Sitagliptin-impurities | Pharmaffiliates

sitagliptin

Sitagliptin impurity B is also known as Defluoro Sitagliptin, an impurity of Sitagliptan, an dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Reference standards of Sitagliptin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

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(
    [pname] => (R)-3-Amino-4-(2-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
    [catalogue_number] => PA 19 0481062
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 371.34
    [form] => C16H17F4N5O
    [cas] => 945261-45-0
    [pslug] => 945261-45-0-r-3-amino-4-2-fluorophenyl-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-butan-1-one-pa190481062
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PA 19 0481062

(R)-3-Amino-4-(2-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one


  • Catalogue No.:PA 19 0481062

  • CAS :

    945261-45-0

  • Molecular Formula : C16H17F4N5O

  • Molecular Weight : 371.34

stdClass Object
(
    [pname] => (R)-3-Amino-4-(2-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
    [catalogue_number] => PA 19 0481063
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 387.79
    [form] => C16H17ClF3N5O
    [cas] => 945261-56-3
    [pslug] => 945261-56-3-r-3-amino-4-2-chlorophenyl-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-butan-1-one-pa190481063
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PA 19 0481063

(R)-3-Amino-4-(2-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one


  • Catalogue No.:PA 19 0481063

  • CAS :

    945261-56-3

  • Molecular Formula : C16H17ClF3N5O

  • Molecular Weight : 387.79

stdClass Object
(
    [pname] => (R)-3-Amino-4-(2,4-dichlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
    [catalogue_number] => PA 19 0481064
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 422.23
    [form] => C16H16Cl2F3N5O
    [cas] => 945261-60-9
    [pslug] => 945261-60-9-r-3-amino-4-2-4-dichlorophenyl-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-butan-1-one-pa190481064
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PA 19 0481064

(R)-3-Amino-4-(2,4-dichlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one


  • Catalogue No.:PA 19 0481064

  • CAS :

    945261-60-9

  • Molecular Formula : C16H16Cl2F3N5O

  • Molecular Weight : 422.23

stdClass Object
(
    [pname] => 7-Nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-5,5,6,6-d4
    [catalogue_number] => PA STI 089295
    [category_ids] => ,71,75,79,80,89,92,98,162,
    [chemical_name] => 
    [weight] => 225.17
    [form] => C6H2D4F3N5O
    [cas] => NA
    [pslug] => 7-nitroso-3-trifluoromethyl-5-6-7-8-tetrahydro-1-2-4-triazolo-4-3-a-pyrazine-5-5-6-6-d4-pasti089295
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PA STI 089295

7-Nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-5,5,6,6-d4


  • Catalogue No.:PA STI 089295

  • CAS :

    NA

  • Molecular Formula : C6H2D4F3N5O

  • Molecular Weight : 225.17

stdClass Object
(
    [pname] => (R)-3-Amino-1-morpholino-4-(2,4,5-trifluorophenyl)butan-1-one
    [catalogue_number] => PA 19 0481066
    [category_ids] => ,80,92,79,75,89,71,
    [chemical_name] => 
    [weight] => 302.3
    [form] => C14H17F3N2O2
    [cas] => 2248445-08-9
    [pslug] => 2248445-08-9-r-3-amino-1-morpholino-4-2-4-5-trifluorophenyl-butan-1-one-pa190481066
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PA 19 0481066

(R)-3-Amino-1-morpholino-4-(2,4,5-trifluorophenyl)butan-1-one


  • Catalogue No.:PA 19 0481066

  • CAS :

    2248445-08-9

  • Molecular Formula : C14H17F3N2O2

  • Molecular Weight : 302.3

stdClass Object
(
    [pname] => 1-Morpholino-4-(2,4,5-trifluorophenyl)butane-1,3-dione
    [catalogue_number] => PA 19 0481065
    [category_ids] => ,80,92,79,75,89,71,
    [chemical_name] => 
    [weight] => 301.27
    [form] => C14H14F3NO3
    [cas] => 2248445-00-1
    [pslug] => 2248445-00-1-1-morpholino-4-2-4-5-trifluorophenyl-butane-1-3-dione-pa190481065
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PA 19 0481065

1-Morpholino-4-(2,4,5-trifluorophenyl)butane-1,3-dione


  • Catalogue No.:PA 19 0481065

  • CAS :

    2248445-00-1

  • Molecular Formula : C14H14F3NO3

  • Molecular Weight : 301.27

stdClass Object
(
    [pname] => (S)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid
    [catalogue_number] => PA 19 0481067
    [category_ids] => ,69,79,75,
    [chemical_name] => 
    [weight] => 233.19
    [form] => C10H10F3NO2
    [cas] => 1217854-08-4
    [pslug] => 1217854-08-4-s-3-amino-4-2-4-5-trifluorophenyl-butanoic-acid-pa190481067
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PA 19 0481067

