Catalogue number: | PA 27 0031380 |
Chemical name: | DC41SMe |
CAS Number: |
1354787-71-5 |
Category: | miscellaneous compounds,Antibody Drug Conjugate |
Synonyms: | (S)-N-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-1H-indol-5-yl)-5-(4-methyl-4-(methyldisulfaneyl)pentanamido)-1H-indole-2-carboxamide; 1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[4-methyl-4-(methyldithio)-1-oxopentyl]amino]-; N-[2-[[(1S)-1-(Chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[4-methyl-4-(methyldithio)-1-oxopentyl]amino]-1H-indole-2-carboxamide; |
Molecular form: | C38H36ClN5O4S2 |
Appearance: | NA |
Mol. Weight: | 726.31 |
Storage: | 2-8°C Refrigerator |
Shipping Conditions: | Ambient |
Applications: | DC41SMe, a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC50s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer |
DC41SMe
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