyl-amino-7-ethoxyquinazolin-6-yl-4-dimethylamino-but-2-enamide-pa2802730
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02730

(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide


  • Catalogue No.:PA 28 02730

  • CAS :

    2085843-51-0

  • Molecular Formula : C22H23ClFN5O2

  • Molecular Weight : 443.9

stdClass Object
(
    [pname] => (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
    [catalogue_number] => PA 28 02740
    [category_ids] => ,89,79,80,78,
    [chemical_name] => 
    [weight] => 429.88
    [form] => C21H21ClFN5O2
    [cas] => 1245555-42-3
    [pslug] => 1245555-42-3-e-n-4-3-chloro-4-fluorophenyl-amino-7-methoxyquinazolin-6-yl-4-dimethylamino-but-2-enamide-pa2802740
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02740

(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide


  • Catalogue No.:PA 28 02740

  • CAS :

    1245555-42-3

  • Molecular Formula : C21H21ClFN5O2

  • Molecular Weight : 429.88

stdClass Object
(
    [pname] => (S)-N-(4-((4-Fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide
    [catalogue_number] => PA 28 02750
    [category_ids] => ,89,79,80,78,71,
    [chemical_name] => 
    [weight] => 368.36
    [form] => C19H17FN4O3
    [cas] => NA
    [pslug] => s-n-4-4-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-formamide-pa2802750
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02750

(S)-N-(4-((4-Fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide


  • Catalogue No.:PA 28 02750

  • CAS :

    NA

  • Molecular Formula : C19H17FN4O3

  • Molecular Weight : 368.36

stdClass Object
(
    [pname] => (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide
    [catalogue_number] => PA 28 02760
    [category_ids] => ,89,79,80,70,82,
    [chemical_name] => 
    [weight] => 458.87
    [form] => C22H20ClFN4O4
    [cas] => 2121530-37-6
    [pslug] => 2121530-37-6-s-e-n-4-3-chloro-4-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-4-hydroxybut-2-enamide-pa2802760
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02760

(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide


  • Catalogue No.:PA 28 02760

  • CAS :

    2121530-37-6

  • Molecular Formula : C22H20ClFN4O4

  • Molecular Weight : 458.87

stdClass Object
(
    [pname] => (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
    [catalogue_number] => PA 28 02800
    [category_ids] => 79,80,89,82,78,70
    [chemical_name] => 
    [weight] => 442.87
    [form] => C22H20ClFN4O3
    [cas] => 2223677-64-1
    [pslug] => 2223677-64-1-s-e-n-4-3-chloro-4-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-but-2-enamide-pa2802800
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02800

(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide


  • Catalogue No.:PA 28 02800

  • CAS :

    2223677-64-1

  • Molecular Formula : C22H20ClFN4O3

  • Molecular Weight : 442.87

stdClass Object
(
    [pname] => 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-2-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
    [catalogue_number] => PA 28 02820
    [category_ids] => ,89,79,80,71,78,
    [chemical_name] => 
    [weight] => 458.87
    [form] => C22H20ClFN4O4
    [cas] => NA
    [pslug] => 1-4-3-chloro-4-fluorophenyl-amino-7-s-tetrahydrofuran-2-yl-oxy-quinazolin-6-yl-5-hydroxypyrrolidin-2-one-pa2802820
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 02820

1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-2-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one


  • Catalogue No.:PA 28 02820

  • CAS :

    NA

  • Molecular Formula : C22H20ClFN4O4

  • Molecular Weight : 458.87

stdClass Object
(
    [pname] => (S)-N-(4-((4-Fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide
    [catalogue_number] => PA 28 0021010
    [category_ids] => ,71,78,79,80,89,
    [chemical_name] => 
    [weight] => 368.37
    [form] => C19H17FN4O3
    [cas] => NA
    [pslug] => s-n-4-4-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-formamide-pa280021010
    [latest_product] => 0
    [linkproducts] => 0
    [offers_id] => 
    [offers_name] => 
    [offers_status] => 
    [offers_start_date] => 
    [offers_end_date] => 
    [pageview] => 
    [offers_slug] => 
    [offers_product_id] => 
    [offers_product_code] => 
    [offers_master_id] => 
    [offer_percentage] => 
    [offers_product_main_cat] => 
)
PA 28 0021010

(S)-N-(4-((4-Fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide


  • Catalogue No.:PA 28 0021010

  • CAS :

    NA

  • Molecular Formula : C19H17FN4O3

  • Molecular Weight : 368.37