Displaying 95 results for ticagrelor

Ticagrelor - API

Ticagrelor


  • Catalogue No.:PA 47 11000

  • CAS : 274693-27-5

  • Molecular Formula : C23H28F2N6O4S

  • Molecular Weight : 522.57

Ticagrelor - In house Impurity

Deshydroxyethoxy Ticagrelor


  • Catalogue No.:PA 47 11510

  • CAS : 220347-05-7

  • Molecular Formula : C21H24F2N6O3S

  • Molecular Weight : 478.52

Ticagrelor - In house Impurity

(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate


  • Catalogue No.:PA 47 11515

  • CAS : NA

  • Molecular Formula : C17H17F2NO3

  • Molecular Weight : 321.32

Ticagrelor - In house Impurity

4-Chloro-6-methoxy-2-(propylthio)-5-pyrimidinamine


  • Catalogue No.:PA 47 11520

  • CAS : 1431867-40-1

  • Molecular Formula : C8H12ClN3OS

  • Molecular Weight : 233.72

Ticagrelor - In house Impurity

Ethyl 2-(3,4-difluorophenyl)cyclopropanecarboxylate


  • Catalogue No.:PA 47 11525

  • CAS : NA

  • Molecular Formula : C12H12F2O2

  • Molecular Weight : 226.22

Ticagrelor - In house Impurity

6-Chloro-5-nitro-2-(propylthio)pyrimidin-4-ol


  • Catalogue No.:PA 47 11530

  • CAS : NA

  • Molecular Formula : C7H8ClN3O3S

  • Molecular Weight : 249.67

Ticagrelor - In house Impurity

2-(2,3-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate


  • Catalogue No.:PA 47 11535

  • CAS : NA

  • Molecular Formula : C17H17F2NO3

  • Molecular Weight : 321.32

Ticagrelor - In house Impurity

6-Chloro-2-(propylthio)pyrimidine-4,5-diamine


  • Catalogue No.:PA 47 11540

  • CAS : NA

  • Molecular Formula : C7H11ClN4S

  • Molecular Weight : 218.71

Ticagrelor - In house Impurity

2-(3,5-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate


  • Catalogue No.:PA 47 11545

  • CAS : NA

  • Molecular Formula : C17H17F2NO3

  • Molecular Weight : 321.32

Ticagrelor - In house Impurity

(R)-1-(((3aS,4R,6S,6aR)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol (2R)-2,3-dihydroxysuccinate


  • Catalogue No.:PA 47 11550

  • CAS : NA

  • Molecular Formula : C14H25NO10

  • Molecular Weight : 367.35

Ticagrelor - In house Impurity

2-(((3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol (2R,3R,4S,5R)-2,3,4,5-tetrahydroxyhexanedioate


  • Catalogue No.:PA 47 11555

  • CAS : 376608-65-0

  • Molecular Formula : C16H29NO12

  • Molecular Weight : 427.40

Ticagrelor - In house Impurity

(1S,2R)-2-(3,4-Difluorophenyl)cyclopropanamine (S)-2-hydroxy-2-phenylacetate


  • Catalogue No.:PA 47 11560

  • CAS : NA

  • Molecular Formula : C17H17F2NO3

  • Molecular Weight : 321.32

Ticagrelor - Impurity B

(1S,2S,3R,5S)-3-[[3-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]amino]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol


  • Catalogue No.:PA 47 11565

  • CAS : 1788033-05-5

  • Molecular Formula : C23H28F2N6O4S

  • Molecular Weight : 522.57

Ticagrelor - In house Impurity

2-(Propylthio)pyrimidine-4,6-diol


  • Catalogue No.:PA 47 11570

  • CAS : NA

  • Molecular Formula : C7H10N2O2S

  • Molecular Weight : 186.23

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-((6-Chloro-5-((3-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)amino)-2-(propylthio)pyrimidin-4-yl)amino)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11575

  • CAS : NA

  • Molecular Formula : C28H42ClN9O8S2

  • Molecular Weight : 732.27

Ticagrelor - In house Impurity

(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylic Acid


  • Catalogue No.:PA 47 11580

  • CAS : 220352-36-3

  • Molecular Formula : C10H8F2O2

  • Molecular Weight : 198.17

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-(7-(((1R,2R)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11585

  • CAS : NA

  • Molecular Formula : C23H28F2N6O4S

  • Molecular Weight : 522.57

Ticagrelor - In house Impurity

(1R,2S)-2-(3,5-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate


  • Catalogue No.:PA 47 11590

  • CAS : NA

  • Molecular Formula : C17H17F2NO3

  • Molecular Weight : 321.32

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-(7-(((1S,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11595

  • CAS : NA

  • Molecular Formula : C23H28F2N6O4S

  • Molecular Weight : 522.57

Ticagrelor - In house Impurity

Benzyl ((3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)carbamate


  • Catalogue No.:PA 47 11600

  • CAS : 274693-54-8

  • Molecular Formula : C18H25NO6

  • Molecular Weight : 351.39

Ticagrelor - In house Impurity

(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride


  • Catalogue No.:PA 47 11610

  • CAS : 1156491-10-9 and 1402222-66-5

  • Molecular Formula : C9H10ClF2N

  • Molecular Weight : 205.63

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-[7-Chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol


