Posenacaftor and its Impurities

Posenacaftor (PTI-801) is an investigational drug developed by Proteostasis Therapeutics for the treatment of cystic fibrosis (CF), a genetic disorder that affects the lungs and other organs. Reference standards of Posenacaftor API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.