Itacitinib and its Impurities

Itacitinib (also known as INCB039110) is an investigational oral drug that acts as a selective Janus kinase 1 (JAK1) inhibitor. It is being developed for its anti-inflammatory and immunomodulatory properties, with potential applications in treating autoimmune diseases, inflammatory conditions, and certain cancers. Reference standards of Itacitinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.