sacubitril

An antihypertensive drug, Sacubitril is used in combination with valsartan for the treatment of heart ailments. A prodrug of sacubitrilat which is an inhibitor of enzyme neprilysin, which aids the degradation of blood pressure-lowering peptides, atrial and brain natriuretic peptide.Reference standards of Sacubitril API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-isopropoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
    [catalogue_number] => PA 19 0661076
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 889.11
    [form] => C50H60CaN2O10
    [cas] => 2984580-05-2
    [pslug] => 2984580-05-2-calcium-4-2s-4r-1-1-1-biphenyl-4-yl-5-isopropoxy-4-methyl-5-oxopentan-2-yl-amino-4-oxobutanoate-pa190661076
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PA 19 0661076

Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-isopropoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate

  • Catalogue No.:PA 19 0661076

  • CAS :

    2984580-05-2

  • Molecular Formula : C50H60CaN2O10

  • Molecular Weight : 889.11

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Details 
stdClass Object
(
    [pname] => rel-4-((3R,5S)-5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoic Acid
    [catalogue_number] => PA 19 0661077
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 365.43
    [form] => C22H23NO4
    [cas] => 2216746-87-9
    [pslug] => 2216746-87-9-rel-4-3r-5s-5-1-1-biphenyl-4-ylmethyl-3-methyl-2-oxopyrrolidin-1-yl-4-oxobutanoic-acid-pa190661077
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PA 19 0661077

rel-4-((3R,5S)-5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoic Acid

  • Catalogue No.:PA 19 0661077

  • CAS :

    2216746-87-9

  • Molecular Formula : C22H23NO4

  • Molecular Weight : 365.43

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Details 
stdClass Object
(
    [pname] => Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(4-ethoxy-4-oxobutanamido)-2-methylpentanoate
    [catalogue_number] => PA 19 0661078
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 439.55
    [form] => C26H33NO5
    [cas] => 2376611-98-0
    [pslug] => 2376611-98-0-ethyl-2r-4s-5-1-1-biphenyl-4-yl-4-4-ethoxy-4-oxobutanamido-2-methylpentanoate-pa190661078
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PA 19 0661078

Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(4-ethoxy-4-oxobutanamido)-2-methylpentanoate

  • Catalogue No.:PA 19 0661078

  • CAS :

    2376611-98-0

  • Molecular Formula : C26H33NO5

  • Molecular Weight : 439.55

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Details 
stdClass Object
(
    [pname] => Cyclohexane, (2-bromoethoxy)
    [catalogue_number] => PA 19 0661079
    [category_ids] => ,171,80,75,70,82,78,
    [chemical_name] => 
    [weight] => 207.11
    [form] => C8H15BrO
    [cas] => 131665-94-6
    [pslug] => 131665-94-6-cyclohexane-2-bromoethoxy-pa190661079
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PA 19 0661079

Cyclohexane, (2-bromoethoxy)

  • Catalogue No.:PA 19 0661079

  • CAS :

    131665-94-6

  • Molecular Formula : C8H15BrO

  • Molecular Weight : 207.11

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Details 
stdClass Object
(
    [pname] => (R)-2-Amino-3-(4-iodophenyl)propan-1-ol
    [catalogue_number] => PA 19 0661080
    [category_ids] => ,80,75,70,82,78,
    [chemical_name] => 
    [weight] => 277.11
    [form] => C9H12INO
    [cas] => 210554-97-5
    [pslug] => 210554-97-5-r-2-amino-3-4-iodophenyl-propan-1-ol-pa190661080
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PA 19 0661080

(R)-2-Amino-3-(4-iodophenyl)propan-1-ol

  • Catalogue No.:PA 19 0661080

  • CAS :

    210554-97-5

  • Molecular Formula : C9H12INO

  • Molecular Weight : 277.11

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Details 
stdClass Object
(
    [pname] => tert-Butyl (R)-(1-hydroxy-3-(4-iodophenyl)propan-2-yl)carbamate
    [catalogue_number] => PA 19 0661081
    [category_ids] => ,80,75,70,82,78,
    [chemical_name] => 
    [weight] => 377.22
    [form] => C14H20INO3
    [cas] => 210962-92-8
    [pslug] => 210962-92-8-tert-butyl-r-1-hydroxy-3-4-iodophenyl-propan-2-yl-carbamate-pa190661081
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PA 19 0661081

tert-Butyl (R)-(1-hydroxy-3-(4-iodophenyl)propan-2-yl)carbamate

  • Catalogue No.:PA 19 0661081

  • CAS :

