| Catalogue number: | PA 27 0020985 |
| Chemical name: | SAR131675 |
CAS Number: |
1092538-80-1 |
| Category: | miscellaneous compounds |
| Synonyms: | 2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; |
| Molecular form: | C18H22N4O4 |
| Appearance: | White to Pale Yellow Solid |
| Mol. Weight: | 358.4 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD. |
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