Ivacaftor-impurities | Pharmaffiliates

ivacaftor

Ivacaftor is used for the treatment of cystic fibrosis in people having one of several specific mutations in the cystic fibrosis transmembrane conductance regulator protein. It is one of the most expensive drugs. Reference standards of Ivacaftor API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Ivacaftor - API Standards 
    [catalogue_number] => PA 09 40000
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 392.49
    [form] => C24H28N2O3
    [cas] => 873054-44-5
    [pslug] => 873054-44-5-ivacaftor-api-pa0940000
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PA 09 40000

Ivacaftor - API Standards


  • Catalogue No.:PA 09 40000

  • CAS :

    873054-44-5

  • Molecular Formula : C24H28N2O3

  • Molecular Weight : 392.49

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stdClass Object
(
    [pname] => 4-Oxo-1,4-dihydroquinoline-3-carboxylic Acid
    [catalogue_number] => PA 09 40510
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 189.17
    [form] => C10H7NO3
    [cas] => 13721-01-2
    [pslug] => 13721-01-2-4-oxo-1-4-dihydroquinoline-3-carboxylic-acid-pa0940510
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PA 09 40510

4-Oxo-1,4-dihydroquinoline-3-carboxylic Acid


  • Catalogue No.:PA 09 40510

  • CAS :

    13721-01-2

  • Molecular Formula : C10H7NO3

  • Molecular Weight : 189.17

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stdClass Object
(
    [pname] => 1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester
    [catalogue_number] => PA 09 40520
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 217.22
    [form] => C12H11NO3
    [cas] => 52980-28-6
    [pslug] => 52980-28-6-1-4-dihydro-4-oxo-3-quinolinecarboxylic-acid-ethyl-ester-pa0940520
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    [offers_product_id] => 2413
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PA 09 40520

1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester


  • Catalogue No.:PA 09 40520

  • CAS :

    52980-28-6

  • Molecular Formula : C12H11NO3

  • Molecular Weight : 217.22

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stdClass Object
(
    [pname] => diethyl 2-((phenylamino)methylene)malonate
    [catalogue_number] => PA 09 0401000
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 263.29
    [form] => C14H17NO4
    [cas] => 54535-22-7
    [pslug] => 54535-22-7-diethyl-2-phenylamino-methylene-malonate-pa090401000
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PA 09 0401000

diethyl 2-((phenylamino)methylene)malonate


  • Catalogue No.:PA 09 0401000

  • CAS :

    54535-22-7

  • Molecular Formula : C14H17NO4

  • Molecular Weight : 263.29

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stdClass Object
(
    [pname] => 4-Hydroxyquinoline-3-carboxylic Acid
    [catalogue_number] => PA 09 0401002
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 189.17
    [form] => C10H7NO3
    [cas] => 34785-11-0
    [pslug] => 34785-11-0-4-hydroxyquinoline-3-carboxylic-acid-pa090401002
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    [offers_product_code] => PA 09 0401002
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PA 09 0401002

4-Hydroxyquinoline-3-carboxylic Acid


  • Catalogue No.:PA 09 0401002

  • CAS :

    34785-11-0

  • Molecular Formula : C10H7NO3

  • Molecular Weight : 189.17

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stdClass Object
(
    [pname] => 2,4-Di-tert-butyl-6-nitrophenol
    [catalogue_number] => PA 09 0401003
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 251.33
    [form] => C14H21NO3
    [cas] => 20039-94-5
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PA 09 0401003

2,4-Di-tert-butyl-6-nitrophenol


  • Catalogue No.:PA 09 0401003

  • CAS :

    20039-94-5

  • Molecular Formula : C14H21NO3

  • Molecular Weight : 251.33

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stdClass Object
(
    [pname] => De-Alkylated Ivacaftor
    [catalogue_number] => PA 09 0401001
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 336.39
    [form] => C20H20N2O3
    [cas] => 873054-39-8
    [pslug] => 873054-39-8-de-alkylated-ivacaftor-pa090401001
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PA 09 0401001