(S)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid


  • Catalogue No.:PA 19 0481067

  • CAS :

    1217854-08-4

  • Molecular Formula : C10H10F3NO2

  • Molecular Weight : 233.19

stdClass Object
(
    [pname] => (R)-1-(4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)urea
    [catalogue_number] => PA 19 0481068
    [category_ids] => ,79,75,71,78,
    [chemical_name] => 
    [weight] => 450.35
    [form] => C17H16F6N6O2
    [cas] => NA
    [pslug] => r-1-4-oxo-4-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-1-2-4-5-trifluorophenyl-butan-2-yl-urea-pa190481068
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PA 19 0481068

(R)-1-(4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)urea


  • Catalogue No.:PA 19 0481068

  • CAS :

    NA

  • Molecular Formula : C17H16F6N6O2

  • Molecular Weight : 450.35

stdClass Object
(
    [pname] => 1-(4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)urea
    [catalogue_number] => PA 19 0481069
    [category_ids] => ,79,75,71,78,
    [chemical_name] => 
    [weight] => 450.35
    [form] => C17H16F6N6O2
    [cas] => NA
    [pslug] => 1-4-oxo-4-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-1-2-4-5-trifluorophenyl-butan-2-yl-urea-pa190481069
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PA 19 0481069

1-(4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)urea


  • Catalogue No.:PA 19 0481069

  • CAS :

    NA

  • Molecular Formula : C17H16F6N6O2

  • Molecular Weight : 450.35

stdClass Object
(
    [pname] => Methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate hydrochloride
    [catalogue_number] => PA 19 0481070
    [category_ids] => ,80,92,79,75,89,71,
    [chemical_name] => 
    [weight] => 283.68
    [form] => C11H13ClF3NO2
    [cas] => 1909309-14-3
    [pslug] => 1909309-14-3-methyl-3-amino-4-2-4-5-trifluorophenyl-butanoate-hydrochloride-pa190481070
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PA 19 0481070

Methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate hydrochloride


  • Catalogue No.:PA 19 0481070

  • CAS :

    1909309-14-3

  • Molecular Formula : C11H13ClF3NO2

  • Molecular Weight : 283.68

stdClass Object
(
    [pname] => 4-(2,5-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butane-1,3-dione
    [catalogue_number] => PA 19 0481071
    [category_ids] => ,80,92,79,75,89,71,
    [chemical_name] => 
    [weight] => 388.3
    [form] => C16H13F5N4O2
    [cas] => 764667-67-6
    [pslug] => 764667-67-6-4-2-5-difluorophenyl-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-butane-1-3-dione-pa190481071
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PA 19 0481071

4-(2,5-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butane-1,3-dione


  • Catalogue No.:PA 19 0481071

  • CAS :

    764667-67-6

  • Molecular Formula : C16H13F5N4O2

  • Molecular Weight : 388.3

stdClass Object
(
    [pname] => Sitagliptin Phosphate Monohydrate - Impurity A (Hydrochloride Salt)
    [catalogue_number] => PA 19 0480011
    [category_ids] => ,80,92,79,75,89,71,
    [chemical_name] => 
    [weight] => 443.78
    [form] => C16H16ClF6N5O
    [cas] => NA
    [pslug] => sitagliptin-phosphate-monohydrate-impurity-a-hydrochloride-salt-pa190480011
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PA 19 0480011

Sitagliptin Phosphate Monohydrate - Impurity A (Hydrochloride Salt)


  • Catalogue No.:PA 19 0480011

  • CAS :

    NA

  • Molecular Formula : C16H16ClF6N5O

  • Molecular Weight : 443.78

stdClass Object
(
    [pname] => (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanamide
    [catalogue_number] => PA 19 0481073
    [category_ids] => ,75,78,70,82,
    [chemical_name] => 
    [weight] => 232.21
    [form] => C10H11F3N2O
    [cas] => 2137101-64-3
    [pslug] => 2137101-64-3-r-3-amino-4-2-4-5-trifluorophenyl-butanamide-pa190481073
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PA 19 0481073

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanamide


  • Catalogue No.:PA 19 0481073

  • CAS :

    2137101-64-3

  • Molecular Formula : C10H11F3N2O

  • Molecular Weight : 232.21

stdClass Object
(
    [pname] => Isopropyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PA 19 0481074
    [category_ids] => ,75,78,70,82,
    [chemical_name] => 
    [weight] => 275.27
    [form] => C13H16F3NO2
    [cas] => 1802495-69-7
    [pslug] => 1802495-69-7-isopropyl-r-3-amino-4-2-4-5-trifluorophenyl-butanoate-pa190481074
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PA 19 0481074

Isopropyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PA 19 0481074

  • CAS :