  • Catalogue No.:PA 47 11620

  • CAS : 1354945-69-9

  • Molecular Formula : C14H20ClN5O4S

  • Molecular Weight : 389.86

Ticagrelor - In house Impurity

2-(((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo [4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl Hydrogen Sulfate


  • Catalogue No.:PA 47 11630

  • CAS : NA

  • Molecular Formula : C23H28F2N6O7S2

  • Molecular Weight : 602.63

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(2,3-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol


  • Catalogue No.:PA 47 11640

  • CAS : 1643378-48-6

  • Molecular Formula : C23H28F2N6O4S

  • Molecular Weight : 522.57

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(4-Fluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol


  • Catalogue No.:PA 47 11650

  • CAS : 1643378-47-5

  • Molecular Formula : C23H29FN6O4S

  • Molecular Weight : 504.58

Ticagrelor - In house Impurity

2-(((3aS,4R,6S,6aR)-6-Amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol


  • Catalogue No.:PA 47 11660

  • CAS : NA

  • Molecular Formula : C10H19NO4

  • Molecular Weight : 217.26

Ticagrelor - In house Impurity

ent-Ticagrelor


  • Catalogue No.:PA 47 11670

  • CAS : NA

  • Molecular Formula : C23H28F2N6O4S

  • Molecular Weight : 522.57

Ticagrelor - In house Impurity

(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride


  • Catalogue No.:PA 47 11680

  • CAS : NA

  • Molecular Formula : C9H10ClF2N

  • Molecular Weight : 205.63

Ticagrelor - In house Impurity

(1S,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride


  • Catalogue No.:PA 47 11690

  • CAS : NA

  • Molecular Formula : C9H10ClF2N

  • Molecular Weight : 205.63

Ticagrelor - In house Impurity

(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide


  • Catalogue No.:PA 47 11700

  • CAS : 1006376-62-0

  • Molecular Formula : C10H9F2NO

  • Molecular Weight : 197.18

Ticagrelor - In house Impurity

Ticagrelor Sulfoxide (Mixture of Diastereomers)


  • Catalogue No.:PA 47 11710

  • CAS : 1644461-85-7

  • Molecular Formula : C23H28F2N6O5S

  • Molecular Weight : 538.57

Ticagrelor - In house Impurity

Ticagrelor Sulfone


  • Catalogue No.:PA 47 11720

  • CAS : 274693-39-9

  • Molecular Formula : C23H28F2N6O6S

  • Molecular Weight : 554.57

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-(7-(((1R,2R)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11730

  • CAS : NA

  • Molecular Formula : C23H28F2N6O5S

  • Molecular Weight : 538.57

Ticagrelor - Impurity D

2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol


  • Catalogue No.:PA 47 11740

  • CAS : 274693-26-4

  • Molecular Formula : C26H32F2N6O4S

  • Molecular Weight : 562.63

Ticagrelor - Impurity A

(1S,2S,3R,5S)-3-(7-Amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11750

  • CAS : 1251765-07-7

  • Molecular Formula : C14H22N6O4S

  • Molecular Weight : 370.43

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-((3-((1S)-2-(3,4-Difluorophenyl)cyclopropyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)amino)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11760

  • CAS : NA

  • Molecular Formula : C23H28F2N6O4S

  • Molecular Weight : 522.57

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-(7-Hydroxy-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11770

  • CAS : 1445580-43-7

  • Molecular Formula : C14H21N5O5S

  • Molecular Weight : 371.41

Ticagrelor - Impurity C

2-(((1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-Dihydroxycyclopentyl)oxy)ethyl Acetate


  • Catalogue No.:PA 47 11780

  • CAS : 1616703-93-5

  • Molecular Formula : C25H30F2N6O5S

  • Molecular Weight : 564.60

Ticagrelor - In house Impurity

Ethyl 2-(((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)acetate


  • Catalogue No.:PA 47 11790

  • CAS : NA

  • Molecular Formula : C25H30F2N6O5S

  • Molecular Weight : 564.60

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-(7-(((1S,2R)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11800

  • CAS : 2096989-56-7

  • Molecular Formula : C23H28F2N6O4S

  • Molecular Weight : 522.57

Ticagrelor - In house Impurity

(1S,2R,3S,4R)-4-(7-(((1S,2R)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)cyclopentane-1,2,3-triol


