| Catalogue number: | PA 20 4060000 |
| Chemical name: | Thailanstatin A |
CAS Number: |
1426953-21-0 |
| Category: | Fine Chemicals,pharmaceutical standards,intermediates,Antibody Drug Conjugate |
| Synonyms: | 2-((3R,5S,7R,8R)-7-((1E,3E)-5-((2S,3S,5R,6R)-5-((S,Z)-4-acetoxypent-2-enamido)-3,6-dimethyltetrahydro-2H-pyran-2-yl)-3-methylpenta-1,3-dien-1-yl)-8-hydroxy-1,6-dioxaspiro[2.5]octan-5-yl)acetic acid; 1,6-Dioxaspiro[2.5]octane-5-acetic acid, 7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-8-hydroxy-, (3R,5S,7R,8R)-; (3R,5S,7R,8R)-7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(Acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-8-hydroxy-1,6-dioxaspiro[2.5]octane-5-acetic acid; |
| Molecular form: | C28H41NO9 |
| Appearance: | Solid |
| Mol. Weight: | 535.63 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC |
Thailanstatin A
Thailanstatin A
Enquire for Thailanstatin A
Order Product
Related Products
EVENTS
Search by Keywords – Buy 1426953-21-0 | Purchase 1426953-21-0 | Order 1426953-21-0 | Enquire 1426953-21-0 | Price of 1426953-21-0 | 1426953-21-0 Cost | 1426953-21-0 Supplier | 1426953-21-0 Distributor | 1426953-21-0 Manufacturer | 1426953-21-0 Exporter
