gefitinib
Gefitinib is used to treat lung cancer. Acting in a similar manner to erlotinib gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. Reference standards of Gefitinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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Gefitinib - API Standards
Catalogue No.:PA 07 24000
Molecular Formula : C22H24ClFN4O3
Molecular Weight : 446.90
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[catalogue_number] => PA 07 24020
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Catalogue No.:PA 07 24020
Molecular Formula : C22H24ClFN4O3
Molecular Weight : 446.90
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[catalogue_number] => PA 07 24510
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[weight] => 145.56
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3-Chloro-4-fluorophenylamine
Catalogue No.:PA 07 24510
Molecular Formula : C6H5ClFN
Molecular Weight : 145.56
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O-Desmorpholinopropyl Gefitinib
Catalogue No.:PA 07 24540
Molecular Formula : C15H11ClFN3O2
Molecular Weight : 319.72
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4-(3-((4-Chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine
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6-Hydroxy-7-methoxy-4(1H)-quinazolinone
Catalogue No.:PA 07 24690
Molecular Formula : C9H8N2O3
Molecular Weight : 192.17
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Gefitinib 4-Desfluoro Hydrochloride Impurity
Catalogue No.:PA 07 24520
Molecular Formula : C22H26Cl2N4O3
Molecular Weight : 465.37
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N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)hydroxylamine
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4-(3-((4-((3-Chloro-4-fluorophenyl)(hydroxy)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine 4-oxide
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N-(3-Morpholinopropyl) Gefitinib
Catalogue No.:PA 07 24580
Molecular Formula : C29H37ClFN5O4
Molecular Weight : 574.09
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N-(3-Chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
Catalogue No.:PA 07 24590
Molecular Formula : C16H13ClFN3O2
Molecular Weight : 333.74
stdClass Object
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N-(4-Fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
Catalogue No.:PA 07 24600
Molecular Formula : C22H25FN4O3
Molecular Weight : 412.46
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Catalogue No.:PA 07 24620
Molecular Formula : C21H22ClFN4O3
Molecular Weight : 432.88
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4-Defluoro-4-hydroxy Gefitinib
Catalogue No.:PA 07 24640
Molecular Formula : C22H25ClN4O4
Molecular Weight : 444.91
stdClass Object
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N-(3,4-Dichlorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
Catalogue No.:PA 07 24650
Molecular Formula : C22H24Cl2N4O3
Molecular Weight : 463.36
stdClass Object
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3-(3-Chloro-4-fluorophenyl)-7-methoxy-4-oxo-3,4-dihydroquinazolin-6-yl Acetate
Catalogue No.:PA 07 24660
Molecular Formula : C17H12ClFN2O4
Molecular Weight : 362.74
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3-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4(3H)-one
Catalogue No.:PA 07 24670
Molecular Formula : C22H23ClFN3O4
Molecular Weight : 447.89
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7,8-Dichloro-N-(3-chloro-4-fluorophenyl)-6-(3-morpholinopropoxy)quinazolin-4-amine
Catalogue No.:PA 07 24680
Molecular Formula : C21H20Cl3FN4O2
Molecular Weight : 485.77
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4-Isopropoxy-7-methoxyquinazolin-6-yl acetate
Catalogue No.:PA 07 24700
Molecular Formula : C14H16N2O4
Molecular Weight : 276.29
stdClass Object
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Catalogue No.:PA STI 044040
Molecular Formula : C22H21D3ClFN4O3
Molecular Weight : 449.92
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1-(2-amino-4’-methoxy-[1,1’-biphenyl]-4-yl)ethanone
Catalogue No.:PA 07 24730
Molecular Formula : C15H23N3O4
Molecular Weight : 309.36
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2-Amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]benzamide
Catalogue No.:PA 07 24740
Molecular Formula : C15H22N2O5
Molecular Weight : 310.35
stdClass Object
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[catalogue_number] => PA 07 24710
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[weight] => 291.35
[form] => C15H21N3O3
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2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
Catalogue No.:PA 07 24710
Molecular Formula : C15H21N3O3
Molecular Weight : 291.35
stdClass Object
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[catalogue_number] => PA 07 24720
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[chemical_name] =>
[weight] => 321.33