  • Catalogue No.:PA 47 11810

  • CAS : NA

  • Molecular Formula : C21H24F2N6O3S

  • Molecular Weight : 478.52

Ticagrelor - In house Impurity

(1R,2S)-2-(3-Fluorophenyl)cyclopropanamine


  • Catalogue No.:PA 47 11820

  • CAS : 220353-83-3

  • Molecular Formula : C9H10FN

  • Molecular Weight : 151.18

Ticagrelor - In house Impurity

(1R,2S)-2-(4-Fluorophenyl)cyclopropanamine


  • Catalogue No.:PA 47 11830

  • CAS : 220349-80-4

  • Molecular Formula : C9H10FN

  • Molecular Weight : 151.18

Ticagrelor - In house Impurity

4,6-Dichloro-2-propylthiopyrimidine-5-amine


  • Catalogue No.:PA 47 11840

  • CAS : 145783-15-9

  • Molecular Formula : C7H9Cl2N3S

  • Molecular Weight : 238.14

Ticagrelor - In house Impurity

4-Chloro-5-nitro-2-(propylthio)pyrimidine


  • Catalogue No.:PA 47 11850

  • CAS : NA

  • Molecular Formula : C7H8ClN3O2S

  • Molecular Weight : 233.68

Ticagrelor - In house Impurity

4-Methoxy-5-nitro-2-(propylthio)pyrimidine


  • Catalogue No.:PA 47 11860

  • CAS : NA

  • Molecular Formula : C8H11N3O3S

  • Molecular Weight : 229.26

Ticagrelor - In house Impurity

5-Nitro-2-(propylthio)pyrimidine-4,6-diol


  • Catalogue No.:PA 47 11870

  • CAS : 145783-13-7

  • Molecular Formula : C7H9N3O4S

  • Molecular Weight : 231.23

Ticagrelor - In house Impurity

5-Amino-2-(propylthio)pyrimidine-4,6-diol


  • Catalogue No.:PA 47 11880

  • CAS : 1482484-92-3

  • Molecular Formula : C7H11N3O2S

  • Molecular Weight : 201.25

Ticagrelor - In house Impurity

5-Amino-6-chloro-2-(propylthio)pyrimidin-4-ol


  • Catalogue No.:PA 47 11890

  • CAS : NA

  • Molecular Formula : C7H10ClN3OS

  • Molecular Weight : 219.69

Ticagrelor - In house Impurity

4,6-Dichloro-2-(propylthio)pyrimidine


  • Catalogue No.:PA 47 11900

  • CAS : 1401318-10-2

  • Molecular Formula : C7H8Cl2N2S

  • Molecular Weight : 223.12

Ticagrelor - In house Impurity

4,6-Dichloro-5-nitroso-2-(propylthio)pyrimidine


  • Catalogue No.:PA 47 11910

  • CAS : NA

  • Molecular Formula : C7H7Cl2N3OS

  • Molecular Weight : 252.12

Ticagrelor - In house Impurity

2-((3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol L-Tartaric Acid


  • Catalogue No.:PA 47 11920

  • CAS : 376608-65-0

  • Molecular Formula : C14H25NO10

  • Molecular Weight : 367.35

Ticagrelor - In house Impurity

Ethyl 2-(((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate Oxalate


  • Catalogue No.:PA 47 11930

  • CAS : NA

  • Molecular Formula : C14H23NO9

  • Molecular Weight : 349.33

Ticagrelor - In house Impurity

(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-hydroxy(phenyl)ethanoate


  • Catalogue No.:PA 47 11940

  • CAS : 376608-71-8

  • Molecular Formula : C17H17F2NO3

  • Molecular Weight : 321.32

Ticagrelor - In house Impurity

2-(3-Chloro-4-fluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate


  • Catalogue No.:PA 47 11950

  • CAS : NA

  • Molecular Formula : C17H17ClFNO3

  • Molecular Weight : 337.77

Ticagrelor - In house Impurity

2-(4-Chloro-3-fluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate


  • Catalogue No.:PA 47 11960

  • CAS : NA

  • Molecular Formula : C17H17ClFNO3

  • Molecular Weight : 337.77

Ticagrelor - In house Impurity

2-(4-Fluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate


  • Catalogue No.:PA 47 11970

  • CAS : NA

  • Molecular Formula : C17H18FNO3

  • Molecular Weight : 303.33

Ticagrelor - In house Impurity

(1S,2R)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate


  • Catalogue No.:PA 47 11980

  • CAS : NA

  • Molecular Formula : C17H17F2NO3

  • Molecular Weight : 321.32

Ticagrelor - In house Impurity

(1S,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate


  • Catalogue No.:PA 47 11990

  • CAS : NA

  • Molecular Formula : C17H17F2NO3

  • Molecular Weight : 321.32

Ticagrelor-d7


  • Catalogue No.:PA STI 083140

  • CAS : 1265911-55-4

  • Molecular Formula : C23H21D7F2N6O4S

  • Molecular Weight : 529.61

Desethoxyhydroxy Ticagrelor-d7


  • Catalogue No.:PA STI 083141

  • CAS : NA

  • Molecular Formula : C21H19D7F2N6O3S

  • Molecular Weight : 487.57

Ticagrelor - In house Impurity

(1R,2R,3S,5R)-3-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11605

  • CAS : NA

  • Molecular Formula : C23H28F2N6O4S

  • Molecular Weight : 522.57

Ticagrelor - In house Impurity

2-(((3aR,4S,6R,6aS)-6-((3-Chloro-2-nitro-5-(propylthio)phenyl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol


  • Catalogue No.:PA 47 11615

  • CAS : NA

  • Molecular Formula : C19H27ClN2O6S

  • Molecular Weight : 446.94

Ticagrelor - In house Impurity

2,2'-(((3aR,3a'R,4S,4'S,6R,6aS,6'R,6a'S)-((2-Amino-5-(propylthio)-1,3-phenylene)bis(azanediyl))bis(2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxole-6,4-diyl))bis(oxy))bis(ethan-1-ol)


  • Catalogue No.:PA 47 11625

  • CAS : NA

  • Molecular Formula : C29H47N3O8S

  • Molecular Weight : 597.77

Ticagrelor - In house Impurity

2-(((3aR,4S,6S,6aS)-6-((2-Amino-3-chloro-5-(propylthio)phenyl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol


  • Catalogue No.:PA 47 11635

  • CAS : NA

  • Molecular Formula : C19H29ClN2O4S

  • Molecular Weight : 416.96

Ticagrelor - In house Impurity

2-(((3aR,4S,6S,6aS)-6-(7-Chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol


  • Catalogue No.:PA 47 11645

  • CAS : NA

  • Molecular Formula : C17H24ClN5O4S

  • Molecular Weight : 429.92

Ticagrelor - In house Impurity

2-(((3aR,4S,6S,6aS)-6-(5-(Butylthio)-7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol


  • Catalogue No.:PA 47 11655

  • CAS : NA

  • Molecular Formula : C27H34F2N6O4S

  • Molecular Weight : 576.66

Ticagrelor - In house Impurity

(1S,2S,3S,5S)-3-(5-(Butylthio)-7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11665

  • CAS : NA

  • Molecular Formula : C23H28F2N6O4S

  • Molecular Weight : 522.57

Ticagrelor - In house Impurity

2-(((3aR,4S,6R,6aS)-6-(5-(Butylthio)-7-(((1S,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol


  • Catalogue No.:PA 47 11675

  • CAS : NA

  • Molecular Formula : C27H34F2N6O4S

  • Molecular Weight : 576.66

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-(5-(Butylthio)-7-(((1S,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11685

  • CAS : NA

  • Molecular Formula : C24H30F2N6O4S

  • Molecular Weight : 536.60

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-(5-(Butylthio)-7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11695

  • CAS : NA

  • Molecular Formula : C24H30F2N6O4S

  • Molecular Weight : 536.60

Ticagrelor - In house Impurity

5-Desthiopropyl-5-hydroxy-ticagrelor


  • Catalogue No.:PA 47 11705

  • CAS : 1644461-81-3

  • Molecular Formula : C20H22F2N6O5

  • Molecular Weight : 464.43

Ticagrelor - In house Impurity

N-Hydroxy Ticagrelor


  • Catalogue No.:PA 47 11715

  • CAS : 1644461-92-6

  • Molecular Formula : C23H28F2N6O5S

  • Molecular Weight : 538.57

Ticagrelor - In house Impurity

(2S,3S)-2-((5-(Butylthio)-3-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)amino)-3-(3,4-difluorophenyl)cyclopropan-1-one


  • Catalogue No.:PA 47 11725

  • CAS : NA

  • Molecular Formula : C24H28F2N6O5S

  • Molecular Weight : 550.58

Ticagrelor - In house Impurity

6-Chloro-N4-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-2-(propylthio)pyrimidine-4,5-diamine


