Sitagliptin-impurities | Pharmaffiliates

sitagliptin

Sitagliptin impurity B is also known as Defluoro Sitagliptin, an impurity of Sitagliptan, an dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Reference standards of Sitagliptin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => (R)-3-Amino-4-(2-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
    [catalogue_number] => PA 19 0481063
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 387.79
    [form] => C16H17ClF3N5O
    [cas] => 945261-56-3
    [pslug] => 945261-56-3-r-3-amino-4-2-chlorophenyl-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-butan-1-one-pa190481063
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PA 19 0481063

(R)-3-Amino-4-(2-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one


  • Catalogue No.:PA 19 0481063

  • CAS :

    945261-56-3

  • Molecular Formula : C16H17ClF3N5O

  • Molecular Weight : 387.79

stdClass Object
(
    [pname] => (R)-3-Amino-4-(2,4-dichlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
    [catalogue_number] => PA 19 0481064
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 422.23
    [form] => C16H16Cl2F3N5O
    [cas] => 945261-60-9
    [pslug] => 945261-60-9-r-3-amino-4-2-4-dichlorophenyl-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-butan-1-one-pa190481064
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PA 19 0481064

(R)-3-Amino-4-(2,4-dichlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one


  • Catalogue No.:PA 19 0481064

  • CAS :

    945261-60-9

  • Molecular Formula : C16H16Cl2F3N5O

  • Molecular Weight : 422.23

stdClass Object
(
    [pname] => Dimethyl ((R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)aspartate
    [catalogue_number] => PAI 19 009021
    [category_ids] => ,70,
    [chemical_name] => 
    [weight] => 551.45
    [form] => C22H23F6N5O
    [cas] => NA
    [pslug] => dimethyl-r-4-oxo-4-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-1-2-4-5-trifluorophenyl-butan-2-yl-aspartate-pai19009021
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PAI 19 009021

Dimethyl ((R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)aspartate


  • Catalogue No.:PAI 19 009021

  • CAS :

    NA

  • Molecular Formula : C22H23F6N5O

  • Molecular Weight : 551.45

stdClass Object
(
    [pname] => Dimethyl Bromosuccinate
    [catalogue_number] => PAI 19 009022
    [category_ids] => ,70,
    [chemical_name] => 
    [weight] => 225.04
    [form] => C6H9BrO4
    [cas] => 760-90-7
    [pslug] => 760-90-7-dimethyl-bromosuccinate-pai19009022
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PAI 19 009022

Dimethyl Bromosuccinate


  • Catalogue No.:PAI 19 009022

  • CAS :

    760-90-7

  • Molecular Formula : C6H9BrO4

  • Molecular Weight : 225.04

stdClass Object
(
    [pname] => 3-Nitroso-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
    [catalogue_number] => PA 19 0481072
    [category_ids] => ,69,70,78,82,162,
    [chemical_name] => 
    [weight] => 421.3
    [form] => C16H13F6N5O2
    [cas] => NA
    [pslug] => 3-nitroso-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-4-2-4-5-trifluorophenyl-butan-1-one-pa190481072
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PA 19 0481072

3-Nitroso-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one


  • Catalogue No.:PA 19 0481072

  • CAS :

    NA

  • Molecular Formula : C16H13F6N5O2

  • Molecular Weight : 421.3

stdClass Object
(
    [pname] => (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanamide
    [catalogue_number] => PA 19 0481073
    [category_ids] => ,75,78,70,82,
    [chemical_name] => 
    [weight] => 232.21
    [form] => C10H11F3N2O
    [cas] => 2137101-64-3
    [pslug] => 2137101-64-3-r-3-amino-4-2-4-5-trifluorophenyl-butanamide-pa190481073
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PA 19 0481073

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanamide


  • Catalogue No.:PA 19 0481073

  • CAS :