[form] => C15H19N3O5
[cas] => 675126-26-8
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4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile
Catalogue No.:PA 07 24720
Molecular Formula : C15H19N3O5
Molecular Weight : 321.33
stdClass Object
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[pname] => N'-(2-Cyano-5-methoxy-4-(3-morpholinopropoxy)phenyl)-N,N-dimethylformimidamide
[catalogue_number] => PA 07 24750
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[chemical_name] =>
[weight] => 346.43
[form] => C18H26N4O3
[cas] => 950596-57-3
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N'-(2-Cyano-5-methoxy-4-(3-morpholinopropoxy)phenyl)-N,N-dimethylformimidamide
Catalogue No.:PA 07 24750
Molecular Formula : C18H26N4O3
Molecular Weight : 346.43
stdClass Object
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[catalogue_number] => PA 07 24760
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[weight] => 234.21
[form] => C11H10N2O4
[cas] => 2469273-16-1
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8-Methoxy-4-oxo-3,4-dihydroquinazolin-7-yl acetate
Catalogue No.:PA 07 24760
Molecular Formula : C11H10N2O4
Molecular Weight : 234.21
stdClass Object
(
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[catalogue_number] => PA 07 24770
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[weight] => 234.21
[form] => C11H10N2O4
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7-Methoxy-4-oxo-3,4-dihydroquinazolin-8-yl Acetate
Catalogue No.:PA 07 24770
Molecular Formula : C11H10N2O4
Molecular Weight : 234.21
stdClass Object
(
[pname] => 4-chloro-7-methoxyquinazolin-6-yl acetate
[catalogue_number] => PA 07 0241000
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 252.65
[form] => C11H9ClN2O3
[cas] => 230955-75-6
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4-chloro-7-methoxyquinazolin-6-yl acetate
Catalogue No.:PA 07 0241000
Molecular Formula : C11H9ClN2O3
Molecular Weight : 252.65
stdClass Object
(
[pname] => Methyl 2-amino-4-methoxy-5-(3-morpholinopropoxy)benzoate
[catalogue_number] => PA 07 0241001
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 324.38
[form] => C16H24N2O5
[cas] => 214472-41-0
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Methyl 2-amino-4-methoxy-5-(3-morpholinopropoxy)benzoate
Catalogue No.:PA 07 0241001
Molecular Formula : C16H24N2O5
Molecular Weight : 324.38
stdClass Object
(
[pname] => Methyl 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzoate
[catalogue_number] => PA 07 0241002
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 354.36
[form] => C16H22N2O7
[cas] => 214472-37-4
[pslug] => 214472-37-4-methyl-4-methoxy-5-3-morpholinopropoxy-2-nitrobenzoate-pa070241002
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Methyl 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzoate
Catalogue No.:PA 07 0241002
Molecular Formula : C16H22N2O7
Molecular Weight : 354.36
stdClass Object
(
[pname] => Gefitinib Nitroso Impurity
[catalogue_number] => PA 07 0241003
[category_ids] => ,70,75,76,78,82,162,
[chemical_name] =>
[weight] => 475.91
[form] => C22H23ClFN5O4
[cas] => NA
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Gefitinib Nitroso Impurity
Catalogue No.:PA 07 0241003
Molecular Formula : C22H23ClFN5O4
Molecular Weight : 475.91
stdClass Object
(
[pname] => Gefitinib-D6
[catalogue_number] => PA STI 089397
[category_ids] => ,98,79,80,71,78,70,82,
[chemical_name] =>
[weight] => 452.94
[form] => C22H18D6ClFN4O3
[cas] => 1228664-49-0
[pslug] => 1228664-49-0-gefitinib-d6-pasti089397
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Catalogue No.:PA STI 089397
Molecular Formula : C22H18D6ClFN4O3
Molecular Weight : 452.94
stdClass Object
(
[pname] => 4-(3-Bromopropyl)morpholine Hydrochloride
[catalogue_number] => PA 07 0241004
[category_ids] => ,78,70,82,
[chemical_name] =>
[weight] => 244.56
[form] => C7H15BrClNO
[cas] => 134187-43-2
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4-(3-Bromopropyl)morpholine Hydrochloride
Catalogue No.:PA 07 0241004
Molecular Formula : C7H15BrClNO
Molecular Weight : 244.56
stdClass Object
(
[pname] => 4-Hydroxy-7-methoxyquinazolin-6-yl Ester Acetic Acid
[catalogue_number] => PA 07 0241005
[category_ids] => ,78,70,82,
[chemical_name] =>
[weight] => 234.21
[form] => C11H10N2O4
[cas] => 179688-53-0
[pslug] => 179688-53-0-4-hydroxy-7-methoxyquinazolin-6-yl-ester-acetic-acid-pa070241005
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4-Hydroxy-7-methoxyquinazolin-6-yl Ester Acetic Acid
Catalogue No.:PA 07 0241005
Molecular Formula : C11H10N2O4
Molecular Weight : 234.21
stdClass Object
(
[pname] => 1,3-Dimorpholinopropane
[catalogue_number] => PA 07 0241006
[category_ids] => ,79,80,71,78,70,82,
[chemical_name] =>
[weight] => 214.31
[form] => C11H22N2O2
[cas] => 48152-09-6
[pslug] => 48152-09-6-1-3-dimorpholinopropane-pa070241006
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Catalogue No.:PA 07 0241006
Molecular Formula : C11H22N2O2
Molecular Weight : 214.31