  • Catalogue No.:PA 47 11735

  • CAS : NA

  • Molecular Formula : C16H17ClF2N4S

  • Molecular Weight : 370.85

Ticagrelor - In house Impurity

2-Mercaptopyrimidine-4,6-diol


  • Catalogue No.:PA 47 11745

  • CAS : NA

  • Molecular Formula : C4H4N2O2S

  • Molecular Weight : 144.15

Ticagrelor - In house Impurity

4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine


  • Catalogue No.:PA 47 11755

  • CAS : 145783-14-8

  • Molecular Formula : C7H7Cl2N3O2S

  • Molecular Weight : 268.11

Ticagrelor - In house Impurity

4,6-Dichloro-2-(propylsulfinyl)pyrimidin-5-amine


  • Catalogue No.:PA 47 11765

  • CAS : 1823431-32-8

  • Molecular Formula : C7H9Cl2N3OS

  • Molecular Weight : 254.13

Ticagrelor - In house Impurity

4,6-Dichloro-2-(propylsulfonyl)pyrimidin-5-amine


  • Catalogue No.:PA 47 11775

  • CAS : NA

  • Molecular Formula : C7H9Cl2N3O2S

  • Molecular Weight : 270.13

Ticagrelor - In house Impurity

2-(((3aR,4R,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol


  • Catalogue No.:PA 47 11785

  • CAS : NA

  • Molecular Formula : C10H19NO4

  • Molecular Weight : 217.27

Ticagrelor - In house Impurity

2-(((3aR,4S,6S,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol


  • Catalogue No.:PA 47 11795

  • CAS : NA

  • Molecular Formula : C10H19NO4

  • Molecular Weight : 217.27

Ticagrelor - In house Impurity

(1S,2S)-2-(3,4-Difluorophenyl)-cyclopropanamine


  • Catalogue No.:PA 47 11805

  • CAS : 1459719-81-3

  • Molecular Formula : C9H9F2N

  • Molecular Weight : 169.17

Ticagrelor - In house Impurity

(1S,2R)-2-(3,4-Difluorophenyl)-cyclopropanamine


  • Catalogue No.:PA 47 11815

  • CAS : 1345413-20-8

  • Molecular Formula : C9H9F2N

  • Molecular Weight : 169.17

Ticagrelor - In house Impurity

(2S,3S)-2-Amino-3-(3,4-difluorophenyl)cyclopropan-1-one


  • Catalogue No.:PA 47 11825

  • CAS : NA

  • Molecular Formula : C9H7F2NO

  • Molecular Weight : 183.16

Ticagrelor - In house Impurity

S-Propyl-2-thiobarbituric Acid


  • Catalogue No.:PA 47 11835

  • CAS : 145783-12-6

  • Molecular Formula : C7H10N2O2S

  • Molecular Weight : 186.23

Ticagrelor - In house impurity

(1S,2S,3R,5S)-3-(5-Amino-6-chloro-2-(propylthio)pyrimidin-4-ylamino)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11875

  • CAS : 1402150-32-6

  • Molecular Formula : C14H23ClN4O4S

  • Molecular Weight : 378.87

Ticagrelor - In house impurity

3-Amino-3-deoxy-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose


  • Catalogue No.:PA 47 11885

  • CAS : 24384-84-7

  • Molecular Formula : C12H21NO5

  • Molecular Weight : 259.30

Ticagrelor - In house impurity

2-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol


  • Catalogue No.:PA 47 11895

  • CAS : 376608-74-1

  • Molecular Formula : C17H27ClN4O4S

  • Molecular Weight : 418.94

Ticagrelor - In house Impurity

2-Hydroxyethyl 2-(((3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate


  • Catalogue No.:PA 47 11845

  • CAS : NA

  • Molecular Formula : C19H29ClN4O6S

  • Molecular Weight : 476.97

Ticagrelor - Impurity E

(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine


  • Catalogue No.:PA 47 11855

  • CAS : 220352-38-5

  • Molecular Formula : C9H9F2N

  • Molecular Weight : 169.17

Ticagrelor - In house Impurity

(1S,2S,3R,5R)-3-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 11865

  • CAS : NA

  • Molecular Formula : C23H28F2N6O4S

  • Molecular Weight : 522.57

Ticagrelor - In house Impurity

(3aS,4R,6S,6aR)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol


  • Catalogue No.:PA 47 11905

  • CAS : 592533-90-9

  • Molecular Formula : C8H15NO3

  • Molecular Weight : 173.21

Ticagrelor - In house Impurity

(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanamine


  • Catalogue No.:PA 47 11915

  • CAS : 1414348-35-8

  • Molecular Formula : C9H9F2N

  • Molecular Weight : 169.17

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-(7-((2-Chloro-3-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 0111000

  • CAS : NA

  • Molecular Formula : C23H27ClF2N6O5S

  • Molecular Weight : 573.01

Ticagrelor - In house Impurity

(1S,2S,3R,5S)-3-(7-((2-Chloro-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol


  • Catalogue No.:PA 47 0111001

  • CAS : NA

  • Molecular Formula : C23H27ClF2N6O5S

  • Molecular Weight : 573.01

Whoops! There was an error.
UnexpectedValueException
The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied UnexpectedValueException thrown with message "The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied" Stacktrace: #10 UnexpectedValueException in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php:107 #9 Monolog\Handler\StreamHandler:write in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Handler/AbstractProcessingHandler.php:37 #8 Monolog\Handler\AbstractProcessingHandler:handle in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Logger.php:337 #7 Monolog\Logger:addRecord in /home/pharmaaffiliates/public_html/vendor/monolog/monolog/src/Monolog/Logger.php:616 #6 Monolog\Logger:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php:179 #5 Illuminate\Log\Logger:writeLog in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php:90 #4 Illuminate\Log\Logger:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Log/LogManager.php:524 #3 Illuminate\Log\LogManager:error in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Exceptions/Handler.php:113 #2 Illuminate\Foundation\Exceptions\Handler:report in /home/pharmaaffiliates/public_html/app/Exceptions/Handler.php:43 #1 App\Exceptions\Handler:report in /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Bootstrap/HandleExceptions.php:81 #0 Illuminate\Foundation\Bootstrap\HandleExceptions:handleException in [internal]:0
10
UnexpectedValueException
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Handler
/
StreamHandler.php
107
9
Monolog
\
Handler
\
StreamHandler
write
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Handler
/
AbstractProcessingHandler.php
37
8
Monolog
\
Handler
\
AbstractProcessingHandler
handle
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Logger.php
337
7
Monolog
\
Logger
addRecord
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Logger.php
616
6
Monolog
\
Logger
error
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
Logger.php
179
5
Illuminate
\
Log
\
Logger
writeLog
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
Logger.php
90
4
Illuminate
\
Log
\
Logger
error
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
LogManager.php
524
3
Illuminate
\
Log
\
LogManager
error
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Exceptions
/
Handler.php
113
2
Illuminate
\
Foundation
\
Exceptions
\
Handler
report
/
app
/
Exceptions
/
Handler.php
43
1
App
\
Exceptions
\
Handler
report
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Bootstrap
/
HandleExceptions.php
81
0
Illuminate
\
Foundation
\
Bootstrap
\
HandleExceptions
handleException
[internal]
0
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Handler
/
StreamHandler.php
    /**
     * {@inheritdoc}
     */
    protected function write(array $record)
    {
        if (!is_resource($this->stream)) {
            if (null === $this->url || '' === $this->url) {
                throw new \LogicException('Missing stream url, the stream can not be opened. This may be caused by a premature call to close().');
            }
            $this->createDir();
            $this->errorMessage = null;
            set_error_handler(array($this, 'customErrorHandler'));
            $this->stream = fopen($this->url, 'a');
            if ($this->filePermission !== null) {
                @chmod($this->url, $this->filePermission);
            }
            restore_error_handler();
            if (!is_resource($this->stream)) {
                $this->stream = null;
                throw new \UnexpectedValueException(sprintf('The stream or file "%s" could not be opened: '.$this->errorMessage, $this->url));
            }
        }
 
