Sitagliptin-impurities | Pharmaffiliates

sitagliptin

Sitagliptin impurity B is also known as Defluoro Sitagliptin, an impurity of Sitagliptan, an dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Reference standards of Sitagliptin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => 3-Amino-4-(2,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
    [catalogue_number] => PA 19 0481056
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 389.33
    [form] => C16H16F5N5O
    [cas] => 1334244-28-8
    [pslug] => 1334244-28-8-3-amino-4-2-4-difluorophenyl-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-butan-1-one-pa190481056
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PA 19 0481056

3-Amino-4-(2,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one


  • Catalogue No.:PA 19 0481056

  • CAS :

    1334244-28-8

  • Molecular Formula : C16H16F5N5O

  • Molecular Weight : 389.33

stdClass Object
(
    [pname] => Tert-butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
    [catalogue_number] => PA 19 0481057
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 507.44
    [form] => C21H23F6N5O3
    [cas] => 1351498-23-1
    [pslug] => 1351498-23-1-tert-butyl-4-oxo-4-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-1-2-4-5-trifluorophenyl-butan-2-yl-carbamate-pa190481057
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PA 19 0481057

Tert-butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate


  • Catalogue No.:PA 19 0481057

  • CAS :

    1351498-23-1

  • Molecular Formula : C21H23F6N5O3

  • Molecular Weight : 507.44

stdClass Object
(
    [pname] => 2-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)acetohydrazide
    [catalogue_number] => PA 19 0481058
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 264.21
    [form] => C8H11F3N6O
    [cas] => 1485732-85-1
    [pslug] => 1485732-85-1-2-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-acetohydrazide-pa190481058
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PA 19 0481058

2-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)acetohydrazide


  • Catalogue No.:PA 19 0481058

  • CAS :

    1485732-85-1

  • Molecular Formula : C8H11F3N6O

  • Molecular Weight : 264.21

stdClass Object
(
    [pname] => 4-(2,4,5-Trifluorobenzyl)azetidin-2-one
    [catalogue_number] => PA 19 0481059
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 215.18
    [form] => C10H8F3NO
    [cas] => 1512811-20-9
    [pslug] => 1512811-20-9-4-2-4-5-trifluorobenzyl-azetidin-2-one-pa190481059
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PA 19 0481059

4-(2,4,5-Trifluorobenzyl)azetidin-2-one


  • Catalogue No.:PA 19 0481059

  • CAS :

    1512811-20-9

  • Molecular Formula : C10H8F3NO

  • Molecular Weight : 215.18

stdClass Object
(
    [pname] => 3,4,5-Trifluoro-dl-phenylglycine
    [catalogue_number] => PA 19 0481060
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 205.14
    [form] => C8H6F3NO2
    [cas] => 261952-27-6
    [pslug] => 261952-27-6-3-4-5-trifluoro-dl-phenylglycine-pa190481060
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PA 19 0481060

3,4,5-Trifluoro-dl-phenylglycine


  • Catalogue No.:PA 19 0481060

  • CAS :

    261952-27-6

  • Molecular Formula : C8H6F3NO2

  • Molecular Weight : 205.14

stdClass Object
(
    [pname] => Tert-Butyl ((R)-4-oxo-4-(((R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)amino)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
    [catalogue_number] => PA 19 0481061
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 722.61
    [form] => C31H31F9N6O4
    [cas] => 2088771-62-2
    [pslug] => 2088771-62-2-tert-butyl-r-4-oxo-4-r-4-oxo-4-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-1-2-4-5-trifluorophenyl-butan-2-yl-amino-1-2-4-5-trifluorophenyl-butan-2-yl-carbamate-pa190481061
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PA 19 0481061

Tert-Butyl ((R)-4-oxo-4-(((R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)amino)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate


  • Catalogue No.:PA 19 0481061

  • CAS :

    2088771-62-2

  • Molecular Formula : C31H31F9N6O4

  • Molecular Weight : 722.61

stdClass Object
(
    [pname] => (R)-3-Amino-4-(2-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
    [catalogue_number] => PA 19 0481062
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 371.34
    [form] => C16H17F4N5O
    [cas] => 945261-45-0
    [pslug] => 945261-45-0-r-3-amino-4-2-fluorophenyl-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-butan-1-one-pa190481062
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PA 19 0481062