    1802495-69-7

  • Molecular Formula : C13H16F3NO2

  • Molecular Weight : 275.27

stdClass Object
(
    [pname] => 1-(2,4,5-Trifluorophenyl)propan-2-amine Hydrochloride
    [catalogue_number] => PA 19 0481076
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 225.64
    [form] => C9H11ClF3N
    [cas] => 1062587-61-4
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PA 19 0481076

1-(2,4,5-Trifluorophenyl)propan-2-amine Hydrochloride


  • Catalogue No.:PA 19 0481076

  • CAS :

    1062587-61-4

  • Molecular Formula : C9H11ClF3N

  • Molecular Weight : 225.64

stdClass Object
(
    [pname] => (R)-3-Amino-N-(2-(3-formyl-5-(trifluoromethyl)-4H-1,2,4-triazol-4-yl)ethyl)-4-(2,4,5-trifluorophenyl)butanamide
    [catalogue_number] => PA 19 0481077
    [category_ids] => ,80,92,79,75,89,
    [chemical_name] => 
    [weight] => 423.32
    [form] => C16H15F6N5O2
    [cas] => 2689015-85-6
    [pslug] => 2689015-85-6-r-3-amino-n-2-3-formyl-5-trifluoromethyl-4h-1-2-4-triazol-4-yl-ethyl-4-2-4-5-trifluorophenyl-butanamide-pa190481077
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PA 19 0481077

(R)-3-Amino-N-(2-(3-formyl-5-(trifluoromethyl)-4H-1,2,4-triazol-4-yl)ethyl)-4-(2,4,5-trifluorophenyl)butanamide


  • Catalogue No.:PA 19 0481077

  • CAS :

    2689015-85-6

  • Molecular Formula : C16H15F6N5O2

  • Molecular Weight : 423.32

stdClass Object
(
    [pname] => (E)-2,2,2-Trifluoro-N'-(1-nitrosopiperazin-2-ylidene)acetohydrazide
    [catalogue_number] => PA 19 0481078
    [category_ids] => ,80,92,79,75,89,71,162,
    [chemical_name] => 
    [weight] => 239.16
    [form] => C6H8F3N5O2
    [cas] => NA
    [pslug] => e-2-2-2-trifluoro-n-1-nitrosopiperazin-2-ylidene-acetohydrazide-pa190481078
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PA 19 0481078

(E)-2,2,2-Trifluoro-N'-(1-nitrosopiperazin-2-ylidene)acetohydrazide


  • Catalogue No.:PA 19 0481078

  • CAS :

    NA

  • Molecular Formula : C6H8F3N5O2

  • Molecular Weight : 239.16

stdClass Object
(
    [pname] => (Z)-3-(Hydroxyimino)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
    [catalogue_number] => PA 19 0481079
    [category_ids] => ,80,92,79,75,89,71,162,
    [chemical_name] => 
    [weight] => 421.3
    [form] => C16H13F6N5O2
    [cas] => 1253056-15-3
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PA 19 0481079

(Z)-3-(Hydroxyimino)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one


  • Catalogue No.:PA 19 0481079

  • CAS :

    1253056-15-3

  • Molecular Formula : C16H13F6N5O2

  • Molecular Weight : 421.3

stdClass Object
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    [pname] => N-Nitroso Sitagliptin Fumarate Adduct
    [catalogue_number] => PA 19 0481080
    [category_ids] => ,75,76,78,82,
    [chemical_name] => 
    [weight] => 552.39
    [form] => C20H18F6N6O6
    [cas] => NA
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PA 19 0481080

N-Nitroso Sitagliptin Fumarate Adduct


  • Catalogue No.:PA 19 0481080

  • CAS :

    NA

  • Molecular Formula : C20H18F6N6O6

  • Molecular Weight : 552.39

stdClass Object
(
    [pname] =>  Tert-butyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PA 19 0481081
    [category_ids] => ,82,78,76,75,70,
    [chemical_name] => 
    [weight] => 289.3
    [form] => C14H18F3NO2
    [cas] => 1964462-19-8
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PA 19 0481081

 Tert-butyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PA 19 0481081

  • CAS :

    1964462-19-8

  • Molecular Formula : C14H18F3NO2

  • Molecular Weight : 289.3

stdClass Object
(
    [pname] => Tert-butyl (R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PA 19 0481082
    [category_ids] => ,82,78,76,75,70,
    [chemical_name] => 
    [weight] => 389.42
    [form] => C19H26F3NO4
    [cas] => 1246961-45-4
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PA 19 0481082

Tert-butyl (R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PA 19 0481082

  • CAS :

    1246961-45-4

  • Molecular Formula : C19H26F3NO4

  • Molecular Weight : 389.42

stdClass Object
(
    [pname] => (E)-4-(2,4,5-Trifluorophenyl)but-3-enoic Acid
    [catalogue_number] => PA 19 0481083
    [category_ids] => ,80,92,79,75,89,71,
    [chemical_name] => 
    [weight] => 216.16
    [form] => C10H7F3O2
    [cas] => 2226094-64-8
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PA 19 0481083