    210962-92-8

  • Molecular Formula : C14H20INO3

  • Molecular Weight : 377.22

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Details 
stdClass Object
(
    [pname] => 5-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-5-oxopentanoic Acid
    [catalogue_number] => PA 19 0661082
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 425.53
    [form] => C25H31NO5
    [cas] => 773820-89-6
    [pslug] => 773820-89-6-5-2s-4r-1-1-1-biphenyl-4-yl-5-ethoxy-4-methyl-5-oxopentan-2-yl-amino-5-oxopentanoic-acid-pa190661082
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PA 19 0661082

5-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-5-oxopentanoic Acid

  • Catalogue No.:PA 19 0661082

  • CAS :

    773820-89-6

  • Molecular Formula : C25H31NO5

  • Molecular Weight : 425.53

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Details 
stdClass Object
(
    [pname] => Methyl 4-([1,1'-biphenyl]-4-yl)-3-oxobutanoate
    [catalogue_number] => PA 19 0661083
    [category_ids] => ,80,75,70,82,78,
    [chemical_name] => 
    [weight] => 268.31
    [form] => C17H16O3
    [cas] => 100160-75-6
    [pslug] => 100160-75-6-methyl-4-1-1-biphenyl-4-yl-3-oxobutanoate-pa190661083
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PA 19 0661083

Methyl 4-([1,1'-biphenyl]-4-yl)-3-oxobutanoate

  • Catalogue No.:PA 19 0661083

  • CAS :

    100160-75-6

  • Molecular Formula : C17H16O3

  • Molecular Weight : 268.31

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Details 
stdClass Object
(
    [pname] => 5-([1,1'-Biphenyl]-4-yl)-2-methylene-4-oxopentanoic Acid
    [catalogue_number] => PA 19 0661084
    [category_ids] => ,80,75,70,82,78,
    [chemical_name] => 
    [weight] => 280.32
    [form] => C18H16O3
    [cas] => 2454675-99-9
    [pslug] => 2454675-99-9-5-1-1-biphenyl-4-yl-2-methylene-4-oxopentanoic-acid-pa190661084
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PA 19 0661084

5-([1,1'-Biphenyl]-4-yl)-2-methylene-4-oxopentanoic Acid

  • Catalogue No.:PA 19 0661084

  • CAS :

    2454675-99-9

  • Molecular Formula : C18H16O3

  • Molecular Weight : 280.32

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Details 
stdClass Object
(
    [pname] => Ethyl 5-([1,1'-biphenyl]-4-yl)-4-hydroxy-2-methylenepentanoate
    [catalogue_number] => PA 19 0661085
    [category_ids] => ,80,75,70,82,78,
    [chemical_name] => 
    [weight] => 310.39
    [form] => C20H22O3
    [cas] => 3059070-67-3
    [pslug] => 3059070-67-3-ethyl-5-1-1-biphenyl-4-yl-4-hydroxy-2-methylenepentanoate-pa190661085
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PA 19 0661085

Ethyl 5-([1,1'-biphenyl]-4-yl)-4-hydroxy-2-methylenepentanoate

  • Catalogue No.:PA 19 0661085

  • CAS :

    3059070-67-3

  • Molecular Formula : C20H22O3

  • Molecular Weight : 310.39

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Details 
stdClass Object
(
    [pname] => Ethyl 5-([1,1'-biphenyl]-4-yl)-2-methylene-4-oxopentanoate
    [catalogue_number] => PA 19 0661086
    [category_ids] => ,80,75,70,82,78,
    [chemical_name] => 
    [weight] => 308.38
    [form] => C20H20O3
    [cas] => 3038727-90-8
    [pslug] => 3038727-90-8-ethyl-5-1-1-biphenyl-4-yl-2-methylene-4-oxopentanoate-pa190661086
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PA 19 0661086

Ethyl 5-([1,1'-biphenyl]-4-yl)-2-methylene-4-oxopentanoate

  • Catalogue No.:PA 19 0661086

  • CAS :

    3038727-90-8

  • Molecular Formula : C20H20O3

  • Molecular Weight : 308.38

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Details 
stdClass Object
(
    [pname] => Ethyl 5-([1,1'-biphenyl]-4-yl)-2-methyl-4-oxopent-2-enoate
    [catalogue_number] => PA 19 0661087
    [category_ids] => ,80,75,70,82,78,
    [chemical_name] => 
    [weight] => 308.38
    [form] => C20H20O3
    [cas] => 3038727-89-5
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PA 19 0661087

Ethyl 5-([1,1'-biphenyl]-4-yl)-2-methyl-4-oxopent-2-enoate

  • Catalogue No.:PA 19 0661087

  • CAS :

    3038727-89-5

  • Molecular Formula : C20H20O3

  • Molecular Weight : 308.38

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