Zanubrutinib-impurities | Pharmaffiliates

Zanubrutinib

Zanubrutinib, sold under the brand name Brukinsa, is for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Reference standards of Zanubrutinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

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    [pname] => (S)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391000
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 500.56
    [form] => C27H28N6O4
    [cas] => NA
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PA 26 0391000

(S)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide


  • Catalogue No.:PA 26 0391000

  • CAS :

    NA

  • Molecular Formula : C27H28N6O4

  • Molecular Weight : 500.56

stdClass Object
(
    [pname] => Zanubrutinib - API Standards 
    [catalogue_number] => PA 26 0390000
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 471.56
    [form] => C27H29N5O3
    [cas] => 1691249-45-2
    [pslug] => 1691249-45-2-zanubrutinib-api-pa260390000
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PA 26 0390000

Zanubrutinib - API Standards


  • Catalogue No.:PA 26 0390000

  • CAS :

    1691249-45-2

  • Molecular Formula : C27H29N5O3

  • Molecular Weight : 471.56

stdClass Object
(
    [pname] => (S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391002
    [category_ids] => ,75,78,70,82,
    [chemical_name] => 
    [weight] => 508.02
    [form] => C27H30ClN5O3
    [cas] => 1633351-79-7
    [pslug] => 1633351-79-7-s-7-1-3-chloropropanoyl-piperidin-4-yl-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391002
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PA 26 0391002

(S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide


  • Catalogue No.:PA 26 0391002

  • CAS :

    1633351-79-7

  • Molecular Formula : C27H30ClN5O3

  • Molecular Weight : 508.02

stdClass Object
(
    [pname] => (S)-7-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
    [catalogue_number] => PA 26 0391003
    [category_ids] => ,75,78,70,82,
    [chemical_name] => 
    [weight] => 453.55
    [form] => C27H27N5O2
    [cas] => 2432022-47-2
    [pslug] => 2432022-47-2-s-7-1-acryloylpiperidin-4-yl-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carbonitrile-pa260391003
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PA 26 0391003

(S)-7-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile


  • Catalogue No.:PA 26 0391003

  • CAS :

    2432022-47-2

  • Molecular Formula : C27H27N5O2

  • Molecular Weight : 453.55

stdClass Object
(
    [pname] => 3-(4-(3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid
    [catalogue_number] => PA 26 0391005
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 489.58
    [form] => C27H31N5O4
    [cas] => NA
    [pslug] => 3-4-3-carbamoyl-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidin-7-yl-piperidin-1-yl-propanoic-acid-pa260391005
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PA 26 0391005

3-(4-(3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid


  • Catalogue No.:PA 26 0391005

  • CAS :

    NA

  • Molecular Formula : C27H31N5O4

  • Molecular Weight : 489.58

stdClass Object
(
    [pname] => 2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine
    [catalogue_number] => PA 26 0391006
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 374.49
    [form] => C23H26N4O
    [cas] => NA
    [pslug] => 2-4-phenoxyphenyl-7-piperidin-4-yl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-pa260391006
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PA 26 0391006

2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine


  • Catalogue No.:PA 26 0391006

  • CAS :

    NA

  • Molecular Formula : C23H26N4O

  • Molecular Weight : 374.49