    2137101-64-3

  • Molecular Formula : C10H11F3N2O

  • Molecular Weight : 232.21

stdClass Object
(
    [pname] => Isopropyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PA 19 0481074
    [category_ids] => ,75,78,70,82,
    [chemical_name] => 
    [weight] => 275.27
    [form] => C13H16F3NO2
    [cas] => 1802495-69-7
    [pslug] => 1802495-69-7-isopropyl-r-3-amino-4-2-4-5-trifluorophenyl-butanoate-pa190481074
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PA 19 0481074

Isopropyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PA 19 0481074

  • CAS :

    1802495-69-7

  • Molecular Formula : C13H16F3NO2

  • Molecular Weight : 275.27

stdClass Object
(
    [pname] => 3-Amino-4-(3,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
    [catalogue_number] => PA 19 0481075
    [category_ids] => ,70,78,82,
    [chemical_name] => 
    [weight] => 389.33
    [form] => C16H16F5N5O
    [cas] => 1334244-24-4
    [pslug] => 1334244-24-4-3-amino-4-3-4-difluorophenyl-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-butan-1-one-pa190481075
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PA 19 0481075

3-Amino-4-(3,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one


  • Catalogue No.:PA 19 0481075

  • CAS :

    1334244-24-4

  • Molecular Formula : C16H16F5N5O

  • Molecular Weight : 389.33

stdClass Object
(
    [pname] => 3-(Dimethylamino)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
    [catalogue_number] => PAI 19 009023
    [category_ids] => ,70,
    [chemical_name] => 
    [weight] => 435.37
    [form] => C18H19F6N5O
    [cas] => 2762634-30-8
    [pslug] => 2762634-30-8-3-dimethylamino-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-4-2-4-5-trifluorophenyl-butan-1-one-pai19009023
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PAI 19 009023

3-(Dimethylamino)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one


  • Catalogue No.:PAI 19 009023

  • CAS :

    2762634-30-8

  • Molecular Formula : C18H19F6N5O

  • Molecular Weight : 435.37

stdClass Object
(
    [pname] => Methyl 3-((tert-butylsulfinyl)amino)-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PAI 19 009024
    [category_ids] => ,70,
    [chemical_name] => 
    [weight] => 351.38
    [form] => C15H20F3NO3S
    [cas] => NA
    [pslug] => methyl-3-tert-butylsulfinyl-amino-4-2-4-5-trifluorophenyl-butanoate-pai19009024
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PAI 19 009024

Methyl 3-((tert-butylsulfinyl)amino)-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PAI 19 009024

  • CAS :

    NA

  • Molecular Formula : C15H20F3NO3S

  • Molecular Weight : 351.38

stdClass Object
(
    [pname] => Methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PAI 19 009025
    [category_ids] => ,70,
    [chemical_name] => 
    [weight] => 248.2
    [form] => C11H11F3O3
    [cas] => 1253056-13-1
    [pslug] => 1253056-13-1-methyl-3-hydroxy-4-2-4-5-trifluorophenyl-butanoate-pai19009025
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PAI 19 009025

Methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PAI 19 009025

  • CAS :

    1253056-13-1

  • Molecular Formula : C11H11F3O3

  • Molecular Weight : 248.2

stdClass Object
(
    [pname] => 1-(2,4,5-Trifluorophenyl)propan-2-amine Hydrochloride
    [catalogue_number] => PA 19 0481076
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 225.64
    [form] => C9H11ClF3N
    [cas] => 1062587-61-4
    [pslug] => 1062587-61-4-1-2-4-5-trifluorophenyl-propan-2-amine-hydrochloride-pa190481076
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PA 19 0481076

1-(2,4,5-Trifluorophenyl)propan-2-amine Hydrochloride


  • Catalogue No.:PA 19 0481076

  • CAS :

    1062587-61-4

  • Molecular Formula : C9H11ClF3N

  • Molecular Weight : 225.64

stdClass Object
(
    [pname] => tert-Butyl 3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
    [catalogue_number] => PAI 19 009026
    [category_ids] => ,70,
    [chemical_name] => 
    [weight] => 292.26
    [form] => C11H15F3N4O2
    [cas] => 877402-43-2
    [pslug] => 877402-43-2-tert-butyl-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazine-7-8h-carboxylate-pai19009026
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PAI 19 009026

tert-Butyl 3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate


  • Catalogue No.:PAI 19 009026

  • CAS :