De-Alkylated Ivacaftor


  • Catalogue No.:PA 09 0401001

  • CAS :

    873054-39-8

  • Molecular Formula : C20H20N2O3

  • Molecular Weight : 336.39

stdClass Object
(
    [pname] => Ivacaftor D4
    [catalogue_number] => PA STI 089107
    [category_ids] => ,98,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 396.52
    [form] => C24H24D4N2O3
    [cas] => NA
    [pslug] => ivacaftor-d4-pasti089107
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PA STI 089107

Ivacaftor D4


  • Catalogue No.:PA STI 089107

  • CAS :

    NA

  • Molecular Formula : C24H24D4N2O3

  • Molecular Weight : 396.52

stdClass Object
(
    [pname] => Ivacaftor D18
    [catalogue_number] => PA STI 089190
    [category_ids] => ,98,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 410.61
    [form] => C24H10D18N2O3
    [cas] => 1413431-05-6
    [pslug] => 1413431-05-6-ivacaftor-d18-pasti089190
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PA STI 089190

Ivacaftor D18


  • Catalogue No.:PA STI 089190

  • CAS :

    1413431-05-6

  • Molecular Formula : C24H10D18N2O3

  • Molecular Weight : 410.61

stdClass Object
(
    [pname] => 4-(3-((2,4-Di-tert-butyl-5-hydroxyphenyl)carbamoyl)-4-oxoquinolin-1(4H)-yl)-4-oxobutanoic Acid
    [catalogue_number] => PA 09 0401004
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 492.57
    [form] => C28H32N2O6
    [cas] => NA
    [pslug] => 4-3-2-4-di-tert-butyl-5-hydroxyphenyl-carbamoyl-4-oxoquinolin-1-4h-yl-4-oxobutanoic-acid-pa090401004
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PA 09 0401004

4-(3-((2,4-Di-tert-butyl-5-hydroxyphenyl)carbamoyl)-4-oxoquinolin-1(4H)-yl)-4-oxobutanoic Acid


  • Catalogue No.:PA 09 0401004

  • CAS :

    NA

  • Molecular Formula : C28H32N2O6

  • Molecular Weight : 492.57

stdClass Object
(
    [pname] => 1-Nitroso-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid
    [catalogue_number] => PA 09 0401005
    [category_ids] => ,70,78,80,82,162,
    [chemical_name] => 
    [weight] => 218.17
    [form] => C10H6N2O4
    [cas] => NA
    [pslug] => 1-nitroso-4-oxo-1-4-dihydroquinoline-3-carboxylic-acid-pa090401005
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PA 09 0401005

1-Nitroso-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid


  • Catalogue No.:PA 09 0401005

  • CAS :

    NA

  • Molecular Formula : C10H6N2O4

  • Molecular Weight : 218.17

stdClass Object
(
    [pname] => 2,4-Di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl 4-oxo-1,4-dihydroquinoline-3-carboxylate
    [catalogue_number] => PA 09 0401006
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 563.65
    [form] => C34H33N3O5
    [cas] => 2760759-55-3
    [pslug] => 2760759-55-3-2-4-di-tert-butyl-5-4-oxo-1-4-dihydroquinoline-3-carboxamido-phenyl-4-oxo-1-4-dihydroquinoline-3-carboxylate-pa090401006
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PA 09 0401006

2,4-Di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl 4-oxo-1,4-dihydroquinoline-3-carboxylate


  • Catalogue No.:PA 09 0401006

  • CAS :

    2760759-55-3

  • Molecular Formula : C34H33N3O5

  • Molecular Weight : 563.65

stdClass Object
(
    [pname] => N-(4-(Tert-butyl)-3-hydroxyphenyl)-1-nitroso-4-oxo-1,4-dihydroquinoline-3-carboxamide
    [catalogue_number] => PA 09 0401007
    [category_ids] => ,70,78,80,82,162,
    [chemical_name] => 
    [weight] => 365.39
    [form] => C20H19N3O4
    [cas] => NA
    [pslug] => n-4-tert-butyl-3-hydroxyphenyl-1-nitroso-4-oxo-1-4-dihydroquinoline-3-carboxamide-pa090401007
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PA 09 0401007

