lumacaftor and its Impurities
Lumacaftor used in combination with Ivacaftor as the fixed dose combination product Orkambi for the management of Cystic Fibrosis in patients aged 6 years and older. It is a drug. It is available in a single pill with ivacaftor. Reference standards of Lumacaftor API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(5-methyl-6-(3-pentanoylphenyl)pyridin-2-yl)cyclopropane-1-carboxamide
1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(5-methyl-6-(3-pentanoylphenyl)pyridin-2-yl)cyclopropane-1-carboxamide
Catalogue No.:PA 12 0951000
CAS :
2760759-54-2
Molecular Formula : C28H26F2N2O4
Molecular Weight : 492.52
3-(6-(3-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-5-hydroxy-2-oxopyrrolidin-1-yl)-3-methylpyridin-2-yl)benzoic Acid
3-(6-(3-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-5-hydroxy-2-oxopyrrolidin-1-yl)-3-methylpyridin-2-yl)benzoic Acid
Catalogue No.:PA 12 0951001
CAS :
2732521-08-1
Molecular Formula : C24H18F2N2O6
Molecular Weight : 468.41
2-(3-Carboxyphenyl)-6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridine 1-oxide
2-(3-Carboxyphenyl)-6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridine 1-oxide
Catalogue No.:PA 12 0951002
CAS :
2760759-52-0
Molecular Formula : C24H18F2N2O6
Molecular Weight : 468.41
N-(6-Chloro-5-methylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide
N-(6-Chloro-5-methylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide
Catalogue No.:PA 12 0951003
CAS :
936727-68-3
Molecular Formula : C17H13ClF2N2O3
Molecular Weight : 366.75
1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(5-methylpyridin-2-yl)cyclopropane-1-carboxamide
1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(5-methylpyridin-2-yl)cyclopropane-1-carboxamide
Catalogue No.:PA 12 0951006
CAS :
1189328-38-8
Molecular Formula : C17H14F2N2O3
Molecular Weight : 332.31