    877402-43-2

  • Molecular Formula : C11H15F3N4O2

  • Molecular Weight : 292.26

stdClass Object
(
    [pname] => tert-Butyl 8-oxo-3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
    [catalogue_number] => PAI 19 009027
    [category_ids] => ,70,
    [chemical_name] => 
    [weight] => 306.25
    [form] => C11H13F3N4O3
    [cas] => 877402-44-3
    [pslug] => 877402-44-3-tert-butyl-8-oxo-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazine-7-8h-carboxylate-pai19009027
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PAI 19 009027

tert-Butyl 8-oxo-3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate


  • Catalogue No.:PAI 19 009027

  • CAS :

    877402-44-3

  • Molecular Formula : C11H13F3N4O3

  • Molecular Weight : 306.25

stdClass Object
(
    [pname] => Methyl 3-azido-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PAI 19 009028
    [category_ids] => ,70,
    [chemical_name] => 
    [weight] => 273.22
    [form] => C11H10F3N3O2
    [cas] => NA
    [pslug] => methyl-3-azido-4-2-4-5-trifluorophenyl-butanoate-pai19009028
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PAI 19 009028

Methyl 3-azido-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PAI 19 009028

  • CAS :

    NA

  • Molecular Formula : C11H10F3N3O2

  • Molecular Weight : 273.22

stdClass Object
(
    [pname] => Methyl 3-(tosyloxy)-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PAI 19 009029
    [category_ids] => ,70,
    [chemical_name] => 
    [weight] => 402.38
    [form] => C18H17F3O5S
    [cas] => NA
    [pslug] => methyl-3-tosyloxy-4-2-4-5-trifluorophenyl-butanoate-pai19009029
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PAI 19 009029

Methyl 3-(tosyloxy)-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PAI 19 009029

  • CAS :

    NA

  • Molecular Formula : C18H17F3O5S

  • Molecular Weight : 402.38

stdClass Object
(
    [pname] => Methyl (Z)-3-(benzylimino)-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PAI 19 009030
    [category_ids] => ,70,
    [chemical_name] => 
    [weight] => 335.33
    [form] => C18H16F3NO2
    [cas] => NA
    [pslug] => methyl-z-3-benzylimino-4-2-4-5-trifluorophenyl-butanoate-pai19009030
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PAI 19 009030

Methyl (Z)-3-(benzylimino)-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PAI 19 009030

  • CAS :

    NA

  • Molecular Formula : C18H16F3NO2

  • Molecular Weight : 335.33

stdClass Object
(
    [pname] =>  Tert-butyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PA 19 0481081
    [category_ids] => ,82,78,76,75,70,
    [chemical_name] => 
    [weight] => 289.3
    [form] => C14H18F3NO2
    [cas] => 1964462-19-8
    [pslug] => 1964462-19-8- tert-butyl-3-amino-4-2-4-5-trifluorophenyl-butanoate-pa190481081
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PA 19 0481081

 Tert-butyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PA 19 0481081

  • CAS :

    1964462-19-8

  • Molecular Formula : C14H18F3NO2

  • Molecular Weight : 289.3

stdClass Object
(
    [pname] => Tert-butyl (R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PA 19 0481082
    [category_ids] => ,82,78,76,75,70,
    [chemical_name] => 
    [weight] => 389.42
    [form] => C19H26F3NO4
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PA 19 0481082

Tert-butyl (R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PA 19 0481082

  • CAS :