N-(4-(Tert-butyl)-3-hydroxyphenyl)-1-nitroso-4-oxo-1,4-dihydroquinoline-3-carboxamide


  • Catalogue No.:PA 09 0401007

  • CAS :

    NA

  • Molecular Formula : C20H19N3O4

  • Molecular Weight : 365.39

stdClass Object
(
    [pname] => Ivacaftor Nitroso Impurity
    [catalogue_number] => PA 09 0401008
    [category_ids] => ,70,78,80,82,162,
    [chemical_name] => 
    [weight] => 421.5
    [form] => C24H27N3O4
    [cas] => NA
    [pslug] => ivacaftor-nitroso-impurity-pa090401008
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PA 09 0401008

Ivacaftor Nitroso Impurity


  • Catalogue No.:PA 09 0401008

  • CAS :

    NA

  • Molecular Formula : C24H27N3O4

  • Molecular Weight : 421.5

stdClass Object
(
    [pname] => N-Nitroso Ivacaftor Ortho Isomer
    [catalogue_number] => PA 09 0401010
    [category_ids] => ,70,78,80,82,162,
    [chemical_name] => 
    [weight] => 421.5
    [form] => C24H27N3O4
    [cas] => NA
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PA 09 0401010

N-Nitroso Ivacaftor Ortho Isomer


  • Catalogue No.:PA 09 0401010

  • CAS :

    NA

  • Molecular Formula : C24H27N3O4

  • Molecular Weight : 421.5

stdClass Object
(
    [pname] => Ethyl 1-nitroso-4-oxo-1,4-dihydroquinoline-3-carboxylate
    [catalogue_number] => PA 09 0401011
    [category_ids] => ,70,78,80,82,162,
    [chemical_name] => 
    [weight] => 246.22
    [form] => C12H10N2O4
    [cas] => NA
    [pslug] => ethyl-1-nitroso-4-oxo-1-4-dihydroquinoline-3-carboxylate-pa090401011
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PA 09 0401011

Ethyl 1-nitroso-4-oxo-1,4-dihydroquinoline-3-carboxylate


  • Catalogue No.:PA 09 0401011

  • CAS :

    NA

  • Molecular Formula : C12H10N2O4

  • Molecular Weight : 246.22

stdClass Object
(
    [pname] => 2,4-Di-tert-butyl-6-nitrophenyl methyl carbonate
    [catalogue_number] => PA 09 0401012
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 309.36
    [form] => C16H23NO5
    [cas] => 873055-56-2
    [pslug] => 873055-56-2-2-4-di-tert-butyl-6-nitrophenyl-methyl-carbonate-pa090401012
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PA 09 0401012

2,4-Di-tert-butyl-6-nitrophenyl methyl carbonate


  • Catalogue No.:PA 09 0401012

  • CAS :

    873055-56-2

  • Molecular Formula : C16H23NO5

  • Molecular Weight : 309.36

stdClass Object
(
    [pname] => Diethyl 2-((nitroso(phenyl)amino)methylene)malonate
    [catalogue_number] => PA 09 0401013
    [category_ids] => ,78,70,82,162,
    [chemical_name] => 
    [weight] => 292.29
    [form] => C14H16N2O5
    [cas] => NA
    [pslug] => diethyl-2-nitroso-phenyl-amino-methylene-malonate-pa090401013
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PA 09 0401013

Diethyl 2-((nitroso(phenyl)amino)methylene)malonate


  • Catalogue No.:PA 09 0401013

  • CAS :

    NA

  • Molecular Formula : C14H16N2O5

  • Molecular Weight : 292.29