        if ($this->useLocking) {
            // ignoring errors here, there's not much we can do about them
            flock($this->stream, LOCK_EX);
        }
 
        $this->streamWrite($this->stream, $record);
 
        if ($this->useLocking) {
            flock($this->stream, LOCK_UN);
        }
    }
 
    /**
     * Write to stream
     * @param resource $stream
     * @param array $record
     */
Arguments
  1. "The stream or file "/home/pharmaaffiliates/public_html/storage/logs/laravel.log" could not be opened: failed to open stream: Permission denied"
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Handler
/
AbstractProcessingHandler.php
 *
 * @author Jordi Boggiano <j.boggiano@seld.be>
 * @author Christophe Coevoet <stof@notk.org>
 */
abstract class AbstractProcessingHandler extends AbstractHandler
{
    /**
     * {@inheritdoc}
     */
    public function handle(array $record)
    {
        if (!$this->isHandling($record)) {
            return false;
        }
 
        $record = $this->processRecord($record);
 
        $record['formatted'] = $this->getFormatter()->format($record);
 
        $this->write($record);
 
        return false === $this->bubble;
    }
 
    /**
     * Writes the record down to the log of the implementing handler
     *
     * @param  array $record
     * @return void
     */
    abstract protected function write(array $record);
 
    /**
     * Processes a record.
     *
     * @param  array $record
     * @return array
     */
    protected function processRecord(array $record)
    {
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571600016 {#33
        date: 2019-10-20 19:33:36.210026 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 19:33:36] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6IlNTaGZ...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6IlNTaGZ...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('92yvmZ8L6clV2xj...', 'eyJpdiI6IlNTaGZ...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Logger.php
            $ts = new \DateTime(null, static::$timezone);
        }
        $ts->setTimezone(static::$timezone);
 
        $record = array(
            'message' => (string) $message,
            'context' => $context,
            'level' => $level,
            'level_name' => $levelName,
            'channel' => $this->name,
            'datetime' => $ts,
            'extra' => array(),
        );
 
        foreach ($this->processors as $processor) {
            $record = call_user_func($processor, $record);
        }
 
        while ($handler = current($this->handlers)) {
            if (true === $handler->handle($record)) {
                break;
            }
 
            next($this->handlers);
        }
 
        return true;
    }
 
    /**
     * Adds a log record at the DEBUG level.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function addDebug($message, array $context = array())
    {
        return $this->addRecord(static::DEBUG, $message, $context);
    }
Arguments
  1. array:8 [
      "message" => "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
      "context" => array:1 [
        "exception" => ErrorException {#31
          #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
          #code: 0
          #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
          #line: 122
          #severity: E_WARNING
        }
      ]
      "level" => 400
      "level_name" => "ERROR"
      "channel" => "local"
      "datetime" => DateTime @1571600016 {#33
        date: 2019-10-20 19:33:36.210026 UTC (+00:00)
      }
      "extra" => []
      "formatted" => """
        [2019-10-20 19:33:36] local.ERROR: file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied {"exception":"[object] (ErrorException(code: 0): file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied at /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
        [stacktrace]\n
        #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(2, 'file_put_conten...', '/home/pharmaaff...', 122, Array)\n
        #1 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home/pharmaaff...', 'eyJpdiI6IlNTaGZ...', 2)\n
        #2 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home/pharmaaff...', 'eyJpdiI6IlNTaGZ...', true)\n
        #3 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('92yvmZ8L6clV2xj...', 'eyJpdiI6IlNTaGZ...')\n
        #4 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
        #5 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #6 /home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #7 /home/pharmaaffiliates/public_html/public/index.php(57): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
        #8 /home/pharmaaffiliates/public_html/index.php(19): require_once('/home/pharmaaff...')\n
        #9 {main}\n
        "} \n
        """
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
monolog
/
monolog
/
src
/
Monolog
/
Logger.php
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function err($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the ERROR level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function error($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string  $message The log message
     * @param  array   $context The log context
     * @return Boolean Whether the record has been processed
     */
    public function crit($message, array $context = array())
    {
        return $this->addRecord(static::CRITICAL, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
Arguments
  1. 400
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
Logger.php
     * @return void
     */
    public function write($level, $message, array $context = [])
    {
        $this->writeLog($level, $message, $context);
    }
 
