Abacavir Sulfate - Impurity C (Freebase)

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Catalogue number: PA 01 01510
Chemical name: [(1S,4R)-4-(2,6-Diamino-9H-purin-9-yl)cyclopent-2-en-1- yl]methanol

CAS Number:


Category: intermediates,pharmaceutical standards,Fine Chemicals,bases and related reagents,nucleotides

(1S,4R)-4-(2,6-Diamino-9H-purin-9-yl)-2-cyclopentene-1-methanol; ((1S,4R)-4-(2,6-diamino-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol; Descyclopropyl Abacavir; [(1S,4R)-4-(2,6-Diamino-9H-purin-9-yl)cyclopent-2-enyl]methanol (USP);

Molecular form: C11H14N6O
Appearance: Off-White to Pale Yellow Solid
Mol. Weight: 246.27
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

[(1S,4R)-4-(2,6-Diamino-9H-purin-9-yl)cyclopent-2-en-1- yl]methanol

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