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Catalogue number: PA 27 0033085
Chemical name: MYX1715

CAS Number:

2445448-66-6

Category: miscellaneous compounds,Antibody Drug Conjugate
Synonyms:

4-(2-(2-(3-(2-Aminoethyl)imidazo[1,2-a]pyridin-6-yl)-5-chlorophenoxy)ethyl)-N,N,1,5-tetramethyl-1H-pyrazole-3-carboxamide; 1H-Pyrazole-3-carboxamide, 4-[2-[2-[3-(2-aminoethyl)imidazo[1,2-a]pyridin-6-yl]-5-chlorophenoxy]ethyl]-N,N,1,5-tetramethyl-; 4-[2-[2-[3-(2-Aminoethyl)imidazo[1,2-a]pyridin-6-yl]-5-chlorophenoxy]ethyl]-N,N,1,5-tetramethyl-1H-pyrazole-3-carboxamide;

Molecular form: C25H29ClN6O2
Appearance: Solid
Mol. Weight: 481
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: MYX1715 is an inhibitor of N-Myristoyltransferase (NMT) with a KD value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC50 values of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin

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