| Catalogue number: | PA 27 0020585 |
| Chemical name: | IWR-1 |
CAS Number: |
1127442-82-3 |
| Category: | miscellaneous compounds |
| Synonyms: | Rel-4-((3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide; |
| Molecular form: | C25H19N3O3 |
| Appearance: | NA |
| Mol. Weight: | 409.45 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b). Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis. |
| BTM: | NA |
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