    1246961-45-4

  • Molecular Formula : C19H26F3NO4

  • Molecular Weight : 389.42

stdClass Object
(
    [pname] => Methyl (Z)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)but-2-enoate
    [catalogue_number] => PAI 19 009031
    [category_ids] => ,70,
    [chemical_name] => 
    [weight] => 345.32
    [form] => C16H18F3NO4
    [cas] => 1234321-77-7
    [pslug] => 1234321-77-7-methyl-z-3-tert-butoxycarbonyl-amino-4-2-4-5-trifluorophenyl-but-2-enoate-pai19009031
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PAI 19 009031

Methyl (Z)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)but-2-enoate


  • Catalogue No.:PAI 19 009031

  • CAS :

    1234321-77-7

  • Molecular Formula : C16H18F3NO4

  • Molecular Weight : 345.32

stdClass Object
(
    [pname] => Methyl 3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PAI 19 009032
    [category_ids] => ,70,
    [chemical_name] => 
    [weight] => 347.33
    [form] => C16H20F3NO4
    [cas] => 1151240-94-6
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PAI 19 009032

Methyl 3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PAI 19 009032

  • CAS :

    1151240-94-6

  • Molecular Formula : C16H20F3NO4

  • Molecular Weight : 347.33

stdClass Object
(
    [pname] => (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid Triethylamine Salt
    [catalogue_number] => PA 19 0481090
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 434.50
    [form] => C21H33F3N2O4
    [cas] => NA
    [pslug] => r-3-tert-butoxycarbonyl-amino-4-2-4-5-trifluorophenyl-butanoic-acid-triethylamine-salt-pa190481090
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PA 19 0481090

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid Triethylamine Salt


  • Catalogue No.:PA 19 0481090

  • CAS :

    NA

  • Molecular Formula : C21H33F3N2O4

  • Molecular Weight : 434.50

stdClass Object
(
    [pname] => (S)-Sitagliptin N-Boc-Acid Impurity Triethylamine Salt
    [catalogue_number] => PA 19 0481092
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 434.50
    [form] => C21H33F3N2O4
    [cas] => NA
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PA 19 0481092

(S)-Sitagliptin N-Boc-Acid Impurity Triethylamine Salt


  • Catalogue No.:PA 19 0481092

  • CAS :

    NA

  • Molecular Formula : C21H33F3N2O4

  • Molecular Weight : 434.50

stdClass Object
(
    [pname] => N,N-Diisopropyl-3-oxo-4-(2,4,5-trifluorophenyl)butanamide
    [catalogue_number] => PA 19 0481093
    [category_ids] => ,69,71,78,70,82,
    [chemical_name] => 
    [weight] => 315.34
    [form] => C16H20F3NO2
    [cas] => NA
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PA 19 0481093

N,N-Diisopropyl-3-oxo-4-(2,4,5-trifluorophenyl)butanamide


  • Catalogue No.:PA 19 0481093

  • CAS :

    NA

  • Molecular Formula : C16H20F3NO2

  • Molecular Weight : 315.34

stdClass Object
(
    [pname] => (R)-10-(2,4,5-Trifluorobenzyl)-3-(trifluoromethyl)-5,6,9,10-tetrahydro-8H-[1,2,4]triazolo[3',4':3,4]pyrazino[1,2-a]pyrimidin-8-one
    [catalogue_number] => PA 19 0481094
    [category_ids] => ,69,71,78,70,82,
    [chemical_name] => 
    [weight] => 403.29
    [form] => C16H11F6N5O
    [cas] => 2821750-76-7
    [pslug] => 2821750-76-7-r-10-2-4-5-trifluorobenzyl-3-trifluoromethyl-5-6-9-10-tetrahydro-8h-1-2-4-triazolo-3-4-3-4-pyrazino-1-2-a-pyrimidin-8-one-pa190481094
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PA 19 0481094

(R)-10-(2,4,5-Trifluorobenzyl)-3-(trifluoromethyl)-5,6,9,10-tetrahydro-8H-[1,2,4]triazolo[3',4':3,4]pyrazino[1,2-a]pyrimidin-8-one


  • Catalogue No.:PA 19 0481094

  • CAS :

    2821750-76-7

  • Molecular Formula : C16H11F6N5O

  • Molecular Weight : 403.29