What services are included in small-molecule synthesis?

Small-molecule synthesis services include route scouting, custom synthesis, impurity synthesis, metabolite synthesis, analytical testing, process optimization, and scale-up for pharmaceutical applications.

What analytical methods are used to verify small-molecule purity and identity?

HPLC, LC-MS, GC-MS, NMR spectroscopy, and mass spectrometry are used to confirm structure, purity, and impurities for pharmaceutical quality control.

Can Pharmaffiliates synthesize impurities and reference standards?

Yes, Pharmaffiliates specializes in impurity synthesis, metabolite synthesis, and reference standards required for analytical method validation and regulatory submissions.

What is the difference between custom synthesis and small-molecule API development?

Custom synthesis creates specific research compounds and impurities, while API development includes process optimization, impurity profiling, analytical validation, and scale-up toward GMP readiness.

How scalable is small-molecule synthesis?

Small-molecule synthesis can be scaled from milligram R&D quantities to gram- and kilogram-scale production using optimized processes and scalable chemistry platforms.

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Small Molecule Synthesis

At Pharmaffiliates, we stand by the principle:

“If you can draw it, we can make it.”

We are your trusted partners in developing, designing, and commercializing complex small molecules that require multistep synthesis. We specialize in synthesizing small molecules that demand advanced chemistry and technical expertise, from milligram to gram scale.

APIs and key intermediates
Chiral standards
Metabolites
Glucuronides
Stable isotopes

Thanks to our integrated operations and low overheads, we provide competitive pricing, high-quality products, quick quotes, and fast deliveries.

Related FAQs

Small-molecule synthesis services include route scouting, custom synthesis, impurity synthesis, metabolite and reference standard synthesis, medicinal chemistry support, analytical testing, process optimization, and small-to-large scale synthesis for pharmaceutical R&D and regulatory purposes.

Common analytical methods include HPLC, LC-MS, GC-MS, NMR spectroscopy, IR, UV-Vis and mass spectrometry. These ensure correct molecular structure, purity, and impurity profiling required for pharma quality control and regulatory submissions.

Yes, Pharmaffiliates specializes in impurity synthesis, metabolite synthesis, custom analog design, and reference standards essential for analytical method development, quality control, bioanalytical studies, and regulatory filings for pharmaceuticals.

Custom synthesis produces specific research molecules and impurities, while API development includes route development, impurity profiling, process scale-up, analytical validation, stability studies, and preparing for regulatory or GMP manufacturing requirements.

Small-molecule synthesis is scalable from milligram-research quantities to gram and kilogram-scale production. Modern chemistry platforms enable smooth transition from R&D to pilot-scale and commercial-scale manufacturing while maintaining purity and specifications.