(R)-3-Amino-4-(2-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one


  • Catalogue No.:PA 19 0481062

  • CAS :

    945261-45-0

  • Molecular Formula : C16H17F4N5O

  • Molecular Weight : 371.34

stdClass Object
(
    [pname] => (R)-3-Amino-4-(2-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
    [catalogue_number] => PA 19 0481063
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 387.79
    [form] => C16H17ClF3N5O
    [cas] => 945261-56-3
    [pslug] => 945261-56-3-r-3-amino-4-2-chlorophenyl-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-butan-1-one-pa190481063
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PA 19 0481063

(R)-3-Amino-4-(2-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one


  • Catalogue No.:PA 19 0481063

  • CAS :

    945261-56-3

  • Molecular Formula : C16H17ClF3N5O

  • Molecular Weight : 387.79

stdClass Object
(
    [pname] => (R)-3-Amino-4-(2,4-dichlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
    [catalogue_number] => PA 19 0481064
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 422.23
    [form] => C16H16Cl2F3N5O
    [cas] => 945261-60-9
    [pslug] => 945261-60-9-r-3-amino-4-2-4-dichlorophenyl-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-butan-1-one-pa190481064
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PA 19 0481064

(R)-3-Amino-4-(2,4-dichlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one


  • Catalogue No.:PA 19 0481064

  • CAS :

    945261-60-9

  • Molecular Formula : C16H16Cl2F3N5O

  • Molecular Weight : 422.23

stdClass Object
(
    [pname] => (R)-1-(4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)urea
    [catalogue_number] => PA 19 0481068
    [category_ids] => ,79,75,71,78,
    [chemical_name] => 
    [weight] => 450.35
    [form] => C17H16F6N6O2
    [cas] => NA
    [pslug] => r-1-4-oxo-4-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-1-2-4-5-trifluorophenyl-butan-2-yl-urea-pa190481068
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PA 19 0481068

(R)-1-(4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)urea


  • Catalogue No.:PA 19 0481068

  • CAS :

    NA

  • Molecular Formula : C17H16F6N6O2

  • Molecular Weight : 450.35

stdClass Object
(
    [pname] => 1-(4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)urea
    [catalogue_number] => PA 19 0481069
    [category_ids] => ,79,75,71,78,
    [chemical_name] => 
    [weight] => 450.35
    [form] => C17H16F6N6O2
    [cas] => NA
    [pslug] => 1-4-oxo-4-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-1-2-4-5-trifluorophenyl-butan-2-yl-urea-pa190481069
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PA 19 0481069

1-(4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)urea


  • Catalogue No.:PA 19 0481069

  • CAS :

    NA

  • Molecular Formula : C17H16F6N6O2

  • Molecular Weight : 450.35

stdClass Object
(
    [pname] => 3-Nitroso-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
    [catalogue_number] => PA 19 0481072
    [category_ids] => ,69,70,78,82,162,
    [chemical_name] => 
    [weight] => 421.3
    [form] => C16H13F6N5O2
    [cas] => NA
    [pslug] => 3-nitroso-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-4-2-4-5-trifluorophenyl-butan-1-one-pa190481072
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PA 19 0481072

3-Nitroso-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one


  • Catalogue No.:PA 19 0481072

  • CAS :

    NA

  • Molecular Formula : C16H13F6N5O2

  • Molecular Weight : 421.3

stdClass Object
(
    [pname] => (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanamide
    [catalogue_number] => PA 19 0481073
    [category_ids] => ,75,78,70,82,
    [chemical_name] => 
    [weight] => 232.21
    [form] => C10H11F3N2O
    [cas] => 2137101-64-3
    [pslug] => 2137101-64-3-r-3-amino-4-2-4-5-trifluorophenyl-butanamide-pa190481073
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PA 19 0481073

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanamide


  • Catalogue No.:PA 19 0481073

  • CAS :

    2137101-64-3

  • Molecular Formula : C10H11F3N2O

  • Molecular Weight : 232.21

stdClass Object
(
    [pname] => Isopropyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PA 19 0481074
    [category_ids] => ,75,78,70,82,
    [chemical_name] => 
    [weight] => 275.27
    [form] => C13H16F3NO2
    [cas] => 1802495-69-7
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PA 19 0481074

Isopropyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PA 19 0481074

  • CAS :

    1802495-69-7

  • Molecular Formula : C13H16F3NO2

  • Molecular Weight : 275.27

stdClass Object
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    [pname] => 3-Amino-4-(3,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
    [catalogue_number] => PA 19 0481075
    [category_ids] => ,70,78,82,
    [chemical_name] => 
    [weight] => 389.33
    [form] => C16H16F5N5O
    [cas] => 1334244-24-4
    [pslug] => 1334244-24-4-3-amino-4-3-4-difluorophenyl-1-3-trifluoromethyl-5-6-dihydro-1-2-4-triazolo-4-3-a-pyrazin-7-8h-yl-butan-1-one-pa190481075
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PA 19 0481075

3-Amino-4-(3,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one


  • Catalogue No.:PA 19 0481075

  • CAS :

    1334244-24-4

  • Molecular Formula : C16H16F5N5O

  • Molecular Weight : 389.33

stdClass Object
(
    [pname] => 1-(2,4,5-Trifluorophenyl)propan-2-amine Hydrochloride
    [catalogue_number] => PA 19 0481076
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 225.64
    [form] => C9H11ClF3N
    [cas] => 1062587-61-4
    [pslug] => 1062587-61-4-1-2-4-5-trifluorophenyl-propan-2-amine-hydrochloride-pa190481076
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PA 19 0481076

1-(2,4,5-Trifluorophenyl)propan-2-amine Hydrochloride


  • Catalogue No.:PA 19 0481076

  • CAS :

    1062587-61-4

  • Molecular Formula : C9H11ClF3N

  • Molecular Weight : 225.64

stdClass Object
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    [pname] => N-Nitroso Sitagliptin Fumarate Adduct
    [catalogue_number] => PA 19 0481080
    [category_ids] => ,75,76,78,82,
    [chemical_name] => 
    [weight] => 552.39
    [form] => C20H18F6N6O6
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PA 19 0481080

N-Nitroso Sitagliptin Fumarate Adduct


  • Catalogue No.:PA 19 0481080

  • CAS :

    NA

  • Molecular Formula : C20H18F6N6O6

  • Molecular Weight : 552.39

stdClass Object
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    [pname] =>  Tert-butyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PA 19 0481081
    [category_ids] => ,82,78,76,75,70,
    [chemical_name] => 
    [weight] => 289.3
    [form] => C14H18F3NO2
    [cas] => 1964462-19-8
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PA 19 0481081

 Tert-butyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PA 19 0481081

  • CAS :

    1964462-19-8

  • Molecular Formula : C14H18F3NO2

  • Molecular Weight : 289.3

stdClass Object
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    [pname] => Tert-butyl (R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate
    [catalogue_number] => PA 19 0481082
    [category_ids] => ,82,78,76,75,70,
    [chemical_name] => 
    [weight] => 389.42
    [form] => C19H26F3NO4
    [cas] => 1246961-45-4
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PA 19 0481082

Tert-butyl (R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate


  • Catalogue No.:PA 19 0481082

  • CAS :

    1246961-45-4

  • Molecular Formula : C19H26F3NO4

  • Molecular Weight : 389.42

stdClass Object
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    [pname] => (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,3,6-trifluorophenyl)butanoic acid
    [catalogue_number] => PA 19 0481084
    [category_ids] => ,79,80,78,75,76,82,
    [chemical_name] => 
    [weight] => 333.31
    [form] => C15H18F3NO4
    [cas] => 611240-53-0
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PA 19 0481084

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,3,6-trifluorophenyl)butanoic acid


  • Catalogue No.:PA 19 0481084

  • CAS :

    611240-53-0

  • Molecular Formula : C15H18F3NO4

  • Molecular Weight : 333.31

stdClass Object
(
    [pname] => (Z)-3-Amino-1-morpholino-4-(2,4,5-trifluorophenyl)but-2-en-1-one
    [catalogue_number] => PA 19 0481085
    [category_ids] => ,79,80,78,75,76,82,
    [chemical_name] => 
    [weight] => 300.28
    [form] => C14H15F3N2O2
    [cas] => NA
    [pslug] => z-3-amino-1-morpholino-4-2-4-5-trifluorophenyl-but-2-en-1-one-pa190481085
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PA 19 0481085