(E)-4-(2,4,5-Trifluorophenyl)but-3-enoic Acid


  • Catalogue No.:PA 19 0481083

  • CAS :

    2226094-64-8

  • Molecular Formula : C10H7F3O2

  • Molecular Weight : 216.16

stdClass Object
(
    [pname] => (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,3,6-trifluorophenyl)butanoic acid
    [catalogue_number] => PA 19 0481084
    [category_ids] => ,79,80,78,75,76,82,
    [chemical_name] => 
    [weight] => 333.31
    [form] => C15H18F3NO4
    [cas] => 611240-53-0
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PA 19 0481084

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,3,6-trifluorophenyl)butanoic acid


  • Catalogue No.:PA 19 0481084

  • CAS :

    611240-53-0

  • Molecular Formula : C15H18F3NO4

  • Molecular Weight : 333.31

stdClass Object
(
    [pname] => (Z)-3-Amino-1-morpholino-4-(2,4,5-trifluorophenyl)but-2-en-1-one
    [catalogue_number] => PA 19 0481085
    [category_ids] => ,79,80,78,75,76,82,
    [chemical_name] => 
    [weight] => 300.28
    [form] => C14H15F3N2O2
    [cas] => NA
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PA 19 0481085

(Z)-3-Amino-1-morpholino-4-(2,4,5-trifluorophenyl)but-2-en-1-one


  • Catalogue No.:PA 19 0481085

  • CAS :

    NA

  • Molecular Formula : C14H15F3N2O2

  • Molecular Weight : 300.28

stdClass Object
(
    [pname] => (R)-(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic N,N'-dicyclohexylcarbamimidic anhydride
    [catalogue_number] => PA 19 0481086
    [category_ids] => ,79,80,78,75,76,82,
    [chemical_name] => 
    [weight] => 539.64
    [form] => C28H40F3N3O4
    [cas] => 2072867-06-0
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PA 19 0481086

(R)-(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic N,N'-dicyclohexylcarbamimidic anhydride


  • Catalogue No.:PA 19 0481086

  • CAS :

    2072867-06-0

  • Molecular Formula : C28H40F3N3O4

  • Molecular Weight : 539.64

stdClass Object
(
    [pname] => (2R,3S)-2-((tert-Butoxycarbonyl)amino)-3-(3-fluoro-4-nitrophenyl)butanoic Acid
    [catalogue_number] => PA 19 0481087
    [category_ids] => ,80,92,79,75,89,71,
    [chemical_name] => 
    [weight] => 342.32
    [form] => C15H19FN2O6
    [cas] => 2467738-84-5
    [pslug] => 2467738-84-5-2r-3s-2-tert-butoxycarbonyl-amino-3-3-fluoro-4-nitrophenyl-butanoic-acid-pa190481087
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PA 19 0481087

(2R,3S)-2-((tert-Butoxycarbonyl)amino)-3-(3-fluoro-4-nitrophenyl)butanoic Acid


  • Catalogue No.:PA 19 0481087

  • CAS :

    2467738-84-5

  • Molecular Formula : C15H19FN2O6

  • Molecular Weight : 342.32

stdClass Object
(
    [pname] => 2-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-N'-(2-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)acetyl)acetohydrazide
    [catalogue_number] => PA 19 0481089
    [category_ids] => ,80,92,79,75,89,71,
    [chemical_name] => 
    [weight] => 496.38
    [form] =>  C16H18F6N10O2
    [cas] => NA
    [pslug] => 2-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-n-2-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-acetyl-acetohydrazide-pa190481089
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PA 19 0481089

2-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-N'-(2-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)acetyl)acetohydrazide


  • Catalogue No.:PA 19 0481089

  • CAS :

    NA

  • Molecular Formula : C16H18F6N10O2

  • Molecular Weight : 496.38

stdClass Object
(
    [pname] => (Z)-2,2,2-Trifluoro-N'-(piperazin-2-ylidene)acetohydrazide
    [catalogue_number] => PA 19 0481091
    [category_ids] => ,80,92,79,75,89,71,
    [chemical_name] => 
    [weight] => 210.16
    [form] => C6H9F3N4O
    [cas] => 763105-70-0
    [pslug] => 763105-70-0-z-2-2-2-trifluoro-n-piperazin-2-ylidene-acetohydrazide-pa190481091
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PA 19 0481091

(Z)-2,2,2-Trifluoro-N'-(piperazin-2-ylidene)acetohydrazide


  • Catalogue No.:PA 19 0481091

  • CAS :

    763105-70-0

  • Molecular Formula : C6H9F3N4O

  • Molecular Weight : 210.16