    /**
     * Write a message to the log.
     *
     * @param  string  $level
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    protected function writeLog($level, $message, $context)
    {
        $this->fireLogEvent($level, $message = $this->formatMessage($message), $context);
 
        $this->logger->{$level}($message, $context);
    }
 
    /**
     * Register a new callback handler for when a log event is triggered.
     *
     * @param  \Closure  $callback
     * @return void
     *
     * @throws \RuntimeException
     */
    public function listen(Closure $callback)
    {
        if (! isset($this->dispatcher)) {
            throw new RuntimeException('Events dispatcher has not been set.');
        }
 
        $this->dispatcher->listen(MessageLogged::class, $callback);
    }
 
    /**
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
Logger.php
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function critical($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log an error message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function error($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a warning message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function warning($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a notice to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
Arguments
  1. "error"
    
  2. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
    
  3. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Log
/
LogManager.php
     *
     * @return void
     */
    public function critical($message, array $context = [])
    {
        return $this->driver()->critical($message, $context);
    }
 
    /**
     * Runtime errors that do not require immediate action but should typically
     * be logged and monitored.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function error($message, array $context = [])
    {
        return $this->driver()->error($message, $context);
    }
 
    /**
     * Exceptional occurrences that are not errors.
     *
     * Example: Use of deprecated APIs, poor use of an API, undesirable things
     * that are not necessarily wrong.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function warning($message, array $context = [])
    {
        return $this->driver()->warning($message, $context);
    }
 
    /**
     * Normal but significant events.
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Exceptions
/
Handler.php
     */
    public function report(Exception $e)
    {
        if ($this->shouldntReport($e)) {
            return;
        }
 
        if (method_exists($e, 'report')) {
            return $e->report();
        }
 
        try {
            $logger = $this->container->make(LoggerInterface::class);
        } catch (Exception $ex) {
            throw $e;
        }
 
        $logger->error(
            $e->getMessage(),
            array_merge($this->context(), ['exception' => $e]
        ));
    }
 
    /**
     * Determine if the exception should be reported.
     *
     * @param  \Exception  $e
     * @return bool
     */
    public function shouldReport(Exception $e)
    {
        return ! $this->shouldntReport($e);
    }
 
    /**
     * Determine if the exception is in the "do not report" list.
     *
     * @param  \Exception  $e
     * @return bool
     */
Arguments
  1. "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
    
  2. array:1 [
      "exception" => ErrorException {#31
        #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
        #code: 0
        #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
        #line: 122
        #severity: E_WARNING
      }
    ]
    
/
home
/
pharmaaffiliates
/
public_html
/
app
/
Exceptions
/
Handler.php
        \Illuminate\Auth\AuthenticationException::class,
        \Illuminate\Auth\Access\AuthorizationException::class,
        \Symfony\Component\HttpKernel\Exception\HttpException::class,
        \Illuminate\Database\Eloquent\ModelNotFoundException::class,
        \Illuminate\Session\TokenMismatchException::class,
        \Illuminate\Validation\ValidationException::class,
    ];
 
    /**
     * Report or log an exception.
     *
     * This is a great spot to send exceptions to Sentry, Bugsnag, etc.
     *
     * @param \Exception $exception
     *
     * @return void
     */
    public function report(Exception $exception)
    {
        parent::report($exception);
    }
 
    /**
     * Render an exception into an HTTP response.
     *
     * @param \Illuminate\Http\Request $request
     * @param \Exception               $exception
     *
     * @return \Illuminate\Http\Response
     */
    public function render($request, Exception $exception)
    {
        //dd($exception);
        if (strpos($request->url(), '/api/') !== false) {
            \Log::debug('API Request Exception - '.$request->url().' - '.$exception->getMessage().(!empty($request->all()) ? ' - '.json_encode($request->except(['password'])) : ''));
 
            if ($exception instanceof AuthorizationException) {
                return $this->setStatusCode(403)->respondWithError($exception->getMessage());
            }
 
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
/
home
/
pharmaaffiliates
/
public_html
/
vendor
/
laravel
/
framework
/
src
/
Illuminate
/
Foundation
/
Bootstrap
/
HandleExceptions.php
    }
 
    /**
     * Handle an uncaught exception from the application.
     *
     * Note: Most exceptions can be handled via the try / catch block in
     * the HTTP and Console kernels. But, fatal error exceptions must
     * be handled differently since they are not normal exceptions.
     *
     * @param  \Throwable  $e
     * @return void
     */
    public function handleException($e)
    {
        if (! $e instanceof Exception) {
            $e = new FatalThrowableError($e);
        }
 
        try {
            $this->getExceptionHandler()->report($e);
        } catch (Exception $e) {
            //
        }
 
        if ($this->app->runningInConsole()) {
            $this->renderForConsole($e);
        } else {
            $this->renderHttpResponse($e);
        }
    }
 