(Z)-3-Amino-1-morpholino-4-(2,4,5-trifluorophenyl)but-2-en-1-one


  • Catalogue No.:PA 19 0481085

  • CAS :

    NA

  • Molecular Formula : C14H15F3N2O2

  • Molecular Weight : 300.28

stdClass Object
(
    [pname] => (R)-(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic N,N'-dicyclohexylcarbamimidic anhydride
    [catalogue_number] => PA 19 0481086
    [category_ids] => ,79,80,78,75,76,82,
    [chemical_name] => 
    [weight] => 539.64
    [form] => C28H40F3N3O4
    [cas] => 2072867-06-0
    [pslug] => 2072867-06-0-r-r-3-tert-butoxycarbonyl-amino-4-2-4-5-trifluorophenyl-butanoic-n-n-dicyclohexylcarbamimidic-anhydride-pa190481086
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PA 19 0481086

(R)-(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic N,N'-dicyclohexylcarbamimidic anhydride


  • Catalogue No.:PA 19 0481086

  • CAS :

    2072867-06-0

  • Molecular Formula : C28H40F3N3O4

  • Molecular Weight : 539.64

stdClass Object
(
    [pname] => (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid Triethylamine Salt
    [catalogue_number] => PA 19 0481090
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 434.50
    [form] => C21H33F3N2O4
    [cas] => NA
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PA 19 0481090

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid Triethylamine Salt


  • Catalogue No.:PA 19 0481090

  • CAS :

    NA

  • Molecular Formula : C21H33F3N2O4

  • Molecular Weight : 434.50

stdClass Object
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    [pname] => (S)-Sitagliptin N-Boc-Acid Impurity Triethylamine Salt
    [catalogue_number] => PA 19 0481092
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 434.50
    [form] => C21H33F3N2O4
    [cas] => NA
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PA 19 0481092

(S)-Sitagliptin N-Boc-Acid Impurity Triethylamine Salt


  • Catalogue No.:PA 19 0481092

  • CAS :

    NA

  • Molecular Formula : C21H33F3N2O4

  • Molecular Weight : 434.50

stdClass Object
(
    [pname] => N,N-Diisopropyl-3-oxo-4-(2,4,5-trifluorophenyl)butanamide
    [catalogue_number] => PA 19 0481093
    [category_ids] => ,69,71,78,70,82,
    [chemical_name] => 
    [weight] => 315.34
    [form] => C16H20F3NO2
    [cas] => NA
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PA 19 0481093

N,N-Diisopropyl-3-oxo-4-(2,4,5-trifluorophenyl)butanamide


  • Catalogue No.:PA 19 0481093

  • CAS :

    NA

  • Molecular Formula : C16H20F3NO2

  • Molecular Weight : 315.34

stdClass Object
(
    [pname] => (R)-10-(2,4,5-Trifluorobenzyl)-3-(trifluoromethyl)-5,6,9,10-tetrahydro-8H-[1,2,4]triazolo[3',4':3,4]pyrazino[1,2-a]pyrimidin-8-one
    [catalogue_number] => PA 19 0481094
    [category_ids] => ,69,71,78,70,82,
    [chemical_name] => 
    [weight] => 403.29
    [form] => C16H11F6N5O
    [cas] => 2821750-76-7
    [pslug] => 2821750-76-7-r-10-2-4-5-trifluorobenzyl-3-trifluoromethyl-5-6-9-10-tetrahydro-8h-1-2-4-triazolo-3-4-3-4-pyrazino-1-2-a-pyrimidin-8-one-pa190481094
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PA 19 0481094

(R)-10-(2,4,5-Trifluorobenzyl)-3-(trifluoromethyl)-5,6,9,10-tetrahydro-8H-[1,2,4]triazolo[3',4':3,4]pyrazino[1,2-a]pyrimidin-8-one


  • Catalogue No.:PA 19 0481094

  • CAS :

    2821750-76-7

  • Molecular Formula : C16H11F6N5O

  • Molecular Weight : 403.29