    /**
     * Render an exception to the console.
     *
     * @param  \Exception  $e
     * @return void
     */
    protected function renderForConsole(Exception $e)
    {
        $this->getExceptionHandler()->renderForConsole(new ConsoleOutput, $e);
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    
[internal]
Arguments
  1. ErrorException {#31
      #message: "file_put_contents(/home/pharmaaffiliates/public_html/storage/framework/sessions/92yvmZ8L6clV2xjAqFIImeammQF7bUMmJo56snkK): failed to open stream: Permission denied"
      #code: 0
      #file: "/home/pharmaaffiliates/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_WARNING
    }
    

Environment & details:

empty
empty
empty
empty
empty
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
HTTP_ACCEPT
"text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8"
HTTP_ACCEPT_ENCODING
"gzip"
HTTP_ACCEPT_LANGUAGE
"en-US,en;q=0.5"
HTTP_CONNECTION
"Keep-Alive"
HTTP_HOST
"www.pharmaffiliates.com"
HTTP_USER_AGENT
"CCBot/2.0 (https://commoncrawl.org/faq/)"
HTTP_IF_MODIFIED_SINCE
"Tue, 16 Jul 2019 07:34:39 PDT"
DOCUMENT_ROOT
"/home/pharmaaffiliates/public_html"
REMOTE_ADDR
"3.228.24.192"
REMOTE_PORT
"60736"
SERVER_ADDR
"172.105.43.57"
SERVER_NAME
"www.pharmaffiliates.com"
SERVER_ADMIN
"webmaster@pharmaffiliates.com"
SERVER_PORT
"443"
REQUEST_URI
"/en/parentapi/ticagrelor"
REDIRECT_URL
"/en/parentapi/ticagrelor"
HTTPS
"on"
REDIRECT_STATUS
"200"
SSL_PROTOCOL
"TLSv1.2"
SSL_SESSION_ID
"6d5c4a6c2d949d861d5ead433a2cfca27feea781ab6d1968472faf1f17603025"
SSL_CIPHER
"ECDHE-RSA-AES256-GCM-SHA384"
SSL_CIPHER_USEKEYSIZE
"256"
SSL_CIPHER_ALGKEYSIZE
"256"
SCRIPT_FILENAME
"/home/pharmaaffiliates/public_html/index.php"
QUERY_STRING
""
SCRIPT_URI
"https://www.pharmaffiliates.com/en/parentapi/ticagrelor"
SCRIPT_URL
"/en/parentapi/ticagrelor"
SCRIPT_NAME
"/index.php"
SERVER_PROTOCOL
"HTTP/1.1"
SERVER_SOFTWARE
"LiteSpeed"
REQUEST_METHOD
"GET"
X-LSCACHE
"on"
PHP_SELF
"/index.php"
REQUEST_TIME_FLOAT
1571600015.9237
REQUEST_TIME
1571600015
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
Key Value
LSPHP_ENABLE_USER_INI
"on"
PATH
"/bin:/usr/bin:/usr/local/bin"
APP_NAME
"Pharmaffiliates"
APP_ENV
"local"
APP_KEY
"base64:RFCl9sOZmDjwzTDiQ02zq5N3i8nxtHLZH+gQ8hVsJ8Q="
APP_DEBUG
"true"
APP_LOG_LEVEL
"debug"
APP_URL
"https://www.pharmaaffiliates.com"
DB_CONNECTION
"mysql"
DB_HOST
"127.0.0.1"
DB_PORT
"3306"
DB_DATABASE
"pharmaaffiliates_pharma"
DB_USERNAME
"pharmaaffiliates_pharma"
DB_PASSWORD
"JU*P#1Gp,B&^"
DB_CONNECTION_SECOND
"mysql"
DB_HOST_SECOND
"127.0.0.1"
DB_PORT_SECOND
"3306"
DB_DATABASE_SECOND
"pharmaaffiliates_reports"
DB_USERNAME_SECOND
"pharmaaffiliates_reports"
DB_PASSWORD_SECOND
"uDAR}Db{$#pz"
ENABLE_REGISTRATION
"true"
REQUIRES_APPROVAL
"false"
BROADCAST_DRIVER
"log"
CACHE_DRIVER
"file"
SESSION_DRIVER
"file"
QUEUE_DRIVER
"sync"
REDIS_HOST
"127.0.0.1"
REDIS_PASSWORD
"null"
REDIS_PORT
"6379"
MAIL_DRIVER
"smtp"
MAIL_HOST
"smtp.gmail.com"
MAIL_PORT
"587"
MAIL_ENCRYPTION
"tls"
MAIL_USERNAME
"pharmasoft959@gmail.com"
MAIL_PASSWORD
"virus@225"
PUSHER_APP_ID
""
PUSHER_APP_KEY
""
PUSHER_APP_SECRET
""
JWT_SECRET
"y5VcU28wcem021i5PlpSYoVjJWxQmtGi"
0. Whoops\Handler\PrettyPageHandler